AU2014220735B2 - Vortioxetine manufacturing process - Google Patents
Vortioxetine manufacturing process Download PDFInfo
- Publication number
- AU2014220735B2 AU2014220735B2 AU2014220735A AU2014220735A AU2014220735B2 AU 2014220735 B2 AU2014220735 B2 AU 2014220735B2 AU 2014220735 A AU2014220735 A AU 2014220735A AU 2014220735 A AU2014220735 A AU 2014220735A AU 2014220735 B2 AU2014220735 B2 AU 2014220735B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- formula
- piperazine
- process according
- equivalents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Compounds Of Unknown Constitution (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361767883P | 2013-02-22 | 2013-02-22 | |
| DKPA201300104 | 2013-02-22 | ||
| DKPA201300104 | 2013-02-22 | ||
| PCT/EP2014/053313 WO2014128207A1 (en) | 2013-02-22 | 2014-02-20 | Vortioxetine manufacturing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014220735A1 AU2014220735A1 (en) | 2015-08-20 |
| AU2014220735B2 true AU2014220735B2 (en) | 2017-06-22 |
Family
ID=59215387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014220735A Active AU2014220735B2 (en) | 2013-02-22 | 2014-02-20 | Vortioxetine manufacturing process |
Country Status (37)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT201800065T1 (it) | 2010-08-18 | 2018-03-08 | Samumed Llc | Dichetoni e idrossichetoni come attivatori della via di segnalazione della catechina |
| ES2709824T3 (es) | 2013-02-22 | 2019-04-17 | Samumed Llc | Gamma-dicetonas como activadores de la ruta de señalización Wnt/beta-catenina |
| SMT201900709T1 (it) | 2014-08-20 | 2020-01-14 | Samumed Llc | Gamma-dichetoni per trattamento e prevenzione di pelle in invecchiamento e rughe |
| WO2016125191A2 (en) | 2015-02-04 | 2016-08-11 | Mylan Laboratories Limited | Processes for the preparation of vortioxetine hydrobromide |
| US20180072690A1 (en) | 2015-03-26 | 2018-03-15 | Cipla Limited | Methods for Making Serotonin Reuptake Inhibitors |
| CN106279065A (zh) * | 2015-05-12 | 2017-01-04 | 北京深蓝海生物医药科技有限公司 | 一种氢溴酸沃替西汀的精制转晶方法 |
| JO3456B1 (ar) | 2015-05-13 | 2020-07-05 | H Lundbeck As | فيروتيوكسيتين بيروجلوتامات |
| CN108473451B (zh) * | 2016-02-08 | 2022-07-15 | H.隆德贝克有限公司 | 1-[2-(2,4-二甲基-苯基硫烷基)-苯基]哌嗪的合成 |
| CA3026728A1 (en) | 2016-07-01 | 2018-01-04 | H. Lundbeck A/S | Vortioxetine dosing regimes for fast onset of antidepressant effect |
| US10519121B2 (en) | 2016-12-30 | 2019-12-31 | Apicore Us Llc | Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts |
| WO2020087031A1 (en) | 2018-10-26 | 2020-04-30 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| CN109912538B (zh) * | 2019-01-22 | 2021-03-12 | 安徽赛乐普制药有限公司 | 一种抗抑郁药沃替西汀的制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003029232A1 (en) * | 2001-10-04 | 2003-04-10 | H. Lundbeck A/S | Phenyl-piperazine derivatives as serotonin reuptake inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1458689B1 (en) * | 2001-12-20 | 2007-04-11 | H. Lundbeck A/S | Aryloxyphenyl and arylsulfanylphenyl derivatives |
| AR061481A1 (es) * | 2006-06-16 | 2008-08-27 | Lundbeck & Co As H | Compuestos con actividad combinada sobre sert, 5-ht3 y 5-ht1a |
| TW201033181A (en) * | 2009-02-17 | 2010-09-16 | Lundbeck & Co As H | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
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2014
- 2014-02-20 MY MYPI2015002072A patent/MY172337A/en unknown
- 2014-02-20 SG SG11201506651SA patent/SG11201506651SA/en unknown
- 2014-02-20 LT LTEP14705524.8T patent/LT2958903T/lt unknown
- 2014-02-20 AP AP2015008640A patent/AP2015008640A0/xx unknown
- 2014-02-20 DK DK14705524.8T patent/DK2958903T3/en active
- 2014-02-20 RU RU2015134407A patent/RU2652265C2/ru active
- 2014-02-20 BR BR112015019268-8A patent/BR112015019268B1/pt active IP Right Grant
- 2014-02-20 EA EA201591349A patent/EA027756B1/ru not_active IP Right Cessation
- 2014-02-20 SM SM20170238T patent/SMT201700238T1/it unknown
- 2014-02-20 RS RS20170399A patent/RS55932B1/sr unknown
- 2014-02-20 JP JP2015558446A patent/JP6464098B2/ja active Active
- 2014-02-20 GE GEAP201413919A patent/GEP201706749B/en unknown
- 2014-02-20 EP EP14705524.8A patent/EP2958903B1/en active Active
- 2014-02-20 MX MX2015010656A patent/MX362355B/es active IP Right Grant
- 2014-02-20 US US14/767,350 patent/US9353073B2/en active Active
- 2014-02-20 ME MEP-2017-91A patent/ME02671B/me unknown
- 2014-02-20 ES ES14705524.8T patent/ES2625380T3/es active Active
- 2014-02-20 HR HRP20170607TT patent/HRP20170607T1/hr unknown
- 2014-02-20 WO PCT/EP2014/053313 patent/WO2014128207A1/en not_active Ceased
- 2014-02-20 SI SI201430214T patent/SI2958903T1/sl unknown
- 2014-02-20 MA MA38338A patent/MA38338B1/fr unknown
- 2014-02-20 AU AU2014220735A patent/AU2014220735B2/en active Active
- 2014-02-20 PT PT147055248T patent/PT2958903T/pt unknown
- 2014-02-20 PE PE2015001720A patent/PE20151589A1/es active IP Right Grant
- 2014-02-20 CN CN201480009227.0A patent/CN104995181B/zh active Active
- 2014-02-20 UA UAA201509642A patent/UA116236C2/uk unknown
- 2014-02-20 KR KR1020157021985A patent/KR102230628B1/ko active Active
- 2014-02-20 PL PL14705524T patent/PL2958903T3/pl unknown
- 2014-02-20 CA CA2901821A patent/CA2901821A1/en not_active Abandoned
-
2015
- 2015-08-06 TN TN2015000335A patent/TN2015000335A1/en unknown
- 2015-08-10 DO DO2015000187A patent/DOP2015000187A/es unknown
- 2015-08-11 IL IL240501A patent/IL240501B/en active IP Right Grant
- 2015-08-17 PH PH12015501807A patent/PH12015501807B1/en unknown
- 2015-08-18 CL CL2015002309A patent/CL2015002309A1/es unknown
- 2015-08-18 CR CR20150423A patent/CR20150423A/es unknown
- 2015-08-20 ZA ZA2015/06050A patent/ZA201506050B/en unknown
-
2017
- 2017-05-03 CY CY20171100483T patent/CY1118883T1/el unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003029232A1 (en) * | 2001-10-04 | 2003-04-10 | H. Lundbeck A/S | Phenyl-piperazine derivatives as serotonin reuptake inhibitors |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE PRIORITY DETAILS TO READ PA201300104 22 FEB 2013 DK |
|
| FGA | Letters patent sealed or granted (standard patent) |