HRP20220332T1 - Farmaceutski pripravak koji sadrži drospirenon za uporabu kao kontraceptiv - Google Patents
Farmaceutski pripravak koji sadrži drospirenon za uporabu kao kontraceptiv Download PDFInfo
- Publication number
- HRP20220332T1 HRP20220332T1 HRP20220332TT HRP20220332T HRP20220332T1 HR P20220332 T1 HRP20220332 T1 HR P20220332T1 HR P20220332T T HRP20220332T T HR P20220332TT HR P20220332 T HRP20220332 T HR P20220332T HR P20220332 T1 HRP20220332 T1 HR P20220332T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutical preparation
- use according
- drospirenone
- dose unit
- active dose
- Prior art date
Links
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 title claims 12
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 title claims 12
- 229960004845 drospirenone Drugs 0.000 title claims 12
- 239000003433 contraceptive agent Substances 0.000 title claims 2
- 230000002254 contraceptive effect Effects 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 15
- 239000002245 particle Substances 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- 239000003826 tablet Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 238000007873 sieving Methods 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- 229960004977 anhydrous lactose Drugs 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 238000007922 dissolution test Methods 0.000 claims 1
- 239000003974 emollient agent Substances 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 238000000227 grinding Methods 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 229940057948 magnesium stearate Drugs 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 238000003801 milling Methods 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 239000000902 placebo Substances 0.000 claims 1
- 229940068196 placebo Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 229960001866 silicon dioxide Drugs 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10305708 | 2010-06-29 | ||
| US36839610P | 2010-07-28 | 2010-07-28 | |
| EP19209672.5A EP3632448B1 (en) | 2010-06-29 | 2011-06-28 | Pharmaceutical composition comprising drospirenone for use as a contraceptive |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220332T1 true HRP20220332T1 (hr) | 2022-05-13 |
Family
ID=42671710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220332TT HRP20220332T1 (hr) | 2010-06-29 | 2011-06-28 | Farmaceutski pripravak koji sadrži drospirenon za uporabu kao kontraceptiv |
Country Status (25)
| Country | Link |
|---|---|
| US (9) | US11452695B2 (enExample) |
| EP (3) | EP3632448B1 (enExample) |
| JP (1) | JP5810159B2 (enExample) |
| KR (3) | KR102164693B1 (enExample) |
| AR (1) | AR081670A1 (enExample) |
| BR (1) | BR112012033391B1 (enExample) |
| CA (3) | CA3003062C (enExample) |
| CY (2) | CY1122544T1 (enExample) |
| DK (1) | DK3632448T3 (enExample) |
| EA (1) | EA028680B1 (enExample) |
| ES (1) | ES2908657T3 (enExample) |
| FR (2) | FR20C1020I1 (enExample) |
| HR (1) | HRP20220332T1 (enExample) |
| HU (3) | HUE058176T2 (enExample) |
| LT (2) | LT3632448T (enExample) |
| NO (2) | NO2020015I1 (enExample) |
| NZ (1) | NZ605176A (enExample) |
| PE (2) | PE20130780A1 (enExample) |
| PH (1) | PH12012502499A1 (enExample) |
| PL (2) | PL2588114T3 (enExample) |
| PT (1) | PT3632448T (enExample) |
| RS (2) | RS63027B1 (enExample) |
| SI (2) | SI2588114T1 (enExample) |
| SM (2) | SMT202200129T1 (enExample) |
| WO (1) | WO2012000981A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR081670A1 (es) | 2010-06-29 | 2012-10-10 | Leon Farma Sa Lab | Composicion farmaceutica que comprende drospirenona y kit anticonceptivo |
| US10849857B2 (en) | 2010-07-28 | 2020-12-01 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
| US11351122B1 (en) | 2010-07-28 | 2022-06-07 | Laboratorios Leon Farma Sa | Synthetic progestogens and pharmaceutical compositions comprising the same |
| US9603860B2 (en) | 2010-07-28 | 2017-03-28 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
| EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
| CU24523B1 (es) | 2015-06-18 | 2021-06-08 | Estetra Sprl | Unidad de dosificación orodispersable que contiene un componente estetrol |
| MA44206B1 (fr) | 2015-06-18 | 2021-04-30 | Estetra Sprl | Comprimé orodispersible comprenant estetrol |
| EP3701944B1 (en) | 2015-06-18 | 2021-12-08 | Estetra SRL | Orodispersible dosage unit containing an estetrol component |
| LT3310345T (lt) | 2015-06-18 | 2021-06-25 | Estetra Sprl | Burnoje disperguojama tabletė, turinti estetrolio |
| JP6827962B2 (ja) * | 2015-06-23 | 2021-02-10 | ラボラトリオス レオン ファーマ エスエー | 過剰体重に影響される女性患者のためのドロスピレノン系避妊薬 |
| EP3108889A1 (en) | 2015-06-23 | 2016-12-28 | Philippe Perrin | Drospirenone-based contraceptive for a female patient affected with excess weight |
| CA3178291A1 (en) | 2016-08-05 | 2018-04-12 | Estetra Srl | Method for the management of dysmenorrhea and menstrual pain |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| EP3781171B1 (en) | 2018-04-19 | 2022-02-09 | Estetra SRL | Compounds and their uses for alleviating menopause-associated symptoms |
| TWI893101B (zh) | 2020-04-16 | 2025-08-11 | 比利時商埃斯特拉有限責任公司 | 具有降低之副作用之避孕組成物 |
| EP4134082A1 (en) | 2021-08-12 | 2023-02-15 | Chemo Research, S.L. | Method for treating endometriosis and providing effective contraception |
| WO2023152658A1 (en) | 2022-02-10 | 2023-08-17 | Lupin Limited | Slow release drospirenone tablet composition |
| EP4486311A1 (en) | 2022-03-01 | 2025-01-08 | Chemo Research, S.L. | Chewable oral contraceptive |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2652761C2 (de) | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| DE3022337A1 (de) | 1980-06-11 | 1982-01-07 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Praeparate zur kontrazeption und zur behandlung gynaekologischer stoerungen |
| JP3282731B2 (ja) | 1990-06-15 | 2002-05-20 | メルク エンド カムパニー インコーポレーテッド | 結晶の構造および大きさを改良する結晶化方法 |
| GB2256648B (en) | 1991-05-29 | 1995-08-30 | Colorcon Ltd | Wax polish composition |
| DE19633685C1 (de) | 1996-08-12 | 1997-10-09 | Schering Ag | Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens |
| DK1380301T3 (da) | 1999-08-31 | 2009-04-20 | Bayer Schering Pharma Ag | Farmaceutisk sammensætning af ethinylestradiol og drospirenon til anvendelse som svangerskabsforebyggende middel |
| US6787531B1 (en) | 1999-08-31 | 2004-09-07 | Schering Ag | Pharmaceutical composition for use as a contraceptive |
| US20020132801A1 (en) | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
| AU2001225413B2 (en) | 2000-01-18 | 2005-06-23 | Bayer Schering Pharma Aktiengesellschaft | Drospirenone for hormone replacement therapy |
| US20040087563A1 (en) | 2002-11-05 | 2004-05-06 | Siegfried Mayerhofer | Hormone replacement therapy with cardiovascular protection using antialdosteronic progestins |
| US7786101B2 (en) | 2002-11-05 | 2010-08-31 | Bayer Schering Pharma Ag | Cardiovascular protection using anti-aldosteronic progestins |
| MY142989A (en) | 2004-03-10 | 2011-02-14 | Bayer Schering Pharma Ag | Stabilised supersaturated solids of lipophilic drugs |
| US20050220825A1 (en) | 2004-03-10 | 2005-10-06 | Adrian Funke | Molecular dispersions of drospirenone |
| DE602005014227D1 (de) | 2004-03-10 | 2009-06-10 | Bayer Schering Pharma Ag | Zusammensetzungen aus drospirenon in molekularer dispersion |
| MY151322A (en) | 2004-04-30 | 2014-05-15 | Bayer Ip Gmbh | Management of breakthrough bleeding in extended hormonal contraceptive regimens |
| AR049707A1 (es) | 2004-07-07 | 2006-08-30 | Wyeth Corp | Regimenes y kits de progestina ciclica |
| EP1625849A1 (en) | 2004-08-09 | 2006-02-15 | Liconsa, Liberacion Controlada de Sustancias Activas, S.A. | Pharmaceutical composition comprising drospirenone and ethynylestradiol |
| ITMI20042338A1 (it) | 2004-12-06 | 2005-03-06 | Ind Chimica Srl | Processo per la preparazione di drospirenone |
| US20060293295A1 (en) | 2005-05-13 | 2006-12-28 | Kai Strothmann | Pharmaceutical composition comprising progestogens and/or estrogens and 5-methyl- (6S)-tetrahydrofolate |
| US8475838B2 (en) | 2005-06-03 | 2013-07-02 | Sandoz Ag | Rapidly-dissolving pharmaceutical composition for inhibiting ovulation |
| TW200727920A (en) | 2005-06-21 | 2007-08-01 | Organon Nv | New regimens for oral monophasic contraceptives |
| ES2311927T5 (es) | 2005-07-21 | 2014-09-08 | Bayer Pharma Aktiengesellschaft | Proceso para la producción de 3-oxo-pregn-4-en-21,17-carbolactonas por la oxidación sin metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos |
| CN101489563A (zh) | 2006-07-06 | 2009-07-22 | 拜耳先灵医药股份有限公司 | 用于避孕和预防先天性畸形风险的药物制剂 |
| US20100086599A1 (en) * | 2006-09-16 | 2010-04-08 | Kairosmed Gmbh | Oral modified release formulations |
| AR066166A1 (es) | 2007-09-21 | 2009-07-29 | Organon Nv | Sistema de suministro de droga |
| AU2009214307A1 (en) | 2008-02-13 | 2009-08-20 | Bayer Intellectual Property Gmbh | Drug delivery system with stabilising effect |
| WO2009138224A1 (en) | 2008-05-14 | 2009-11-19 | Helm Ag | Pharmaceutical composition comprising drospirenone |
| DE102008037025C5 (de) | 2008-08-08 | 2016-07-07 | Jesalis Pharma Gmbh | Verfahren zur Herstellung kristalliner Wirkstoff-Mikropartikel bzw. einer Wirkstoffpartikel-Festkörperform |
| TW201008569A (en) * | 2008-08-08 | 2010-03-01 | Bayer Schering Pharma Ag | Progestin-containing drug delivery system |
| AR081670A1 (es) * | 2010-06-29 | 2012-10-10 | Leon Farma Sa Lab | Composicion farmaceutica que comprende drospirenona y kit anticonceptivo |
| US11351122B1 (en) | 2010-07-28 | 2022-06-07 | Laboratorios Leon Farma Sa | Synthetic progestogens and pharmaceutical compositions comprising the same |
| US10849857B2 (en) | 2010-07-28 | 2020-12-01 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
| US9603860B2 (en) | 2010-07-28 | 2017-03-28 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
-
2011
- 2011-06-27 AR ARP110102229A patent/AR081670A1/es not_active Application Discontinuation
- 2011-06-28 EA EA201291372A patent/EA028680B1/ru unknown
- 2011-06-28 PH PH1/2012/502499A patent/PH12012502499A1/en unknown
- 2011-06-28 CA CA3003062A patent/CA3003062C/en active Active
- 2011-06-28 KR KR1020177019333A patent/KR102164693B1/ko active Active
- 2011-06-28 WO PCT/EP2011/060795 patent/WO2012000981A1/en not_active Ceased
- 2011-06-28 KR KR1020137001350A patent/KR20130048227A/ko not_active Ceased
- 2011-06-28 RS RS20220179A patent/RS63027B1/sr unknown
- 2011-06-28 SI SI201131838T patent/SI2588114T1/sl unknown
- 2011-06-28 EP EP19209672.5A patent/EP3632448B1/en active Active
- 2011-06-28 PL PL11727985T patent/PL2588114T3/pl unknown
- 2011-06-28 BR BR112012033391-7A patent/BR112012033391B1/pt active IP Right Grant
- 2011-06-28 SM SM20220129T patent/SMT202200129T1/it unknown
- 2011-06-28 CA CA2803721A patent/CA2803721C/en active Active
- 2011-06-28 CA CA3061421A patent/CA3061421C/en active Active
- 2011-06-28 SI SI201132044T patent/SI3632448T1/sl unknown
- 2011-06-28 ES ES19209672T patent/ES2908657T3/es active Active
- 2011-06-28 PL PL19209672T patent/PL3632448T3/pl unknown
- 2011-06-28 PE PE2012002518A patent/PE20130780A1/es active IP Right Grant
- 2011-06-28 NZ NZ605176A patent/NZ605176A/en unknown
- 2011-06-28 DK DK19209672.5T patent/DK3632448T3/da active
- 2011-06-28 EP EP11727985.1A patent/EP2588114B1/en active Active
- 2011-06-28 LT LTEP19209672.5T patent/LT3632448T/lt unknown
- 2011-06-28 PE PE2016002187A patent/PE20161410A1/es unknown
- 2011-06-28 HR HRP20220332TT patent/HRP20220332T1/hr unknown
- 2011-06-28 JP JP2013517245A patent/JP5810159B2/ja active Active
- 2011-06-28 SM SM20200063T patent/SMT202000063T1/it unknown
- 2011-06-28 PT PT192096725T patent/PT3632448T/pt unknown
- 2011-06-28 EP EP22150746.0A patent/EP4056186A1/en active Pending
- 2011-06-28 RS RS20200081A patent/RS59826B1/sr unknown
- 2011-06-28 KR KR1020217002806A patent/KR102539030B1/ko active Active
- 2011-06-28 HU HUE19209672A patent/HUE058176T2/hu unknown
-
2020
- 2020-02-03 CY CY20201100088T patent/CY1122544T1/el unknown
- 2020-06-11 NO NO2020015C patent/NO2020015I1/no unknown
- 2020-06-11 FR FR20C1020C patent/FR20C1020I1/fr active Active
- 2020-06-11 HU HUS2000016C patent/HUS2000016I1/hu unknown
-
2022
- 2022-03-10 CY CY20221100198T patent/CY1125061T1/el unknown
- 2022-04-11 US US17/717,550 patent/US11452695B2/en active Active
- 2022-05-10 HU HUS2200018C patent/HUS2200018I1/hu unknown
- 2022-06-22 LT LTPA2022513C patent/LTPA2022513I1/lt unknown
- 2022-06-23 FR FR22C1031C patent/FR22C1031I2/fr active Active
- 2022-06-29 US US17/853,623 patent/US11478487B1/en active Active
- 2022-06-30 US US17/855,432 patent/US11491113B1/en active Active
- 2022-07-01 US US17/856,605 patent/US11504334B2/en active Active
- 2022-07-11 NO NO2022030C patent/NO2022030I1/no unknown
- 2022-10-17 US US17/967,767 patent/US12090231B2/en active Active
-
2023
- 2023-08-04 US US18/365,877 patent/US11951213B2/en active Active
-
2024
- 2024-07-05 US US18/765,167 patent/US12280151B2/en active Active
-
2025
- 2025-03-20 US US19/085,309 patent/US20250213487A1/en active Pending
- 2025-03-20 US US19/085,343 patent/US20250213488A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2979707B1 (en) | Composite structural material and pharmaceutical composition thereof | |
| JP2016540021A5 (enExample) | ||
| HRP20180129T1 (hr) | Oralno raspadajuća čvrsta jedinica doze koja sadrži estetrol komponentu | |
| JP2013529665A5 (enExample) | ||
| JP2015166379A5 (enExample) | ||
| NZ599031A (en) | A dosage form containing two or more active pharmaceutical ingredients in different physical forms | |
| UA110853C2 (uk) | Лікарські форми інгібітора гістондеацетилази у комбінації з бендамустином та їхнє застосування | |
| JP2008543758A5 (enExample) | ||
| JP2013509395A5 (enExample) | ||
| HRP20131088T1 (hr) | Äśvrsti farmaceutski pripravci s fiksnom dozom koji sadrže irbesartan i amlodipin, njihova priprava i terapijska primjena | |
| CN108524527B (zh) | 塞来昔布药物组合物及其制备方法 | |
| JP2018527305A5 (enExample) | ||
| WO2021129735A1 (zh) | 一种固体制剂及其制备方法和用途 | |
| EP3150201A1 (en) | Composite preparation comprising 5- -reductase inhibitor-containing film coating layer, and method for producing the composite preparation | |
| CN101015519B (zh) | 一种氯雷他定口服复方药物组合物 | |
| EP3013327A1 (en) | Pharmaceutical capsule composite formulation comprising tadalafil and tamsulosin | |
| CA2672157C (en) | Method for producing solid preparation | |
| JP6308938B2 (ja) | 粒状物を製造する方法 | |
| JP6147711B2 (ja) | 医薬用組成物及びその製造方法、並びに口腔内崩壊錠及びその製造方法 | |
| CN105997909A (zh) | 一种奥贝胆酸口崩片及其制备方法 | |
| CN102580097A (zh) | 一种含阿齐沙坦的药物组合物 | |
| FI3930691T3 (fi) | Asetominofeenia ja ibuprofeenia sisältävä lääkekoostumus | |
| TW200920371A (en) | A combination treatment | |
| JPH0797325A (ja) | 安定な固形製剤およびその製造法 | |
| JP2008518895A5 (enExample) |