HRP20230420T1 - Pripravak - Google Patents
Pripravak Download PDFInfo
- Publication number
- HRP20230420T1 HRP20230420T1 HRP20230420TT HRP20230420T HRP20230420T1 HR P20230420 T1 HRP20230420 T1 HR P20230420T1 HR P20230420T T HRP20230420T T HR P20230420TT HR P20230420 T HRP20230420 T HR P20230420T HR P20230420 T1 HRP20230420 T1 HR P20230420T1
- Authority
- HR
- Croatia
- Prior art keywords
- nicotine
- inhalation
- solvent
- carbon dioxide
- weight
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 12
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 21
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 15
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 15
- 229960002715 nicotine Drugs 0.000 claims 15
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 15
- 239000002904 solvent Substances 0.000 claims 13
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 12
- 239000001569 carbon dioxide Substances 0.000 claims 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000003571 electronic cigarette Substances 0.000 claims 4
- 239000006185 dispersion Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/241—Extraction of specific substances
- A24B15/243—Nicotine
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/281—Treatment of tobacco products or tobacco substitutes by chemical substances the action of the chemical substances being delayed
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/287—Treatment of tobacco products or tobacco substitutes by chemical substances by inorganic substances only
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
- A24F40/42—Cartridges or containers for inhalable precursors
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Manufacture Of Tobacco Products (AREA)
- Confectionery (AREA)
Claims (16)
1. Pripravak za inhalaciju, pogodan za uporabu u elektroničkoj cigareti, koja sadrži najmanje 1 g/L nikotina i najmanje 2 g/L ugljičnog dioksida otopljenog ili raspršenog u otapalu koje sadrži glicerol i vodu, naznačen time što je molarni omjer ugljičnog dioksida prema nikotinu najmanje 0.1:1;
pri čemu je glicerol prisutan u količini od najmanje 40% po težini, temeljeno na ukupnoj težini pripravka za inhalaciju;
pri čemu je voda prisutna u količini od 1-20% po težini, temeljeno na ukupnoj težini pripravka za inhalaciju;
i
pri čemu je propilen glikol, kada je prisutan, prisutan u količini ne većoj od 10% po težini, temeljeno na ukupnoj težini pripravka za inhalaciju.
2. Pripravak prema zahtjevu 1, sadrži 1-60 g/L nikotina, poželjno 5-60 g/L nikotina.
3. Pripravak prema bilo kojem prethodnom zahtjevu, sadrži 2-40 g/L ugljičnog dioksida.
4. Pripravak prema bilo kojem prethodnom zahtjevu, naznačen time što je molarni omjer ugljičnog dioksida prema nikotinu u rasponu od 0.1:1 do 10:1, poželjno 0.25 do 7.5:1, poželjnije 0.4:1 do 5:1.
5. Pripravak prema zahtjevu 1, naznačen time što je propilen glikol, kada je prisutan, prisutan u količini ne većoj od 5% po težini, temeljeno na ukupnoj težini pripravka za inhalaciju.
6. Pripravak prema zahtjevu 1, naznačen time što otapalo sadrži glicerol u količini od najmanje 50%, poželjno najmanje 60%, poželjnije najmanje 70% po težini temeljeno na ukupnoj težini pripravka za inhalaciju.
7. Pripravak prema bilo kojem od zahtjeva 1-6, naznačen time što je voda prisutna u količini od 1-15% po težini, poželjno 1-10% po težini, temeljeno na ukupnoj težini pripravka za inhalaciju.
8. Pripravak prema bilo kojem prethodnom zahtjevu, naznačen time što pripravak sadrži manje od 10 g/L zapaljivog otapala kao što je etanol, poželjno pri čemu pripravak ne sadrži zapaljivo otapalo kao što je etanol.
9. Pripravak prema bilo kojem prethodnom zahtjevu nadalje sadrži jedan ili više spojeva za poboljšanje okusa.
10. Uložak prikladan za uporabu s uređajem za elektroničku cigaretu, navedeni uložak sadrži pripravak za inhalaciju prema bilo kojem od zahtjeva 1-9.
11. Uređaj za elektroničku cigaretu koji sadrži uložak prema zahtjevu 10.
12. Postupak za izradu pripravka za inhalaciju prema bilo kojem od zahtjeva 1-9, sadrži korake
dodavanja najmanje 1 g/L nikotina u otapalo koje sadrži glicerol i vodu unutar posude koja se može zatvoriti da se dobije otopina ili disperzija nikotina; i uvođenje ugljičnog dioksida u posudu tako da je tlak unutar posude u rasponu od 1 do 15 atmosfera mjereno na 20 °C, tako da se najmanje 2 g/L ugljičnog dioksida otopi ili rasprši u otapalu, i tako da je molarni omjer ugljičnog dioksida i nikotina najmanje 0.1:1; gdje je glicerol prisutan u količini od najmanje 40% po težini, temeljeno na ukupnoj težini pripravka za inhalaciju;
pri čemu je voda prisutna u količini od 1-20% po težini, temeljeno na ukupnoj težini pripravka za inhalaciju;
i
pri čemu je propilen glikol, kada je prisutan, prisutan u količini ne većoj od 10% po težini, temeljeno na ukupnoj težini pripravka za inhalaciju.
13. Pripravak za inhalaciju, pogodan za uporabu u elektroničkoj cigareti, koji sadrži najmanje 1 g/L nikotina i najmanje 0.027 g/L ugljičnog dioksida otopljenog ili raspršenog u otapalu, pri čemu je molarni omjer ugljičnog dioksida i nikotina najmanje 0.025:1, pri čemu otapalo sadrži najviše 5% volumena vode u odnosu na ukupan volumen otapala.
14. Pripravak prema zahtjevu 13, koji nadalje sadrži 1-60 g/L nikotina, poželjno najmanje 3 g/L nikotina, poželjnije pri čemu otapalo sadrži glicerol, ili propilen glikol, ili vodu, ili njihove mješavine.
15. Pripravak prema zahtjevu 14, naznačen time što je udio glicerola u odnosu na propilen glikol prisutan u otapalu u rasponu od 95:5 do 5:95 po volumenu, poželjno 80:20 do 20:80 po volumenu, poželjnije 70:30 do 30:70 po volumenu.
16. Postupak za izradu pripravka za inhalaciju prema bilo kojem od zahtjeva 13-15, koji sadrži korake
dodavanje najmanje 1 g/L nikotina u otapalo unutar posude koja se može zatvoriti da se dobije otopina ili disperzija nikotina; i
uvođenje ugljičnog dioksida u posudu tako da je tlak unutar posude u rasponu od 1 do 15 atmosfera mjereno na 20 °C, tako da se najmanje 0.027 g/L ugljičnog dioksida otopi ili rasprši u otapalu, i tako da je molarni omjer ugljičnog dioksida i nikotina najmanje 0.025:1.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18202355 | 2018-10-24 | ||
| EP19175946 | 2019-05-22 | ||
| EP19794142.0A EP3840596B1 (en) | 2018-10-24 | 2019-10-23 | Composition |
| PCT/EP2019/078957 WO2020084024A1 (en) | 2018-10-24 | 2019-10-23 | Composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20230420T1 true HRP20230420T1 (hr) | 2023-07-07 |
Family
ID=68342927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20230420TT HRP20230420T1 (hr) | 2018-10-24 | 2019-10-23 | Pripravak |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11684080B2 (hr) |
| EP (1) | EP3840596B1 (hr) |
| JP (2) | JP7177926B2 (hr) |
| KR (2) | KR20210154875A (hr) |
| CN (1) | CN112739223B (hr) |
| AU (1) | AU2019365396B2 (hr) |
| BR (1) | BR122022014023B1 (hr) |
| CA (1) | CA3111709C (hr) |
| DK (1) | DK3840596T3 (hr) |
| ES (1) | ES2943840T3 (hr) |
| FI (1) | FI3840596T3 (hr) |
| GB (2) | GB2583851B (hr) |
| HR (1) | HRP20230420T1 (hr) |
| HU (1) | HUE061610T2 (hr) |
| LT (1) | LT3840596T (hr) |
| MX (1) | MX2021004564A (hr) |
| PL (1) | PL3840596T3 (hr) |
| RS (1) | RS64142B1 (hr) |
| SI (1) | SI3840596T1 (hr) |
| WO (1) | WO2020084024A1 (hr) |
| ZA (1) | ZA202102675B (hr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11690396B2 (en) | 2018-10-24 | 2023-07-04 | Zanoprima Lifesciences Limited | Electronic cigarette compositions, devices, and related methods |
| CA3111709C (en) | 2018-10-24 | 2022-01-18 | Zanoprima Lifesciences Limited | Composition |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3878580A (en) | 1969-02-06 | 1975-04-22 | Rayette Faberge | Brush |
| US4830028A (en) | 1987-02-10 | 1989-05-16 | R. J. Reynolds Tobacco Company | Salts provided from nicotine and organic acid as cigarette additives |
| US20040013752A1 (en) * | 2002-07-05 | 2004-01-22 | Wolfson Philip E. | Buccal and sublingual mucosally absorbed herbal compositions for relieving nicotine withdrawal symptoms and craving for nicotine and nicotine containing substances |
| CN1206946C (zh) * | 2003-02-11 | 2005-06-22 | 中国科学技术大学 | 无烟香烟及其制备方法 |
| GB0712308D0 (en) * | 2007-06-25 | 2007-08-01 | Kind Group Ltd | An inhalable composition |
| KR101208473B1 (ko) * | 2011-07-25 | 2012-12-05 | 장남숙 | 전자 담배용 무화용액 조성물 |
| US9326547B2 (en) | 2012-01-31 | 2016-05-03 | Altria Client Services Llc | Electronic vaping article |
| CN103371430A (zh) * | 2012-04-26 | 2013-10-30 | 北京创业恒基国际贸易有限公司 | 香烟吸入剂及其制备、应用 |
| CN111729161A (zh) * | 2012-11-28 | 2020-10-02 | 方特慕控股第一私人有限公司 | 用于化合物递送的方法和设备 |
| US10034988B2 (en) * | 2012-11-28 | 2018-07-31 | Fontem Holdings I B.V. | Methods and devices for compound delivery |
| US20140216237A1 (en) * | 2013-02-05 | 2014-08-07 | David Larry Butler | Suppressor For Firearm |
| EP2993999B1 (en) | 2013-05-06 | 2021-01-27 | Juul Labs, Inc. | Nicotine salt formulations for electronic cigarettes and method of delivering nicotine |
| EP3073846B1 (en) * | 2013-05-22 | 2023-07-05 | Njoy, Inc. | Compositions, devices, and methods for nicotine aerosol delivery |
| US10660365B2 (en) * | 2013-07-19 | 2020-05-26 | Altria Client Services Llc | Liquid aerosol formulation of an electronic smoking article |
| CN103720030B (zh) * | 2013-12-13 | 2015-08-05 | 浙江中烟工业有限责任公司 | 一种利用烟末提取物制备的电子烟烟液及其制备方法 |
| CN103989244B (zh) * | 2014-06-06 | 2016-10-05 | 山东中烟工业有限责任公司 | 一种中式电子烟烟液及其制备方法 |
| CN103989245B (zh) * | 2014-06-06 | 2015-08-05 | 山东中烟工业有限责任公司 | 一种有效降低口腔甜腻感的中式烤烟香型电子烟烟液 |
| KR101623426B1 (ko) * | 2014-07-14 | 2016-05-23 | (주)아이비허브 | 무화기용 액상 조성물 및 그의 제조방법 |
| GB2528673B (en) * | 2014-07-25 | 2020-07-01 | Nicoventures Holdings Ltd | Aerosol provision system |
| ES2964622T3 (es) * | 2014-09-30 | 2024-04-08 | Philip Morris Products Sa | Recuperación de los constituyentes del tabaco a partir del procesamiento |
| WO2016050244A1 (en) * | 2014-10-03 | 2016-04-07 | Fertin Pharma A/S | Electronic nicotine delivery system |
| CA2963722C (en) * | 2014-12-15 | 2019-12-03 | Philip Morris Products S.A. | Continuous mode heater assembly for aerosol-generating system |
| KR20160097425A (ko) * | 2015-02-06 | 2016-08-18 | 홍종국 | 전자담배용 액상 조성물 및 그의 제조 방법 |
| KR20160119459A (ko) * | 2015-04-06 | 2016-10-14 | (주)에스제이바이오텍 | 전자담배액 조성물 |
| KR20160119549A (ko) * | 2015-04-06 | 2016-10-14 | 주식회사 모바일컨버전스 | 네트워크 ｖｐｎ 기반의 네트워크 가상화 시스템 |
| GB201521626D0 (en) * | 2015-12-08 | 2016-01-20 | British American Tobacco Co | Tobacco composition |
| CN105581378B (zh) | 2016-03-17 | 2018-05-18 | 云南中烟工业有限责任公司 | 一种自生气体超声雾化电子烟气传输系统 |
| US20190116863A1 (en) * | 2017-10-24 | 2019-04-25 | Rai Strategic Holdings, Inc. | Method for formulating aerosol precursor for aerosol delivery device |
| US11388924B2 (en) * | 2018-02-02 | 2022-07-19 | 10150703 Canada Inc. | Nicotine ion pair formulation neutralized with CO2 and process therefor |
| CA3111709C (en) | 2018-10-24 | 2022-01-18 | Zanoprima Lifesciences Limited | Composition |
-
2019
- 2019-10-23 CA CA3111709A patent/CA3111709C/en active Active
- 2019-10-23 KR KR1020217040597A patent/KR20210154875A/ko active IP Right Grant
- 2019-10-23 DK DK19794142.0T patent/DK3840596T3/da active
- 2019-10-23 LT LTEPPCT/EP2019/078957T patent/LT3840596T/lt unknown
- 2019-10-23 EP EP19794142.0A patent/EP3840596B1/en active Active
- 2019-10-23 HU HUE19794142A patent/HUE061610T2/hu unknown
- 2019-10-23 WO PCT/EP2019/078957 patent/WO2020084024A1/en active Application Filing
- 2019-10-23 MX MX2021004564A patent/MX2021004564A/es unknown
- 2019-10-23 JP JP2021523242A patent/JP7177926B2/ja active Active
- 2019-10-23 BR BR122022014023-8A patent/BR122022014023B1/pt active IP Right Grant
- 2019-10-23 FI FIEP19794142.0T patent/FI3840596T3/fi active
- 2019-10-23 SI SI201930523T patent/SI3840596T1/sl unknown
- 2019-10-23 CN CN201980060295.2A patent/CN112739223B/zh active Active
- 2019-10-23 PL PL19794142.0T patent/PL3840596T3/pl unknown
- 2019-10-23 GB GB2010926.0A patent/GB2583851B/en active Active
- 2019-10-23 US US17/279,003 patent/US11684080B2/en active Active
- 2019-10-23 ES ES19794142T patent/ES2943840T3/es active Active
- 2019-10-23 HR HRP20230420TT patent/HRP20230420T1/hr unknown
- 2019-10-23 GB GB2010902.1A patent/GB2583657B/en active Active
- 2019-10-23 AU AU2019365396A patent/AU2019365396B2/en active Active
- 2019-10-23 KR KR1020217009611A patent/KR102350585B1/ko active IP Right Grant
- 2019-10-23 RS RS20230296A patent/RS64142B1/sr unknown
-
2021
- 2021-04-21 ZA ZA2021/02675A patent/ZA202102675B/en unknown
-
2022
- 2022-07-29 JP JP2022121295A patent/JP7457069B2/ja active Active
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