WO2010034971A3 - Sub-critical water extraction of medicinal plants - Google Patents

Sub-critical water extraction of medicinal plants Download PDF

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Publication number
WO2010034971A3
WO2010034971A3 PCT/GB2009/002229 GB2009002229W WO2010034971A3 WO 2010034971 A3 WO2010034971 A3 WO 2010034971A3 GB 2009002229 W GB2009002229 W GB 2009002229W WO 2010034971 A3 WO2010034971 A3 WO 2010034971A3
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WO
WIPO (PCT)
Prior art keywords
related species
extracts
extraction
sub
swe
Prior art date
Application number
PCT/GB2009/002229
Other languages
French (fr)
Other versions
WO2010034971A2 (en
Inventor
Gary William Wheatley
Kenneth Davison
Original Assignee
Gary William Wheatley
Kenneth Davison
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0817354A external-priority patent/GB2463531B/en
Priority claimed from GB0817353A external-priority patent/GB2463530B/en
Application filed by Gary William Wheatley, Kenneth Davison filed Critical Gary William Wheatley
Publication of WO2010034971A2 publication Critical patent/WO2010034971A2/en
Publication of WO2010034971A3 publication Critical patent/WO2010034971A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/84—Valerianaceae (Valerian family), e.g. valerian
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The patent describes the application of Sub-Critical Water Extraction (SWE) to a range of medicinal plants traditionally used in Europe or Asia to produce pharmaceutical extracts. The extraction of the following plants is covered by the scope of this patent: Rosmarinus officinalis (rosemary) and related species Matricaria recutita (German chamomile) and related species Cassia angustifolia (senna) and related species Valeriana officinalis (valerian) and related species Scutellaria baicalensis (Baikal skullcap) and related species Schisandra chinensis (Wuweizu) and related species. Zingiber officinale (ginger) and related species. Astragalus Membranaceus and related species. It is demonstrated that SWE can produce materials essentially similar, as indicated by chromatographic fingerprint, to extracts produced using conventional solvents with polarity in the range approximately represented by 50% aqueous ethanol through to methanol. Thus as the subcritical water extracts of the herbs as described in this invention are demonstrated to exhibit a composition essentially similar to that of the corresponding methanol or aqueous alcohol extract, then it can be expected that these extracts will exhibit comparable pharmacological activities to these and to the compounds contained therein. In addition to the above claims relating to the extraction of the plant material, as the water solubility of many of the active compounds is low, both oral formulations and topical formulations which improve the bioavailability and hence efficacy of the extracts are included.
PCT/GB2009/002229 2008-09-23 2009-09-17 Sub-critical water extraction of medicinal plants WO2010034971A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0817353.6 2008-09-23
GB0817354A GB2463531B (en) 2008-09-23 2008-09-23 The sub-critical water extraction of Baikal Skullcap
GB0817354.4 2008-09-23
GB0817353A GB2463530B (en) 2008-09-23 2008-09-23 The sub-critical water extraction of German Chamomile flowers

Publications (2)

Publication Number Publication Date
WO2010034971A2 WO2010034971A2 (en) 2010-04-01
WO2010034971A3 true WO2010034971A3 (en) 2010-05-20

Family

ID=41426346

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/002229 WO2010034971A2 (en) 2008-09-23 2009-09-17 Sub-critical water extraction of medicinal plants

Country Status (1)

Country Link
WO (1) WO2010034971A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2473069A (en) * 2009-09-01 2011-03-02 Gary William Wheatley Methods for the Production of Sub-critical Water Extracts of Certain Plants with Healthcare Applications.
GB2476070A (en) * 2009-12-10 2011-06-15 Kenneth Davison Subcritical water extraction of Hawthorn Crategus monogyna, Pueraria lobata and Centella asiatica
GB2483934A (en) * 2010-09-27 2012-03-28 Gary William Wheatley Botanical extracts obtained by subcritical water extraction
WO2013018103A2 (en) 2011-08-04 2013-02-07 Ramaswamy Rajendran Extraction of b-vitamins from plant matter
WO2013018105A2 (en) * 2011-08-04 2013-02-07 Ramaswamy Rajendran Extraction of vitamins and minerals from plant matter
CN102382714A (en) * 2011-09-22 2012-03-21 中国海洋大学 Method for extracting honeysuckle volatile oil from sub-critical fluid
ITRM20130294A1 (en) * 2013-05-16 2014-11-17 Aboca Spa Societa Agricola SENNA EXTRACTS AND THEIR USES
CN103450808B (en) * 2013-08-22 2015-03-11 山东省康福德实业有限公司 Method for extracting ginger oleoresin by adopting subcritical fluid butane
CN105403654B (en) * 2015-12-11 2017-04-05 陇西保和堂药业有限责任公司 A kind of method for improving the identification of Radix Astragali thin-layer chromatography
JP6240300B1 (en) * 2016-12-05 2017-11-29 三生医薬株式会社 Method for producing gingerol-containing composition
CN106841500B (en) * 2017-03-03 2018-12-28 四川德成动物保健品有限公司 The thin-layered chromatography detection method of baked ginger in a kind of female biochemical mixture of benefit
FR3072874B1 (en) * 2017-11-02 2020-11-20 Laboratoire Phenobio PARTICULAR EXTRACT OF PERFUME, AROMATIC AND MEDICINAL PLANTS, PROCESS FOR OBTAINING IT, COMPOSITIONS INCLUDING IT AND USES
CN110057950B (en) * 2019-04-12 2021-06-22 舟山市食品药品检验检测研究院 Detection wavelength switching-based Pudilan antiphlogistic tablet HPLC fingerprint construction method
BR102019013936A2 (en) * 2019-07-04 2021-01-12 Natura Cosméticos S.A BIOACTIVE INGREDIENTS, USES OF BIOACTIVE INGREDIENTS AND COSMETIC COMPOSITION
GB202020183D0 (en) * 2020-12-18 2021-02-03 Givaudan Sa Method

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001256A (en) * 1996-09-25 1999-12-14 Energy & Environmental Research Center Method of manipulating the chemical properties of water to improve the effectiveness of a desired chemical process
WO2006078699A2 (en) * 2005-01-18 2006-07-27 A.M. Todd Company Oral care compositions derived from the labiatae family
US20070014912A1 (en) * 2005-05-13 2007-01-18 Giuseppe Mazza Extraction of phytochemicals

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001256A (en) * 1996-09-25 1999-12-14 Energy & Environmental Research Center Method of manipulating the chemical properties of water to improve the effectiveness of a desired chemical process
WO2006078699A2 (en) * 2005-01-18 2006-07-27 A.M. Todd Company Oral care compositions derived from the labiatae family
US20070014912A1 (en) * 2005-05-13 2007-01-18 Giuseppe Mazza Extraction of phytochemicals

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HERRERO M ET AL: "Sub- and supercritical fluid extraction of functional ingredients from different natural sources: Plants, food-by-products, algae and microalgae", FOOD CHEMISTRY, ELSEVIER SCIENCE PUBLISHERS LTD, GB, vol. 98, no. 1, 1 January 2006 (2006-01-01), pages 136 - 148, XP025129874, ISSN: 0308-8146, [retrieved on 20060101] *
IBANEZ ELENA ET AL: "SUBCRITICAL WATER EXTRACTION OF ANTIOXIDANT COMPOUNDS FROM ROSEMARY PLANTS", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON; US, vol. 51, no. 2, 7 December 2002 (2002-12-07), pages 375 - 382, XP009085418, ISSN: 0021-8561 *
XU ZHIHONG ET AL: "Study on subcritical water extraction of baicalin from Radix Scutellariae coupled to high performance liquid chromatographic analysis", SEPU - CHINESE JOURNAL OF CHROMATOGRAPHY, HUAXUE ZAZHI CHUBANSHE, DALIAN, CN, vol. 22, no. 1, 1 January 2004 (2004-01-01), pages 44 - 47, XP009127530, ISSN: 1000-8713 *

Also Published As

Publication number Publication date
WO2010034971A2 (en) 2010-04-01

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