HRP20171609T1 - Inhibitori histon demetilaze - Google Patents
Inhibitori histon demetilaze Download PDFInfo
- Publication number
- HRP20171609T1 HRP20171609T1 HRP20171609TT HRP20171609T HRP20171609T1 HR P20171609 T1 HRP20171609 T1 HR P20171609T1 HR P20171609T T HRP20171609T T HR P20171609TT HR P20171609 T HRP20171609 T HR P20171609T HR P20171609 T1 HRP20171609 T1 HR P20171609T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- heterocyclyl
- compound according
- heteroaryl
- carbocyclyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791406P | 2013-03-15 | 2013-03-15 | |
| EP14768099.5A EP2970211B1 (en) | 2013-03-15 | 2014-03-12 | Histone demethylase inhibitors |
| PCT/US2014/024998 WO2014151106A1 (en) | 2013-03-15 | 2014-03-12 | Histone demethylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171609T1 true HRP20171609T1 (hr) | 2017-12-15 |
Family
ID=51580888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171609TT HRP20171609T1 (hr) | 2013-03-15 | 2014-03-12 | Inhibitori histon demetilaze |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9994562B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2970211B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6332654B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014235280B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2903465A1 (cg-RX-API-DMAC7.html) |
| CY (1) | CY1119476T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2970211T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2644828T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20171609T1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE034906T2 (cg-RX-API-DMAC7.html) |
| LT (1) | LT2970211T (cg-RX-API-DMAC7.html) |
| PL (1) | PL2970211T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2970211T (cg-RX-API-DMAC7.html) |
| RS (1) | RS56561B1 (cg-RX-API-DMAC7.html) |
| SI (1) | SI2970211T1 (cg-RX-API-DMAC7.html) |
| SM (1) | SMT201700493T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014151106A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS55764B1 (sr) | 2012-10-02 | 2017-07-31 | Gilead Sciences | Inhibitori histonskih demetilaza |
| JP6514117B2 (ja) | 2013-02-27 | 2019-05-15 | エピセラピューティクス アーペーエス | ヒストン脱メチル化酵素の阻害剤 |
| HUE034906T2 (hu) | 2013-03-15 | 2018-03-28 | Quanticel Pharmaceuticals Inc | Hiszton-demetiláz inhibitorok |
| JP2017526675A (ja) | 2014-08-27 | 2017-09-14 | ギリアード サイエンシーズ， インコーポレイテッド | ヒストンデメチラーゼを阻害するための化合物および方法 |
| JP6552608B2 (ja) | 2014-09-17 | 2019-07-31 | セルジーン クオンティセル リサーチ，インク． | ヒストンデメチラーゼ阻害剤 |
| US10030017B2 (en) | 2014-09-17 | 2018-07-24 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| WO2016068580A2 (en) | 2014-10-29 | 2016-05-06 | Dong-A Socio Holdings Co., Ltd. | Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (kdms) |
| CN107406418B (zh) * | 2015-01-09 | 2021-10-29 | 基因泰克公司 | 4,5-二氢咪唑衍生物及其作为组蛋白脱甲基酶(kdm2b)抑制剂的用途 |
| WO2016112284A1 (en) * | 2015-01-09 | 2016-07-14 | Genentech, Inc. | (piperidin-3-yl)(naphthalen-2-yl)methanone derivatives and related compounds as inhibitors of the histone demethylase kdm2b for the treatment of cancer |
| US20170057955A1 (en) * | 2015-08-26 | 2017-03-02 | Dong-A Socio Holdings Co., Ltd. | Pyridopyrimidinone Compounds for Modulating the Catalytic Activity of Histone Lysine Demethylases (KDMs) |
| WO2017161012A1 (en) * | 2016-03-15 | 2017-09-21 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
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| JOP20180008A1 (ar) | 2017-02-02 | 2019-01-30 | Gilead Sciences Inc | مركبات لعلاج إصابة بعدوى فيروس الالتهاب الكبدي b |
| WO2018175670A1 (en) | 2017-03-22 | 2018-09-27 | The Research Foundation For The State University Of New York | Matrix metalloproteinase-9 hemopexin domain inhibitors and methods of treatment using same |
| JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
| JP7098748B2 (ja) | 2017-12-20 | 2022-07-11 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール，ヴイ．ヴイ．アイ． | Ｓｔｉｎｇアダプタータンパク質を活性化するホスホン酸結合を有する２’３’環状ジヌクレオチド |
| AU2018392213B2 (en) | 2017-12-20 | 2021-03-04 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein |
| CN118084940A (zh) | 2018-02-13 | 2024-05-28 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
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| US10870691B2 (en) | 2018-04-05 | 2020-12-22 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis B virus protein X |
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| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
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| CN112955435B (zh) | 2018-10-24 | 2024-09-06 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| ES2979163T3 (es) | 2018-10-31 | 2024-09-24 | Gilead Sciences Inc | Compuestos de 6-azabenzimidazol sustituidos como inhibidores de HPK1 |
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| WO2020178768A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| AU2020231201B2 (en) | 2019-03-07 | 2025-02-20 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| US11453681B2 (en) | 2019-05-23 | 2022-09-27 | Gilead Sciences, Inc. | Substituted eneoxindoles and uses thereof |
| UA129329C2 (uk) | 2019-06-25 | 2025-03-19 | Гіліад Сайєнсіз, Інк. | ЗЛИТІ БІЛКИ FLT3L-Fc |
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Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034393A (en) * | 1989-07-27 | 1991-07-23 | Dowelanco | Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives |
| HRP970371A2 (en) * | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| WO2003078427A1 (en) | 2002-03-15 | 2003-09-25 | Vertex Pharmaceuticals, Inc. | Azolylaminoazines as inhibitors of protein kinases |
| WO2005007658A2 (en) * | 2003-07-14 | 2005-01-27 | Arena Pharmaceuticals, Inc. | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
| JP2008510823A (ja) | 2004-08-23 | 2008-04-10 | メルク エンド カムパニー インコーポレーテッド | Ａｋｔ活性阻害剤 |
| US20110319409A1 (en) * | 2010-06-23 | 2011-12-29 | Cox Christopher D | 7-aza-quinazoline pde10 inhibitors |
| GB201112607D0 (en) | 2011-07-22 | 2011-09-07 | Glaxo Group Ltd | Novel compounds |
| HUE034906T2 (hu) | 2013-03-15 | 2018-03-28 | Quanticel Pharmaceuticals Inc | Hiszton-demetiláz inhibitorok |
| JP6552608B2 (ja) | 2014-09-17 | 2019-07-31 | セルジーン クオンティセル リサーチ，インク． | ヒストンデメチラーゼ阻害剤 |
-
2014
- 2014-03-12 HU HUE14768099A patent/HUE034906T2/hu unknown
- 2014-03-12 SI SI201430421T patent/SI2970211T1/sl unknown
- 2014-03-12 AU AU2014235280A patent/AU2014235280B2/en not_active Ceased
- 2014-03-12 DK DK14768099.5T patent/DK2970211T3/en active
- 2014-03-12 EP EP14768099.5A patent/EP2970211B1/en active Active
- 2014-03-12 JP JP2016501713A patent/JP6332654B2/ja not_active Expired - Fee Related
- 2014-03-12 WO PCT/US2014/024998 patent/WO2014151106A1/en not_active Ceased
- 2014-03-12 PL PL14768099T patent/PL2970211T3/pl unknown
- 2014-03-12 LT LTEP14768099.5T patent/LT2970211T/lt unknown
- 2014-03-12 ES ES14768099.5T patent/ES2644828T3/es active Active
- 2014-03-12 SM SM20170493T patent/SMT201700493T1/it unknown
- 2014-03-12 US US14/774,335 patent/US9994562B2/en active Active
- 2014-03-12 CA CA2903465A patent/CA2903465A1/en not_active Abandoned
- 2014-03-12 PT PT147680995T patent/PT2970211T/pt unknown
- 2014-03-12 HR HRP20171609TT patent/HRP20171609T1/hr unknown
- 2014-03-12 RS RS20171070A patent/RS56561B1/sr unknown
-
2017
- 2017-10-23 CY CY20171101101T patent/CY1119476T1/el unknown
-
2018
- 2018-05-04 US US15/971,912 patent/US10526327B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2970211A4 (en) | 2016-08-03 |
| JP2016512834A (ja) | 2016-05-09 |
| PT2970211T (pt) | 2017-10-31 |
| SMT201700493T1 (it) | 2017-11-15 |
| JP6332654B2 (ja) | 2018-05-30 |
| LT2970211T (lt) | 2017-10-25 |
| SI2970211T1 (sl) | 2017-12-29 |
| RS56561B1 (sr) | 2018-02-28 |
| AU2014235280A1 (en) | 2015-09-17 |
| EP2970211B1 (en) | 2017-07-26 |
| US9994562B2 (en) | 2018-06-12 |
| HUE034906T2 (hu) | 2018-03-28 |
| US20160039808A1 (en) | 2016-02-11 |
| PL2970211T3 (pl) | 2018-01-31 |
| US20180319793A1 (en) | 2018-11-08 |
| EP2970211A1 (en) | 2016-01-20 |
| US10526327B2 (en) | 2020-01-07 |
| CA2903465A1 (en) | 2014-09-25 |
| ES2644828T3 (es) | 2017-11-30 |
| DK2970211T3 (en) | 2017-10-16 |
| AU2014235280B2 (en) | 2017-08-31 |
| CY1119476T1 (el) | 2018-03-07 |
| WO2014151106A1 (en) | 2014-09-25 |
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