PE46999A1 - Inhibidores de cicloalquilo de la enzima farnesiltransferasa de las proteinas - Google Patents
Inhibidores de cicloalquilo de la enzima farnesiltransferasa de las proteinasInfo
- Publication number
- PE46999A1 PE46999A1 PE1997001119A PE00111997A PE46999A1 PE 46999 A1 PE46999 A1 PE 46999A1 PE 1997001119 A PE1997001119 A PE 1997001119A PE 00111997 A PE00111997 A PE 00111997A PE 46999 A1 PE46999 A1 PE 46999A1
- Authority
- PE
- Peru
- Prior art keywords
- proteins
- enzyme
- inhibitors
- farnesil
- transferase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA A-N(R1)-C(R2)(CH2-RQ)-CONR3-CH(R14)-CONR4R5, EN DONDE: RQ ES -(CH2)x-IMIDAZOL-4IL OPCIONALMENTE SUSTITUIDO EN N POR ALQUILO C1-C6; x ES 0 o 1; "A" ES CORa, CO2Ra`, CONHRa', ENTRE OTROS; Ra Y Ra' SON ALQUILO C1-C6, CICLOALQUILO-(CR14R14)m, ARIL-(CR14R14)m o HETEROARIL-(CR14R14)m; m ES 0-3; R1, R2 Y R4 SON H o ALQUILO C1-C6; R3 ES ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R5 ES CRcRd-CICLOALQUILO(C3-C5)-FENILO SUSTITUIDO CON Rg, Rh Y Ri o CRcRd-CICLOALQUILO(C3-C5)-HETEROARILO SUSTITUIDO CON Rg, Rh Y Ri; n ES 2-4; Ri, Rg Y Rh SON H, HALOGENO, ALQUILO C1-C6, CN, OPO3H2, CH2PO3H2, O-FENIL, ENTRE OTROS; Rc Y Rd SON ALQUILO C1-C6, (CH2)m-CICLOALQUILO o H. TAMBIEN SE REFIERE A LOS COMPUESTOS DE FORMULA (II), EN DONDE: R6 ES O-BENCIL, OCH(ALQUILO C1-C6)-FENIL, NH-BENCIL, ENTRE OTROS; R8 ES H, HALOGENO, ALQUILO C1-C6, O-BENCILO; R10 Y R13 SON H o ALQUILO C1-C6; R12 ES FENILO SUSTITUIDO CON Rj, Rk, Rl o PIRIDINA-2-IL; R14 ES H o CH3; Rj, Rk Y Rl SON H, NHRa, HALOGENO, ENTRE OTROS. ADEMAS SE REFIERE A LOS COMPUESTO DE FORMULA (III), EN DONDE: n ES 2-4; "X" ES NH, O, NCH3; R15 ES O-BENCIL, CF3, H, HALOGENO, OH, FENIL, ALQUILO C1-C6, CH2-O-PIRIDILO o O-ALQUILO C1-C6. ESTOS COMPUESTOS ACTUAN INHIBIENDO LA ENZIMA FARNESIL PROTEINA TRANSFERASA (FPT), SIENDO UTILES EN EL TRATAMIENTO DEL CANCER, PSORIASIS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3366196P | 1996-12-17 | 1996-12-17 | |
| US5683197P | 1997-08-22 | 1997-08-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE46999A1 true PE46999A1 (es) | 1999-05-20 |
Family
ID=26709973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997001119A PE46999A1 (es) | 1996-12-17 | 1997-12-16 | Inhibidores de cicloalquilo de la enzima farnesiltransferasa de las proteinas |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6281194B1 (es) |
| EP (1) | EP0951471B1 (es) |
| JP (1) | JP2001506265A (es) |
| KR (1) | KR20000057601A (es) |
| AT (1) | ATE261987T1 (es) |
| AU (1) | AU721786C (es) |
| BR (1) | BR9713744A (es) |
| CA (1) | CA2264207A1 (es) |
| CO (1) | CO4920227A1 (es) |
| DE (1) | DE69728165T2 (es) |
| DK (1) | DK0951471T3 (es) |
| ES (1) | ES2216189T3 (es) |
| HR (1) | HRP970693B1 (es) |
| ID (1) | ID19142A (es) |
| IL (1) | IL128546A0 (es) |
| NO (1) | NO992933D0 (es) |
| NZ (1) | NZ334702A (es) |
| PE (1) | PE46999A1 (es) |
| PT (1) | PT951471E (es) |
| TW (1) | TW552259B (es) |
| WO (1) | WO1998027109A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001506265A (ja) | 1996-12-17 | 2001-05-15 | ワーナー−ランバート・コンパニー | タンパク質ファルネシルトランスフェラーゼのシクロアルキル阻害剤 |
| US6369034B1 (en) * | 1998-04-27 | 2002-04-09 | Warner-Lambert Company | Functionalized alkyl and alenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors |
| US6455734B1 (en) * | 2000-08-09 | 2002-09-24 | Magnesium Diagnostics, Inc. | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states |
| AU2007229363B2 (en) * | 2001-08-24 | 2009-06-04 | University Of South Florida | Piperazinone Compounds as Anti-Tumor and Anti-Cancer Agents and the Methods of Treatment |
| JP2005504771A (ja) * | 2001-08-24 | 2005-02-17 | エール ユニヴァーシティ | 抗腫瘍・抗癌剤としてのピペラジノン化合物と処置方法 |
| WO2005049589A2 (en) * | 2003-10-14 | 2005-06-02 | Cadila Healthcare Limited | Heterocyclic compounds for the treatment of hyperlipidemia, diabetes, obesity and similar diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3597863B2 (ja) | 1993-11-05 | 2004-12-08 | ワーナー−ランバート・コンパニー | タンパク質：ファルネシルトランスフェラーゼの置換されたジ‐およびトリペプチド阻害剤 |
| US5571792A (en) | 1994-06-30 | 1996-11-05 | Warner-Lambert Company | Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase |
| JP2001506265A (ja) | 1996-12-17 | 2001-05-15 | ワーナー−ランバート・コンパニー | タンパク質ファルネシルトランスフェラーゼのシクロアルキル阻害剤 |
-
1997
- 1997-12-16 JP JP52794298A patent/JP2001506265A/ja not_active Abandoned
- 1997-12-16 EP EP97954575A patent/EP0951471B1/en not_active Expired - Lifetime
- 1997-12-16 AT AT97954575T patent/ATE261987T1/de not_active IP Right Cessation
- 1997-12-16 IL IL12854697A patent/IL128546A0/xx unknown
- 1997-12-16 CO CO97073366A patent/CO4920227A1/es unknown
- 1997-12-16 AU AU58990/98A patent/AU721786C/en not_active Ceased
- 1997-12-16 DK DK97954575T patent/DK0951471T3/da active
- 1997-12-16 WO PCT/US1997/023280 patent/WO1998027109A1/en not_active Application Discontinuation
- 1997-12-16 NZ NZ334702A patent/NZ334702A/xx unknown
- 1997-12-16 PE PE1997001119A patent/PE46999A1/es not_active Application Discontinuation
- 1997-12-16 US US09/319,422 patent/US6281194B1/en not_active Expired - Fee Related
- 1997-12-16 DE DE69728165T patent/DE69728165T2/de not_active Expired - Fee Related
- 1997-12-16 PT PT97954575T patent/PT951471E/pt unknown
- 1997-12-16 ES ES97954575T patent/ES2216189T3/es not_active Expired - Lifetime
- 1997-12-16 KR KR1019990705384A patent/KR20000057601A/ko not_active Application Discontinuation
- 1997-12-16 CA CA002264207A patent/CA2264207A1/en not_active Abandoned
- 1997-12-16 BR BR9713744A patent/BR9713744A/pt not_active Application Discontinuation
- 1997-12-17 HR HR970693A patent/HRP970693B1/xx not_active IP Right Cessation
- 1997-12-17 ID IDP973902A patent/ID19142A/id unknown
-
1998
- 1998-05-26 TW TW086119079A patent/TW552259B/zh active
-
1999
- 1999-06-16 NO NO992933A patent/NO992933D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2216189T3 (es) | 2004-10-16 |
| DK0951471T3 (da) | 2004-07-19 |
| WO1998027109A1 (en) | 1998-06-25 |
| TW552259B (en) | 2003-09-11 |
| HRP970693B1 (en) | 2002-06-30 |
| JP2001506265A (ja) | 2001-05-15 |
| PT951471E (pt) | 2004-08-31 |
| KR20000057601A (ko) | 2000-09-25 |
| AU721786B2 (en) | 2000-07-13 |
| HRP970693A2 (en) | 1998-10-31 |
| BR9713744A (pt) | 2000-03-21 |
| NZ334702A (en) | 2000-11-24 |
| IL128546A0 (en) | 2000-01-31 |
| CA2264207A1 (en) | 1998-06-25 |
| DE69728165T2 (de) | 2005-01-20 |
| CO4920227A1 (es) | 2000-05-29 |
| NO992933L (no) | 1999-06-16 |
| NO992933D0 (no) | 1999-06-16 |
| ID19142A (id) | 1998-06-18 |
| EP0951471A1 (en) | 1999-10-27 |
| AU5899098A (en) | 1998-07-15 |
| AU721786C (en) | 2001-08-02 |
| ATE261987T1 (de) | 2004-04-15 |
| US6281194B1 (en) | 2001-08-28 |
| DE69728165D1 (de) | 2004-04-22 |
| EP0951471B1 (en) | 2004-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |