HRP20170607T1 - Proizvodni postupak vortioksetina - Google Patents

Proizvodni postupak vortioksetina Download PDF

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Publication number
HRP20170607T1
HRP20170607T1 HRP20170607TT HRP20170607T HRP20170607T1 HR P20170607 T1 HRP20170607 T1 HR P20170607T1 HR P20170607T T HRP20170607T T HR P20170607TT HR P20170607 T HRP20170607 T HR P20170607T HR P20170607 T1 HRP20170607 T1 HR P20170607T1
Authority
HR
Croatia
Prior art keywords
process according
formula
compound
equivalents
piperazine
Prior art date
Application number
HRP20170607TT
Other languages
English (en)
Croatian (hr)
Inventor
Thomas Ruhland
Kim Lasse Christensen
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of HRP20170607T1 publication Critical patent/HRP20170607T1/hr

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02Iron compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)
HRP20170607TT 2013-02-22 2014-02-20 Proizvodni postupak vortioksetina HRP20170607T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361767883P 2013-02-22 2013-02-22
DKPA201300104 2013-02-22
PCT/EP2014/053313 WO2014128207A1 (en) 2013-02-22 2014-02-20 Vortioxetine manufacturing process
EP14705524.8A EP2958903B1 (en) 2013-02-22 2014-02-20 Vortioxetine manufacturing process

Publications (1)

Publication Number Publication Date
HRP20170607T1 true HRP20170607T1 (hr) 2017-06-30

Family

ID=59215387

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20170607TT HRP20170607T1 (hr) 2013-02-22 2014-02-20 Proizvodni postupak vortioksetina

Country Status (37)

Country Link
US (1) US9353073B2 (cg-RX-API-DMAC7.html)
EP (1) EP2958903B1 (cg-RX-API-DMAC7.html)
JP (1) JP6464098B2 (cg-RX-API-DMAC7.html)
KR (1) KR102230628B1 (cg-RX-API-DMAC7.html)
CN (1) CN104995181B (cg-RX-API-DMAC7.html)
AP (1) AP2015008640A0 (cg-RX-API-DMAC7.html)
AU (1) AU2014220735B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015019268B1 (cg-RX-API-DMAC7.html)
CA (1) CA2901821A1 (cg-RX-API-DMAC7.html)
CL (1) CL2015002309A1 (cg-RX-API-DMAC7.html)
CR (1) CR20150423A (cg-RX-API-DMAC7.html)
CY (1) CY1118883T1 (cg-RX-API-DMAC7.html)
DK (1) DK2958903T3 (cg-RX-API-DMAC7.html)
DO (1) DOP2015000187A (cg-RX-API-DMAC7.html)
EA (1) EA027756B1 (cg-RX-API-DMAC7.html)
ES (1) ES2625380T3 (cg-RX-API-DMAC7.html)
GE (1) GEP201706749B (cg-RX-API-DMAC7.html)
HR (1) HRP20170607T1 (cg-RX-API-DMAC7.html)
IL (1) IL240501B (cg-RX-API-DMAC7.html)
LT (1) LT2958903T (cg-RX-API-DMAC7.html)
MA (1) MA38338B1 (cg-RX-API-DMAC7.html)
ME (1) ME02671B (cg-RX-API-DMAC7.html)
MX (1) MX362355B (cg-RX-API-DMAC7.html)
MY (1) MY172337A (cg-RX-API-DMAC7.html)
PE (1) PE20151589A1 (cg-RX-API-DMAC7.html)
PH (1) PH12015501807B1 (cg-RX-API-DMAC7.html)
PL (1) PL2958903T3 (cg-RX-API-DMAC7.html)
PT (1) PT2958903T (cg-RX-API-DMAC7.html)
RS (1) RS55932B1 (cg-RX-API-DMAC7.html)
RU (1) RU2652265C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201506651SA (cg-RX-API-DMAC7.html)
SI (1) SI2958903T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201700238T1 (cg-RX-API-DMAC7.html)
TN (1) TN2015000335A1 (cg-RX-API-DMAC7.html)
UA (1) UA116236C2 (cg-RX-API-DMAC7.html)
WO (1) WO2014128207A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201506050B (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2592694C2 (ru) 2010-08-18 2016-07-27 СЭМЬЮМЕД, ЭлЭлСи Дикетоны и гидроксикетоны в качестве активатора сигнального пути катенина
BR112015020391B1 (pt) 2013-02-22 2022-07-26 Samumed, Llc Gama-dicetonas como ativadoras da via de sinalização de wnt/beta-catenina
DK3206686T3 (da) 2014-08-20 2019-12-16 Samumed Llc Gamma-diketoner til behandling og forebyggelse af ældning af huden og rynker
WO2016125191A2 (en) 2015-02-04 2016-08-11 Mylan Laboratories Limited Processes for the preparation of vortioxetine hydrobromide
EP3274330A1 (en) 2015-03-26 2018-01-31 Cipla Limited Method for making serotonin reuptake inhibitors
CN106279065A (zh) * 2015-05-12 2017-01-04 北京深蓝海生物医药科技有限公司 一种氢溴酸沃替西汀的精制转晶方法
JO3456B1 (ar) 2015-05-13 2020-07-05 H Lundbeck As فيروتيوكسيتين بيروجلوتامات
CN108473451B (zh) * 2016-02-08 2022-07-15 H.隆德贝克有限公司 1-[2-(2,4-二甲基-苯基硫烷基)-苯基]哌嗪的合成
MX2018015759A (es) 2016-07-01 2019-03-21 H Lundbeck As Regimenes de dosificacion de vortioxetina para el rapido inicio del efecto antidepresivo.
US10519121B2 (en) 2016-12-30 2019-12-31 Apicore Us Llc Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts
EP3870292A4 (en) 2018-10-26 2022-11-09 The Research Foundation for The State University of New York COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA
CN109912538B (zh) * 2019-01-22 2021-03-12 安徽赛乐普制药有限公司 一种抗抑郁药沃替西汀的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
JP2005513128A (ja) * 2001-12-20 2005-05-12 ハー・ルンドベック・アクチエゼルスカベット アリールオキシフェニル及びアリールスルファニルフェニル誘導体
MY150647A (en) * 2006-06-16 2014-02-14 Lundbeck & Co As H 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment
TW201033181A (en) * 2009-02-17 2010-09-16 Lundbeck & Co As H Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine

Also Published As

Publication number Publication date
CN104995181B (zh) 2017-03-08
AU2014220735B2 (en) 2017-06-22
WO2014128207A1 (en) 2014-08-28
MA38338B1 (fr) 2018-10-31
EA027756B1 (ru) 2017-08-31
UA116236C2 (uk) 2018-02-26
SMT201700238T1 (it) 2017-07-18
LT2958903T (lt) 2017-08-25
IL240501A0 (en) 2015-09-24
TN2015000335A1 (en) 2017-01-03
DOP2015000187A (es) 2015-11-30
CL2015002309A1 (es) 2016-03-04
ME02671B (me) 2017-06-20
ZA201506050B (en) 2017-08-30
KR20150118146A (ko) 2015-10-21
SI2958903T1 (sl) 2017-09-29
MY172337A (en) 2019-11-21
BR112015019268A2 (pt) 2020-01-28
MX362355B (es) 2019-01-14
RS55932B1 (sr) 2017-09-29
EP2958903B1 (en) 2017-04-12
US9353073B2 (en) 2016-05-31
RU2015134407A (ru) 2017-03-28
HK1216098A1 (en) 2016-10-14
PE20151589A1 (es) 2015-12-03
MX2015010656A (es) 2015-12-17
GEP201706749B (en) 2017-10-10
DK2958903T3 (en) 2017-05-15
PL2958903T3 (pl) 2017-08-31
EA201591349A1 (ru) 2015-12-30
AP2015008640A0 (en) 2015-08-31
PT2958903T (pt) 2017-05-26
RU2652265C2 (ru) 2018-04-27
AU2014220735A1 (en) 2015-08-20
JP2016509042A (ja) 2016-03-24
CR20150423A (es) 2015-10-20
CA2901821A1 (en) 2014-08-28
MA38338A1 (fr) 2016-09-30
PH12015501807A1 (en) 2015-11-09
US20160009670A1 (en) 2016-01-14
SG11201506651SA (en) 2015-09-29
ES2625380T3 (es) 2017-07-19
CN104995181A (zh) 2015-10-21
KR102230628B1 (ko) 2021-03-22
IL240501B (en) 2018-08-30
BR112015019268B1 (pt) 2023-01-10
PH12015501807B1 (en) 2019-05-31
EP2958903A1 (en) 2015-12-30
CY1118883T1 (el) 2018-01-10
JP6464098B2 (ja) 2019-02-06

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