HRP20191196T1 - Dermalni injektivni sterilni pripravak - Google Patents
Dermalni injektivni sterilni pripravak Download PDFInfo
- Publication number
- HRP20191196T1 HRP20191196T1 HRP20191196TT HRP20191196T HRP20191196T1 HR P20191196 T1 HRP20191196 T1 HR P20191196T1 HR P20191196T T HRP20191196T T HR P20191196TT HR P20191196 T HRP20191196 T HR P20191196T HR P20191196 T1 HRP20191196 T1 HR P20191196T1
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- Prior art keywords
- cross
- gel
- hyaluronic acid
- linking
- linked
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 8
- 230000002500 effect on skin Effects 0.000 title 1
- 239000000499 gel Substances 0.000 claims 20
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 15
- 229920002674 hyaluronan Polymers 0.000 claims 15
- 229960003160 hyaluronic acid Drugs 0.000 claims 15
- PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 claims 10
- 229920000768 polyamine Polymers 0.000 claims 9
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims 8
- 238000004132 cross linking Methods 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 6
- 229940063675 spermine Drugs 0.000 claims 5
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical group NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 claims 4
- ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 claims 3
- 239000012190 activator Substances 0.000 claims 3
- 150000001718 carbodiimides Chemical class 0.000 claims 3
- 230000008878 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 238000005859 coupling reaction Methods 0.000 claims 3
- 239000003431 cross linking reagent Substances 0.000 claims 3
- 230000002349 favourable effect Effects 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- FPIRBHDGWMWJEP-UHFFFAOYSA-N 1-hydroxy-7-azabenzotriazole Chemical compound C1=CN=C2N(O)N=NC2=C1 FPIRBHDGWMWJEP-UHFFFAOYSA-N 0.000 claims 2
- 239000002537 cosmetic Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 229940063673 spermidine Drugs 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- GVJXGCIPWAVXJP-UHFFFAOYSA-N 2,5-dioxo-1-oxoniopyrrolidine-3-sulfonate Chemical compound ON1C(=O)CC(S(O)(=O)=O)C1=O GVJXGCIPWAVXJP-UHFFFAOYSA-N 0.000 claims 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims 1
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 1
- 239000007822 coupling agent Substances 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 229940010747 sodium hyaluronate Drugs 0.000 claims 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 1
- -1 sulfo NHS Chemical compound 0.000 claims 1
- 230000037303 wrinkles Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Claims (16)
1. Gel umrežene hijaluronske kiseline koji potječe od umrežavanja hijaluronske kiseline ili njezine soli u prisutnosti najmanje učinkovite količine najmanje jednog endogenog poliamina kao sredstva za umrežavanje, pri čemu se navedeno umrežavanje provodi u uvjetima povoljnim za kovalentno spajanje navedene hijaluronske kiseline i navedenog(ih) endogenog(ih) poliamina, navedeni gel ima stupanj modifikacije manji ili jednak 1%, a stupanj modifikacije je omjer između broja molova endogenog poliamina vezanog za hijaluronsku kiselinu i broja molova hijaluronske kiseline koja tvori navedeni umreženi gel.
2. Gel prema zahtjevu 1, naznačen time što je endogeni poliamin odabran od spermidina, spermina, i njihove smjese, i još bolje spermina.
3. Gel prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što se sparivanje provodi u prisutnosti najmanje jednog aktivatora i, gdje je to prikladno, u kombinaciji s najmanje jednim pomoćnim sredstvom za sparivanje, sa pri čemu se navedeni aktivator poželjno bira od karbodiimida topivih u vodi, kao što je 1-etil-3-(3-dimetilaminopropil)karbodiimid (EDC), 1-etil-3-(3- trimetilaminopropil)karbodiimid (ETC), 1-cikloheksil-3-(2-morfilinoetil)karbodiimid (CMC), kao i njihovih soli, i njihovih smjesa, a poželjno je predstavljen s EDC, i navedeno pomoćno sredstvo za sparivanje, kada je prisutno, poželjno je odabrano od N-hidroksisukcinimida (NHS), N-hidroksibenzotriazola (HOBt), 3,4-dihidro-3-hidroksi-4-okso-1,2,3-benzotriazola (HOOBt), 1-hidroksi-7-azabenzotriazola (HAt) i N-hidroksisulfosukcinimida (sulfo NHS), i njihovih smjesa, a poželjno je predstavljeno s HOBt.
4. Gel prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što navedeni gel ima stupanj modifikacije između 0.1% i 1%, i još bolje između 0.4% i 0.8%.
5. Gel prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što navedeni gel ima modul elastičnosti (G') od između 20 i 1000 Pa, poželjno između 40 Pa i 400 Pa, kombiniran s faznim kutom (δ) manjim od 45°.
6. Gel prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što navedeni gel ima poprečni presjek naprezanja veći od 100 Pa.
7. Postupak za pripravu gela umrežene hijaluronske kiseline kako je definirano u bilo kojem od patentnih zahtjeva 1 do 6 koji sadrži barem korake koji se sastoje od:
a) dobivanja vodenog gela hijaluronske kiseline ili njezine soli, u neumreženom stanju,
b) dovođenje gela dobivenog u koraku a) u kontakt s učinkovitom količinom najmanje jednog endogenog poliamina, te po izboru u prisutnosti dodatnog sredstva za umrežavanje,
c) umrežavanje navedene smjese nastale u koraku b), pri čemu se navedeno umrežavanje provodi u uvjetima povoljnim za kovalentno vezanje navedene hijaluronske kiseline i navedenog(ih) endogenog(ih) poliamina,
d) obnavljanje navedenog umreženog hidrogela, i po izboru
e) zaustavljanje umrežavanja izlaganjem umreženog gela uvjetima koji su povoljni za zaustavljanje njegovog umrežavanja, ovaj neobavezni korak e) provodi se prije, zajedno s ili nakon koraka obnavljanja d).
8. Postupak prema patentnom zahtjevu 7, naznačen time što je (su) endogeni poliamin(i) odabrani od spermidina, spermina, i njihove smjese, i još bolje, spermina.
9. Postupak prema bilo kojem od zahtjeva 7 i 8, naznačen time što se endogeni poliamin(i) koriste u sadržaju između 0.1% i 3%, poželjno između 0.5% i 1.5%, prema broju molova poliamina odnosu na broj molova hijaluronske kiseline koji su prisutni u smjesi iz koraka b).
10. Postupak prema bilo kojem od zahtjeva 7 do 9, naznačen time što hijaluronska kiselina ili njezina sol upotrebljava u sadržaju između 0.5% i 12 težinskih %, poželjno između 1% i 4 težinskih %, u odnosu na ukupnu težinu smjese dobivene na kraju koraka b).
11. Postupak prema bilo kojem od patentnih zahtjeva 7 do 10, naznačen time što se koristi (i) natrijev hijaluronat, (ii) spermin, kao sredstvo za umrežavanje, i (iii) EDC u kombinaciji s HOBt, kao, odgovarajući, aktivator i pomoćno sredstvo za spajanje.
12. Sterilni dermatološki pripravak za injektiranje naznačen time što sadrži, u fiziološki prihvatljivom mediju, barem jedan gel umrežene hijaluronske kiseline kako je definiran u bilo kojem od patentnih zahtjeva 1 do 6.
13. Kozmetički ili dermatološki pripravak naznačen time što sadrži najmanje jedan gel umrežene hijaluronske kiseline kako je definirano u bilo kojem od patentnih zahtjeva 1 do 6.
14. Komplet naznačen time što sadrži:
- pakiranje koje sadrži najmanje jednu dozu gela umrežene hijaluronske kiseline kako je definirano u bilo kojem od patentnih zahtjeva 1 do 6 ili pripravka kako je definiran u zahtjevu 12; i
- uređaj za injektiranje u ili kroz kožu ili uređaj za mikroperforaciju kože, namijenjen primjeni navedene doze.
15. Uporaba gela umrežene hijaluronske kiseline kako je definirano prema bilo kojem od patentnih zahtjeva 1 do 6 ili pripravka kako je definiran u zahtjevu 12, naznačena time što je za punjenje oštećenja volumena kože i naročito za punjenje bora.
16. Postupak kozmetičkog tretmana kože, naznačen time što sadrži barem jedan korak davanja, u ili kroz kožu, gela umrežene hijaluronske kiseline kako je definirano prema bilo kojem od patentnih zahtjeva 1 do 6 ili pripravka kako je definiran u zahtjevu 12.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1260146A FR2997014B1 (fr) | 2012-10-24 | 2012-10-24 | Composition sterile dermo-injectable |
| PCT/IB2013/059607 WO2014064632A1 (en) | 2012-10-24 | 2013-10-24 | Dermal injectable sterile composition |
| EP13820892.1A EP2912074B2 (en) | 2012-10-24 | 2013-10-24 | Dermal injectable sterile composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191196T1 true HRP20191196T1 (hr) | 2019-10-18 |
Family
ID=47754646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191196TT HRP20191196T1 (hr) | 2012-10-24 | 2019-07-01 | Dermalni injektivni sterilni pripravak |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9907739B2 (hr) |
| EP (1) | EP2912074B2 (hr) |
| JP (1) | JP6521862B2 (hr) |
| KR (1) | KR102178252B1 (hr) |
| AU (1) | AU2013336274B2 (hr) |
| BR (1) | BR112015009162B1 (hr) |
| CA (1) | CA2888616C (hr) |
| DK (1) | DK2912074T4 (hr) |
| ES (1) | ES2735017T5 (hr) |
| FR (1) | FR2997014B1 (hr) |
| HR (1) | HRP20191196T1 (hr) |
| HU (1) | HUE044362T2 (hr) |
| PL (1) | PL2912074T5 (hr) |
| PT (1) | PT2912074T (hr) |
| RS (1) | RS59079B1 (hr) |
| RU (1) | RU2653729C2 (hr) |
| SI (1) | SI2912074T1 (hr) |
| TR (1) | TR201911149T4 (hr) |
| WO (1) | WO2014064632A1 (hr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6906885B2 (ja) | 2014-11-14 | 2021-07-21 | ロレアル | しわを減少させるためのマイクロニードルシート |
| FR3034195B1 (fr) | 2015-03-24 | 2017-04-21 | Teoxane | Procede d'evaluation des performances mecaniques d'un gel de comblement |
| RU2750684C2 (ru) * | 2016-10-13 | 2021-07-01 | Аллерган, Инк. | Коацерватные гидрогели на основе гиалуроновой кислоты для применения в дермальных филлерах |
| WO2018122343A1 (en) * | 2016-12-29 | 2018-07-05 | Nestlé Skin Health Sa | Micro- or nanoparticular vesicles comprising crosslinked hyaluronic acid, compositions comprising the same and method for their use in skin care |
| EP3562470A1 (en) | 2016-12-29 | 2019-11-06 | Nestlé Skin Health SA | Composition comprising a crosslinked hyaluronic acid (ha) in combination with a low-molecular ha and/or an agent stimulating endogenous ha synthesis |
| EP3562468A1 (en) * | 2016-12-29 | 2019-11-06 | Nestlé Skin Health SA | Micro- or nanoparticular multilamellar vesicles, compositions comprising the same and method for their use in skin care |
| CN111727033A (zh) * | 2018-02-16 | 2020-09-29 | 东洋纺株式会社 | 防污染剂及皮肤外用组合物 |
| MA52880A (fr) | 2018-06-15 | 2021-09-22 | Croma Pharma Ges M B H | Composition d'hydrogel comprenant un polymère réticulé |
| JP2021528443A (ja) | 2018-06-29 | 2021-10-21 | ザ プロクター アンド ギャンブル カンパニーＴｈｅ Ｐｒｏｃｔｅｒ ＆ Ｇａｍｂｌｅ Ｃｏｍｐａｎｙ | 二相製品 |
| CN112384307B (zh) * | 2018-06-29 | 2023-06-16 | 宝洁公司 | 双相产品分配器 |
| US11583479B2 (en) | 2018-06-29 | 2023-02-21 | The Procter & Gamble Company | Dual phase products |
| US20210268143A1 (en) * | 2018-07-06 | 2021-09-02 | Lg Chem, Ltd. | Hyaluronic acid filler having high viscoelasticity and high cohesiveness |
| RU2770541C1 (ru) * | 2018-07-10 | 2022-04-18 | ЭлДжи КЕМ, ЛТД. | Наполнитель с гиалуроновой кислотой, имеющий высокую способность лифтинга и низкую силу инъекции |
| KR102566287B1 (ko) * | 2018-11-30 | 2023-08-11 | 주식회사 엘지화학 | 히알루론산을 포함하는 활액보충재용 조성물 |
| TWI739241B (zh) * | 2018-12-20 | 2021-09-11 | 南韓商Ｌｇ化學股份有限公司 | 具優異填料性質之包含玻尿酸水凝膠之填料、其製法及其用途 |
| JP1665824S (hr) | 2019-08-21 | 2020-08-11 | ||
| WO2021042127A1 (en) * | 2019-08-30 | 2021-03-04 | The Procter & Gamble Company | A packaged hair care composition |
| MX2023004234A (es) | 2020-10-27 | 2023-04-21 | Procter & Gamble | Acondicionador de calentamiento. |
| USD1006632S1 (en) | 2020-12-11 | 2023-12-05 | The Procter & Gamble Company | Container for hair care products |
| USD1012718S1 (en) | 2020-12-21 | 2024-01-30 | The Procter & Gamble Company | Container for hair care product |
| WO2022217069A1 (en) * | 2021-04-09 | 2022-10-13 | Colorado School Of Mines | Radical crosslinked zwitterionic gels and uses thereof |
| CN113896915B (zh) * | 2021-11-10 | 2024-02-13 | 爱美客技术发展股份有限公司 | 一种凝胶材料及其制备方法与应用 |
| WO2023082084A1 (zh) * | 2021-11-10 | 2023-05-19 | 爱美客技术发展股份有限公司 | 一种凝胶材料及其制备方法与应用 |
| AR128245A1 (es) | 2022-01-11 | 2024-04-10 | Gpq S R L | Nuevos derivados de ácido hialurónico como rellenos innovadores |
| WO2023221082A1 (zh) * | 2022-05-20 | 2023-11-23 | 爱美客技术发展股份有限公司 | 一种接枝聚合物材料及其制备方法与应用 |
| WO2024040480A1 (zh) * | 2022-08-24 | 2024-02-29 | 爱美客技术发展股份有限公司 | 一种凝胶材料及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2752843B1 (fr) | 1996-08-30 | 1998-10-16 | Sod Conseils Rech Applic | Copolymeres reticules a base de polymeres polycarboxyliques et leur utilisation comme support de composition pharmaceutique |
| IT1303735B1 (it) | 1998-11-11 | 2001-02-23 | Falorni Italia Farmaceutici S | Acidi ialuronici reticolati e loro usi medici. |
| KR100375299B1 (ko) | 2000-10-10 | 2003-03-10 | 주식회사 엘지생명과학 | 히알루론산의 가교결합형 아마이드 유도체와 이의 제조방법 |
| US20040162235A1 (en) * | 2003-02-18 | 2004-08-19 | Trubetskoy Vladimir S. | Delivery of siRNA to cells using polyampholytes |
| US8524213B2 (en) | 2003-12-30 | 2013-09-03 | Genzyme Corporation | Polymeric materials, their preparation and use |
| NO20044818D0 (no) | 2004-11-05 | 2004-11-05 | Bioforsk As | Spermin i kosmetiske preparater |
| US20060105022A1 (en) | 2004-11-15 | 2006-05-18 | Shiseido Co., Ltd. | Process for preparing crosslinked hyaluronic acid gel |
| DK1817347T3 (en) | 2004-11-24 | 2017-08-14 | Albumedix As | Process for Crosslinking Hyaluronic Acid with Divinyl Sulfone |
| EP1884231A1 (en) | 2006-08-01 | 2008-02-06 | Auriga International S.A. | Cosmetic or pharmaceutical composition containing hyaluronic acid |
| FR2908415B1 (fr) | 2006-11-10 | 2009-01-23 | Abr Dev Sarl | Acide hyaluronique reticule et son procede de preparation |
| WO2010049562A1 (es) | 2008-10-28 | 2010-05-06 | Universidade De Santiago De Compostela | Sistemas nanoparticulares elaborados a base de polímeros aniónicos. |
| FR2945293B1 (fr) * | 2009-05-11 | 2011-06-17 | Teoxane | Procede de preparation d'un gel reticule. |
| ES2368307B1 (es) * | 2010-04-28 | 2012-10-17 | Universidade De Santiago De Compostela | Hidrogeles elaborados a base de polímeros aniónicos de origen natural. |
| WO2012008722A2 (ko) * | 2010-07-12 | 2012-01-19 | 신풍제약 주식회사 | 조직 증강용 충전 조성물 |
-
2012
- 2012-10-24 FR FR1260146A patent/FR2997014B1/fr active Active
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2013
- 2013-10-24 SI SI201331513T patent/SI2912074T1/sl unknown
- 2013-10-24 PL PL13820892T patent/PL2912074T5/pl unknown
- 2013-10-24 HU HUE13820892 patent/HUE044362T2/hu unknown
- 2013-10-24 JP JP2015538611A patent/JP6521862B2/ja active Active
- 2013-10-24 KR KR1020157013662A patent/KR102178252B1/ko active IP Right Grant
- 2013-10-24 ES ES13820892T patent/ES2735017T5/es active Active
- 2013-10-24 US US14/437,917 patent/US9907739B2/en active Active
- 2013-10-24 CA CA2888616A patent/CA2888616C/en active Active
- 2013-10-24 EP EP13820892.1A patent/EP2912074B2/en active Active
- 2013-10-24 RU RU2015118969A patent/RU2653729C2/ru active
- 2013-10-24 BR BR112015009162-8A patent/BR112015009162B1/pt active IP Right Grant
- 2013-10-24 AU AU2013336274A patent/AU2013336274B2/en active Active
- 2013-10-24 PT PT13820892T patent/PT2912074T/pt unknown
- 2013-10-24 RS RS20190862A patent/RS59079B1/sr unknown
- 2013-10-24 TR TR2019/11149T patent/TR201911149T4/tr unknown
- 2013-10-24 DK DK13820892.1T patent/DK2912074T4/da active
- 2013-10-24 WO PCT/IB2013/059607 patent/WO2014064632A1/en active Application Filing
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2018
- 2018-01-18 US US15/874,144 patent/US10307362B2/en active Active
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- 2019-07-01 HR HRP20191196TT patent/HRP20191196T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI2912074T1 (sl) | 2019-08-30 |
| DK2912074T4 (da) | 2022-03-14 |
| RU2015118969A (ru) | 2016-12-20 |
| FR2997014A1 (fr) | 2014-04-25 |
| PT2912074T (pt) | 2019-07-19 |
| AU2013336274A1 (en) | 2015-05-07 |
| RU2653729C2 (ru) | 2018-05-14 |
| JP6521862B2 (ja) | 2019-05-29 |
| US10307362B2 (en) | 2019-06-04 |
| AU2013336274B2 (en) | 2017-08-24 |
| BR112015009162B1 (pt) | 2021-10-13 |
| PL2912074T5 (pl) | 2022-04-04 |
| EP2912074B1 (en) | 2019-05-01 |
| FR2997014B1 (fr) | 2015-03-20 |
| US20150272851A1 (en) | 2015-10-01 |
| PL2912074T3 (pl) | 2019-09-30 |
| EP2912074B2 (en) | 2021-12-22 |
| CA2888616C (en) | 2020-09-15 |
| TR201911149T4 (tr) | 2019-08-21 |
| DK2912074T3 (da) | 2019-07-22 |
| ES2735017T5 (es) | 2022-04-28 |
| RS59079B1 (sr) | 2019-09-30 |
| ES2735017T3 (es) | 2019-12-13 |
| WO2014064632A1 (en) | 2014-05-01 |
| JP2016507592A (ja) | 2016-03-10 |
| KR20150079786A (ko) | 2015-07-08 |
| CA2888616A1 (en) | 2014-05-01 |
| BR112015009162A2 (pt) | 2017-10-03 |
| US20180140530A1 (en) | 2018-05-24 |
| HUE044362T2 (hu) | 2019-10-28 |
| KR102178252B1 (ko) | 2020-11-13 |
| US9907739B2 (en) | 2018-03-06 |
| EP2912074A1 (en) | 2015-09-02 |
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