HRP20190940T1 - Čvrsti oblici za popravak tkiva - Google Patents
Čvrsti oblici za popravak tkiva Download PDFInfo
- Publication number
- HRP20190940T1 HRP20190940T1 HRP20190940TT HRP20190940T HRP20190940T1 HR P20190940 T1 HRP20190940 T1 HR P20190940T1 HR P20190940T T HRP20190940T T HR P20190940TT HR P20190940 T HRP20190940 T HR P20190940T HR P20190940 T1 HRP20190940 T1 HR P20190940T1
- Authority
- HR
- Croatia
- Prior art keywords
- platform structure
- platform
- growth factor
- phase
- bone
- Prior art date
Links
- 230000017423 tissue regeneration Effects 0.000 title claims 3
- 239000007787 solid Substances 0.000 title claims 2
- 210000000845 cartilage Anatomy 0.000 claims 6
- 210000000988 bone and bone Anatomy 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 4
- 238000000576 coating method Methods 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 229920000249 biocompatible polymer Polymers 0.000 claims 3
- 239000003102 growth factor Substances 0.000 claims 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 2
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 2
- 235000014653 Carica parviflora Nutrition 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- 241000243321 Cnidaria Species 0.000 claims 2
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- 229920002683 Glycosaminoglycan Polymers 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
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- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 2
- 102000014429 Insulin-like growth factor Human genes 0.000 claims 2
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 2
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- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims 2
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- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
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- 102000016942 Elastin Human genes 0.000 claims 1
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- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 1
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- 101000846416 Homo sapiens Fibroblast growth factor 1 Proteins 0.000 claims 1
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- 229920002385 Sodium hyaluronate Polymers 0.000 claims 1
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- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
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- 239000002738 chelating agent Substances 0.000 claims 1
- 210000000038 chest Anatomy 0.000 claims 1
- 229940045110 chitosan Drugs 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 229920002549 elastin Polymers 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 210000001624 hip Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
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- 210000003041 ligament Anatomy 0.000 claims 1
- 230000005499 meniscus Effects 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000000963 osteoblast Anatomy 0.000 claims 1
- 210000002997 osteoclast Anatomy 0.000 claims 1
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- 230000001023 pro-angiogenic effect Effects 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
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- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 229940010747 sodium hyaluronate Drugs 0.000 claims 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical group C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 1
Classifications
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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Claims (16)
1. Struktura platforme za popravak tkiva, navedena struktura platforme sadrži dvije faze, pri čemu:
• prva od navedene dvije faze obuhvaća kruti koralj, koji sadrži biokompatibilni polimer; i
• druga faza od navedene dvije faze sadrži kruti koralj i navedena druga faza nadalje sadrži seriju udubljenja duž uzdužne osi u navedenoj drugoj fazi, koja je pogodna za pojačanu vaskularizaciju ili olakšavanje regrutiranja progenitorskih (unipotentnih) stanica ili kombinacije ovih stanica.
2. Struktura platforme sukladno patentnom zahtjevu 1, pri čemu prva faza navedene strukture platforme sadrži biokompatibilni polimer koji sadrži glikozaminoglikan, kitozan, umreženi kitozan, alginat, kalcij alginat, umreženi kalcij alginat, kolagen, elastin, svilu i kombinaciju bilo kojih od navedenih.
3. Struktura platforme sukladno patentnom zahtjevu 2, pri čemu je navedeni glikozaminoglikan hijaluronska kiselina, izborno natrij hijaluronat ili umrežena hijaluronska kiselina.
4. Struktura platforme sukladno patentnom zahtjevu 1, pri čemu navedena struktura platforme još sadrži protu-upalni spoj, anti-infektivni spoj, faktor rasta, kelator, antibiotik, populaciju stanice, proangiogeni faktor ili njihovu kombinaciju.
5. Struktura platforme sukladno patentnom zahtjevu 4, pri čemu je faktor rasta epidermalni faktor rasta (EGF), transformacijski faktor rasta - beta (TGF-β), faktor rasta humanih endotelnih stanica (ECGF), faktor stimulacije kolonije granulocitnih makrofaga (GM- CSF), koštani morfogenetski protein (BMP), faktor rasta živaca (NGF), faktor rasta vaskularnog endotela (VEGF), faktor rasta fibroblasta (FGF), inzulinu sličan faktor rasta (IGF), morfogenetski protein izveden iz hrskavice (CDMP), faktor rasta izveden iz trombocita (PDGF), ili kombinacija navedenih.
6. Struktura platforme sukladno patentnom zahtjevu 1, pri čemu navedena struktura platforme nasadi s populacijom stanica, čija populacija sadrži mezenhimne matične stanice, osteoblaste, osteocite, osteoklaste, hondroblaste, hondrocite, fibroblaste, ili kombinacija istih.
7. Struktura platforme sukladno patentnom zahtjevu 1, pri čemu je navedeni biokompatibilni polimer inkorporiran unutar barem dijela navedene strukture platforme.
8. Struktura platforme sukladno patentnom zahtjevu 1, pri čemu se navedena struktura platforme približava obliku cilindra, konusa, taka, vijka, pravokutne šipke, ploče, diska, piramide, granule, kugle ili kocke.
9. Struktura platforme sukladno patentnom zahtjevu 1, pri čemu navedena struktura platforme podrazumijeva oblik koji se približava meniskusu kakvo ima koljeno ili lakat; zglob; površina zgloba kosti, dio prsnog koša, kuk, zdjelica, uho, nos, ligament, bronhijalna cijev ili intervertebralni disk.
10. Strukturna platforme sukladno patentnom zahtjevu 1, pri čemu navedena struktura platforme ima oblik cilindra i ima presjek od oko 5-40 mm, i visinu od oko 5-25 mm.
11. Struktura platforme sukladno patentnom zahtjevu 1, pri čemu navedena prva ili navedena druga faza nadalje sadrži polimerni premaz.
12. Struktura platforme sukladno patentnom zahtjevu 11, pri čemu spomenuti polimerni premaz, formira polimerni sloj povezan sa dijelom spomenute strukture platforme.
13. Struktura platforme sukladno patentnom zahtjevu 12, pri čemu je navedeni polimerni oblog prisutan na terminusu navedene strukture platforme i navedeni oblog je debljine od između 0,1 -10 mm.
14. Struktura platforme sukladno patentnom zahtjevu 1, pri čemu je navedena struktura platforme pogodna za nanošenje na kost na tkivo hrskavice u primjeni u postupku induciranja ili pospješenja oporavka, regeneracije ili pospješenja stvaranja hrskavice, kosti ili njihove kombinacije.
15. Struktura platforme sukladno patentnom zahtjevu 1, pri čemu je navedena struktura platforme pogodna za primjenu na tkivo koristi i hrskavice, tako da se navedena prva faza može ugraditi unutar ili proksimalno u tkivo hrskavice i spomenuta druga faza se može ugraditi unutar ili proksimalno do koštanog tkiva.
16. Komplet za popravak hrskavice i kosti koji sadrži platformu sukladno zahtjevu 1; upute za korištenje spomenute platforme u tkivu popravak; i po izboru alat za optimalno umetanje navedene platforme, po izboru pri čemu spomenuti komplet obuhvaća niz platformi različitih veličina, oblika ili njihove kombinacije.
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| US10271938B2 (en) | 2009-06-15 | 2019-04-30 | Cartiheal (2009) Ltd | Multi-phasic solid implants for tissue repair |
| SI2442749T1 (sl) * | 2009-06-15 | 2019-08-30 | Cartiheal (2009) Ltd. | Trdne oblike za obnovo tkiva |
| WO2012048289A1 (en) | 2010-10-08 | 2012-04-12 | Board Of Regents, The University Of Texas System | Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications |
| US8946194B2 (en) | 2010-10-08 | 2015-02-03 | Board Of Regents, University Of Texas System | One-step processing of hydrogels for mechanically robust and chemically desired features |
| US20140370094A1 (en) | 2011-11-08 | 2014-12-18 | Tufts University | Silk-based scaffold platform for engineering tissue constructs |
| US9394348B2 (en) | 2011-11-16 | 2016-07-19 | Commonwealth Scientific And Industrial Research Organisation | Collagen-like silk genes |
| HUE046178T2 (hu) | 2012-05-17 | 2020-02-28 | Cartiheal 2009 Ltd | Biomátrix hidrogélek és alkalmazási eljárásaik |
| HUE034310T2 (en) | 2012-11-12 | 2018-02-28 | Cartiheal 2009 Ltd | Tools and systems for solid and graft implantation |
| US11565027B2 (en) | 2012-12-11 | 2023-01-31 | Board Of Regents, The University Of Texas System | Hydrogel membrane for adhesion prevention |
| MX2015007410A (es) | 2012-12-11 | 2015-12-15 | Univ Texas | Membrana de hidrogel para prevencion de la adhesion. |
| WO2014125477A1 (en) * | 2013-02-13 | 2014-08-21 | Cartiheal (2009) Ltd | Solid substrates for mitigating or preventing cell and tissue adhesion and vascularization |
| JP6084884B2 (ja) * | 2013-04-11 | 2017-02-22 | 日本特殊陶業株式会社 | 生体インプラント |
| CN107567312B (zh) | 2015-05-06 | 2022-06-17 | 卡尔蒂希尔(2009)公司 | 优化的固体基质、与其一起使用的工具及其用于促进细胞和组织生长的用途 |
| US10531957B2 (en) | 2015-05-21 | 2020-01-14 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| EP3349815B1 (en) * | 2015-09-14 | 2020-03-11 | Ecole Polytechnique Federale de Lausanne (EPFL) | Composition for bone regeneration |
| EP3838195A1 (en) | 2015-11-25 | 2021-06-23 | Subchondral Solutions, Inc. | Methods, systems and devices for repairing anatomical joint conditions |
| US10485665B2 (en) | 2015-12-09 | 2019-11-26 | Reconstrata, Llc | Apparatus and method for constructing implantable cartilage structures |
| DE102016124049B4 (de) * | 2016-12-12 | 2018-09-27 | Christoph Karl | Gelenkimplantat zur Gewebeneubildung am Gelenk |
| CN106726014B (zh) * | 2017-01-09 | 2018-10-19 | 北京积水潭医院 | 用于处理穹顶样髋臼骨缺损的人工骨垫块 |
| US11980700B2 (en) | 2017-03-08 | 2024-05-14 | Alafair Biosciences, Inc. | Hydrogel medium for the storage and preservation of tissue |
| CN111787886A (zh) | 2018-01-02 | 2020-10-16 | 卡尔蒂希尔(2009)公司 | 用于促进细胞和组织生长的优化固体基质的植入工具和方案 |
| US20190307928A1 (en) * | 2018-04-06 | 2019-10-10 | University Of Southern California | Polymeric patch scaffolds for articular cartilage regeneration |
| CN108618837A (zh) * | 2018-05-30 | 2018-10-09 | 上海交通大学医学院附属第九人民医院 | 个体化骨缺损填充用金属内固定器、其制备方法及用途 |
| IL261820B1 (en) | 2018-09-16 | 2024-04-01 | Cartiheal 2009 Ltd | Optimal cage systems encourage repairs and bone connections |
| JP2021122748A (ja) * | 2020-02-07 | 2021-08-30 | マイセル・テクノロジーズ，インコーポレイテッド | 生分解性層を有するステント |
| CN111235886A (zh) * | 2020-03-23 | 2020-06-05 | 动之医学技术(上海)有限公司 | 壳聚糖基复合纤维的制备方法以及组织工程支架 |
| WO2022098774A1 (en) * | 2020-11-06 | 2022-05-12 | Smith & Nephew, Inc. | Graft composite for hip labrum reconstruction |
| CN113361182A (zh) * | 2021-07-02 | 2021-09-07 | 哈尔滨理工大学 | 一种基于免疫系统作用的骨折愈合仿真方法 |
| CN118043010A (zh) * | 2021-08-03 | 2024-05-14 | 卡尔蒂希尔(2009)公司 | 促进包括大病损和高危群体在内骨软骨细胞和组织生长的方法 |
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| HUE046178T2 (hu) | 2012-05-17 | 2020-02-28 | Cartiheal 2009 Ltd | Biomátrix hidrogélek és alkalmazási eljárásaik |
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2010
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- 2010-05-23 CN CN201080037022.5A patent/CN102665604B/zh active Active
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