HRP20171050T1 - Derivati 1,3-dihidro-2h-benzimidazol-2-ona supstituirani s heterociklima kao antivirusna sredstva za respiratorni sincicijski virus - Google Patents
Derivati 1,3-dihidro-2h-benzimidazol-2-ona supstituirani s heterociklima kao antivirusna sredstva za respiratorni sincicijski virus Download PDFInfo
- Publication number
- HRP20171050T1 HRP20171050T1 HRP20171050TT HRP20171050T HRP20171050T1 HR P20171050 T1 HRP20171050 T1 HR P20171050T1 HR P20171050T T HRP20171050T T HR P20171050TT HR P20171050 T HRP20171050 T HR P20171050T HR P20171050 T1 HRP20171050 T1 HR P20171050T1
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- Croatia
- Prior art keywords
- compound
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- respiratory syncytial
- syncytial virus
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Links
- 125000000623 heterocyclic group Chemical group 0.000 title claims 2
- SILNNFMWIMZVEQ-UHFFFAOYSA-N 1,3-dihydrobenzimidazol-2-one Chemical group C1=CC=C2NC(O)=NC2=C1 SILNNFMWIMZVEQ-UHFFFAOYSA-N 0.000 title 1
- 241000725643 Respiratory syncytial virus Species 0.000 title 1
- 239000003443 antiviral agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 12
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 208000030925 respiratory syncytial virus infectious disease Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (10)
1. Spoj s formulom (I),
[image]
ili njegov stereoizomerni oblik, naznačen time da Het je heterocikal koji ima formulu (c-1a)
[image]
R3C je H;
R2c je -(CR8R9)m-RIOc pri čemu R8 i R9 su svaki H, m je 3 i R1Oc predstavlja CN ili SO2CH3;
R4 je odabran iz skupine koju čini aril;
aril je fenil supstituiran s dva supstituenta koji su svaki neovisno odabrani iz skupine koju čine halo, Ci-C4alkiloksi ili C1-C4alkil;
svaki R8 i R9 su neovisno odabrani iz skupine koju čine H, C1-C10alkil i C3-C7cikloalkil; Z je N i R5 je odsutan; ili njegova farmaceutski prihvatljiva adicijska sol ili solvat.
2. Spoj prema zahtjevu 1 naznačen time da spoj je
[image]
3. Spoj prema zahtjevu 1 naznačen time da spoj je
[image]
4. Spoj kako je definiran u bilo kojem od zahtjeva 1 do 3 naznačen time da je za uporabu kao lijek.
5. Farmaceutski pripravak, naznačen time da sadrži farmaceutski prihvatljiv nosač, te kao aktivni sastojak terapeutski učinkovitu količinu spoja kako je definirano u bilo kojem od zahtjeva 1 do 3.
6. Spoj prema bilo kojem od zahtjeva 1 do 3 naznačen time daje za uporabu za liječenje infekcije respiratornim sincicijskim virusom.
7. Spoj naznačen time da je odabran od
[image]
ili njihova farmaceutski prihvatljiva adicijska sol ili solvat.
8. Spoj prema zahtjevu 7 naznačen time daje za uporabu kao lijek.
9. Farmaceutski pripravak, naznačen time, da sadrži farmaceutski prihvatljiv nosač, te kao aktivni sastojak terapeutski djelotvornu količinu spoja prema zahtjevu 7.
10. Spoj prema zahtjevu 7 naznačen time da je za uporabu za liječenje infekcije respiratornim sincicijskim virusom.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12172271 | 2012-06-15 | ||
| EP12182550 | 2012-08-31 | ||
| EP13728404.8A EP2864323B1 (en) | 2012-06-15 | 2013-06-14 | 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents |
| PCT/EP2013/062322 WO2013186333A1 (en) | 2012-06-15 | 2013-06-14 | 1,3 -dihydro- 2h-benzimidazol- 2 -one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171050T1 true HRP20171050T1 (hr) | 2017-10-06 |
Family
ID=48613635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171050TT HRP20171050T1 (hr) | 2012-06-15 | 2017-07-10 | Derivati 1,3-dihidro-2h-benzimidazol-2-ona supstituirani s heterociklima kao antivirusna sredstva za respiratorni sincicijski virus |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20150111868A1 (hr) |
| EP (1) | EP2864323B1 (hr) |
| JP (1) | JP6259451B2 (hr) |
| KR (1) | KR102092612B1 (hr) |
| CN (1) | CN104540817B (hr) |
| AR (1) | AR091455A1 (hr) |
| AU (1) | AU2013276519B2 (hr) |
| CA (1) | CA2873920C (hr) |
| CY (1) | CY1119289T1 (hr) |
| DK (1) | DK2864323T3 (hr) |
| EA (1) | EA028240B1 (hr) |
| ES (1) | ES2632914T3 (hr) |
| HR (1) | HRP20171050T1 (hr) |
| HU (1) | HUE033848T2 (hr) |
| LT (1) | LT2864323T (hr) |
| PL (1) | PL2864323T3 (hr) |
| PT (1) | PT2864323T (hr) |
| SI (1) | SI2864323T1 (hr) |
| TW (1) | TWI643850B (hr) |
| WO (1) | WO2013186333A1 (hr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI501967B (zh) * | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| CN104540817B (zh) | 2012-06-15 | 2017-03-01 | 爱尔兰詹森科学公司 | 作为呼吸道合胞病毒抗病毒剂的用杂环取代的1，3‑二氢‑2h‑苯并咪唑‑2‑酮衍生物 |
| SG11201600977XA (en) | 2013-08-21 | 2016-03-30 | Alios Biopharma Inc | Antiviral compounds |
| EP3177299A4 (en) * | 2014-08-05 | 2018-04-04 | Alios Biopharma, Inc. | Combination therapy for treating a paramyxovirus |
| MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| US10881666B2 (en) | 2017-09-29 | 2021-01-05 | Enanta Pharmaceuticals, Inc. | Combination pharmaceutical agents as RSV inhibitors |
| MX2022005257A (es) * | 2019-10-30 | 2022-06-09 | Janssen Sciences Ireland Unlimited Co | Sintesis de 3-({5-cloro-1-[3-(metilsulfonil)propil]-1h-indol-2-il} metil)-1-(2,2,2-trifluoroetil)-1,3-dihidro-2h-imidazo[4,5-c]pirid in-2-ona. |
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| JP2002514162A (ja) | 1996-07-08 | 2002-05-14 | デュポン ファーマシューティカルズ カンパニー | Ｘａ因子阻害薬およびトロンビン阻害薬としてのアミジノインドール類、アミジノアゾール類、およびそれらの類似体 |
| WO2000020400A1 (en) | 1998-10-05 | 2000-04-13 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions for treating hepatitis c infections |
| EP1140859A2 (en) | 1998-12-18 | 2001-10-10 | Axys Pharmaceuticals, Inc. | (hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors |
| UA74787C2 (en) | 1999-06-28 | 2006-02-15 | Janssen Pharmaceutica Nv | Respiratory syncytial virus replication inhibitors |
| SK18942001A3 (sk) | 1999-06-28 | 2002-10-08 | Janssen Pharmaceutica N. V. | Inhibítory replikácie respiračného syncytiálneho vírusu |
| WO2001012600A1 (en) | 1999-08-12 | 2001-02-22 | Cor Therapeutics, Inc. | INHIBITORS OF FACTOR Xa |
| EP1263754A1 (en) | 2000-02-01 | 2002-12-11 | Millennium Pharmaceuticals, Inc. | INDALONE AND BENZIMIDAZOLONE INHIBITORS OF FACTOR Xa |
| AU2001236605A1 (en) | 2000-02-01 | 2001-08-14 | Cor Therapeutics, Inc. | Indole and benzimidazole inhibitors of factor xa |
| US6489338B2 (en) * | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| US6506738B1 (en) | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
| US6919331B2 (en) | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| JP2005511714A (ja) * | 2001-12-10 | 2005-04-28 | ブリストル−マイヤーズ スクイブ カンパニー | Ｒｓｖ融合インヒビターのジ塩酸塩・モノ水和物 |
| US20030180957A1 (en) | 2001-12-21 | 2003-09-25 | Sense Proteomic Limited | Target and method |
| AU2003294249A1 (en) | 2002-11-08 | 2004-06-03 | Trimeris, Inc. | Hetero-substituted benzimidazole compounds and antiviral uses thereof |
| PE20050068A1 (es) * | 2003-02-06 | 2005-03-11 | Novartis Ag | 2-cianopirrolopirimidinas como inhibidores de la catepsina s |
| US7343930B2 (en) | 2004-12-03 | 2008-03-18 | Masco Corporation Of Indiana | Sprayer with non-faucet control |
| MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| WO2008147697A1 (en) * | 2007-05-22 | 2008-12-04 | Boehringer Ingelheim International Gmbh | Benzimidazolone chymase inhibitors |
| FR2926556B1 (fr) | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
| TWI515187B (zh) * | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI541241B (zh) * | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| TWI527814B (zh) | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI501967B (zh) | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| TWI530495B (zh) * | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| JP6145044B2 (ja) | 2010-12-17 | 2017-06-07 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬剤投与 |
| EA201590020A1 (ru) | 2012-06-15 | 2015-03-31 | ЯНССЕН Ар ЭНД Ди АЙРЛЭНД | Новые производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные бензимидазолами, в качестве противовирусных средств против респираторного синцитиального вируса |
| CN104540817B (zh) | 2012-06-15 | 2017-03-01 | 爱尔兰詹森科学公司 | 作为呼吸道合胞病毒抗病毒剂的用杂环取代的1，3‑二氢‑2h‑苯并咪唑‑2‑酮衍生物 |
| KR20150028969A (ko) | 2012-06-15 | 2015-03-17 | 얀센 알 앤드 디 아일랜드 | 호흡기 합포체 바이러스의 항바이러스제로서의 벤즈이미다졸로 치환된 4-치환된 1,3-디하이드로-2h-벤즈이미다졸-2-온 유도체 |
| CN104540816A (zh) | 2012-06-15 | 2015-04-22 | 爱尔兰詹森研发公司 | 作为呼吸道合胞病毒抗病毒剂的被杂环取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物 |
| LT2909195T (lt) | 2012-10-16 | 2017-09-25 | Janssen Sciences Ireland Uc | Antivirusiniai rsv junginiai |
-
2013
- 2013-06-14 CN CN201380031144.7A patent/CN104540817B/zh active Active
- 2013-06-14 US US14/407,134 patent/US20150111868A1/en not_active Abandoned
- 2013-06-14 EA EA201590022A patent/EA028240B1/ru not_active IP Right Cessation
- 2013-06-14 WO PCT/EP2013/062322 patent/WO2013186333A1/en active Application Filing
- 2013-06-14 PL PL13728404T patent/PL2864323T3/pl unknown
- 2013-06-14 HU HUE13728404A patent/HUE033848T2/en unknown
- 2013-06-14 CA CA2873920A patent/CA2873920C/en active Active
- 2013-06-14 PT PT137284048T patent/PT2864323T/pt unknown
- 2013-06-14 ES ES13728404.8T patent/ES2632914T3/es active Active
- 2013-06-14 KR KR1020157000509A patent/KR102092612B1/ko active IP Right Grant
- 2013-06-14 AR ARP130102108 patent/AR091455A1/es active IP Right Grant
- 2013-06-14 EP EP13728404.8A patent/EP2864323B1/en active Active
- 2013-06-14 SI SI201330706T patent/SI2864323T1/sl unknown
- 2013-06-14 LT LTEP13728404.8T patent/LT2864323T/lt unknown
- 2013-06-14 JP JP2015516621A patent/JP6259451B2/ja active Active
- 2013-06-14 TW TW102121025A patent/TWI643850B/zh not_active IP Right Cessation
- 2013-06-14 AU AU2013276519A patent/AU2013276519B2/en not_active Ceased
- 2013-06-14 DK DK13728404.8T patent/DK2864323T3/en active
-
2016
- 2016-01-08 US US14/991,815 patent/US9845321B2/en active Active
-
2017
- 2017-07-10 HR HRP20171050TT patent/HRP20171050T1/hr unknown
- 2017-07-18 CY CY20171100765T patent/CY1119289T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA028240B1 (ru) | 2017-10-31 |
| TW201410669A (zh) | 2014-03-16 |
| TWI643850B (zh) | 2018-12-11 |
| SI2864323T1 (sl) | 2017-08-31 |
| CA2873920C (en) | 2021-07-20 |
| CA2873920A1 (en) | 2013-12-19 |
| EP2864323B1 (en) | 2017-04-19 |
| LT2864323T (lt) | 2017-07-25 |
| US20160122346A1 (en) | 2016-05-05 |
| CN104540817B (zh) | 2017-03-01 |
| EP2864323A1 (en) | 2015-04-29 |
| US20150111868A1 (en) | 2015-04-23 |
| CN104540817A (zh) | 2015-04-22 |
| WO2013186333A1 (en) | 2013-12-19 |
| KR102092612B1 (ko) | 2020-03-25 |
| US9845321B2 (en) | 2017-12-19 |
| EA201590022A1 (ru) | 2015-04-30 |
| AU2013276519B2 (en) | 2017-05-25 |
| PT2864323T (pt) | 2017-07-14 |
| KR20150033646A (ko) | 2015-04-01 |
| AR091455A1 (es) | 2015-02-04 |
| HUE033848T2 (en) | 2018-01-29 |
| CY1119289T1 (el) | 2018-02-14 |
| ES2632914T3 (es) | 2017-09-18 |
| AU2013276519A1 (en) | 2014-12-04 |
| JP2015519386A (ja) | 2015-07-09 |
| DK2864323T3 (en) | 2017-08-14 |
| PL2864323T3 (pl) | 2017-09-29 |
| JP6259451B2 (ja) | 2018-01-10 |
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