HRP20171780T1 - Postupak za pripremanje umreženog gela - Google Patents
Postupak za pripremanje umreženog gela Download PDFInfo
- Publication number
- HRP20171780T1 HRP20171780T1 HRP20171780TT HRP20171780T HRP20171780T1 HR P20171780 T1 HRP20171780 T1 HR P20171780T1 HR P20171780T T HRP20171780T T HR P20171780TT HR P20171780 T HRP20171780 T HR P20171780T HR P20171780 T1 HRP20171780 T1 HR P20171780T1
- Authority
- HR
- Croatia
- Prior art keywords
- cross
- carried out
- linking
- homogenization
- minutes
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 238000000034 method Methods 0.000 claims 14
- 238000004132 cross linking Methods 0.000 claims 6
- 238000000265 homogenisation Methods 0.000 claims 6
- 239000000499 gel Substances 0.000 claims 5
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims 3
- 150000004676 glycans Chemical class 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- HPILSDOMLLYBQF-UHFFFAOYSA-N 2-[1-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COC(CCC)OCC1CO1 HPILSDOMLLYBQF-UHFFFAOYSA-N 0.000 claims 2
- 239000003431 cross linking reagent Substances 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 230000006835 compression Effects 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- -1 polyethylene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229940010747 sodium hyaluronate Drugs 0.000 claims 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Colloid Chemistry (AREA)
Claims (15)
1. Postupak za pripremanje umreženog gela barem jednog polisaharida ili jedne od njegovih soli, koji sadrži barem korake koji se sastoje od:
a) osiguravanja vodenog medija koji sadrži navedeni polisaharid,
b) nastajanje homogenog gela iz medija iz koraka a),
c) dovođenje gela dobivenog u koraku b) u kontakt s učinkovitom količinom barem jednog sredstva za umrežavanje;
d) umrežavanje navedene smjese nastale u koraku c); i
e) obnavljanje navedenog umreženog hidrogela,
naznačen time da se
- barem navedeni koraci a) do d) provode unutar hermetičke šupljine omeđene barem djelomično s deformirajućom stjenkom, navedena šupljina je izrađena unutar vrećica koja se može deformirati, te se smjesa koja se nalazi u šupljini izlaže, u koraku d), uvjetima pogodnim za umrežavanje;
- homogenizacija, razmatrana u koraku b) se provodi pomoću proizvoljno uzastopnih, mehaničkih deformacija vanjske strane deformirajuće stjenke ili vrećice.
2. Postupak prema zahtjevu 1, naznačen time da nadalje sadrži korak f) zaustavljanja umrežavanja, navedeni korak f) se provodi prije, zajedno s ili nakon koraka obnavljanja e).
3. Postupak prema zahtjevu 2, naznačen time da se korak umrežavanja f) provodi prije koraka obnavljanja e).
4. Postupak prema prethodnom zahtjevu, naznačen time da se svi koraci od a) do d) i f) provode unutar navedene šupljine.
5. Postupak prema bilo kojem od prethodnih zahtjeva, naznačen time da je navedena vrećica opremljena sa sustavom otvaranja.
6. Postupak prema bilo kojem od prethodnih zahtjeva, naznačen time da je navedena vrećica izrađena od plastike, poželjno od polietilena farmaceutske kvalitete.
7. Postupak prema bilo kojem od prethodnih zahtjeva, naznačen time da se homogenizacija odvija tijekom vremena trajanja manjeg od 400 minuta, poželjno manjeg od 150 minuta, čak još poželjnije između 30 i 100 minuta.
8. Postupak prema bilo kojem od prethodnih zahtjeva, naznačen time da se korak umrežavanja provodi pomoću toplinskih sredstava.
9. Postupak prema bilo kojem od prethodnih zahtjeva, naznačen time da se korak umrežavanja odvija tijekom vremena trajanja u rasponu od 30 do 300 minuta, poželjno od 100 do 200 minuta.
10. Postupak prema bilo kojem od prethodnih zahtjeva, naznačen time da polisaharid je hijaluronska kiselina ili jedna od njezinih soli.
11. Postupak prema bilo kojem od prethodnih zahtjeva, naznačen time da koristi natrijev hijaluronat u alkalnom mediju s butandiol diglicidil eterom (BDDE), kao sredstvom za umrežavanje.
12. Postupak prema bilo kojem od prethodnih zahtjeva, naznačen time da umreženi gel je kruti gel.
13. Postupak prema zahtjevu 1, naznačen time da se navedena homogenizacija iz koraka b) provodi ručno, naročito pomoći jednostavni uzastopnih ručnih kompresija vanjskih strana stjenke ili vrećice.
14. Postupak prema zahtjevu 1, naznačen time da se navedena homogenizacija iz koraka b) provodi pomoću sustava s dvije oštrice jedne pored druge koje naizmjenično pritišću stjenku koja se može deformirati ili barem jedne od stjenki koja se može deformirati nakon kretanja unatrag i naprijed.
15. Postupak prema zahtjevu 1, naznačen time da se navedena homogenizacija iz koraka b) provodi prvo pomoću opipavanja, zatim korištenjem mehaničkog uređaja, ili naizmjeničnim korištenjem tih sredstva homogenizacije.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0953108A FR2945293B1 (fr) | 2009-05-11 | 2009-05-11 | Procede de preparation d'un gel reticule. |
| PCT/IB2010/052027 WO2010131175A1 (en) | 2009-05-11 | 2010-05-07 | Process for preparing a crosslinked gel |
| EP10726239.6A EP2429486B1 (en) | 2009-05-11 | 2010-05-07 | Process for preparing a crosslinked gel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171780T1 true HRP20171780T1 (hr) | 2017-12-29 |
Family
ID=41571500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171780TT HRP20171780T1 (hr) | 2009-05-11 | 2017-11-16 | Postupak za pripremanje umreženog gela |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9353194B2 (hr) |
| EP (1) | EP2429486B1 (hr) |
| JP (1) | JP5871793B2 (hr) |
| KR (1) | KR101732530B1 (hr) |
| AU (1) | AU2010247068B2 (hr) |
| BR (1) | BRPI1014306B8 (hr) |
| CA (1) | CA2760197C (hr) |
| CY (1) | CY1119812T1 (hr) |
| DK (1) | DK2429486T3 (hr) |
| ES (1) | ES2647547T3 (hr) |
| FR (1) | FR2945293B1 (hr) |
| HR (1) | HRP20171780T1 (hr) |
| HU (1) | HUE034942T2 (hr) |
| LT (1) | LT2429486T (hr) |
| NO (1) | NO2429486T3 (hr) |
| PL (1) | PL2429486T3 (hr) |
| PT (1) | PT2429486T (hr) |
| RU (1) | RU2540667C2 (hr) |
| SI (1) | SI2429486T1 (hr) |
| WO (1) | WO2010131175A1 (hr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2968305B1 (fr) | 2010-12-06 | 2014-02-28 | Teoxane | Procede de preparation d'un gel reticule |
| EP2807196B1 (en) * | 2012-01-24 | 2017-12-27 | Total Research & Technology Feluy | Method for processing polyethylene |
| FR2997014B1 (fr) * | 2012-10-24 | 2015-03-20 | Teoxane | Composition sterile dermo-injectable |
| FR2997085B1 (fr) | 2012-10-24 | 2015-05-29 | Teoxane | Procede de preparation d'un gel reticule |
| FR3006689A1 (fr) * | 2013-06-11 | 2014-12-12 | Benedicte Vincente Tauzin | Procede de reticulation de l'acide hyaluronique; procede de preparation d'un hydrogel injectable; hydrogel obtenu; utilisation de l'hydroget obtenu |
| US9421198B2 (en) | 2013-07-30 | 2016-08-23 | Teoxane | Composition comprising hyaluronic acid and mepivacaine |
| FR3029928B1 (fr) | 2014-12-15 | 2018-03-09 | Teoxane | Gel reticule |
| US10004824B2 (en) | 2015-05-11 | 2018-06-26 | Laboratoires Vivacy | Compositions comprising at least one polyol and at least one anesthetic |
| CZ2015398A3 (cs) * | 2015-06-15 | 2017-02-08 | Contipro A.S. | Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin |
| FR3037797B1 (fr) * | 2015-06-24 | 2018-08-17 | Kylane Laboratoires Sa | Procede de preparation d'un hydrogel reticule injectable; hydrogel obtenu; utilisation de l'hydrogel obtenu |
| US10898613B2 (en) | 2016-09-21 | 2021-01-26 | Nestlé Skin Health Sa | Hyaluronic acid gel with a divalent zinc cation |
| KR20180076063A (ko) * | 2016-12-27 | 2018-07-05 | (주) 삼보 | 덱스트란 기반의 창상피복재 및 그 제조방법 |
| EP3354258A1 (en) | 2017-01-31 | 2018-08-01 | Teoxane SA | Use of a cohesive gel as a matrix material in a periodontal pocket |
| US11311472B2 (en) | 2017-09-18 | 2022-04-26 | Teoxane | Topical composition comprising crosslinked hyaluronic acid and a polyacrylate compound |
| CA3089896A1 (en) | 2018-02-06 | 2019-08-15 | Regen Lab Sa | Cross-linked hyaluronic acids and combinations with prp/bmc |
| KR102053913B1 (ko) * | 2018-10-12 | 2019-12-09 | 바이오플러스 주식회사 | 다당류를 이용한 가교 중점도 용액의 제조 방법 |
| EP3659632A1 (en) * | 2018-11-29 | 2020-06-03 | Nestlé Skin Health SA | Post-crosslinking partial degradation of amide crosslinked hydrogels |
| LU101045B1 (en) | 2018-12-11 | 2020-06-11 | Qventis GmbH | Method for the manufacture and use of a bionic hydrogel composition for medical applications |
| KR102146499B1 (ko) * | 2020-01-31 | 2020-08-20 | 장진희 | 전자선을 이용하여 펜던트를 제거하는 필러 시술용 히알루론산 하이드로겔의 제조 방법 |
| KR102521838B1 (ko) * | 2020-12-28 | 2023-04-17 | (주)아크로스 | 탄성력 및 안전성이 우수한 조직수복용 생체재료의 제조 방법 |
| US20230233441A1 (en) * | 2022-01-24 | 2023-07-27 | The Procter & Gamble Company | Skin care composition containing sodium hyaluronate and method of making the same |
| WO2023198920A1 (fr) | 2022-04-15 | 2023-10-19 | Teoxane SA | Procede de preparation d'un hydrogel |
| DE102022113526A1 (de) * | 2022-05-30 | 2023-11-30 | Louna Aesthetics SAS | Verfahren zur Herstellung einer Zusammensetzung, Zusammensetzung und Verwendung der Zusammensetzung |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE788274A (fr) | 1971-09-06 | 1973-02-28 | Unilever Nv | Dispositifs servant a melanger des matieres |
| SU827492A1 (ru) * | 1978-07-27 | 1981-05-07 | Ордена Ленина Институт Элементоор-Ганических Соединений Ah Cccp | Сшитые гели на основе хитозана |
| SE442820B (sv) * | 1984-06-08 | 1986-02-03 | Pharmacia Ab | Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut |
| DE4014051A1 (de) | 1990-05-02 | 1991-11-07 | Schreiber Hans | Verfahren und vorrichtung zum mischen von wenigstens zwei materialkomponenten, insbesondere von zahnaerztlichen abdruckmaterialien |
| US5497913A (en) | 1993-12-15 | 1996-03-12 | Denny D. Baker | Mixing bag arrangement and method |
| DE4426421A1 (de) | 1994-07-26 | 1996-02-01 | Heinz Hartmann | Verfahren und Vorrichtung zur Herstellung disperser Systeme, insbesondere Salben, Cremes, Suspensionen, Emulsionen, Gele oder Pasten |
| IL112816A0 (en) | 1995-02-27 | 1995-05-26 | Travenol Lab Israel Ltd | Infusion bag with injection port |
| US5863551A (en) * | 1996-10-16 | 1999-01-26 | Organogel Canada Ltee | Implantable polymer hydrogel for therapeutic uses |
| GB9819897D0 (en) | 1998-09-11 | 1998-11-04 | Seward Limited | Devices for blending materials |
| FR2811996B1 (fr) * | 2000-07-19 | 2003-08-08 | Corneal Ind | Reticulation de polysaccharide(s), preparation d'hydrogel(s) ; polysaccharide(s) et hydrogel(s) obtenus,leurs utilisations |
| EP1549689B1 (en) * | 2002-10-02 | 2010-05-26 | Coloplast A/S | A hydrogel |
| EP1701981B1 (en) * | 2003-12-30 | 2017-06-07 | Genzyme Corporation | Cohesive gels from cross-linked hyaluronan and/or hylan,their preparation and use |
| US8524213B2 (en) | 2003-12-30 | 2013-09-03 | Genzyme Corporation | Polymeric materials, their preparation and use |
| FR2865737B1 (fr) * | 2004-02-03 | 2006-03-31 | Anteis Sa | Gel reticule biocompatible |
| DE102004021731A1 (de) | 2004-04-30 | 2005-11-24 | Albrecht Konietzko | Beutelmix |
| US20050281880A1 (en) * | 2004-05-20 | 2005-12-22 | Wei Wang | Methods for making injectable polymer hydrogels |
| WO2006051950A1 (ja) * | 2004-11-15 | 2006-05-18 | Shiseido Co., Ltd. | 架橋ヒアルロン酸ゲルの製造方法 |
| US20060105022A1 (en) | 2004-11-15 | 2006-05-18 | Shiseido Co., Ltd. | Process for preparing crosslinked hyaluronic acid gel |
| ES2636998T3 (es) | 2004-11-24 | 2017-10-10 | Albumedix A/S | Método de reticulación de ácido hialurónico con divinil sulfona |
| FR2909560B1 (fr) | 2006-12-06 | 2012-12-28 | Fabre Pierre Dermo Cosmetique | Gel d'acide hyaluronique pour injection intradermique |
| JP5071766B2 (ja) | 2006-12-08 | 2012-11-14 | 独立行政法人日本原子力研究開発機構 | 多糖類を原料とするゲルの製造方法 |
| FR2968305B1 (fr) * | 2010-12-06 | 2014-02-28 | Teoxane | Procede de preparation d'un gel reticule |
-
2009
- 2009-05-11 FR FR0953108A patent/FR2945293B1/fr active Active
-
2010
- 2010-05-07 CA CA2760197A patent/CA2760197C/en active Active
- 2010-05-07 BR BRPI1014306A patent/BRPI1014306B8/pt not_active IP Right Cessation
- 2010-05-07 HU HUE10726239A patent/HUE034942T2/en unknown
- 2010-05-07 PL PL10726239T patent/PL2429486T3/pl unknown
- 2010-05-07 WO PCT/IB2010/052027 patent/WO2010131175A1/en active Application Filing
- 2010-05-07 DK DK10726239.6T patent/DK2429486T3/da active
- 2010-05-07 AU AU2010247068A patent/AU2010247068B2/en active Active
- 2010-05-07 ES ES10726239.6T patent/ES2647547T3/es active Active
- 2010-05-07 EP EP10726239.6A patent/EP2429486B1/en active Active
- 2010-05-07 US US13/266,638 patent/US9353194B2/en active Active
- 2010-05-07 LT LTEP10726239.6T patent/LT2429486T/lt unknown
- 2010-05-07 JP JP2012510410A patent/JP5871793B2/ja active Active
- 2010-05-07 RU RU2011145421/05A patent/RU2540667C2/ru active
- 2010-05-07 PT PT107262396T patent/PT2429486T/pt unknown
- 2010-05-07 NO NO10726239A patent/NO2429486T3/no unknown
- 2010-05-07 KR KR1020117029306A patent/KR101732530B1/ko active IP Right Grant
- 2010-05-07 SI SI201031584T patent/SI2429486T1/en unknown
-
2017
- 2017-11-16 CY CY20171101199T patent/CY1119812T1/el unknown
- 2017-11-16 HR HRP20171780TT patent/HRP20171780T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US9353194B2 (en) | 2016-05-31 |
| AU2010247068A1 (en) | 2011-11-17 |
| FR2945293A1 (fr) | 2010-11-12 |
| RU2011145421A (ru) | 2013-06-20 |
| LT2429486T (lt) | 2017-12-11 |
| RU2540667C2 (ru) | 2015-02-10 |
| BRPI1014306B8 (pt) | 2018-08-07 |
| DK2429486T3 (da) | 2017-11-27 |
| JP5871793B2 (ja) | 2016-03-01 |
| PT2429486T (pt) | 2017-11-20 |
| HUE034942T2 (en) | 2018-03-28 |
| US20120108537A1 (en) | 2012-05-03 |
| CY1119812T1 (el) | 2018-06-27 |
| NO2429486T3 (hr) | 2018-01-20 |
| BRPI1014306B1 (pt) | 2018-02-06 |
| KR20120027315A (ko) | 2012-03-21 |
| KR101732530B1 (ko) | 2017-05-04 |
| JP2012526889A (ja) | 2012-11-01 |
| CA2760197C (en) | 2017-03-28 |
| SI2429486T1 (en) | 2018-01-31 |
| EP2429486B1 (en) | 2017-08-23 |
| ES2647547T3 (es) | 2017-12-22 |
| EP2429486A1 (en) | 2012-03-21 |
| PL2429486T3 (pl) | 2018-02-28 |
| WO2010131175A1 (en) | 2010-11-18 |
| BRPI1014306A2 (pt) | 2016-04-05 |
| AU2010247068B2 (en) | 2014-07-17 |
| FR2945293B1 (fr) | 2011-06-17 |
| CA2760197A1 (en) | 2010-11-18 |
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