JP5536793B2 - 組織修復用固体鋳型 - Google Patents
組織修復用固体鋳型 Download PDFInfo
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- JP5536793B2 JP5536793B2 JP2011537009A JP2011537009A JP5536793B2 JP 5536793 B2 JP5536793 B2 JP 5536793B2 JP 2011537009 A JP2011537009 A JP 2011537009A JP 2011537009 A JP2011537009 A JP 2011537009A JP 5536793 B2 JP5536793 B2 JP 5536793B2
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- scaffold
- cartilage
- coral
- present
- cartilage repair
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Description
[実施例]
サンゴは、150μmの平均孔サイズ及び1.7g/cm3の密度を有するヒドロサンゴであるアナサンゴモドキから収集する。この材料から、所望の形の3次元(3−D)サンゴスカフォールド移植物を、まずサンゴを切り出し、研磨することにより調製する。このことは、望ましくない尖った先端部を有しない形成されたサンゴフォームを提供する。この機械的な処理の後、サンゴを4%HCl中に2度、それぞれ15分間浸し、その後、4M NaOHで処理して捕捉された粒子、デブリ及び有機残渣を除去する。その後サンゴを外科的処置の前にオートクレーブし、ガス滅菌により処理する。
材料と方法
1%、3%、5%及び10%ヒアルロン酸(hyaluronic acid、HA)を含有するヒドロゲルをさらに含むサンゴスカフォールドを調製した。
図5Aは、前述の漏斗内へのスカフォールド挿入と緊密な適合とを示す写真であり、このことにより、図5Bに示されるように漏斗に適用されるものに対するスカフォールドの一部の曝露がもたらされ、ここではHAヒドロゲルが漏斗に適用される。図5Bでは、スカフォールドをHAヒドロゲルと共に含む漏斗を回転させることにより、スカフォールド内へのヒドロゲルの十分な組込みがもたらされている。
直径3.5mm、長さ6mmの丸味を帯びた移植物を用いて、成体のイヌで骨軟骨欠損の回復を行う。軟骨組織及び骨組織の3×7mmコアをそれぞれのイヌの内側大腿顆から穿孔して除去し、移植物を軟骨修復部位内へと適合させる(例えば、図9に図示される通り)。動物は、移植後様々な時点で屠殺される。それは例えば、手術後4週間、8週間及び16週間である。
関節及び/又は骨修復部位内への本発明のスカフォールドの挿入は、特殊なツールの使用を介するものであってもよい。本発明のスカフォールドの挿入において利用されるツールの実施形態の1つの概略例が、図10に示されている。ハーベスタ10−1は、ブレードエッジを含んでいてもよい交換可能なアダプタ10−4を有し、これは機械力の適用と共に軟骨及び骨の貫通を容易にする。このツールは、交換可能なパンチャーヘッド10−5を含んでいてもよい。このツールはさらに、器具が挿入される深さを示すのに役立ち、そのことによって骨内への挿入が深すぎることを回避する、或いは、適切な深さでの貫通が達成されなかったことを示す、インジケータ10−3を含んでいてもよい。
Claims (15)
- 固形サンゴを含んでなり、露出表面の第1の部分を複数含み、前記第1の部分が前記固形サンゴの前記露出表面の複数の第2の部分に対して起立している軟骨又は骨軟骨欠損の修復用スカフォールドにおいて、前記固形サンゴの前記第1の部分が、前記第1の部分の長軸に沿った複数の中空に近接し、前記中空が、露出表面を有し、かつ、任意の機械的手段により構築され、前記第2の部分が、前記中空と隣接し、前記第1の部分が、前記固形サンゴを軟骨又は骨軟骨欠損の修復部位内特異的に配置及び固定する領域を少なくとも1つ含む、スカフォールド。
- 固形サンゴがポリマーコーティングを含む、請求項1に記載のスカフォールド。
- ポリマーコーティングが透過性である、請求項2に記載のスカフォールド。
- ポリマーコーティングが非連続的であり、任意で凝集体又は粒子の形である、請求項2又は3に記載のスカフォールド。
- ポリマーコーティングのポリマーが、コラーゲン、エラスチン、絹、ヒアルロン酸、キトサン、及びこれらのあらゆる組合せを含む天然ポリマーを含む、請求項2〜4のいずれかに記載のスカフォールド。
- コラーゲン又はヒアルロン酸が、架橋コラーゲン又は架橋ヒアルロン酸である、請求項5に記載のスカフォールド。
- サイトカイン、骨形成タンパク質(BMP)、キレート剤、細胞集団、治療化合物、抗生物質、又はこれらのあらゆる組合せを含む、請求項1〜6のいずれかに記載のスカフォールド。
- 固形サンゴに細胞集団が播種され、前記細胞集団が、間葉系幹細胞、骨芽細胞、軟骨細胞、軟骨若しくは骨軟骨修復に関与する他の細胞、又はこれらの組合せを含む、請求項7に記載のスカフォールド。
- 治療化合物が、抗炎症性化合物、抗感染性化合物、成長因子、血管新生促進因子又はこれらの組合せを含む、請求項7に記載のスカフォールド。
- 円錐、鋲、ネジ、円柱、長方形棒、皿、円盤、角錐、粒、球又は立方体を含む形状を有する、請求項1〜9のいずれかに記載のスカフォールド。
- スカフォールドの少なくとも一部が骨を貫通し、結果として前記一部が軟骨修復部位に近接する骨髄内へと挿入される、請求項1〜10のいずれかに記載のスカフォールド。
- 軟骨修復の誘導又は亢進方法への適用に適するように構築され、スカフォールドの領域が骨を貫通し、結果として前記領域が、対象における軟骨修復部位に近接する骨髄内へと挿入される、請求項1〜11のいずれかに記載のスカフォールド。
- 骨軟骨欠損の治療方法への適用に適するように構築され、スカフォールドの領域が骨を貫通し、結果として前記領域が、対象における骨軟骨修復部位に近接する骨髄内へと挿入される、請求項1〜11のいずれかに記載のスカフォールド。
- サンゴ粒子を内包するポリマー鋳型を含む、請求項1〜11のいずれかに記載のスカフォールド。
- ポリマーが、コラーゲン、エラスチン、絹、ヒアルロン酸、キトサン、及びこれらのあらゆる組合せを含む天然ポリマーを含む、請求項14に記載のスカフォールド。
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PCT/IL2009/001092 WO2010058400A1 (en) | 2008-11-20 | 2009-11-19 | Solid forms for tissue repair background of the invention |
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JP2012509128A JP2012509128A (ja) | 2012-04-19 |
JP2012509128A5 JP2012509128A5 (ja) | 2012-11-01 |
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EP (1) | EP2367556B1 (ja) |
JP (1) | JP5536793B2 (ja) |
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ES2721876T3 (es) | 2009-06-15 | 2019-08-06 | Cartiheal 2009 Ltd | Formas sólidas para reparación tisular |
US9498334B2 (en) * | 2012-03-27 | 2016-11-22 | DePuy Synthes Products, Inc. | Glenoid defect-filling component |
EP2833933B1 (en) | 2012-04-05 | 2020-10-14 | Cartiheal (2009) Ltd | Multi-phasic solid implants for tissue repair |
WO2013171736A1 (en) | 2012-05-17 | 2013-11-21 | Cartiheal(2009) Ltd | Biomatrix hydrogels and methods of use thereof |
AU2013299505B2 (en) * | 2012-08-10 | 2016-12-22 | Spinalcyte, Llc | Generation of cartilage ex vivo from fibroblasts |
RS56046B1 (sr) * | 2012-11-12 | 2017-09-29 | Cartiheal (2009) Ltd | Instrumenti i sistemi za implantaciju čvrstih oblika i graftova |
AU2014217485B2 (en) | 2013-02-13 | 2017-02-16 | Cartiheal (2009) Ltd | Solid substrates for mitigating or preventing cell and tissue adhesion and vascularization |
US10492921B2 (en) | 2015-04-29 | 2019-12-03 | Institute for Musculoskeletal Science and Education, Ltd. | Implant with arched bone contacting elements |
WO2016176496A1 (en) | 2015-04-29 | 2016-11-03 | Institute for Musculoskeletal Science and Education, Ltd. | Coiled implants and systems and methods of use thereof |
US10449051B2 (en) | 2015-04-29 | 2019-10-22 | Institute for Musculoskeletal Science and Education, Ltd. | Implant with curved bone contacting elements |
US10709570B2 (en) | 2015-04-29 | 2020-07-14 | Institute for Musculoskeletal Science and Education, Ltd. | Implant with a diagonal insertion axis |
EP3461462B1 (en) * | 2015-05-06 | 2023-06-21 | Cartiheal (2009) Ltd. | Optimized solid substrates |
JP7143079B2 (ja) * | 2015-05-06 | 2022-09-28 | カルティヒール(2009)リミティド | 最適化された固体基材、それとともに使用するためのツールならびに細胞及び組織の成長を促進するためのその使用 |
WO2017077539A1 (en) | 2015-11-03 | 2017-05-11 | Ariel-University Research And Development Company Ltd. | Compositions for regeneration and repair of neural tissue |
CN106110394A (zh) * | 2016-06-27 | 2016-11-16 | 梅庆波 | 一种纳米骨修复材料的制备方法 |
US10478312B2 (en) | 2016-10-25 | 2019-11-19 | Institute for Musculoskeletal Science and Education, Ltd. | Implant with protected fusion zones |
US10512549B2 (en) | 2017-03-13 | 2019-12-24 | Institute for Musculoskeletal Science and Education, Ltd. | Implant with structural members arranged around a ring |
US10357377B2 (en) | 2017-03-13 | 2019-07-23 | Institute for Musculoskeletal Science and Education, Ltd. | Implant with bone contacting elements having helical and undulating planar geometries |
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AU2016200421A1 (en) | 2016-02-11 |
AU2016200421B2 (en) | 2017-10-26 |
TR201901133T4 (tr) | 2019-02-21 |
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CA2743461A1 (en) | 2010-05-27 |
JP2012509128A (ja) | 2012-04-19 |
AU2009318835B2 (en) | 2015-11-19 |
DK2367556T3 (da) | 2019-05-06 |
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EP2367556A4 (en) | 2013-07-17 |
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PL2367556T3 (pl) | 2019-07-31 |
AU2009318835A1 (en) | 2010-05-27 |
CA2743461C (en) | 2017-07-11 |
US8808725B2 (en) | 2014-08-19 |
US20220023050A1 (en) | 2022-01-27 |
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