HRP20161594T1 - Pripravci za liječenje rozaceje koji sadrže kitozan i amid dikarboksilne kiseline - Google Patents

Pripravci za liječenje rozaceje koji sadrže kitozan i amid dikarboksilne kiseline Download PDF

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Publication number
HRP20161594T1
HRP20161594T1 HRP20161594TT HRP20161594T HRP20161594T1 HR P20161594 T1 HRP20161594 T1 HR P20161594T1 HR P20161594T T HRP20161594T T HR P20161594TT HR P20161594 T HRP20161594 T HR P20161594T HR P20161594 T1 HRP20161594 T1 HR P20161594T1
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HR
Croatia
Prior art keywords
preparation according
dicarboxylic acid
preparation
amide
hydroxyalkylchitosan
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HRP20161594TT
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English (en)
Inventor
Federico Mailland
Emanuela Mura
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Polichem Sa
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40140031&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20161594(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Polichem Sa filed Critical Polichem Sa
Publication of HRP20161594T1 publication Critical patent/HRP20161594T1/hr

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/194Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/722Chitin, chitosan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/362Polycarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/736Chitin; Chitosan; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (17)

1. Pripravak, naznačen time što sadrži: (A) najmanje kitozan, hidroksialkilkitozan i/ili njegovu fiziološki prihvatljivu sol, i; (B) najmanje nerazgranati i/ili amid alkil C6-C12-dikarboksilne kiseline i/ili njegovu fiziološki prihvatljivu sol.
2. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je navedeni hidroksialkilkitozan topiv u vodi.
3. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je navedeni hidroksialkilkitozan hidroksipropilkitozan.
4. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je fiziološki prihvatljiva sol navedenog kitozana, hidroksialkilkitozana i/ili amida C6-C12-dikarboksilne kiseline sol s natrijem i/ili kalijem.
5. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je navedena C6-C12-dikarboksilna kiselina C8-C10-dikarboksilna kiselina, po mogućnosti C9-dikarboksilna kiselina.
6. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je navedena dikarboksilna kiselina azelainska kiselina.
7. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što navedeni amid C6-C12-dikarboksilne kiseline ima sljedeću formulu: ROC-(CH2)n-COR gdje: • n se kreće između 4 i 10, po mogućnosti između 6 i 8, a poželjnije je 7; • R je skupina -N(R′)(R″), gdje: • R′ je H ili C1-C4-alkilna skupina, a • R″ je H, C1-C4-alkilna skupina ili C1-C4-karboksi skupina.
8. Pripravak u skladu s patentnim zahtjevom 7, naznačen time što je navedena C1-C4-alkilna skupina metil i/ili etil, a navedena C1-C4-karboksi skupina je karboksimetil.
9. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je navedeni amid C6-C12-dikarboksilne kiseline azeloildiglicin.
10. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je navedena sol amida C6-C12-dikarboksilne kiseline kalijev azeloildiglicinat.
11. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što komponenta (A) je prisutna u količinama od 0,1 do 10%, po mogućnosti od 0,2 do 5%, poželjnije od 0,25 do 2,0%, u odnosu na težinu cijelog pripravka.
12. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što komponenta (B) je prisutna u količinama od 0,1 do 30%, po mogućnosti od 0,25 do 25%, poželjnije od 0,5 do 20%, težinski, u odnosu na težinu cijelog pripravka.
13. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je u tekućem, polutekućem ili polučvrstom obliku, uključujući otopinu, suspenziju, losion, emulziju, koloid, kremu ili gel.
14. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što sadrži farmaceutski i/ili kozmetički prihvatljive aktivne sastojke, pomoćne tvari, adjuvanse i/ili podloge.
15. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 14, naznačen time što je namijenjen upotrebi u liječenju i/ili sprječavanju rozaceje.
16. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 14, naznačen time što je namijenjen upotrebi u liječenju i/ili sprječavanju teleangektazije, po mogućnosti teleangektazije nogu.
17. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 14, naznačen time što je namijenjen upotrebi u liječenju i/ili sprječavanju eritroze lica.
HRP20161594TT 2008-08-05 2016-11-30 Pripravci za liječenje rozaceje koji sadrže kitozan i amid dikarboksilne kiseline HRP20161594T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08161799A EP2116237A1 (en) 2008-08-05 2008-08-05 Compositions for treating rosacea comprising chitosan and a dicarboxylic acid
PCT/EP2009/059749 WO2009150257A2 (en) 2008-08-05 2009-07-28 Compositions for treating rosacea
EP09761818.5A EP2306999B1 (en) 2008-08-05 2009-07-28 Compositions for treating rosacea comprising chitosan and a dicarboxylic acid amide

Publications (1)

Publication Number Publication Date
HRP20161594T1 true HRP20161594T1 (hr) 2017-01-13

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ID=40140031

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20161594TT HRP20161594T1 (hr) 2008-08-05 2016-11-30 Pripravci za liječenje rozaceje koji sadrže kitozan i amid dikarboksilne kiseline

Country Status (29)

Country Link
US (1) US9034845B2 (hr)
EP (2) EP2116237A1 (hr)
JP (1) JP5646477B2 (hr)
KR (1) KR101623375B1 (hr)
CN (1) CN102105142B (hr)
AR (1) AR072917A1 (hr)
AU (1) AU2009256524B2 (hr)
BR (1) BRPI0917584B8 (hr)
CA (1) CA2731138C (hr)
CL (1) CL2011000174A1 (hr)
CY (1) CY1118256T1 (hr)
DK (1) DK2306999T3 (hr)
EA (1) EA020417B1 (hr)
ES (1) ES2606233T3 (hr)
HK (1) HK1150774A1 (hr)
HR (1) HRP20161594T1 (hr)
HU (1) HUE031171T2 (hr)
IL (1) IL210695A (hr)
LT (1) LT2306999T (hr)
MX (1) MX2011001369A (hr)
NZ (1) NZ590800A (hr)
PE (1) PE20110564A1 (hr)
PL (1) PL2306999T3 (hr)
PT (1) PT2306999T (hr)
RS (1) RS55507B1 (hr)
SI (1) SI2306999T1 (hr)
SM (1) SMT201600403B (hr)
WO (1) WO2009150257A2 (hr)
ZA (1) ZA201100350B (hr)

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CA2731138A1 (en) 2009-12-17
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IL210695A0 (en) 2011-03-31
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