HRP20161095T1 - Otopina bojila - Google Patents
Otopina bojila Download PDFInfo
- Publication number
- HRP20161095T1 HRP20161095T1 HRP20161095TT HRP20161095T HRP20161095T1 HR P20161095 T1 HRP20161095 T1 HR P20161095T1 HR P20161095T T HRP20161095T T HR P20161095TT HR P20161095 T HRP20161095 T HR P20161095T HR P20161095 T1 HRP20161095 T1 HR P20161095T1
- Authority
- HR
- Croatia
- Prior art keywords
- preparation
- dye
- intended
- density
- water
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 claims 17
- 208000001351 Epiretinal Membrane Diseases 0.000 claims 13
- 239000000975 dye Substances 0.000 claims 11
- 239000012528 membrane Substances 0.000 claims 8
- 241001465754 Metazoa Species 0.000 claims 6
- 238000010186 staining Methods 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 229930182559 Natural dye Natural products 0.000 claims 4
- 239000000978 natural dye Substances 0.000 claims 4
- AAAQKTZKLRYKHR-UHFFFAOYSA-N triphenylmethane Chemical compound C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 claims 4
- 239000000987 azo dye Substances 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 3
- IHZXTIBMKNSJCJ-UHFFFAOYSA-N 3-{[(4-{[4-(dimethylamino)phenyl](4-{ethyl[(3-sulfophenyl)methyl]amino}phenyl)methylidene}cyclohexa-2,5-dien-1-ylidene)(ethyl)azaniumyl]methyl}benzene-1-sulfonate Chemical group C=1C=C(C(=C2C=CC(C=C2)=[N+](C)C)C=2C=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S(O)(=O)=O)=C1 IHZXTIBMKNSJCJ-UHFFFAOYSA-N 0.000 claims 2
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 claims 2
- 150000002772 monosaccharides Chemical class 0.000 claims 2
- 150000003267 reducing disaccharides Chemical class 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
- C09B67/0071—Process features in the making of dyestuff preparations; Dehydrating agents; Dispersing agents; Dustfree compositions
- C09B67/0083—Solutions of dyes
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
- C09B67/0071—Process features in the making of dyestuff preparations; Dehydrating agents; Dispersing agents; Dustfree compositions
- C09B67/0084—Dispersions of dyes
- C09B67/0085—Non common dispersing agents
- C09B67/0089—Non common dispersing agents non ionic dispersing agent, e.g. EO or PO addition products
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
Claims (13)
1. Biokompatibilni pripravak na bazi vode, naznačen time što je namijenjen upotrebi u kirurškom liječenju oka, koje se sastoji u selektivnom bojanju unutarnje ograničavajuće membrane (ILM) i/ili epiretinalnih membrana (ERM) u ljudskom ili životinjskom oku i uklanjanju obojene membrane, koji sadrži u najmanju ruku jedno bojilo koje se bira iz skupine koju čine: trifenilmetanska bojila, cijaninska bojila i/ili prirodna bojila ili njihove smjese, gdje pripravak ima gustoću u rasponu od 1,01 g/cm3 do 1,5 g/cm3, gdje se za podešavanje gustoće ne upotrebljava monosaharid ili reducirajući disaharid.
2. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što dodatno sadrži bojilo koje se bira iz skupine koju čine azo bojila, cijaninska bojila i/ili prirodna bojila ili njihove smjese.
3. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što je trifenilmetansko bojilo Coomassie Violet R200.
4. Pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je namijenjen upotrebi kao bojilo za negativno prikazivanje epiretinalnih membrana.
5. Pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što pripravak ima dinamičnu viskoznost u rasponu od 1 do 500 mPas, po mogućnosti u rasponu od 50 do 275 mPas, na 25 °C i brzinu smicanja 10 s-1.
6. Pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je osmolarnost dobivenih otopina u rasponu od 280-330 mosmol/l, po mogućnosti 300 mosmol/l.
7. Pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što pripravak sadrži sredstvo za podešavanje gustoće.
8. Komplet koji sadrži injekcijsku špricu s cilindrom i kanilom i pripravak na bazi vode u skladu s bilo kojim od patentnih zahtjeva 1 do 7, naznačen time što je namijenjen selektivnom bojanju unutarnje ograničavajuće membrane (ILM) i/ili epiretinalnih membrana (ERM) u ljudskom ili životinjskom oku, gdje je omjer promjera cilindra i promjera kanile je od 10 do 2:1 do 0,2, po mogućnosti 20:1 do 4:1.
9. Komplet u skladu s patentnim zahtjevom 8, naznačen time što je namijenjen upotrebi u kirurškom liječenju oka, koje se sastoji u selektivnom bojanju unutarnje ograničavajuće membrane (ILM) i/ili epiretinalnih membrana (ERM) u ljudskom ili životinjskom oku i uklanjanju obojene membrane.
10. Biokompatibilni pripravak na bazi vode naznačen time što je namijenjen selektivnom bojanju in vivo unutarnje ograničavajuće membrane (ILM) i/ili epiretinalnih membrana (ERM) u ljudskom ili životinjskom oku, koji sadrži u najmanju ruku jedno trifenilmetansko bojilo, azo bojilo ili prirodno bojilo ili njihove smjese, gdje pripravak sadrži sredstvo za podešavanje gustoće u rasponu od 1,01 g/cm3 do 1,5 g/cm3, te gdje se za podešavanje gustoće ne upotrebljava monosaharid ili reducirajući disaharid.
11. Biokompatibilni pripravak na bazi vode, naznačen time što je namijenjen selektivnom bojanju unutarnje ograničavajuće membrane (ILM) i/ili epiretinalnih membrana (ERM) u ljudskom ili životinjskom oku, koji sadrži u najmanju ruku Coomassie Violet R200 kao bojilo, gdje pripravak ima gustoću u rasponu od 1,01 g/cm3 do 1,5 g/cm3.
12. Biokompatibilni pripravak na bazi vode, naznačen time što je namijenjen selektivnom bojanju unutarnje ograničavajuće membrane (ILM) i/ili epiretinalnih membrana (ERM) u ljudskom ili životinjskom oku, koji sadrži u najmanju ruku jedno trifenilmetansko bojilo, azo bojilo, cijaninsko bojilo ili prirodno bojilo ili njihove smjese, gdje se gustoću u rasponu od 1,01 g/cm3 do 1,5 g/cm3 podešava upotrebom teške vode.
13. Biokompatibilni pripravak na bazi vode u skladu s patentnim zahtjevom 11, naznačen time što pripravak sadrži sredstvo za podešavanje gustoće.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008064065A DE102008064065B9 (de) | 2008-12-19 | 2008-12-19 | Farbstofflösung |
| EP12183372.7A EP2532370B1 (de) | 2008-12-19 | 2009-12-18 | Farbstofflösung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20161095T1 true HRP20161095T1 (hr) | 2016-11-04 |
Family
ID=42138955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161095TT HRP20161095T1 (hr) | 2008-12-19 | 2016-08-26 | Otopina bojila |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9498547B2 (hr) |
| EP (2) | EP2274019B1 (hr) |
| JP (2) | JP5419990B2 (hr) |
| CN (1) | CN102256627A (hr) |
| AU (1) | AU2009336797B2 (hr) |
| BR (1) | BRPI0922570B8 (hr) |
| CA (1) | CA2747673C (hr) |
| CY (1) | CY1117965T1 (hr) |
| DE (2) | DE102008064065B9 (hr) |
| DK (1) | DK2532370T3 (hr) |
| EA (1) | EA023688B1 (hr) |
| ES (2) | ES2394064T3 (hr) |
| HK (2) | HK1147439A1 (hr) |
| HR (1) | HRP20161095T1 (hr) |
| HU (1) | HUE030485T2 (hr) |
| MX (1) | MX2011006359A (hr) |
| PL (1) | PL2532370T3 (hr) |
| PT (1) | PT2532370T (hr) |
| SI (1) | SI2532370T1 (hr) |
| UA (1) | UA103066C2 (hr) |
| WO (1) | WO2010078942A2 (hr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008064065B9 (de) * | 2008-12-19 | 2011-01-05 | Fluoron Gmbh | Farbstofflösung |
| JP5889273B2 (ja) * | 2010-04-01 | 2016-03-22 | メディカル・テクロノジー・トランスファー・ホールディング・ベー・フェー | 染色組成物 |
| EP2392355A1 (en) * | 2010-06-03 | 2011-12-07 | Medical Technology Transfer Holding B.V. | Staining composition |
| EP2371395A1 (en) * | 2010-04-01 | 2011-10-05 | Medical Technology Transfer Holding B.V. | Staining Composition |
| DE102012103097A1 (de) | 2012-04-11 | 2013-10-17 | Fluoron Gmbh | Färbemittel zum Einfärben einer ophthalmischen Membran |
| US20130272962A1 (en) * | 2012-04-11 | 2013-10-17 | Fluoron Gmbh | Staining agent for corneal staining |
| DE102012110745A1 (de) * | 2012-11-09 | 2014-05-15 | Fluoron Gmbh | Färbemittel für Hornhautfärbung |
| EP2867330B1 (en) * | 2012-06-27 | 2018-10-10 | Siemens Healthcare Diagnostics Inc. | Compositions and methods for liquid mixing assessment |
| WO2014123844A1 (en) * | 2013-02-05 | 2014-08-14 | Tripath Imaging, Inc. | Cytological staining compositions and uses thereof |
| ITUB20150864A1 (it) * | 2015-05-26 | 2016-11-26 | Al Chi Mi A S R L | Molecola colorante e composizioni coloranti, in particolare per uso in metodi chirurgici di chirurgia oftalmica e per la colorazione di proteine |
| CA2965904A1 (en) * | 2016-05-02 | 2017-11-02 | James M. Rynerson | Methods and devices for detecting biofilms on the eyelid margin |
| WO2019068355A1 (en) | 2017-10-06 | 2019-04-11 | Alfa Instruments S.R.L. | BLUE GLYING (BBG) COLOR DERIVATIVES AND COLORING COMPOUNDS COMPRISING THEM FOR SELECTIVELY COLORING BIOLOGICAL SUBSTRATES |
| CN113481739A (zh) * | 2021-06-23 | 2021-10-08 | 马鞍山金姿纺织装饰用品有限公司 | 一种台布染色用辅助剂配方以及洋红染料的制作方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1025560B (de) * | 1956-02-03 | 1958-03-06 | Basf Ag | Grundierungsmittel fuer die Zurichtung von Leder |
| US3947573A (en) * | 1969-12-01 | 1976-03-30 | Burton, Parsons And Company, Inc. | Opthalmic solution |
| US3843782A (en) * | 1971-07-26 | 1974-10-22 | Flow Pharma Inc | Eye solution and method of using same |
| US3920810A (en) | 1974-04-23 | 1975-11-18 | Burton Parsons And Company Inc | Polyacrylamide containing ophthalmic solutions |
| US4490351A (en) | 1982-03-15 | 1984-12-25 | Children's Hospital Medical Center | Methods of treating disorders of an eye with liquid perfluorocarbons |
| SE454842B (sv) | 1984-11-01 | 1988-06-06 | Pharmacia Ab | Komposition for anvendning vid oftalmologiska applikationer innehallande en vattenlosning av en hogmolekyler polymer och ett lost polymert fergemne |
| US5928663A (en) | 1997-07-30 | 1999-07-27 | Vitrophage, Inc. | Intraocular perfluorcarbon compositions and surgical methods of using same |
| EP0974367A1 (en) | 1998-05-08 | 2000-01-26 | Gerrit Reinold Jacob Melles | The use of a vital dye for facilitating surgical procedures for vitreo-retinal surgery |
| US6944493B2 (en) | 1999-09-10 | 2005-09-13 | Akora, Inc. | Indocyanine green (ICG) compositions and related methods of use |
| AUPQ496500A0 (en) * | 2000-01-06 | 2000-02-03 | University Of Sydney, The | Kit |
| EP1132065A1 (en) * | 2000-03-07 | 2001-09-12 | Gerrit Reinold Jacob Melles | Coloured visco-elastic composition |
| US6692526B1 (en) * | 2000-03-15 | 2004-02-17 | Michael E. Snyder | Ophthalmological surgery colorant and delivery system |
| US6802829B2 (en) * | 2001-11-16 | 2004-10-12 | Infinite Vision, Llc | Spray device |
| US7014991B2 (en) * | 2001-11-16 | 2006-03-21 | Infinite Vision, Llc | Use of injectable dyes for staining an anterior lens capsule and vitreo-retinal interface |
| US20050031540A1 (en) | 2001-11-20 | 2005-02-10 | Nielsen Per Julius | Visco dye |
| US6698424B2 (en) | 2001-12-21 | 2004-03-02 | Kimberly-Clark Worldwide, Inc. | Medical connector for a respiratory assembly |
| DE10255601C5 (de) * | 2002-10-14 | 2017-10-19 | Fluoron Gmbh | Verwendung eines Triphenylmethanfarbstoffs zur Herstellung eines Färbemittels bei der Netzhaut- und Glaskörperchirurgie |
| GB0404693D0 (en) * | 2004-03-02 | 2004-04-07 | Univ London | Pharmaceutical preparations for the treatment of ocular surface and other disorders |
| US20050202097A1 (en) * | 2004-03-12 | 2005-09-15 | Melbj Holdings, Llc, Florida | Lubricant for the ocular surface |
| CA2567411A1 (en) | 2004-05-31 | 2005-12-08 | Senju Pharmaceutical Co., Ltd. | Transparent tissue-visualizing preparation |
| PT1819366E (pt) * | 2004-12-06 | 2009-06-25 | Univ Kyushu Nat Univ Corp | Composição de coloração para corar uma membrana oftálmica |
| US7659260B2 (en) * | 2005-01-14 | 2010-02-09 | Eddie Francis Kadrmas | Tamponade compositions and methods for retinal repair |
| EP1733744A1 (en) * | 2005-06-17 | 2006-12-20 | Ludwig-Maximilians-Universität München | Method, dye and medicament for staining the internal limiting membrane and/or the capsule of an eye |
| US20110264026A1 (en) | 2008-11-24 | 2011-10-27 | Raghavan Rajagopalan | Azo Derivatives and Uses Thereof in Phototherapy |
| DE102008064065B9 (de) * | 2008-12-19 | 2011-01-05 | Fluoron Gmbh | Farbstofflösung |
| US20130272962A1 (en) | 2012-04-11 | 2013-10-17 | Fluoron Gmbh | Staining agent for corneal staining |
-
2008
- 2008-12-19 DE DE102008064065A patent/DE102008064065B9/de active Active
-
2009
- 2009-12-18 PL PL12183372.7T patent/PL2532370T3/pl unknown
- 2009-12-18 HU HUE12183372A patent/HUE030485T2/en unknown
- 2009-12-18 CN CN2009801515483A patent/CN102256627A/zh active Pending
- 2009-12-18 DK DK12183372.7T patent/DK2532370T3/en active
- 2009-12-18 AU AU2009336797A patent/AU2009336797B2/en active Active
- 2009-12-18 DE DE202009017759U patent/DE202009017759U1/de not_active Expired - Lifetime
- 2009-12-18 WO PCT/EP2009/009144 patent/WO2010078942A2/de active Application Filing
- 2009-12-18 CA CA2747673A patent/CA2747673C/en active Active
- 2009-12-18 SI SI200931513A patent/SI2532370T1/sl unknown
- 2009-12-18 ES ES09801410T patent/ES2394064T3/es active Active
- 2009-12-18 BR BRPI0922570A patent/BRPI0922570B8/pt active IP Right Grant
- 2009-12-18 ES ES12183372.7T patent/ES2592520T3/es active Active
- 2009-12-18 EA EA201100950A patent/EA023688B1/ru not_active IP Right Cessation
- 2009-12-18 JP JP2011541226A patent/JP5419990B2/ja active Active
- 2009-12-18 MX MX2011006359A patent/MX2011006359A/es active IP Right Grant
- 2009-12-18 EP EP09801410A patent/EP2274019B1/de active Active
- 2009-12-18 US US12/990,427 patent/US9498547B2/en active Active
- 2009-12-18 EP EP12183372.7A patent/EP2532370B1/de active Active
- 2009-12-18 UA UAA201109003A patent/UA103066C2/ru unknown
- 2009-12-18 PT PT121833727T patent/PT2532370T/pt unknown
-
2011
- 2011-02-18 HK HK11101645.4A patent/HK1147439A1/xx unknown
-
2013
- 2013-06-11 HK HK13106875.2A patent/HK1179181A1/zh unknown
- 2013-07-12 JP JP2013147126A patent/JP2013241431A/ja active Pending
-
2016
- 2016-08-26 HR HRP20161095TT patent/HRP20161095T1/hr unknown
- 2016-09-02 CY CY20161100868T patent/CY1117965T1/el unknown
- 2016-09-29 US US15/279,655 patent/US9872927B2/en active Active
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