BR112018007683A2 - uso de um primeiro derivado de polissacarídeo e de um segundo derivado de polissacarídeo, primeiro e segundo derivados de polissacarídeo, combinação de um primeiro derivado de ácido hialurônico (ah) e de um segundo derivado de ácido hialurônico (ah), sistema de seringa multicilindro, kit para a formação localmente de um hidrogel de polissacarídeo reticulado, método para a formação localmente de um hidrogel reticulado - Google Patents

uso de um primeiro derivado de polissacarídeo e de um segundo derivado de polissacarídeo, primeiro e segundo derivados de polissacarídeo, combinação de um primeiro derivado de ácido hialurônico (ah) e de um segundo derivado de ácido hialurônico (ah), sistema de seringa multicilindro, kit para a formação localmente de um hidrogel de polissacarídeo reticulado, método para a formação localmente de um hidrogel reticulado

Info

Publication number
BR112018007683A2
BR112018007683A2 BR112018007683A BR112018007683A BR112018007683A2 BR 112018007683 A2 BR112018007683 A2 BR 112018007683A2 BR 112018007683 A BR112018007683 A BR 112018007683A BR 112018007683 A BR112018007683 A BR 112018007683A BR 112018007683 A2 BR112018007683 A2 BR 112018007683A2
Authority
BR
Brazil
Prior art keywords
polysaccharide
derivative
cross
hyaluronic acid
hydrogel
Prior art date
Application number
BR112018007683A
Other languages
English (en)
Inventor
Krause Andreas
Original Assignee
Merz Pharma Gmbh & Co Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma Gmbh & Co Kgaa filed Critical Merz Pharma Gmbh & Co Kgaa
Publication of BR112018007683A2 publication Critical patent/BR112018007683A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/738—Cross-linked polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/594—Mixtures of polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits
    • A61K2800/882—Mixing prior to application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/95—Involves in-situ formation or cross-linking of polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Birds (AREA)
  • Polymers & Plastics (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Cosmetics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

a presente invenção se refere a composições estéreis de polissacarídeo reticulável localmente para aumentar, preencher ou substituir tecidos moles em várias aplicações cosméticas e terapêuticas. a composição compreende um primeiro derivado de polissacarídeo funcionalizado com um grupo nucleofílico e um segundo derivado de polissacarídeo funcionalizado com um grupo eletrofílico. os ditos grupos funcionais nucleofílicos e eletrofílicos espontaneamente formam ligações covalentes localmente após a co-injeção no corpo de um paciente, resultando na formação de um hidrogel reticulado no local da co-injeção.
BR112018007683A 2015-10-16 2016-10-14 uso de um primeiro derivado de polissacarídeo e de um segundo derivado de polissacarídeo, primeiro e segundo derivados de polissacarídeo, combinação de um primeiro derivado de ácido hialurônico (ah) e de um segundo derivado de ácido hialurônico (ah), sistema de seringa multicilindro, kit para a formação localmente de um hidrogel de polissacarídeo reticulado, método para a formação localmente de um hidrogel reticulado BR112018007683A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15002953.6A EP3156044A1 (en) 2015-10-16 2015-10-16 In situ cross-linkable polysaccharide compositions and uses thereof
PCT/EP2016/001710 WO2017063749A1 (en) 2015-10-16 2016-10-14 In situ cross-linkable polysaccharide compositions and uses thereof

Publications (1)

Publication Number Publication Date
BR112018007683A2 true BR112018007683A2 (pt) 2018-11-06

Family

ID=54540785

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018007683A BR112018007683A2 (pt) 2015-10-16 2016-10-14 uso de um primeiro derivado de polissacarídeo e de um segundo derivado de polissacarídeo, primeiro e segundo derivados de polissacarídeo, combinação de um primeiro derivado de ácido hialurônico (ah) e de um segundo derivado de ácido hialurônico (ah), sistema de seringa multicilindro, kit para a formação localmente de um hidrogel de polissacarídeo reticulado, método para a formação localmente de um hidrogel reticulado

Country Status (16)

Country Link
US (1) US11000467B2 (pt)
EP (2) EP3156044A1 (pt)
JP (2) JP7368940B2 (pt)
KR (1) KR20180064390A (pt)
CN (1) CN108348454A (pt)
AR (1) AR106367A1 (pt)
AU (1) AU2016338072B2 (pt)
BR (1) BR112018007683A2 (pt)
CA (1) CA3000588C (pt)
HK (1) HK1254733A1 (pt)
IL (1) IL258205B (pt)
MX (1) MX2018004235A (pt)
RU (1) RU2734419C2 (pt)
TW (1) TWI789338B (pt)
WO (1) WO2017063749A1 (pt)
ZA (1) ZA201801761B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11819664B2 (en) 2017-06-13 2023-11-21 Merz Pharma Gmbh & Co. Kgaa Mixing nozzle, application device, kit and method using the mixing nozzle or application device
WO2019002371A1 (en) * 2017-06-28 2019-01-03 Nestlé Skin Health Sa GLYCOSAMINOGLYCAN GEL WITH BIS-TRIS BUFFER
WO2019073386A1 (en) * 2017-10-10 2019-04-18 E.N.A. Impeccable Skincare Solutions Ltd MANUFACTURING METHOD AND DERMAL BLEMISHING COMPOSITIONS CONTAINING HYALURONIC ACID AND HYDROXYAPATITE
CN116891541A (zh) * 2018-06-28 2023-10-17 哈鲁拉公司 交联的多羧酸化多糖及其使用方法
WO2020127407A1 (en) * 2018-12-19 2020-06-25 Merz Pharma Gmbh & Co. Kgaa Aldehyde-modified hyaluronic acid, method for preparing same and applications thereof
AU2019401735B2 (en) * 2018-12-20 2022-08-25 Lg Chem, Ltd. Filler having excellent filler properties comprising hyaluronic acid hydrogel
CN109880125B (zh) * 2019-02-21 2021-07-13 武汉纺织大学 一种皮下填充透明质酸凝胶的制备方法
CN112538171A (zh) * 2019-09-20 2021-03-23 天津大学 一种可注射可降解肝素水凝胶及其制备方法和应用
CN111249532A (zh) * 2020-01-16 2020-06-09 广东省人民医院(广东省医学科学院) 一种用于软骨修复的可注射透明质酸水凝胶及其制备方法
EP4100072A1 (en) * 2020-02-04 2022-12-14 Boston Scientific Scimed Inc. Injectable in vivo crosslinking materials for use as soft tissue fillers
CN111253629B (zh) * 2020-03-17 2021-06-15 江苏地韵医疗科技有限公司 一种凝胶、其成套原料及应用
CN113929792B (zh) * 2020-07-13 2023-03-10 孛朗孚(杭州)生物科技有限公司 一种醛基化修饰的透明质酸(钠)及其合成方法和应用
CN112280105A (zh) * 2020-11-11 2021-01-29 河北大学 一种纤维素基自修复水凝胶及其制备方法与应用
CN112472819B (zh) * 2020-11-30 2022-04-22 西安交通大学 一种共载阿霉素和吲哚菁绿的多糖基纳米粒子及其制备方法和应用
CN113024845A (zh) * 2021-03-17 2021-06-25 广西医科大学 一种醛肼交联型抗菌水凝胶敷料的制备方法
CN113827779B (zh) * 2021-08-14 2022-07-26 中国海洋大学 一种生物多糖水凝胶及其制备方法和应用
WO2023191553A1 (ko) * 2022-04-01 2023-10-05 한양대학교 산학협력단 신축성 자가치유 하이드로젤
CN115463262A (zh) * 2022-08-11 2022-12-13 南方医科大学第五附属医院 一种水凝胶复合修复补片及其制备方法与应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616568A (en) 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
WO2001040314A1 (en) 1999-11-26 2001-06-07 The Regents Of The University Of Michigan Reversible cross-linked hydrogels
US7465766B2 (en) 2004-01-08 2008-12-16 The Cleveland Clinic Foundation Hydroxyphenyl cross-linked macromolecular network and applications thereof
EP2254944B1 (en) 2008-02-29 2018-12-19 PVAC Medical Technologies Ltd. Composition for the formation of gels
ITRM20080636A1 (it) * 2008-11-28 2010-05-29 Univ Palermo Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
US8186843B2 (en) 2008-12-17 2012-05-29 M-Edge Accessories, Llc Booklight for a protective cover of an eReader
CZ2009835A3 (cs) 2009-12-11 2011-06-22 Contipro C A.S. Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace
US8197849B2 (en) 2010-02-12 2012-06-12 National Health Research Institutes Cross-linked oxidated hyaluronic acid for use as a vitreous substitute
WO2012113529A1 (en) * 2011-02-22 2012-08-30 Merz Pharma Gmbh & Co. Kgaa In situ formation of a filler
JPWO2012165462A1 (ja) * 2011-05-31 2015-02-23 国立大学法人 東京大学 ハイドロゲル及びその製造方法
US20140105960A1 (en) * 2012-10-12 2014-04-17 Children's Medical Center Corporation Hydrogels for tissue regeneration
WO2014169708A1 (en) * 2013-04-18 2014-10-23 The Hong Kong University Of Science And Technology Biocompatible in situ hydrogel
WO2016097211A1 (en) 2014-12-18 2016-06-23 Galderma S.A. Grafting of cyclodextrin by amide bonds to an ether cross-linked hyaluronic acid and uses thereof
CN104940944A (zh) * 2015-06-04 2015-09-30 浙江大学 蛋白聚糖酶抑制剂结合体外交联透明质酸水凝胶的制作方法及在治疗骨关节炎药物中的应用

Also Published As

Publication number Publication date
MX2018004235A (es) 2018-08-01
IL258205B (en) 2021-02-28
EP3156044A1 (en) 2017-04-19
JP7368940B2 (ja) 2023-10-25
ZA201801761B (en) 2021-09-29
RU2018109536A (ru) 2019-11-18
TW201718035A (zh) 2017-06-01
AU2016338072B2 (en) 2021-12-02
AU2016338072A1 (en) 2018-05-10
HK1254733A1 (zh) 2019-07-26
EP3324931A1 (en) 2018-05-30
KR20180064390A (ko) 2018-06-14
US20180318203A1 (en) 2018-11-08
JP2018530547A (ja) 2018-10-18
TWI789338B (zh) 2023-01-11
CN108348454A (zh) 2018-07-31
IL258205A (en) 2018-05-31
RU2018109536A3 (pt) 2020-01-17
EP3324931B1 (en) 2023-11-29
JP2022136103A (ja) 2022-09-15
RU2734419C2 (ru) 2020-10-16
US11000467B2 (en) 2021-05-11
WO2017063749A1 (en) 2017-04-20
AR106367A1 (es) 2018-01-10
CA3000588A1 (en) 2017-04-20
CA3000588C (en) 2023-08-01

Similar Documents

Publication Publication Date Title
BR112018007683A2 (pt) uso de um primeiro derivado de polissacarídeo e de um segundo derivado de polissacarídeo, primeiro e segundo derivados de polissacarídeo, combinação de um primeiro derivado de ácido hialurônico (ah) e de um segundo derivado de ácido hialurônico (ah), sistema de seringa multicilindro, kit para a formação localmente de um hidrogel de polissacarídeo reticulado, método para a formação localmente de um hidrogel reticulado
CY1119616T1 (el) Συζευγματα ανθρωπινου αντισωματος-φαρμακου κατα του ιστικου παραγοντα
BR112019006278A2 (pt) composições de vacina pneumocócica multivalente que compreendem conjugados de polissacarídeo-proteína
BRPI0907087A2 (pt) ácidos nucleicos de fórmula (i) (nuglxmgnnv)a e derivados dos mesmos como um agente imunoestimulante/adjuvante
BR112012030455A2 (pt) processo para fabricar uma composição hesmostática seca e estável, método para dispensar uma composição hemostática a um sítio alvo em um corpo do paciente, recipiente acabado final, método para prover uma composição hemostática pronta para uso, e, kit para administrar uma composição hemostática
BR112014008789A2 (pt) prevenção e tratamento de condições oculares
BR112019008854A2 (pt) ligantes contendo peptídeo para conjugados de anticorpo-fármaco
PE20161209A1 (es) Conjugados de anticuerpos anti-drosophila similar a delta 3 (anti-dll3) y medicamentos para usarse en el tratamiento contra melanoma
BR112014028633A8 (pt) tratamento de amd usando sflt-1 de aav
BR112013012626A2 (pt) formulação, composição imunogênica, e, seringa pré-carregada
BR112015017246A8 (pt) composição farmacêutica aquosa, seu uso e seringa
AU2015287920A8 (en) Micronized Wharton's Jelly
BR112016012410A2 (pt) conjugado de droga e anticorpo, composto conjugado de droga e anticorpo, composto não-peptídico, método de tratamento de doenças em seres humanos e composição farmacêutica
BR112015018252A2 (pt) composição farmacêutica aquosa de dose fixa estável para administração nasal para um ser humano, composição de suspensão aquosa farmacêutica de dose fixa estável para administração nasal para um ser humano, suspensão estável adequada para administração nasal a um ser humano, método para tratar rinite em um ser humano necessitando do mesmo, uso da composição farmacêutica para administração nasal, método para liberar uma composição farmacêutica e kit
BR112018007560A2 (pt) composição cosmética tendo bactérias probióticas
MX2015015589A (es) Composiciones y metodos para el suministro de agentes activos hidrófobos.
BR112015032200A2 (pt) conjugado anticorpo-droga com estabilidade melhorada, método de preparação, composição farmacêutica e uso do mesmo
BR112015011896A2 (pt) derivado fotorreativo de ácido hialurônico, método de preparação do derivado fotorreativo, método de preparação de derivados 3d reticulados de ácido hialurônico, derivado 3d reticulado de ácido hialurônico e uso do derivado 3d reticulado
BR112018013979A2 (pt) composições em gel para liberação transdérmica para maximizar as concentrações de fármacos no estrato córneo e no soro e métodos de uso dos mesmos
BR112015031329A2 (pt) composições compreendendo ciclodextrina e ácido hialurônico reticulado
CY1122899T1 (el) Υδατικη συσταση περιλαμβανουσα παρακεταμολη και ιβουπροφαινη
MX2020011712A (es) Vacunas de nanoparticulas multivalentes contra la influenza.
BR112012024655A2 (pt) derivado de polietilenoglicol ramificado, composição, método para produção de derivados de peg ramificado, uso de um derivado de peg ramificado e dispositivo médico ou dispositivo protético ou parafuso ou dispositivo através do qual fluídos corporais circulam e retornam para o corpo, ou implante ou implante de eletrodo com um revestimento de superfície
BRPI0518619A2 (pt) mÉtodo de tratar cÂncer em um mamÍfero, combinaÇço farmacÊutica, uso de uma composiÇço ou combinaÇço farmacÊutica e composiÇço imunogÊnica
BR112021025394A2 (pt) Derivados de antraciclina, conjugados de fármaco e molécula de ligação ao alvo, uso de conjugado de fármaco e molécula de ligação ao alvo, método de tratamento de uma doença em um paciente em necessidade de tratamento, e composição farmacêutica

Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: A61K 9/00 , A61L 27/20 , A61K 8/73 , A61K 47/36 , A61K 8/04 , A61K 31/728 , A61K 31/738 , C08B 37/08

Ipc: A61K 8/73 (2006.01), A61K 8/04 (2006.01), A61Q 19/

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]