HRP20190697T1 - Čvrsta konstrukcija za obnovu tkiva - Google Patents

Čvrsta konstrukcija za obnovu tkiva Download PDF

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Publication number
HRP20190697T1
HRP20190697T1 HRP20190697TT HRP20190697T HRP20190697T1 HR P20190697 T1 HRP20190697 T1 HR P20190697T1 HR P20190697T T HRP20190697T T HR P20190697TT HR P20190697 T HRP20190697 T HR P20190697T HR P20190697 T1 HRP20190697 T1 HR P20190697T1
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HR
Croatia
Prior art keywords
bioscaffold
polymer
bioscaffold according
cells
segment
Prior art date
Application number
HRP20190697TT
Other languages
English (en)
Inventor
Nir Altschuler
Razi Vago
Original Assignee
Cartiheal (2009) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Cartiheal (2009) Ltd filed Critical Cartiheal (2009) Ltd
Publication of HRP20190697T1 publication Critical patent/HRP20190697T1/hr

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Claims (12)

1. Bioskela za obnovu hrskavice ili popravak osteohondralnih defekata s koraljnim kosturom, koji se sastoji od najmanje jednog segmenta s izloženom površinom, koji je izdignut u odnosu na drugi segment izložene površine koraljnog kostura, pri čemu prvi segment obuhvaća područje koje pozicionira i obrubljuje navedeni koraljni kostur i pri čemu se uzduž duge osi skele nalazi serija šupljina.
2. Bioskela sukladno zahtjevu 1, pri čemu se bar prvi segment navedenog koraljnog kostura nalazi u blizini šupljine ili šupljina uzduž njegove longitudinalne osi i pri čemu se barem drugi segment naslanja na navedenu šupljinu ili šupljine.
3. Bioskela sukladno zahtjevu 1, pri čemu navedeni koraljni kostur uključuje oblogu od polimera.
4. Bioskela sukladno zahtjevu 3, pri čemu je navedena obloga od polimera propusna.
5. Bioskela sukladno zahtjevu 3, pri čemu navedeni polimer nije uniforman nego po mogućnosti dolazi u obliku nakupina ili čestica.
6. Bioskela sukladno zahtjevu 3, pri čemu navedeni polimer dolazi kao prirodni polimer s kolagenom, elastinom, svilom, hijaluronskom kiselinom, hitozanom ili bilo kojom njihovom kombinacijom.
7. Bioskela sukladno zahtjevu 3, pri čemu navedeni polimer dolazi kao sintetički biorazgradivi polimer.
8. Bioskela sukladno zahtjevu 3, pri čemu navedena obloga od polimera uključuje citokin, koštani morfogenetski protein (BMP), helator, populaciju stanica, terapeutsko sredstvo, antibiotik ili bilo koju njihovu kombinaciju.
9. Bioskela sukladno zahtjevu 8, pri čemu navedena populacija stanica obuhvaća mezenhimalne matične stanice ili osteoblaste ili hondrocite ili druge stanice koje se koriste za obnovu hrskavice ili popravak osteohondralnog defekta, ili neka njihova kombinacija.
10. Bioskela sukladno zahtjevu 8, pri čemu terapeutsko sredstvo obuhvaća antiupalno sredstvo, antiinfektivno sredstvo, faktor rasta, proangiogene faktore ili neku njihovu kombinaciju.
11. Bioskela sukladno zahtjevu 1, pri čemu je na navedeni koraljni kostur nasađena (nacjepljena) populacija stanica.
12. Bioskela sukladno zahtjevu 11, pri čemu navedena populacija stanica obuhvaća mezenhimalne matične stanice i/ili osteoblaste i/ili hondrocite i/ili druge stanice koje se koriste za obnovu hrskavice.
HRP20190697TT 2008-11-20 2019-04-15 Čvrsta konstrukcija za obnovu tkiva HRP20190697T1 (hr)

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US11650308P 2008-11-20 2008-11-20
EP09827265.1A EP2367556B1 (en) 2008-11-20 2009-11-19 Solid forms for tissue repair
PCT/IL2009/001092 WO2010058400A1 (en) 2008-11-20 2009-11-19 Solid forms for tissue repair background of the invention

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