ATE200085T1 - Histidine und homohistidine derivate zur verwendung als protein farnesyltransferase hemmstoffe - Google Patents

Histidine und homohistidine derivate zur verwendung als protein farnesyltransferase hemmstoffe

Info

Publication number
ATE200085T1
ATE200085T1 AT95921421T AT95921421T ATE200085T1 AT E200085 T1 ATE200085 T1 AT E200085T1 AT 95921421 T AT95921421 T AT 95921421T AT 95921421 T AT95921421 T AT 95921421T AT E200085 T1 ATE200085 T1 AT E200085T1
Authority
AT
Austria
Prior art keywords
homohistidine
histidine
derivatives
transferase inhibitors
farnesyl transferase
Prior art date
Application number
AT95921421T
Other languages
English (en)
Inventor
Gary Louis Bolton
John Cooke Hodges
Michael William Wilson
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE200085T1 publication Critical patent/ATE200085T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT95921421T 1994-06-30 1995-05-30 Histidine und homohistidine derivate zur verwendung als protein farnesyltransferase hemmstoffe ATE200085T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/268,364 US5571792A (en) 1994-06-30 1994-06-30 Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
PCT/US1995/006660 WO1996000736A1 (en) 1994-06-30 1995-05-30 Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase

Publications (1)

Publication Number Publication Date
ATE200085T1 true ATE200085T1 (de) 2001-04-15

Family

ID=23022659

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95921421T ATE200085T1 (de) 1994-06-30 1995-05-30 Histidine und homohistidine derivate zur verwendung als protein farnesyltransferase hemmstoffe

Country Status (17)

Country Link
US (1) US5571792A (de)
EP (1) EP0767800B1 (de)
JP (1) JPH10502078A (de)
AT (1) ATE200085T1 (de)
AU (1) AU699629B2 (de)
CA (1) CA2190977A1 (de)
DE (1) DE69520499T2 (de)
DK (1) DK0767800T3 (de)
ES (1) ES2158115T3 (de)
GR (1) GR3035936T3 (de)
HR (1) HRP950337B1 (de)
MX (1) MX9605945A (de)
NO (1) NO315427B1 (de)
NZ (1) NZ287696A (de)
PT (1) PT767800E (de)
WO (1) WO1996000736A1 (de)
ZA (1) ZA955411B (de)

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US5756528A (en) * 1995-06-06 1998-05-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997002817A1 (en) * 1995-07-13 1997-01-30 University Of Cincinnati Compounds useful in the treatment of neurofibromatosis
US6008372A (en) * 1996-01-16 1999-12-28 Warner-Lambert Company Substituted dinaphthylmethyl and diheteroarylmethylacetyl histidine inhibitors of protein farnesyltransferase
EP0877610A4 (de) * 1996-01-30 1999-09-15 Merck & Co Inc Inhibitoren der farnesyl-protein transferase
AU703203B2 (en) * 1996-01-30 1999-03-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5981562A (en) * 1996-01-30 1999-11-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
AU704087B2 (en) * 1996-01-30 1999-04-15 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5968965A (en) * 1996-01-30 1999-10-19 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1997036584A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5922883A (en) * 1996-04-03 1999-07-13 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
IL126833A0 (en) * 1996-05-22 1999-08-17 Warner Lambert Co Inhibitors of protein farnesyl transferase
US6300501B1 (en) * 1996-05-22 2001-10-09 Warner-Lambert Company Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase
US6093816A (en) 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
DE69731003D1 (de) * 1996-07-01 2004-11-04 Lilly Co Eli Blutzuckersenkende und lipidsenkende verbindungen
US5977134A (en) * 1996-12-05 1999-11-02 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5932590A (en) * 1996-12-05 1999-08-03 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6015817A (en) * 1996-12-05 2000-01-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5972966A (en) * 1996-12-05 1999-10-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
PE46999A1 (es) * 1996-12-17 1999-05-20 Warner Lambert Co Inhibidores de cicloalquilo de la enzima farnesiltransferasa de las proteinas
US6265382B1 (en) * 1997-04-11 2001-07-24 Warner-Lambert Company Dipeptide inhibitors of protein farnesyltransferase
US6737410B1 (en) 1997-04-11 2004-05-18 Warner-Lambert Company Inhibitors of protein farnesyl transferase
US6060038A (en) * 1997-05-15 2000-05-09 Merck & Co., Inc. Radiolabeled farnesyl-protein transferase inhibitors
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NZ507165A (en) * 1998-04-27 2003-06-30 Warner Lambert Co Functionalized alkyl and alkenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors
GEP20032996B (en) 1998-05-12 2003-06-25 Warner Lambert Co Combinations of Protein Farnesyltransferase and HMG CoA Reductase Inhibitors, Pharmaceutical Compositions and Methods for Treatment
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Also Published As

Publication number Publication date
ES2158115T3 (es) 2001-09-01
US5571792A (en) 1996-11-05
HRP950337B1 (en) 2001-12-31
MX9605945A (es) 1997-12-31
DK0767800T3 (da) 2001-06-18
CA2190977A1 (en) 1996-01-11
WO1996000736A1 (en) 1996-01-11
NZ287696A (en) 1997-12-19
DE69520499D1 (de) 2001-05-03
PT767800E (pt) 2001-08-30
HRP950337A2 (en) 1997-08-31
NO315427B1 (no) 2003-09-01
AU2650495A (en) 1996-01-25
EP0767800A1 (de) 1997-04-16
DE69520499T2 (de) 2001-07-26
NO965604D0 (no) 1996-12-27
JPH10502078A (ja) 1998-02-24
GR3035936T3 (en) 2001-08-31
EP0767800B1 (de) 2001-03-28
NO965604L (no) 1997-02-25
ZA955411B (en) 1996-02-05
AU699629B2 (en) 1998-12-10

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