HRP20170011T1 - Postupak za izradu pemetrekseda i njegove lizinske soli - Google Patents
Postupak za izradu pemetrekseda i njegove lizinske soli Download PDFInfo
- Publication number
- HRP20170011T1 HRP20170011T1 HRP20170011TT HRP20170011T HRP20170011T1 HR P20170011 T1 HRP20170011 T1 HR P20170011T1 HR P20170011T T HRP20170011T T HR P20170011TT HR P20170011 T HRP20170011 T HR P20170011T HR P20170011 T1 HRP20170011 T1 HR P20170011T1
- Authority
- HR
- Croatia
- Prior art keywords
- pemetrexed
- lysine
- salt
- acid
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000398A ITRM20120398A1 (it) | 2012-08-08 | 2012-08-08 | Procedimento di sintesi pemetrexed e suo sale di lisina. |
| PCT/IB2013/056497 WO2014024164A1 (en) | 2012-08-08 | 2013-08-08 | Process for the preparation of pemetrexed and lysin salt thereof |
| EP13777144.0A EP2882753B1 (en) | 2012-08-08 | 2013-08-08 | Process for the preparation of pemetrexed and lysin salt thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20170011T1 true HRP20170011T1 (hr) | 2017-03-10 |
Family
ID=47018368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170011TT HRP20170011T1 (hr) | 2012-08-08 | 2013-08-08 | Postupak za izradu pemetrekseda i njegove lizinske soli |
Country Status (23)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107641124A (zh) * | 2016-07-22 | 2018-01-30 | 上海创诺制药有限公司 | 一种培美曲塞二酸新晶型及其制备方法 |
| CN109836425B (zh) * | 2017-11-24 | 2023-01-24 | 江苏创诺制药有限公司 | 一种合成培美酸的制备工艺 |
| CN110128427A (zh) * | 2018-02-09 | 2019-08-16 | 鲁南制药集团股份有限公司 | 培美曲塞缬氨酸盐 |
| CN110128426B (zh) * | 2018-02-09 | 2021-12-14 | 鲁南制药集团股份有限公司 | 培美曲塞谷氨酸盐 |
| CN110128428A (zh) * | 2018-02-09 | 2019-08-16 | 鲁南制药集团股份有限公司 | 培美曲塞丙氨酸盐 |
| CN111333658A (zh) * | 2020-05-06 | 2020-06-26 | 贵州联科中贝制药科技有限公司 | 一种培美曲塞二钠水合物的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990005128A1 (en) | 1988-10-31 | 1990-05-17 | Mitsui Toatsu Chemicals, Inc. | Process for preparing organic group-substituted sodium aluminum hydride |
| KR0162654B1 (ko) | 1989-12-11 | 1998-11-16 | 알렌 제이. 시니스갤리 | N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체 |
| IL96531A (en) | 1989-12-11 | 1995-08-31 | Univ Princeton | History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them) |
| US5416211A (en) | 1992-09-25 | 1995-05-16 | Eli Lilly And Company | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines |
| IL107041A (en) * | 1992-09-25 | 2000-02-17 | Lilly Co Eli | Process for preparing omega(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo-6-¬2,3-d¾pyrimidin-5-YL)alkarylcarboxylic acids and N-(omega-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo¬2,3-d¾pyrimidin-5-YL)alk-aroyl-4-glutamic acids |
| DE19725647A1 (de) | 1997-06-18 | 1998-12-24 | Basf Ag | Cyclopenta[I]phenanthren-Metallkomplex-Katalysatorsysteme |
| ZA987550B (en) | 1997-09-26 | 2000-02-21 | Lilly Co Eli | Processes and intermediates useful to make antifolates. |
| HU229704B1 (en) | 2000-02-25 | 2014-05-28 | Lilly Co Eli | A novel crystalline form of n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and process for its preparation |
| KR101101443B1 (ko) * | 2006-08-14 | 2012-01-03 | 시코르, 인크. | 페메트렉세드의 중간체의 제조 방법 |
| JP2008543975A (ja) * | 2006-08-14 | 2008-12-04 | シコール インコーポレイティド | 高度に純粋なペメトレキセド二酸およびその調製方法 |
| CN101591247B (zh) * | 2008-05-30 | 2012-09-05 | 上海希迪制药有限公司 | 合成4-(4-甲酯基苯基)丁醛的方法 |
| IT1401677B1 (it) * | 2010-07-22 | 2013-08-02 | Chemi Spa | Nuovo processo per la sintesi di pemetrexed sale disodico |
| CA2804855A1 (en) | 2010-07-28 | 2012-02-02 | Eagle Pharmaceuticals, Inc. | Pharmaceutical compositions containing pemetrexed having extended storage stability |
| WO2012056285A1 (en) * | 2010-10-25 | 2012-05-03 | Fresenius Kabi Oncology Ltd. | An improved process for the preparation of pemetrexed |
-
2012
- 2012-08-08 IT IT000398A patent/ITRM20120398A1/it unknown
-
2013
- 2013-08-06 TW TW102128058A patent/TWI609017B/zh active
- 2013-08-08 RU RU2015108042A patent/RU2609006C2/ru active
- 2013-08-08 BR BR112015002429A patent/BR112015002429A8/pt not_active Application Discontinuation
- 2013-08-08 SI SI201330427A patent/SI2882753T1/sl unknown
- 2013-08-08 DK DK13777144.0T patent/DK2882753T3/en active
- 2013-08-08 LT LTEP13777144.0T patent/LT2882753T/lt unknown
- 2013-08-08 MX MX2015001712A patent/MX362858B/es active IP Right Grant
- 2013-08-08 AU AU2013301156A patent/AU2013301156B2/en active Active
- 2013-08-08 HU HUE13777144A patent/HUE032304T2/en unknown
- 2013-08-08 ES ES13777144.0T patent/ES2607890T3/es active Active
- 2013-08-08 RS RS20161202A patent/RS55515B1/sr unknown
- 2013-08-08 HR HRP20170011TT patent/HRP20170011T1/hr unknown
- 2013-08-08 IN IN833DEN2015 patent/IN2015DN00833A/en unknown
- 2013-08-08 KR KR1020157005932A patent/KR102288417B1/ko active Active
- 2013-08-08 CN CN201380041935.8A patent/CN104736540B/zh active Active
- 2013-08-08 PT PT137771440T patent/PT2882753T/pt unknown
- 2013-08-08 PL PL13777144T patent/PL2882753T3/pl unknown
- 2013-08-08 WO PCT/IB2013/056497 patent/WO2014024164A1/en active Application Filing
- 2013-08-08 SM SM20160474T patent/SMT201600474T1/it unknown
- 2013-08-08 EP EP13777144.0A patent/EP2882753B1/en active Active
-
2015
- 2015-03-06 ZA ZA2015/01549A patent/ZA201501549B/en unknown
-
2016
- 2016-12-28 SM SM201600474T patent/SMT201600474B/it unknown
- 2016-12-28 CY CY20161101351T patent/CY1118514T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20170011T1 (hr) | Postupak za izradu pemetrekseda i njegove lizinske soli | |
| ES2534096T3 (es) | Derivados de piridina y pirazina bicíclicos condensados como inhibidores de quinasa | |
| JP6755922B2 (ja) | 新規な化合物、それらの調製及びそれらの使用 | |
| ES2404415T3 (es) | Compuestos de imidazo[1,2-a]pirazina para el tratamiento de infecciones virales tales como la hepatitis | |
| ES2751491T3 (es) | Derivados de purina como moduladores de la actividad de TNF | |
| ES2779225T3 (es) | Reactivos de merilformilo sustituido y procedimiento de uso de los mismos para modificar propiedades fisicoquímicas y/o farmacocinéticas de compuestos | |
| CA2673965A1 (en) | Pyrazolopyrimidine compound | |
| KR20130102099A (ko) | Trpa1 길항제로서의 2-아미노-4-아릴티아졸 화합물 | |
| ES2642720T3 (es) | Derivados de 1,5-naftiridina como inhibidores de MELK | |
| ES2830444T3 (es) | Derivados de tiofeno condensado útiles como inhibidores de NaPi-IIb | |
| ES2819249T3 (es) | Derivados de tetrahidroimidazopiridina como moduladores de la actividad de TNF | |
| EP4320100A1 (en) | Deuterated dhodh inhibitors | |
| CA3234823A1 (en) | A synthesis scheme and procedures for preparing a sik3 inhibitor and intermediates thereof | |
| ES2729490T3 (es) | Derivados de isoindolina | |
| ITMI20011764A1 (it) | Metodo per l'ottenimento del pemirolast ad elevata purezza | |
| DE602004008486T2 (de) | Verfahren zur herstellung von (1s,4r)-cis-4-ä2-amino-6-chlor-9h-purin-9-ylü-2-cyclopenten-1-methanol | |
| CN104557877A (zh) | 一种阿伐那非中间体及其制备方法和应用 | |
| IL176471A (en) | PROCESS FOR THE PREPARATION OF 2-AMINO [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | |
| US8952153B2 (en) | One pot process for preparing pemetrexed disodium | |
| MXPA06007400A (es) | Proceso para la preparacion de triazolopirimidinas | |
| Kochergin et al. | Synthesis of 2-amino-6-(nitroimidazolyl) thiopurines | |
| HK1209426B (en) | Process for the preparation of pemetrexed and lysin salt thereof |