HRP20110845T1 - Antitumorski dihidropiran-2-onski spojevi - Google Patents
Antitumorski dihidropiran-2-onski spojevi Download PDFInfo
- Publication number
- HRP20110845T1 HRP20110845T1 HR20110845T HRP20110845T HRP20110845T1 HR P20110845 T1 HRP20110845 T1 HR P20110845T1 HR 20110845 T HR20110845 T HR 20110845T HR P20110845 T HRP20110845 T HR P20110845T HR P20110845 T1 HRP20110845 T1 HR P20110845T1
- Authority
- HR
- Croatia
- Prior art keywords
- image
- tautomer
- pharmaceutically acceptable
- stereoisomer
- acceptable salt
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 44
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 23
- 239000001257 hydrogen Substances 0.000 claims abstract 23
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims abstract 8
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims abstract 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract 5
- 229910003827 NRaRb Inorganic materials 0.000 claims abstract 4
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims 42
- 150000002431 hydrogen Chemical class 0.000 claims 13
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 241000689227 Cora <basidiomycete fungus> Species 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06380173 | 2006-06-16 | ||
| PCT/EP2007/055959 WO2007144423A1 (en) | 2006-06-16 | 2007-06-15 | Antitumoral dihydropyran-2-one compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110845T1 true HRP20110845T1 (hr) | 2011-12-31 |
Family
ID=38508885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110845T HRP20110845T1 (hr) | 2006-06-16 | 2011-11-14 | Antitumorski dihidropiran-2-onski spojevi |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US8324406B2 (es) |
| EP (3) | EP2032551B9 (es) |
| JP (2) | JP5117491B2 (es) |
| KR (1) | KR101474031B1 (es) |
| CN (2) | CN101679340B (es) |
| AR (1) | AR061506A1 (es) |
| AT (1) | ATE522514T1 (es) |
| AU (1) | AU2007259257B8 (es) |
| BR (2) | BRPI0722429A2 (es) |
| CA (1) | CA2654334C (es) |
| CY (1) | CY1112103T1 (es) |
| DK (1) | DK2032551T3 (es) |
| ES (1) | ES2371942T3 (es) |
| HK (1) | HK1130052A1 (es) |
| HR (1) | HRP20110845T1 (es) |
| IL (1) | IL195676A (es) |
| MX (1) | MX2008015754A (es) |
| MY (1) | MY145788A (es) |
| NO (2) | NO341508B1 (es) |
| NZ (1) | NZ573706A (es) |
| PL (1) | PL2032551T3 (es) |
| PT (1) | PT2032551E (es) |
| RS (1) | RS52034B (es) |
| RU (2) | RU2444519C2 (es) |
| SG (1) | SG174830A1 (es) |
| SI (1) | SI2032551T1 (es) |
| TW (2) | TWI373469B (es) |
| UA (1) | UA97369C2 (es) |
| WO (1) | WO2007144423A1 (es) |
| ZA (1) | ZA200810315B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA119963C2 (uk) * | 2007-12-20 | 2019-09-10 | Фарма Мар, С.А. | Протипухлинні сполуки |
| KR101590202B1 (ko) | 2008-02-20 | 2016-01-29 | 액테리온 파마슈티칼 리미티드 | 아자트리사이클 항생 화합물 |
| AR070458A1 (es) | 2008-02-22 | 2010-04-07 | Actelion Pharmaceuticals Ltd | Derivados de oxazolidina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de una infeccion bacteriana. |
| AR073774A1 (es) | 2008-10-07 | 2010-12-01 | Actelion Pharmaceuticals Ltd | Compuestos antibioticos oxazolidinona triciclicos |
| TWI436999B (zh) | 2008-10-10 | 2014-05-11 | Actelion Pharmaceuticals Ltd | 唑啶基抗生素 |
| WO2010149688A2 (en) | 2009-06-24 | 2010-12-29 | Pharma Mar, S.A. | Antitumoral compounds |
| GB201309807D0 (en) * | 2013-05-31 | 2013-07-17 | Pharma Mar Sau | Antibody drug conjugates |
| CN108467378A (zh) * | 2017-02-23 | 2018-08-31 | 复旦大学 | 一种二氢吡喃酮类化合物及其制备方法和用途 |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
| CN110790737B (zh) * | 2019-11-07 | 2022-07-22 | 河南中烟工业有限责任公司 | 一种2,3-二氢-3,5-二羟基-6-乙基-4h-吡喃-4-酮的制备方法 |
| EP4419513A1 (en) | 2021-10-22 | 2024-08-28 | Pharma Mar S.A. | Antitumoral compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA938019B (en) * | 1992-11-13 | 1995-04-28 | Upjohn Co | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses |
| JP3684426B2 (ja) * | 1993-11-19 | 2005-08-17 | パーク・デイビス・アンド・カンパニー | プロテアーゼ阻害剤および抗ウイルス剤としての５，６−ジヒドロピロン誘導体 |
| US7446196B2 (en) * | 2004-06-03 | 2008-11-04 | Kosan Biosciences, Incorporated | Leptomycin compounds |
-
2007
- 2007-06-15 EP EP07765445A patent/EP2032551B9/en active Active
- 2007-06-15 EP EP11177479A patent/EP2404913A3/en not_active Withdrawn
- 2007-06-15 MX MX2008015754A patent/MX2008015754A/es active IP Right Grant
- 2007-06-15 NZ NZ573706A patent/NZ573706A/en unknown
- 2007-06-15 PL PL07765445T patent/PL2032551T3/pl unknown
- 2007-06-15 RS RS20110495A patent/RS52034B/en unknown
- 2007-06-15 DK DK07765445.7T patent/DK2032551T3/da active
- 2007-06-15 CN CN2007800222645A patent/CN101679340B/zh active Active
- 2007-06-15 RU RU2009101150/04A patent/RU2444519C2/ru active
- 2007-06-15 SG SG2011067998A patent/SG174830A1/en unknown
- 2007-06-15 US US12/304,123 patent/US8324406B2/en active Active
- 2007-06-15 CA CA2654334A patent/CA2654334C/en active Active
- 2007-06-15 KR KR1020097000830A patent/KR101474031B1/ko active IP Right Grant
- 2007-06-15 BR BRPI0722429-0A patent/BRPI0722429A2/pt not_active IP Right Cessation
- 2007-06-15 AT AT07765445T patent/ATE522514T1/de active
- 2007-06-15 UA UAA200900292A patent/UA97369C2/ru unknown
- 2007-06-15 JP JP2009514811A patent/JP5117491B2/ja active Active
- 2007-06-15 BR BRPI0713031A patent/BRPI0713031B8/pt active IP Right Grant
- 2007-06-15 ES ES07765445T patent/ES2371942T3/es active Active
- 2007-06-15 AU AU2007259257A patent/AU2007259257B8/en active Active
- 2007-06-15 MY MYPI20085040A patent/MY145788A/en unknown
- 2007-06-15 SI SI200730781T patent/SI2032551T1/sl unknown
- 2007-06-15 CN CN2011102036625A patent/CN102336730A/zh active Pending
- 2007-06-15 WO PCT/EP2007/055959 patent/WO2007144423A1/en active Application Filing
- 2007-06-15 PT PT07765445T patent/PT2032551E/pt unknown
- 2007-06-15 EP EP11177474A patent/EP2404912A3/en not_active Withdrawn
- 2007-06-19 AR ARP070102670A patent/AR061506A1/es active IP Right Grant
- 2007-06-20 TW TW096122071A patent/TWI373469B/zh active
- 2007-06-20 TW TW100146802A patent/TW201213316A/zh unknown
-
2008
- 2008-12-02 IL IL195676A patent/IL195676A/en active IP Right Grant
- 2008-12-04 ZA ZA2008/10315A patent/ZA200810315B/en unknown
-
2009
- 2009-01-06 NO NO20090054A patent/NO341508B1/no unknown
- 2009-09-03 HK HK09108044.0A patent/HK1130052A1/xx unknown
-
2011
- 2011-06-29 US US13/171,567 patent/US8501968B2/en active Active
- 2011-08-05 RU RU2011133128/04A patent/RU2011133128A/ru not_active Application Discontinuation
- 2011-09-14 NO NO20111248A patent/NO20111248L/no not_active Application Discontinuation
- 2011-10-05 JP JP2011220925A patent/JP2012021023A/ja active Pending
- 2011-11-14 HR HR20110845T patent/HRP20110845T1/hr unknown
- 2011-11-30 CY CY20111101175T patent/CY1112103T1/el unknown
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