HRP20120856T1 - Transmukozni veterinarski pripravak koji sadrži detomidin - Google Patents

Transmukozni veterinarski pripravak koji sadrži detomidin Download PDF

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Publication number
HRP20120856T1
HRP20120856T1 HRP20120856TT HRP20120856T HRP20120856T1 HR P20120856 T1 HRP20120856 T1 HR P20120856T1 HR P20120856T T HRP20120856T T HR P20120856TT HR P20120856 T HRP20120856 T HR P20120856T HR P20120856 T1 HRP20120856 T1 HR P20120856T1
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Croatia
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preparation according
pharmaceutical preparation
range
preparation
relation
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HRP20120856TT
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English (en)
Inventor
Mirja Huhtinen
Piritta Koistinen
Lasse Leino
Maria Rantala
Helena Kaukinen
Kaija Af Ursin
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Orion Corporation
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Publication of HRP20120856T1 publication Critical patent/HRP20120856T1/hr

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)

Claims (23)

1. Farmaceutski veterinarski pripravak u obliku transmukoznog gela, naznačen time, da sadrži, u odnosu na ukupnu masu pripravka, 0,1 - 5 % (w/w) detomidina ili njegove farmaceutski prihvatljive soli; 0,3 - 40 % (w/w) sredstva za geliranje; 0,2 - 15 % (w/w) sredstva za poboljšanje transmukozne penetracije; 5 - 50 % (w/w) organskog kootapala koje se miješa s vodom; te 30 - 80 % (w/w) vode.
2. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time, da je organsko kootapalo koje se miješa s vodom glikol ili C2-C4 alkohol.
3. Farmaceutski pripravak u skladu s patentnim zahtjevom 2, naznačen time, da je organsko kootapalo koje se miješa s vodom propilen glikol.
4. Farmaceutski pripravak u skladu s patentnim zahtjevom 3, naznačen time, da je udjel propilen glikola u rasponu od 10 do 45% (w/w) u odnosu na ukupnu masu pripravka.
5. Farmaceutski pripravak u skladu s patentnim zahtjevom 4, naznačen time, da je udjel propilen glikola u rasponu od 15 to 40% (w/w) u odnosu na ukupnu masu pripravka.
6. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time, da je sredstvo za geliranje odabrano između derivata celuloze, poliakrilnih kiselina i kopolimera polioksietilena/polioksipropilena.
7. Farmaceutski pripravak u skladu s patentnim zahtjevom 6, naznačen time, da je sredstvo za geliranje hidroksipropil celuloza ili hidroksietil celuloza.
8. Farmaceutski pripravak u skladu s patentnim zahtjevom 7, naznačen time, da je udjel sredstva za geliranje u rasponu od 0,5 do 40 % u odnosu na ukupnu masu pripravka.
9. Farmaceutski pripravak u skladu s patentnim zahtjevom 8, naznačen time, da je udjel sredstva za geliranje u rasponu od 1 do 30 % (w/w) u odnosu na ukupnu masu pripravka.
10. Farmaceutski pripravak u skladu s patentnim zahtjevom 6, naznačen time, da je sredstvo za geliranje karbomer.
11. Farmaceutski pripravak u skladu s patentnim zahtjevom 10, naznačen time, da je udjel karbomera u rasponu od 0,3 do 5,0 % (w/w) u odnosu na ukupnu masu pripravka.
12. Farmaceutski pripravak u skladu s patentnim zahtjevom 11, naznačen time, da je udjel karbomera u rasponu od 0,5 do 3,0 % (w/w), u odnosu na ukupnu masu pripravka.
13. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time, da je sredstvo za poboljšanje transmukozne penetracije masna kiselina s 5 do 30 atoma ugljika, sulfatna sol masne kiseline s 5 do 30 atoma ugljika ili DMSO.
14. Farmaceutski pripravak u skladu s patentnim zahtjevom 13, naznačen time, da je udjel sredstva za poboljšanje transmukozne penetracije u rasponu od 0,5 do 10 % (w/w) u odnosu na ukupnu masu pripravka.
15. Farmaceutski pripravak u skladu s patentnim zahtjevom 13 ili 14, naznačen time, da je sredstvo za poboljšanje transmukozne penetracije natrijev lauril sulfat.
16. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time, da mu je pH vrijednost u rasponu od 5 do 7.
17. Farmaceutski pripravak u skladu s patentnim zahtjevom 16, naznačen time, da mu je pH vrijednost u rasponu od 5,5 do 6,5.
18. Veterinarski pribor, naznačen time, da sadrži pripravak u skladu s patentnim zahtjevom 1, spremnik koji sadrži navedeni pripravak te upute za davanje navedenog pripravka u mukozu životinje.
19. Pribor u skladu s patentnim zahtjevom 18, naznačen time, da je spremnik u obliku štrcaljke.
20. Pripravak u skladu s patentnim zahtjevom 1, naznačen time, da je namijenjen za davanje u mukozu životinje.
21. Pripravak u skladu s patentnim zahtjevom 20, naznačen time, da je navedena mukoza oralna mukoza.
22. Pripravak u skladu s patentnim zahtjevom 20 ili 21, naznačen time, da je namijenjen za uspavljivanje ili obuzdavanje konja, ponija ili goveda ili za postizanje analgetičkog ili anksiolitičkog učinka kod konja, ponija ili goveda.
23. Pripravak u skladu s patentnim zahtjevom 20, naznačen time, da se pripravak (u obujmu od 1 do 10 ml) daje liječenoj životinji sublingvalno iz unaprijed napunjene štrcaljke.
HRP20120856TT 2004-11-05 2012-10-23 Transmukozni veterinarski pripravak koji sadrži detomidin HRP20120856T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62512904P 2004-11-05 2004-11-05
FI20041425A FI20041425A0 (fi) 2004-11-05 2004-11-05 Transmukosaalinen veterinäärinen koostumus
PCT/FI2005/000470 WO2006048501A1 (en) 2004-11-05 2005-11-03 A transmucosal veterinary composition comprising detomidine

Publications (1)

Publication Number Publication Date
HRP20120856T1 true HRP20120856T1 (hr) 2012-11-30

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ID=33515193

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20120856TT HRP20120856T1 (hr) 2004-11-05 2012-10-23 Transmukozni veterinarski pripravak koji sadrži detomidin

Country Status (22)

Country Link
US (2) US7863311B2 (hr)
EP (1) EP1811995B1 (hr)
JP (1) JP4996472B2 (hr)
KR (1) KR101257672B1 (hr)
AR (1) AR054987A1 (hr)
AU (1) AU2005300451B2 (hr)
BR (1) BRPI0517719B1 (hr)
CA (1) CA2583876C (hr)
DK (1) DK1811995T3 (hr)
ES (1) ES2388442T3 (hr)
FI (1) FI20041425A0 (hr)
HR (1) HRP20120856T1 (hr)
IL (1) IL182541A (hr)
MX (1) MX2007005238A (hr)
NO (1) NO338158B1 (hr)
NZ (1) NZ554521A (hr)
PL (1) PL1811995T3 (hr)
PT (1) PT1811995E (hr)
RS (1) RS52504B (hr)
SI (1) SI1811995T1 (hr)
WO (1) WO2006048501A1 (hr)
ZA (1) ZA200703486B (hr)

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ES2393814T3 (es) * 2007-04-04 2012-12-28 Sigmoid Pharma Limited Una composición farmacéutica oral
US20090246256A1 (en) * 2008-03-27 2009-10-01 Al-Ghananeem Abeer M Compositions and Methods for Transmucosal Delivery of Lofexidine
KR101517415B1 (ko) 2008-05-14 2015-05-07 에스케이바이오팜 주식회사 난용성 항경련제를 함유하는 경비 항경련성 약학 조성물
KR20120060833A (ko) * 2009-09-04 2012-06-12 가부시키가이샤 시세이도 O/w 유화 조성물의 제조 방법
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BR112015008459B1 (pt) * 2012-10-15 2020-11-10 Orion Corporation uso de dexmedetomidina, medetomidina ou um sal farmaceuticamente aceitável destas para a fabricação de um medicamento para aliviar a aversão ao ruído em um animal
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JP7534795B2 (ja) 2019-05-01 2024-08-15 クレキシオ バイオサイエンシーズ エルティーディー. そう痒症を治療する方法
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Also Published As

Publication number Publication date
PL1811995T3 (pl) 2012-12-31
PT1811995E (pt) 2012-08-03
NZ554521A (en) 2010-09-30
BRPI0517719B1 (pt) 2018-11-06
SI1811995T1 (sl) 2012-10-30
NO20072864L (no) 2007-06-05
US20110071203A1 (en) 2011-03-24
MX2007005238A (es) 2007-07-09
ZA200703486B (en) 2008-06-25
CA2583876A1 (en) 2006-05-11
US20070299121A1 (en) 2007-12-27
US8309591B2 (en) 2012-11-13
IL182541A (en) 2011-02-28
CA2583876C (en) 2012-05-29
RS52504B (en) 2013-04-30
AU2005300451B2 (en) 2011-01-20
WO2006048501A1 (en) 2006-05-11
AU2005300451A1 (en) 2006-05-11
JP2008519012A (ja) 2008-06-05
EP1811995B1 (en) 2012-07-25
EP1811995A1 (en) 2007-08-01
BRPI0517719A (pt) 2008-10-21
KR20070085284A (ko) 2007-08-27
AR054987A1 (es) 2007-08-01
US7863311B2 (en) 2011-01-04
FI20041425A0 (fi) 2004-11-05
DK1811995T3 (da) 2012-08-20
KR101257672B1 (ko) 2013-04-24
JP4996472B2 (ja) 2012-08-08
IL182541A0 (en) 2007-09-20
ES2388442T3 (es) 2012-10-15
NO338158B1 (no) 2016-08-01

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