HRP20110322T1 - Postupak za pročišćavanje montelukasta - Google Patents
Postupak za pročišćavanje montelukasta Download PDFInfo
- Publication number
- HRP20110322T1 HRP20110322T1 HR20110322T HRP20110322T HRP20110322T1 HR P20110322 T1 HRP20110322 T1 HR P20110322T1 HR 20110322 T HR20110322 T HR 20110322T HR P20110322 T HRP20110322 T HR P20110322T HR P20110322 T1 HRP20110322 T1 HR P20110322T1
- Authority
- HR
- Croatia
- Prior art keywords
- montelukast
- process according
- purification process
- salt
- aqueous phase
- Prior art date
Links
- UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 title claims abstract 25
- 229960005127 montelukast Drugs 0.000 title claims abstract 22
- 238000000746 purification Methods 0.000 title claims abstract 17
- 238000000034 method Methods 0.000 title claims abstract 5
- 150000003839 salts Chemical class 0.000 claims abstract 13
- 239000000203 mixture Substances 0.000 claims abstract 12
- 239000008346 aqueous phase Substances 0.000 claims abstract 11
- 239000003960 organic solvent Substances 0.000 claims abstract 11
- 239000002253 acid Substances 0.000 claims abstract 6
- 238000000638 solvent extraction Methods 0.000 claims abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000012535 impurity Substances 0.000 claims abstract 3
- 239000012453 solvate Substances 0.000 claims abstract 2
- 239000012074 organic phase Substances 0.000 claims 5
- 238000005406 washing Methods 0.000 claims 5
- 238000009835 boiling Methods 0.000 claims 4
- 238000000926 separation method Methods 0.000 claims 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Natural products CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 238000000605 extraction Methods 0.000 claims 2
- 238000001914 filtration Methods 0.000 claims 2
- 239000012429 reaction media Substances 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 150000007529 inorganic bases Chemical class 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
- 230000020477 pH reduction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83687306P | 2006-08-09 | 2006-08-09 | |
| EP06118689A EP1886997A1 (en) | 2006-08-09 | 2006-08-09 | Process for the purification of montelukast |
| PCT/EP2007/058176 WO2008017667A1 (en) | 2006-08-09 | 2007-08-07 | Process for the purification of montelukast |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110322T1 true HRP20110322T1 (hr) | 2011-06-30 |
Family
ID=37667497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110322T HRP20110322T1 (hr) | 2006-08-09 | 2011-05-03 | Postupak za pročišćavanje montelukasta |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20100029945A1 (pl) |
| EP (2) | EP1886997A1 (pl) |
| JP (1) | JP2010500324A (pl) |
| KR (1) | KR20090037445A (pl) |
| CN (1) | CN101490005B (pl) |
| AT (1) | ATE499345T1 (pl) |
| AU (1) | AU2007283613A1 (pl) |
| CA (1) | CA2657017A1 (pl) |
| DE (1) | DE602007012728D1 (pl) |
| ES (1) | ES2361239T3 (pl) |
| HR (1) | HRP20110322T1 (pl) |
| IL (1) | IL195622A (pl) |
| MX (1) | MX2008015135A (pl) |
| NO (1) | NO20090748L (pl) |
| PL (1) | PL2066638T3 (pl) |
| PT (1) | PT2066638E (pl) |
| RU (1) | RU2009108271A (pl) |
| SI (1) | SI2066638T1 (pl) |
| WO (1) | WO2008017667A1 (pl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1652128B1 (en) | 2003-07-07 | 2014-05-14 | Insurance Services Office, Inc. | Traffic information system |
| EP1904448B1 (en) | 2005-07-05 | 2011-02-02 | Teva Pharmaceutical Industries, Ltd. | Purification of montelukast |
| EP2552892A1 (en) | 2010-03-31 | 2013-02-06 | KRKA, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
| JP5553096B2 (ja) * | 2012-08-29 | 2014-07-16 | 大日本印刷株式会社 | 高純度モンテルカストの製造法 |
| CN103570619B (zh) * | 2013-11-08 | 2015-12-09 | 南京靖龙药物研发有限公司 | 一种孟鲁司特钠衍生物的制备方法 |
| CN105646344B (zh) * | 2016-02-29 | 2018-08-14 | 山东新时代药业有限公司 | 一种孟鲁司特的纯化方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
| KR20060117356A (ko) * | 2004-01-30 | 2006-11-16 | 테바 파마슈티컬 인더스트리즈 리미티드 | 몬테루카스트 유리산 다형체 |
| CA2554927A1 (en) * | 2004-02-03 | 2005-08-18 | Chemagis Ltd. | Stable amorphous forms of montelukast sodium |
| US7189853B2 (en) * | 2004-04-15 | 2007-03-13 | Dr. Reddy's Laboratories Limited | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts |
| WO2006058545A1 (en) * | 2004-11-30 | 2006-06-08 | Medichem, S.A. | New process for the preparation of a leukotriene antagonist |
| WO2006064269A2 (en) * | 2004-12-17 | 2006-06-22 | Cipla Limited | Salts of leukotriene antagonist montelukast |
-
2006
- 2006-08-09 EP EP06118689A patent/EP1886997A1/en not_active Withdrawn
-
2007
- 2007-08-07 US US12/376,773 patent/US20100029945A1/en not_active Abandoned
- 2007-08-07 ES ES07788278T patent/ES2361239T3/es active Active
- 2007-08-07 KR KR1020097002300A patent/KR20090037445A/ko not_active Application Discontinuation
- 2007-08-07 SI SI200730588T patent/SI2066638T1/sl unknown
- 2007-08-07 RU RU2009108271/04A patent/RU2009108271A/ru not_active Application Discontinuation
- 2007-08-07 AU AU2007283613A patent/AU2007283613A1/en not_active Abandoned
- 2007-08-07 EP EP07788278A patent/EP2066638B8/en active Active
- 2007-08-07 CN CN2007800263787A patent/CN101490005B/zh not_active Expired - Fee Related
- 2007-08-07 CA CA002657017A patent/CA2657017A1/en not_active Abandoned
- 2007-08-07 PL PL07788278T patent/PL2066638T3/pl unknown
- 2007-08-07 DE DE602007012728T patent/DE602007012728D1/de active Active
- 2007-08-07 MX MX2008015135A patent/MX2008015135A/es active IP Right Grant
- 2007-08-07 JP JP2009523275A patent/JP2010500324A/ja active Pending
- 2007-08-07 AT AT07788278T patent/ATE499345T1/de not_active IP Right Cessation
- 2007-08-07 WO PCT/EP2007/058176 patent/WO2008017667A1/en active Application Filing
- 2007-08-07 PT PT07788278T patent/PT2066638E/pt unknown
-
2008
- 2008-12-01 IL IL195622A patent/IL195622A/en not_active IP Right Cessation
-
2009
- 2009-02-17 NO NO20090748A patent/NO20090748L/no not_active Application Discontinuation
-
2011
- 2011-05-03 HR HR20110322T patent/HRP20110322T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SI2066638T1 (sl) | 2011-06-30 |
| RU2009108271A (ru) | 2010-09-20 |
| WO2008017667A1 (en) | 2008-02-14 |
| AU2007283613A1 (en) | 2008-02-14 |
| ATE499345T1 (de) | 2011-03-15 |
| PL2066638T3 (pl) | 2011-07-29 |
| MX2008015135A (es) | 2008-12-15 |
| CN101490005A (zh) | 2009-07-22 |
| DE602007012728D1 (de) | 2011-04-07 |
| NO20090748L (no) | 2009-03-09 |
| JP2010500324A (ja) | 2010-01-07 |
| EP2066638A1 (en) | 2009-06-10 |
| EP2066638B8 (en) | 2011-10-12 |
| PT2066638E (pt) | 2011-05-16 |
| US20100029945A1 (en) | 2010-02-04 |
| CA2657017A1 (en) | 2008-02-14 |
| IL195622A0 (en) | 2009-09-01 |
| ES2361239T3 (es) | 2011-06-15 |
| EP2066638B1 (en) | 2011-02-23 |
| IL195622A (en) | 2011-03-31 |
| KR20090037445A (ko) | 2009-04-15 |
| EP1886997A1 (en) | 2008-02-13 |
| AU2007283613A8 (en) | 2009-01-22 |
| CN101490005B (zh) | 2011-08-31 |
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