HRP20120827T1 - Mutantni, dvostruko ciklizirani receptorski peptidi koji inhibiraju protutijela na adrenoceptor beta 1 - Google Patents

Mutantni, dvostruko ciklizirani receptorski peptidi koji inhibiraju protutijela na adrenoceptor beta 1 Download PDF

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Publication number
HRP20120827T1
HRP20120827T1 HRP20120827AT HRP20120827T HRP20120827T1 HR P20120827 T1 HRP20120827 T1 HR P20120827T1 HR P20120827A T HRP20120827A T HR P20120827AT HR P20120827 T HRP20120827 T HR P20120827T HR P20120827 T1 HRP20120827 T1 HR P20120827T1
Authority
HR
Croatia
Prior art keywords
cys
cyclic peptide
arg
asp
ala
Prior art date
Application number
HRP20120827AT
Other languages
English (en)
Croatian (hr)
Inventor
Roland Jahns
Valérie JAHNS
Martin Lohse
Viacheslav Nikolaev
Original Assignee
Julius-Maximilians-Universität Würzburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Julius-Maximilians-Universität Würzburg filed Critical Julius-Maximilians-Universität Würzburg
Publication of HRP20120827T1 publication Critical patent/HRP20120827T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
HRP20120827AT 2007-08-24 2008-08-22 Mutantni, dvostruko ciklizirani receptorski peptidi koji inhibiraju protutijela na adrenoceptor beta 1 HRP20120827T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07016637 2007-08-24
PCT/EP2008/006932 WO2009027063A2 (en) 2007-08-24 2008-08-22 MUTANT DOUBLE CYCLIZED RECEPTOR PEPTIDES INHIBITING β1-ADRENOCEPTOR ANTIBODIES

Publications (1)

Publication Number Publication Date
HRP20120827T1 true HRP20120827T1 (hr) 2012-11-30

Family

ID=40130559

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20120827AT HRP20120827T1 (hr) 2007-08-24 2008-08-22 Mutantni, dvostruko ciklizirani receptorski peptidi koji inhibiraju protutijela na adrenoceptor beta 1

Country Status (13)

Country Link
US (1) US9062095B2 (enExample)
EP (3) EP2197900B9 (enExample)
JP (3) JP5248610B2 (enExample)
CN (2) CN101835793B (enExample)
AU (1) AU2008291296B2 (enExample)
CA (1) CA2697108C (enExample)
DK (1) DK2197900T3 (enExample)
ES (1) ES2391358T3 (enExample)
HR (1) HRP20120827T1 (enExample)
PL (1) PL2197900T3 (enExample)
PT (1) PT2197900E (enExample)
SI (1) SI2197900T1 (enExample)
WO (1) WO2009027063A2 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2197900T3 (pl) * 2007-08-24 2012-12-31 Univ Wuerzburg J Maximilians Zmutowane podwójnie cyklizowane peptydy receptorowe hamujące przeciwciała przeciwko beta 1-adrenoreceptorowi
EP2391637A1 (en) * 2009-01-27 2011-12-07 Julius-Maximilians-Universität Würzburg Novel peptide-homologues for inhibiting beta1-adrenoceptor antibodies
DE102010018878B4 (de) 2009-04-30 2013-09-26 Julius-Maximilians-Universität Würzburg Neue Zell-Linie zur Fluoreszenz-basierten Detektion von funktionell aktiven Antikörpern und Autoantikörpern gegen den Beta1-adrenergen Rezeptor
EP2402016A1 (en) * 2010-06-29 2012-01-04 Charité - Universitätsmedizin Berlin Aptamers that inhibit interaction between antibody and 1st or 2nd extracellular loop of human beta-1-adrenergic receptor
EP2718324A1 (en) 2011-06-10 2014-04-16 Corimmun GmbH Binding compounds to human 1-adrenoreceptor ( 1-ar) and their use in the measurement of auto-anti- a1-ar antibodies
IN2014MN01642A (enExample) 2012-02-16 2015-07-03 Atyr Pharma Inc
US9587235B2 (en) 2013-03-15 2017-03-07 Atyr Pharma, Inc. Histidyl-tRNA synthetase-Fc conjugates
WO2015022953A1 (ja) * 2013-08-14 2015-02-19 株式会社新日本科学 血液脳関門障害改善剤
CN110536694A (zh) 2017-04-20 2019-12-03 Atyr 医药公司 用于治疗肺部炎症的组合物和方法
CN108218963B (zh) * 2018-01-19 2020-10-13 首都医科大学 一种环肽及其制备方法和用途
MA55296A (fr) * 2019-03-14 2022-03-23 Hoffmann La Roche Traitement du cancer avec des anticorps bispécifiques de her2xcd3 en combinaison avec un mab anti-her2
US11986536B2 (en) 2019-03-23 2024-05-21 Ablevia Biotech Gmbh Compound for the sequestration of undesirable antibodies in a patient
EP3715374A1 (en) 2019-03-23 2020-09-30 Ablevia biotech GmbH Compound for the sequestration of undesirable antibodies in a patient
IL301332A (en) * 2020-09-23 2023-05-01 Ablevia Biotech Gmbh Compound for the prevention or treatment of autoantibody-mediated conditions
CN112266330B (zh) * 2020-10-15 2023-02-24 长沙博源医疗科技有限公司 一种甲氧基肾上腺素衍生物、免疫原、抗甲氧基肾上腺素特异性抗体及其制备方法与应用
EP4392430A4 (en) 2021-08-27 2026-04-29 Univ Yale EXTRACELLULAR PROTEIN MOLECULAR DEGRADING AGENTS
JP2023117892A (ja) * 2022-02-14 2023-08-24 公益財団法人 鷹揚郷 ヘプシジン結合ペプチド
CN120647762B (zh) * 2025-06-16 2026-01-23 首都医科大学附属北京友谊医院 一种抗β1-AR-ECII抗体及其应用

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4880635B1 (en) 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
US5792608A (en) 1991-12-12 1998-08-11 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
US5525711A (en) 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
DE50013435D1 (de) * 1999-09-21 2006-10-19 Fresenius Medical Care Affina Peptide gegen dcm hervorrufende autoantikörper
JP2003513942A (ja) * 1999-11-05 2003-04-15 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア インビボ遺伝子送達による心血管疾患を処理するための技術および組成物
US20040001827A1 (en) * 2002-06-28 2004-01-01 Dennis Mark S. Serum albumin binding peptides for tumor targeting
JP4541490B2 (ja) * 2000-04-07 2010-09-08 株式会社カネカ 拡張型心筋症用吸着体
WO2001083693A2 (en) * 2000-04-28 2001-11-08 Glaxo Group Limited Compounds having affinity for the vascular endothelial growth factor receptor-2 (vegfr-2) and associated uses
KR20040004538A (ko) * 2001-08-23 2004-01-13 질랜드 파마 에이/에스 세포간 커뮤니케이션을 촉진시켜주는 화합물의 신규한의약적 용도
US7041790B2 (en) * 2002-03-26 2006-05-09 Dyax Corp. Fibrinogen binding moieties
WO2004069863A2 (en) * 2003-02-04 2004-08-19 New York University Constrained hiv v3 loop peptides as immunogens and receptor antagonists
EP1536020A1 (en) 2003-11-26 2005-06-01 Bayerische Julius-Maximilians-Universität Würzburg Means and methods for optical determination of cAMP in vitro and in vivo
EP2518082A3 (en) * 2005-03-31 2013-03-13 Julius-Maximilians-Universität Würzburg Means for the inhibition of anti-beta1-adrenergic receptor antibodies
PL2197900T3 (pl) * 2007-08-24 2012-12-31 Univ Wuerzburg J Maximilians Zmutowane podwójnie cyklizowane peptydy receptorowe hamujące przeciwciała przeciwko beta 1-adrenoreceptorowi

Also Published As

Publication number Publication date
EP2559698A3 (en) 2013-03-06
JP2013176369A (ja) 2013-09-09
JP5248610B2 (ja) 2013-07-31
US20100209445A1 (en) 2010-08-19
US9062095B2 (en) 2015-06-23
SI2197900T1 (sl) 2012-11-30
CN103992406A (zh) 2014-08-20
EP2497777A3 (en) 2012-10-10
EP2197900B1 (en) 2012-08-01
CA2697108A1 (en) 2009-03-05
AU2008291296A1 (en) 2009-03-05
CA2697108C (en) 2018-05-22
WO2009027063A2 (en) 2009-03-05
PL2197900T3 (pl) 2012-12-31
EP2497777A2 (en) 2012-09-12
AU2008291296B2 (en) 2014-02-06
EP2197900B9 (en) 2013-01-09
EP2559698A2 (en) 2013-02-20
ES2391358T3 (es) 2012-11-23
CN101835793A (zh) 2010-09-15
PT2197900E (pt) 2012-10-24
CN101835793B (zh) 2014-04-23
DK2197900T3 (da) 2012-10-22
JP2010536356A (ja) 2010-12-02
EP2197900A2 (en) 2010-06-23
EP2559698B1 (en) 2014-11-12
WO2009027063A3 (en) 2009-07-23
HK1176363A1 (en) 2013-07-26
JP2013138679A (ja) 2013-07-18

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