HRP20140873T1 - Tekuä†i pripravak koji sadrži kompleks pimobendana i ciklodekstrina - Google Patents
Tekuä†i pripravak koji sadrži kompleks pimobendana i ciklodekstrina Download PDFInfo
- Publication number
- HRP20140873T1 HRP20140873T1 HRP20140873TT HRP20140873T HRP20140873T1 HR P20140873 T1 HRP20140873 T1 HR P20140873T1 HR P20140873T T HRP20140873T T HR P20140873TT HR P20140873 T HRP20140873 T HR P20140873T HR P20140873 T1 HRP20140873 T1 HR P20140873T1
- Authority
- HR
- Croatia
- Prior art keywords
- liquid preparation
- preparation according
- cyclodextrin
- pimobendan
- mass
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title claims 18
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title claims 7
- 229960002164 pimobendan Drugs 0.000 title claims 5
- GLBJJMFZWDBELO-UHFFFAOYSA-N pimobendane Chemical compound C1=CC(OC)=CC=C1C1=NC2=CC=C(C=3C(CC(=O)NN=3)C)C=C2N1 GLBJJMFZWDBELO-UHFFFAOYSA-N 0.000 title claims 5
- 229920000858 Cyclodextrin Polymers 0.000 title claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 4
- 206010019280 Heart failures Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 206010056370 Congestive cardiomyopathy Diseases 0.000 claims 3
- 201000010046 Dilated cardiomyopathy Diseases 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 2
- 206010002091 Anaesthesia Diseases 0.000 claims 1
- 208000001762 Gastric Dilatation Diseases 0.000 claims 1
- 208000010496 Heart Arrest Diseases 0.000 claims 1
- 206010063897 Renal ischaemia Diseases 0.000 claims 1
- 206010047697 Volvulus Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 230000037005 anaesthesia Effects 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000009084 cardiovascular function Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 201000007647 intestinal volvulus Diseases 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002107 myocardial effect Effects 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nanotechnology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (14)
1. Tekući pripravak, naznačen time, da obuhvaća derivat eterificiranog ciklodekstrina i pimobendan ili njegovu farmaceutski prihvatljivu sol, pri čemu je derivat eterificiranog ciklodekstrina odabran iz skupine koju čine: alfa-ciklodekstrin-eter, beta-ciklodekstrin-eter i gama-ciklodekstrin-eter, te pritom tekući pripravak ima pH vrijednost od 5,5 do 8,5.
2. Tekući pripravak prema zahtjevu 1, naznačen time, da derivat etirificiranog ciklodekstrina je hidroksipropil-beta-ciklodekstrin.
3. Tekući pripravak prema bilo kojem od zahtjeva 1 do 2, naznačen time, da udio derivata etirificiranog ciklodekstrina iznosi 15 do 40% (masa/volumen).
4. Tekući pripravak prema zahtjevu 3, naznačen time, da udio derivata eterificiranog ciklodekstrina iznosi 20 do 30% (masa/volumen).
5. Tekući pripravak prema bilo kojem od zahtjeva 1 do 4, naznačen time, da udio pimobendana ili njegove farmaceutski prihvatljive soli iznosi 0,005 do 0,15% (masa/volumen).
6. Tekući pripravak prema bilo kojem od zahtjeva 1 do 5, naznačen time, da pripravak ima pH vrijednost od 6,5 do 7,5 i osmolalnost od 280 do 300 mOsm/kg.
7. Tekući pripravak prema bilo kojem od zahtjeva 1 do 6, naznačen time, da pripravak obuhvaća sljedeće:
a) hidroksipropil-beta-ciklodekstrin od 20 do 30% (masa/volumen);
b) pimobendan ili njegova farmaceutski prihvatljiva sol od 0,005 do 0,15% (masa/volumen);
te pri čemu je pH vrijednost tekućine namještena na 6,5 do 7,5, a osmolalnost je 280 do 300 mOsm/kg.
8. Postupak proizvodnje tekućeg pripravka prema bilo kojem od zahtjeva 1 do 5, naznačen time, da obuhvaća sljedeće korake:
a) otapanje derivata eterificiranog ciklodekstrina u otapalu;
b) dodavanje pimobendana ili njegove farmaceutski prihvatljive soli u otopinu koja je dobivena u koraku a); i
c) miješanje dobivene smjese iz koraka b) za dobivanje tekućeg pripravka u obliku vodene otopine koja ima pH vrijednost od 5,5 do 8,5.
9. Postupak prema zahtjevu 8, naznačen time, da otapalo je voda.
10. Tekući pripravak prema bilo kojem od zahtjeva 1 do 7, naznačen time, da se upotrebljava kao lijek.
11. Tekući pripravak prema bilo kojem od zahtjeva 1 do 7, naznačen time, da se upotrebljava u liječenju ili prevenciji bolesti kod subjekta kojem je to liječenje potrebno, dok je ono odabrano od sljedećih indikacija: kongestivni srčani zastoj (CHF), akutni CHF, dekompenzirana endokardioza (DCE), dilatacijska kardiomiopatija (DCM), asimptomatični (okultni) CHF, asimptomatična DCM, održavanje kardiovaskularne funkcije i/ili renalne perfuzije za vrijeme anestezije, šoka, gastričke dilatacije, volvulusa, miokardijske i renalne ishemije.
12. Tekući pripravak prema zahtjevu 11, naznačen time, da subjekt kojem je potrebno takvo liječenje je konj, pas ili mačka.
13. Tekući pripravak prema zahtjevu 11 ili 12, naznačen time, da se farmaceutski sastav primjenjuje pomoću injekcije ili infuzije.
14. Garnitura, naznačena time, da obuhvaća sljedeće:
a) tekući pripravak prema bilo kojem od zahtjeva 1 do 7; i
b) pakirani listić koji sadrži uputu kako se tekući pripravak treba koristiti za prevenciju i/ili liječenje kongestivnog srčanog zastoja kod subjekta kojem je potrebna takva prevencija ili takvo liječenje.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06123567A EP1920785A1 (en) | 2006-11-07 | 2006-11-07 | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| PCT/EP2007/061879 WO2008055871A1 (en) | 2006-11-07 | 2007-11-05 | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140873T1 true HRP20140873T1 (hr) | 2014-12-05 |
Family
ID=37735786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140873TT HRP20140873T1 (hr) | 2006-11-07 | 2014-09-12 | Tekuä†i pripravak koji sadrži kompleks pimobendana i ciklodekstrina |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US9107952B2 (hr) |
| EP (3) | EP1920785A1 (hr) |
| JP (1) | JP5565794B2 (hr) |
| KR (1) | KR101434324B1 (hr) |
| CN (3) | CN101534864A (hr) |
| AR (1) | AR063587A1 (hr) |
| AU (1) | AU2007316712B2 (hr) |
| BR (1) | BRPI0718541B8 (hr) |
| CA (1) | CA2668733C (hr) |
| CL (1) | CL2007003201A1 (hr) |
| CY (1) | CY1115710T1 (hr) |
| DK (2) | DK2789349T3 (hr) |
| ES (2) | ES2649718T3 (hr) |
| HR (1) | HRP20140873T1 (hr) |
| HU (1) | HUE035821T2 (hr) |
| MX (1) | MX2009004767A (hr) |
| NZ (1) | NZ577067A (hr) |
| PL (2) | PL2089060T3 (hr) |
| PT (1) | PT2089060E (hr) |
| SI (1) | SI2089060T1 (hr) |
| TW (1) | TWI432425B (hr) |
| WO (1) | WO2008055871A1 (hr) |
| ZA (1) | ZA200902085B (hr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004011512B4 (de) | 2004-03-08 | 2022-01-13 | Boehringer Ingelheim Vetmedica Gmbh | Pharmazeutische Zubereitung enthaltend Pimobendan |
| US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
| EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| US8664252B2 (en) * | 2008-11-25 | 2014-03-04 | Boehringer Ingelheim Vetmedica Gmbh | Phosphodiesterase type III (PDE III) inhibitors or CA2+-sensitizing agents for the treatment of hypertrophic cardiomyopathy |
| NL1037569C2 (en) * | 2009-12-18 | 2011-06-21 | Eurovet Animal Health B V | Crystalline pimobendan, process for the preparation thereof, pharmaceutical composition and use. |
| US10052345B2 (en) | 2010-10-19 | 2018-08-21 | University Of Miami | Assays, methods and kits for predicting renal disease and personalized treatment strategies |
| EP2825159B1 (en) | 2012-03-15 | 2022-06-22 | Boehringer Ingelheim Vetmedica GmbH | Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof |
| CA2870316C (en) | 2012-04-13 | 2022-04-19 | L&F Health Llc | Hydroxypropyl beta cyclodextrin in the treatment of a proteinuric glomerural disease |
| WO2015007759A1 (en) * | 2013-07-19 | 2015-01-22 | Boehringer Ingelheim Vetmedica Gmbh | Etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition |
| AU2014292086B2 (en) | 2013-07-19 | 2019-08-08 | Boehringer Ingelheim Vetmedica Gmbh | Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition |
| EP2925305B1 (en) | 2013-12-04 | 2016-07-27 | Boehringer Ingelheim Vetmedica GmbH | Improved pharmaceutical compositions of pimobendan |
| KR102429646B1 (ko) * | 2016-03-14 | 2022-08-04 | 산텐 세이야꾸 가부시키가이샤 | 메글루민 또는 그의 염을 포함하는 방부제 |
| US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
| KR101829685B1 (ko) * | 2016-07-28 | 2018-02-19 | 씨제이헬스케어 주식회사 | 안정성 및 용해도가 개선된 주사용 조성물 |
| CN106729723A (zh) * | 2016-11-21 | 2017-05-31 | 青岛农业大学 | 一种含匹莫苯丹的药物组合物及其制备方法 |
| KR102034760B1 (ko) | 2018-12-31 | 2019-10-22 | 지앤에스건설 주식회사 | 긴장시스템을 도입한 일체형 현장타설 말뚝 시공방법이 적용된 구조 |
| CN114599353A (zh) * | 2019-10-23 | 2022-06-07 | 皮埃蒙特动物健康公司 | 匹莫苯制剂及其使用方法 |
| WO2022073954A1 (en) | 2020-10-08 | 2022-04-14 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan in the anaesthesia of non-human mammals |
| KR102546153B1 (ko) | 2022-08-01 | 2023-06-20 | 함정아 | 횡방향 지지력이 증가된 교량용 말뚝 및 그 시공방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1045031A (en) | 1963-04-30 | 1966-10-05 | Iwao Kawakami | Dentifrice |
| US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
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| CA950833A (en) | 1971-02-02 | 1974-07-09 | Carl M. Kosti | Composition for the treatment of hypertrophied oral tissue |
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- 2007-11-05 CN CNA2007800414452A patent/CN101534864A/zh active Pending
- 2007-11-05 CN CN201510090079.6A patent/CN104688680A/zh active Pending
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- 2007-11-05 EP EP14171537.5A patent/EP2789349B1/en active Active
- 2007-11-05 KR KR1020097011741A patent/KR101434324B1/ko active IP Right Grant
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