HRP20151236T1 - Postupak proizvodnje lijeka na biljnoj bazi - Google Patents
Postupak proizvodnje lijeka na biljnoj bazi Download PDFInfo
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- HRP20151236T1 HRP20151236T1 HRP20151236TT HRP20151236T HRP20151236T1 HR P20151236 T1 HRP20151236 T1 HR P20151236T1 HR P20151236T T HRP20151236T T HR P20151236TT HR P20151236 T HRP20151236 T HR P20151236T HR P20151236 T1 HRP20151236 T1 HR P20151236T1
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- 239000003814 drug Substances 0.000 title claims 26
- 238000004519 manufacturing process Methods 0.000 title claims 3
- 235000008216 herbs Nutrition 0.000 title 1
- 239000000284 extract Substances 0.000 claims 44
- 241000196324 Embryophyta Species 0.000 claims 34
- 238000000034 method Methods 0.000 claims 26
- 239000000203 mixture Substances 0.000 claims 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 16
- 240000004804 Iberis amara Species 0.000 claims 13
- 235000012633 Iberis amara Nutrition 0.000 claims 12
- 241000628997 Flos Species 0.000 claims 8
- 239000000126 substance Substances 0.000 claims 8
- 239000000419 plant extract Substances 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 238000000605 extraction Methods 0.000 claims 4
- 239000012675 alcoholic extract Substances 0.000 claims 3
- LNSXRXFBSDRILE-UHFFFAOYSA-N Cucurbitacin Natural products CC(=O)OC(C)(C)C=CC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(C)(C)C(O)C(O)CC4(C)C3(C)C(=O)CC12C LNSXRXFBSDRILE-UHFFFAOYSA-N 0.000 claims 2
- CVKKIVYBGGDJCR-SXDZHWHFSA-N Cucurbitacin B Natural products CC(=O)OC(C)(C)C=CC(=O)[C@@](C)(O)[C@@H]1[C@@H](O)C[C@]2(C)C3=CC[C@@H]4C(C)(C)C(=O)[C@H](O)C[C@@]4(C)[C@@H]3CC(=O)[C@@]12C CVKKIVYBGGDJCR-SXDZHWHFSA-N 0.000 claims 2
- 150000001904 cucurbitacins Chemical class 0.000 claims 2
- PIGAXYFCLPQWOD-UHFFFAOYSA-N dihydrocucurbitacin I Natural products CC12C(=O)CC3(C)C(C(C)(O)C(=O)CCC(C)(O)C)C(O)CC3(C)C1CC=C1C2C=C(O)C(=O)C1(C)C PIGAXYFCLPQWOD-UHFFFAOYSA-N 0.000 claims 2
- NDYMQXYDSVBNLL-LAMASETHSA-N (23E)-25-acetyloxy-2,16alpha,20-trihydroxy-9beta-methyl-19-nor-10alpha-lanosta-1,5,23-triene-3,11,22-trione Chemical compound C([C@H]1[C@]2(C)C[C@@H](O)[C@@H]([C@]2(CC(=O)[C@]11C)C)[C@@](C)(O)C(=O)C=CC(C)(C)OC(=O)C)C=C2[C@H]1C=C(O)C(=O)C2(C)C NDYMQXYDSVBNLL-LAMASETHSA-N 0.000 claims 1
- NDYMQXYDSVBNLL-UHFFFAOYSA-N (9beta,10alpha,16alpha,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione Natural products CC12C(=O)CC3(C)C(C(C)(O)C(=O)C=CC(C)(C)OC(=O)C)C(O)CC3(C)C1CC=C1C2C=C(O)C(=O)C1(C)C NDYMQXYDSVBNLL-UHFFFAOYSA-N 0.000 claims 1
- PTCAIPUXGKZZBJ-UHFFFAOYSA-N 11-deoxocucurbitacin I Natural products CC12CCC3(C)C(C(C)(O)C(=O)C=CC(C)(O)C)C(O)CC3(C)C1CC=C1C2C=C(O)C(=O)C1(C)C PTCAIPUXGKZZBJ-UHFFFAOYSA-N 0.000 claims 1
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims 1
- IVGSDBLLLAUYTL-UHFFFAOYSA-N cucurbitacin E Natural products CC(=O)OC(C)(C)C=CC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(C=C(O)C(=O)C4(C)C)C3(C)CCC12C IVGSDBLLLAUYTL-UHFFFAOYSA-N 0.000 claims 1
- NISPVUDLMHQFRQ-ILFSFOJUSA-N cucurbitacin I Natural products CC(C)(O)C=CC(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C NISPVUDLMHQFRQ-ILFSFOJUSA-N 0.000 claims 1
- NISPVUDLMHQFRQ-MKIKIEMVSA-N cucurbitacin I Chemical compound C([C@H]1[C@]2(C)C[C@@H](O)[C@@H]([C@]2(CC(=O)[C@]11C)C)[C@@](C)(O)C(=O)/C=C/C(C)(O)C)C=C2[C@H]1C=C(O)C(=O)C2(C)C NISPVUDLMHQFRQ-MKIKIEMVSA-N 0.000 claims 1
- 229930003935 flavonoid Natural products 0.000 claims 1
- 150000002215 flavonoids Chemical class 0.000 claims 1
- 235000017173 flavonoids Nutrition 0.000 claims 1
- 241000411851 herbal medicine Species 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000012907 medicinal substance Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/235—Foeniculum (fennel)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Claims (26)
1. Postupak proizvodnje lijeka na biljnoj bazi koji sadrži Iberis amara, Menthae piperitae folium, Matricariae flos, Carvi fructus, Melissae folium, Angelicae radix, Liquiritiae radix, Cardui mariae fructus i Chelidonii herba, u obliku alkoholnih ekstrakata, naznačen time, da se u prvom koraku a) miješaju zajedno ekstrakt od Angelicae radix i ekstrakt od Liquiritiae radix u omjeru volumena od 1:6 do 3:1, i naknadno se u barem jednom dodatnom koraku, mješavina iz koraka a) pomiješa zajedno s ekstraktima sljedećih sastojaka ili s mješavinama koje sadrže iste, koji su proizvedeni odvojeno i gdje je to primjenjivo, dodatno sadrže Liquiritiae radix.
2. Postupak proizvodnje lijeka na biljnoj bazi prema zahtjevu 1, naznačen time, da se u koraku b) proizvodi mješavina koja sadrži ekstrakte od Matricariae flos, Iberis amara i Carvi fructus, zatim se mješavina iz koraka a) dodaje u nju, a u koraku c) se dodaju ekstrakti od Cardui mariae fructus, Menthae piperitae folium, Melissae folium i Chelidonii herba.
3. Postupak proizvodnje lijeka na biljnoj bazi prema zahtjevu 1 ili 2, naznačen time, da se mješavine koje sadrže ekstrakte od Menthae piperitae folium, Carvi fructus i Melissae folium; zatim od Cardui mariae fructus i Matricariae flos; te od Iberis amara i Chelidonii herba, proizvode odvojeno.
4. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 3, naznačen time, da se ekstrakt od Angelicae radix i ekstrakt od Liquiritiae radix miješaju zajedno u koraku a) u omjeru volumena od 1:2 do 2:1.
5. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 4, naznačen time, da se ekstrakt od Angelicae radix i ekstrakt od Liquiritiae radix miješaju zajedno u koraku a) u omjeru volumena 1:1.
6. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 5, naznačen time, da se u koraku b) mješavina iz koraka a) pomiješa zajedno s mješavinom koja sadrži ekstrakte od Menthae piperitae folium, Carvi fructus i Melissae folium, a u koraku c) se dodaje mješavina koja sadrži ekstrakte od Cardui mariae fructus i Matricariae flos, te se u koraku d) dodaje mješavina koja sadrži ekstrakte od Iberis amara i Chelidonii herba.
7. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 6, naznačen time, da se u koraku b) mješavina iz koraka a) pomiješa zajedno s mješavinom koja sadrži ekstrakte od Menthae piperitae folium, Carvi fructus i Melissae folium, zatim se u koraku e) mješavina koja sadrži ekstrakte od Cardui mariae fructus i Matricariae flos, pomiješa zajedno s mješavinom koja sadrži ekstrakte od Iberis amara i Chelidonii herba, te se u koraku f) pomiješaju zajedno mješavine iz koraka b) i koraka e).
8. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 7, naznačen time, da mješavina koja sadrži ekstrakte od Menthae piperitae folium, Carvi fructus i Melissae folium, dodatno sadrži ekstrakt od Liquiritiae radix.
9. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 8, naznačen time, da mješavina koja sadrži ekstrakte od Menthae piperitae folium, Carvi fructus i Melissae folium, dodatno sadrži ekstrakt od Liquiritiae radix, pri čemu je volumen sadržaja ekstrakta od Liquiritiae radix u omjeru 1:1 prema volumenu ekstrakta od Liquiritiae radix, koji je sadržan u mješavini ekstrakta od Angelicae radix i ekstrakta od Liquiritiae radix iz koraka a).
10. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 9, naznačen time, da obuhvaća sljedeće:
Iberis amara od 15 do 40 volumenskih %,
Menthae piperitae folium od 5 do 30 volumenskih %,
Matricariae flos od 20 do 40 volumenskih %,
Carvis fructus od 10 do 30 volumenskih %,
Melissae folium od 10 do 30 volumenskih %,
Angelicae radix od 5 do 30 volumenskih %,
Liquiritiae radix od 10 do 30 volumenskih %,
Cardui mariae fructus od 5 do 30 volumenskih %, i
Chelidonii herba od 5 do 30 volumenskih %,
u obliku alkoholnih ekstrakata.
11. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 10, naznačen time, da obuhvaća sljedeće:
15 volumenskih % Iberis amara,
5 volumenskih % Menthae piperitae folium,
20 volumenskih % Matricariae flos,
10 volumenskih % Carvis fructus,
10 volumenskih % Melissae folium,
10 volumenskih % Angelicae radix,
10 volumenskih % Liquiritiae radix,
10 volumenskih % Cardui mariae fructus, i
10 volumenskih % Chelidonii herba,
u obliku alkoholnih ekstrakata.
12. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 11, naznačen time, da se upotrebljavaju ekstrakti od svježih biljaka ili ekstrakti od ljekovitih tvari.
13. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 12, naznačen time, da ekstrakt od Iberis amara je ekstrakt od svježe biljke Iberis amara totalis (cvijeće, lišće, peteljke i korijenje).
14. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 13, naznačen time, da ekstrakt od Iberis amara je ekstrakt od svježe biljke koja ima sadržaj flavonoida od 0,05 do 0,2 mg/ml.
15. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 14, naznačen time, da ekstrakt od Iberis amara je ekstrakt od svježe biljke koja ima sadržaj kukurbitacina od 0 do 200 μg/ml.
16. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 15, naznačen time, da ekstrakt od Iberis amara je ekstrakt od svježe biljke koja ima sadržaj kukurbitacina od 35 do 185 μg/ml.
17. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 16, naznačen time, da ekstrakt od Iberis amara je ekstrakt od svježe biljke koja ima sadržaj kukurbitacina I od 0 do 100 μg/ml i sadržaj kukurbitacina E od 0 do 100 μg/ml.
18. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 17, naznačen time, da su ekstrakti od Menthae piperitae folium, Matricariae flos, Carvi fructus, Melissae folium, Angelicae radix, Liquiritiae radix, Cardui mariae fructus i Chelidonii herba, ekstrakti od ljekovitih tvari.
19. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 18, naznačen time, da je omjer macerirane/perkolirane biljke prema biljnom ekstraktu od 1 gram:10 ml (10 grama) do 1 gram:1 ml (1 gram), u ekstraktu od svježe biljke.
20. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 19, naznačen time, da je omjer macerirane/perkolirane biljke prema biljnom ekstraktu od 1 gram:1,5 ml (1,5 grama) do 1 gram:2,5 ml (2,5 grama), u ekstraktu od svježe biljke.
21. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 20, naznačen time, da je omjer tvari prema ekstraktu od 1 gram:1 ml (1 gram) do 1 gram:10 ml (10 grama), u ekstraktu od ljekovite tvari.
22. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 21, naznačen time, da je omjer tvari prema ekstraktu od 1 gram:2 ml (2 grama) do 1 gram:4 ml (4 grama), u ekstraktu od ljekovite tvari.
23. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 22, naznačen time, da je omjer tvari prema ekstraktu od 1 gram:2,5 ml (2,5 grama) do 1 gram:3,5 ml (3,5 grama), u ekstraktu od ljekovite tvari.
24. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 23, naznačen time, da sredstvo za ekstrakciju obuhvaća vodu i vodeni etanol s koncentracijom etanola od 0,1 do 60 volumenskih %.
25. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 24, naznačen time, da sredstvo za ekstrakciju obuhvaća vodeni etanol s koncentracijom etanola od 30 do 50 volumenskih %.
26. Postupak proizvodnje lijeka na biljnoj bazi prema jednom od zahtjeva 1 do 25, naznačen time, da sredstvo za ekstrakciju za ekstrakt od svježe biljke je vodeni etanol s koncentracijom etanola od 50 volumenskih %, a sredstvo za ekstrakciju za ekstrakte od ljekovitih tvari je vodeni etanol s koncentracijom etanola od 30 volumenskih %.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| DE102008002685A DE102008002685A1 (de) | 2008-06-26 | 2008-06-26 | Verfahren zur Herstellung eines Arzneimittels auf pflanzlicher Basis |
| EP09163367.7A EP2138182B1 (de) | 2008-06-26 | 2009-06-22 | Verfahren zur Herstellung eines Arzneimittels auf pflanzlicher Basis |
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| HRP20151236T1 true HRP20151236T1 (hr) | 2016-03-11 |
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| HRP20151236TT HRP20151236T1 (hr) | 2008-06-26 | 2015-11-16 | Postupak proizvodnje lijeka na biljnoj bazi |
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| EP (1) | EP2138182B1 (hr) |
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| CN (2) | CN105147783A (hr) |
| AR (1) | AR072298A1 (hr) |
| AU (1) | AU2009202537B2 (hr) |
| BR (1) | BRPI0902143B8 (hr) |
| CA (1) | CA2670659C (hr) |
| CL (1) | CL2009001480A1 (hr) |
| CO (1) | CO6200113A1 (hr) |
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| EA (1) | EA019477B1 (hr) |
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| HK (1) | HK1137350A1 (hr) |
| HR (1) | HRP20151236T1 (hr) |
| HU (1) | HUE028151T2 (hr) |
| IL (1) | IL199473A (hr) |
| MA (1) | MA31073B1 (hr) |
| ME (1) | ME00815B (hr) |
| MX (1) | MX2009006862A (hr) |
| MY (1) | MY145794A (hr) |
| NZ (1) | NZ577867A (hr) |
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| DE4125024A1 (de) * | 1991-07-29 | 1993-02-04 | Steigerwald Arzneimittelwerk | Arzneimittel auf pflanzlicher basis zur tonuserhoehung und zur tonusmodulierung der glatt muskulaeren organe |
| US7572469B2 (en) * | 2002-04-15 | 2009-08-11 | Tetsuo Santo | Therapeutic lotion for dermatitis |
| KR20050080882A (ko) * | 2004-02-11 | 2005-08-18 | 채규윤 | 애기똥풀의 잎으로부터 분리한 스틸로핀을 유효성분으로함유하는 항염증제 조성물 |
| CN1899570A (zh) * | 2006-07-03 | 2007-01-24 | 丛吉兵 | 一种治疗消化系统疾病的药物 |
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