HRP20110780T2 - Aminoarilsulfonamidni spojevi i njihova upotreba kao ligandi 5-ht6 - Google Patents

Aminoarilsulfonamidni spojevi i njihova upotreba kao ligandi 5-ht6 Download PDF

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HRP20110780T2
HRP20110780T2 HRP20110780TT HRP20110780T HRP20110780T2 HR P20110780 T2 HRP20110780 T2 HR P20110780T2 HR P20110780T T HRP20110780T T HR P20110780TT HR P20110780 T HRP20110780 T HR P20110780T HR P20110780 T2 HRP20110780 T2 HR P20110780T2
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sulfonyl
diamine
dimethylethane
methylindole
phenyl
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Venkata Satya Ramakrishna Nirogi
Sastri Kambhampati Rama
Karbhari Shinde Anil
Vishwottam Kandikere Nagaraj
Jasti Venkateswarlu
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Suven Life Sciences Limited
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Abstract

Spoj formule (I) naznačen time što R1 predstavlja vodik, hidroksil, halogen, (C1-C3)alkil, halogen(C1-C3)alkil, (C1-C3)alkoksi, halogen(C1-C3)alkoksi, ciklo(C3-C6)alkil ili ciklo(C3-C6)alkoksi; R2 predstavlja vodik, halogen, (C1-C3)alkil, halogen(C1-C3)alkil, (C1-C3)alkoksi ili halogen(C1-C3)alkoksi, ciklo(C3-C6)alkil ili ciklo(C3-C6)alkoksi; R predstavlja vodik ili (C1-C3)alkil ili (C3-C6)cikloalkil; "n" predstavlja 0 do 4; "p" predstavlja 0 do 6; "q" predstavlja 0 do 4. Patent sadrži još 12 patentnih zahtjeva.

Claims (13)

1. Spoj formule (I) [image] naznačen time što R1 predstavlja vodik, hidroksil, halogen, (C1-C3)alkil, halogen(C1-C3)alkil, (C1-C3)alkoksi, halogen(C1-C3)alkoksi, ciklo(C3-C6)alkil ili ciklo(C3-C6)alkoksi; R2 predstavlja vodik, halogen, (C1-C3)alkil, halogen(C1-C3)alkil, (C1-C3)alkoksi ili halogen(C1-C3)alkoksi, ciklo(C3-C6)alkil ili ciklo(C3-C6)alkoksi; R predstavlja vodik ili (C1-C3)alkil ili (C3-C6)cikloalkil; "n" predstavlja 0 do 4; "p" predstavlja 0 do 6; "q" predstavlja 0 do 4.
2. Spoj u skladu s patentnim zahtjevom 1, naznačen time što R1 je po mogućnosti vodik, hidroksil, halogen, (C1-C3)alkil, halogen(C1-C3)alkil, (C1-C3)alkoksi ili halogen(C1-C3)alkoksi.
3. Spoj u skladu s patentnim zahtjevom 1, naznačen time što R2 je po mogućnosti vodik, halogen, (C1-C3)alkil, halogen(C1-C3)alkil, (C1-C3)alkoksi, halogen(C1-C3)alkoksi, ciklo(C3-C6)alkil ili ciklo(C3-C6)alkoksi.
4. Spoj u skladu s patentnim zahtjevom 1, naznačen time što R je po mogućnosti vodik ili (C1-C3)alkil.
5. Spoj u skladu s patentnim zahtjevom 1, naznačen time što ga se bira se iz skupine koju čine: N'-[2-Metoksi-5-(5-metoksi-3-metilindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[5-(3-Klor-5-metoksiindolo-1-sulfonil)-2-metoksifenil]-N,N-dimetileten-1,2-diamin; N'-[5-(3-Klor-indol-1-sulfonil)-2-metoksifenil]-N,N-dimetiletan-1,2-diamin; N'-[5-(Indol-1-sulfonil)-2-metoksifenil]-N,N-dimetiletan-1,2-diamin; N'-[2-Metoksi-5-(3-metilindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[5-(5-Metoksi-3-metilindol-1-sulfonil)-2-metilfenil]-N,N-dimetilpropan-1,3-diamin; N'-[5-(5-Metoksiindol-1-sulfonil)-2-metilfenil]-N,N-dimetiletan-1,2-diamin; N'-[5-(5-Metoksi-3-metilindol-1-sulfonil)-2-metilfenil]-N,N-dimetiletan-1,2-diamin; N'-[5-(5-Metoksiindol-1-sulfonil)-2-metilfenil]-N,N-dimetilpropan-1,3-diamin; N'-[3-(4-Klor-3-metilindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[3-(5-Klor-3-metilindol-1-sulfonil)-2-etilfenil]-N,N-dimetiletan-1,2-diamin; N'-[2-Etil-5-(5-fluor-3-metilindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[2-Etil-5-(5-fluorindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[2-Etil-5-(5-klorindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[2-Etil-5-(5-metoksi-3-metilindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[3-(5-Izopropoksi-3-metilindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[5-(5-Brom-3-metilindol-1-sulfonil)-2-klorfenil]-N,N-dimetiletan-1,2-diamin; N'-[3-(5-Etoksi-3-metilindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[5-(5-Brom-3-metilindol-1-sulfonil)-2-etilfenil]-N,N-dimetiletan-1,2-diamin; N'-[5-(6-Klorindol-1-sulfonil)-2-metilfenil]-N,N-dimetiletan-1,2-diamin; N'-[3-(5-Bromindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[3-(5-Izopropoksiindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[3-(6-Klorindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[5-(5-Bromindol-1-sulfonil)-2-etilfenil]-N,N-dimetiletan-1,2-diamin; N'-[3-(4-Klorindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[2-Etil-5-(5-metoksiindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[3-(5-Metoksi-3-metilindol-1-sulfonil)fenil]-N,N-dimetilpropan-1,3-diamin; N'-[2-Metoksi-5-(5-klor-3-metilindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[3-(5-Metoksi-3-metilindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[2-Metoksi-5-(5-klor-3-metilindol-1-sulfonil)fenil]-N,N-dimetilpropan-1,3-diamin; N'-[2-Metoksi-5-(3-metilindol-1-sulfonil)fenil]-N,N-dimetilpropan-1,3-diamin; N'-[2-Metoksi-5-(5-brom-3-metilindol-1-sulfonil)fenil]-N,N-dimetilpropan-1,3-diamin; N'-[2-Metoksi-5-(5-fluor-3-metilindol-1-sulfonil)fenil]-N,N-dimetilpropan-1,3-diamin; N'-[2-Metoksi-5-(5-fluor-3-metilindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[2-Metoksi-5-(5-metoksi-3-metilindol-1-sulfonil)fenil]-N,N-dimetilpropan-1,3-diamin; N'-[3-(5-Fluor-3-metilindol-1-sulfonil)-5-metoksifenil]-N,N-dimetiletan-1,2-diamin; N'-[3-Klor-5-(5-etil-3-metilindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[3-(5-Fluor-3-metilindol-1-sulfonil)-5-metilfenil]-N,N-dimetiletan-1,2-diamin; N'-[4-Metoksi-3-(5-metilindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[4-Brom-3-(5-metoksiindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; N'-[3-(5-Etil-3-metilindol-1-sulfonil)-4-metilfenil]-N,N-dimetiletan-1,2-diamin; N'-[2-Klor-3-(5-metoksi-2-metilindol-1-sulfonil)fenil]-N,N-dimetiletan-1,2-diamin; njihovi stereoizomeri i njihove farmaceutski prihvatljive soli.
6. 5. Postupak dobivanja spoja formule (I) [image] gdje R1 predstavlja vodik, hidroksil, halogen, (C1-C3)alkil, halogen(C1-C3)alkil, (C1-C3)alkoksi, halogen(C1-C3)alkoksi, ciklo(C3-C6)alkil ili ciklo(C3-C6)alkoksi; R2 predstavlja vodik, halogen, (C1-C3)alkil, halogen(C1-C3)alkil, (C1-C3)alkoksi ili halogen(C1-C3)alkoksi, ciklo(C3-C6)alkil ili ciklo(C3-C6)alkoksi; R predstavlja vodik ili (C1-C3)alkil ili (C3-C6)cikloalkil; "n" predstavlja 0 do 4; "p" predstavlja 0 do 6; "q" predstavlja 0 do 4; naznačen time što se sastoji u reakciji spoja formule (a) [image] gdje su svi supstituenti kao stoje opisano gore; s aminskim derivatima, uz upotrebu pogodne baze, u prisutnosti inertnog otapala, na temperaturi okoliša.
7. 6. Postupak u skladu s patentnim zahtjevom 6, naznačen time što se navedenu bazu bira između kalijevog karbonata i natrijevog hidroksida.
8. 7. Postupak u skladu s patentnim zahtjevom 6 i/ili 7, naznačen time što se navedeno inertno otapalo bira između diklormetana, dimetilformamida, dimetil-sulfoksida i w-ksilena.
9. 8. Farmaceutski pripravak, naznačen time što sadrži spoj formule (I) u skladu s patentnim zahtjevom 1 do 5 i farmaceutski prihvatljivu podlogu, razrjeđivač, pomoćnu tvar ili solvat.
10. 9. 10. Farmaceutski pripravak u skladu s patentnim zahtjevom 9, naznačen time stoje u obliku tablete, kapsule, praška, sirupa, otopine, injekcije ili suspenzije i primijenjuje se kao jednu dozu ili više jedinica doze.
11. 10. 11. Farmaceutski pripravak u skladu s patentnim zahtjevom 9 i/ili 10, naznačen time stoje namijenjen upotrebi u liječenju bolesti ili poremećaja središnjeg živčanog sustava povezanih s ili pod utjecajem receptora 5-HT6 i bira ih se iz skupine koju čine motorički poremećaj, anksiozni poremećaj, kognitivni poremećaj, neurodegenerativni poremećaj, Alzheimerova bolest, Huntingtonova koreja, gastrointestinalni, kognitivni poremećaj povezan sa shizofrenijom, blagi kognitivni poremećaj, poremećaji hranjenja, anksioznost, depresija, pretilost i/ili Parkinsonova bolest.
12. 11. Spoj formule (I), u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što ga se upotrebljava u proizvodnji medikamenta za liječenje ili sprječavanje bolesti ili poremećaja središnjeg živčanog sustava povezanih s ili pod utjecajem receptora 5-HT6 i bira ih se iz skupine koju čine motorički poremećaj, anksiozni poremećaj, kognitivni poremećaj, neurodegenerativni poremećaj, Alzheimerova bolest, Huntingtonova koreja, gastrointestinalni, kognitivni poremećaj povezan sa shizofrenijom, poremećaji hranjenja, anksioznost, depresija, pretilost i/ili Parkinsonova bolest.
13. 12. Sredstvo za sprječavanje ili liječenje bolesti ili poremećaja središnjeg živčanog sustava povezanih s ili pod utjecajem receptora 5-HT6 i biraju se iz skupine koju čine motorički poremećaj, anksiozni poremećaj, kognitivni poremećaj, neurodegenerativni poremećaj, Alzheimerova bolest, Huntingtonova koreja, gastrointestinalni, kognitivni poremećaj povezan sa shizofrenijom, poremećaji hranjenja, anksioznost, depresija, pretilost i/ili Parkinsonova bolest; naznačeno time što kao aktivni sastojak sadrži spoj formule (I) u skladu s bilo kojim od prethodnih patentnih zahtjeva.
HRP20110780TT 2007-10-26 2011-10-26 Aminoarilsulfonamidni spojevi i njihova upotreba kao ligandi 5-ht6 HRP20110780T2 (hr)

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IN2433CH2007 2007-10-26
EP08776656A EP2200980B9 (en) 2007-10-26 2008-05-02 Amino arylsulfonamide compounds and their use as 5-ht6 ligands field of invention
PCT/IN2008/000281 WO2009053997A1 (en) 2007-10-26 2008-05-02 Amino arylsulfonamide compounds and their use as 5-ht6 ligands

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HRP20110780T2 true HRP20110780T2 (hr) 2018-06-29

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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102153884B (zh) * 2011-02-16 2013-06-19 连云港清泰化工有限公司 一种墨水型染料及其制备方法与用途
EP2763676B1 (en) 2011-10-03 2019-12-25 The University of Utah Research Foundation Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome
CA2862363C (en) * 2012-02-02 2021-06-08 Joan M. Fallon Enzyme compositions and use thereof for wound healing
CN104725295B (zh) 2013-12-20 2019-05-24 广东东阳光药业有限公司 芳杂环类衍生物及其在药物上的应用
NZ728907A (en) * 2014-08-16 2017-12-22 Suven Life Sciences Ltd Active metabolite of 1-[(2-bromophenyl) sulfonyl]-5-methoxy-3- [(4-methyl-1-piperazinyl) methyl]-1h-indole dimesylate monohydrate and dimesylate dihydrate salt of active metabolite

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DZ2376A1 (fr) 1996-12-19 2002-12-28 Smithkline Beecham Plc Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
HUP0003073A3 (en) 1997-07-11 2002-10-28 Smithkline Beecham Plc Benzenesulfonamide derivatives, process for producing them and their use as medicines
SI0930302T1 (en) * 1998-01-16 2003-10-31 F. Hoffmann-La Roche Ag Benzosulfone derivatives
GB9801392D0 (en) 1998-01-22 1998-03-18 Smithkline Beecham Plc Novel compounds
GB9803411D0 (en) 1998-02-18 1998-04-15 Smithkline Beecham Plc Novel compounds
DE69937372T2 (de) 1999-04-21 2008-06-26 Nps Allelix Corp., Mississauga Piperidin-indol derivate mit 5-ht6 affinität
GB9926302D0 (en) 1999-11-05 2000-01-12 Smithkline Beecham Plc Novel compounds
DE60214990T2 (de) 2001-01-30 2007-04-05 Eli Lilly And Co., Indianapolis Benzolsulfonsäureester-indol-5-yl als 5-ht6 rezeptor-antagonisten
WO2002098878A1 (en) 2001-02-08 2002-12-12 Memory Pharmaceuticals Corporation Trifluoromethylpurines as phosphodiesterase 4 inhibitors
SK16052003A3 (en) 2001-06-07 2004-10-05 Hoffmann La Roche New indole derivatives with 5-HT6 receptor affinity
JP2005528587A (ja) 2002-02-01 2005-09-22 バイエル・ヘルスケア・アクチェンゲゼルシャフト 新規ヒト５−ｈｔ６受容体に関連する疾患のための診断用および治療用物質
EP1471912A1 (en) 2002-02-05 2004-11-03 Glaxo Group Limited Method of promoting neuronal growth
WO2003080580A2 (en) 2002-03-27 2003-10-02 Glaxo Group Limited Quinoline derivatives and their use as 5-ht6 ligands
ES2274285T3 (es) * 2002-10-18 2007-05-16 F. Hoffmann-La Roche Ag 4-piperanzinilbencenosulfonilindoles con afinidad al receptor 5-ht6.
ES2310243T3 (es) 2002-11-28 2009-01-01 Suven Life Sciences Limited Indoles n-aril-3-sulfonil sustituidos que tienen afinidad por receptores de serotonina, proceso para su preparacion y composicion farmaceutica que los contiene.
KR100776118B1 (ko) 2002-11-28 2007-11-15 수벤 라이프 사이언시스 리미티드 엔-아릴술포닐-3-아미노알콕시인돌
WO2004048331A1 (en) * 2002-11-28 2004-06-10 Suven Life Sciences Limited N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands
JP4571507B2 (ja) * 2002-12-18 2010-10-27 スベン ライフ サイエンシズ リミティド セロトニン受容体親和性を有する四環系３−置換インドール
CN101258144B (zh) * 2005-08-12 2012-05-30 苏文生命科学有限公司 作为功能性5-ht6配体的氨基芳基磺酰胺衍生物

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US7964627B2 (en) 2011-06-21
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