HRP20110045T1 - Sinteza acilaminoalkenilen amida korisnih kao antagonista supstance p - Google Patents
Sinteza acilaminoalkenilen amida korisnih kao antagonista supstance p Download PDFInfo
- Publication number
- HRP20110045T1 HRP20110045T1 HR20110045T HRP20110045T HRP20110045T1 HR P20110045 T1 HRP20110045 T1 HR P20110045T1 HR 20110045 T HR20110045 T HR 20110045T HR P20110045 T HRP20110045 T HR P20110045T HR P20110045 T1 HRP20110045 T1 HR P20110045T1
- Authority
- HR
- Croatia
- Prior art keywords
- formula
- compound
- protecting group
- boc protecting
- image
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title claims 3
- 150000001408 amides Chemical class 0.000 title 1
- 239000003890 substance P antagonist Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 34
- 125000006847 BOC protecting group Chemical group 0.000 claims abstract 23
- 125000005843 halogen group Chemical group 0.000 claims abstract 11
- 229910052736 halogen Inorganic materials 0.000 claims abstract 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 9
- 125000001424 substituent group Chemical group 0.000 claims abstract 9
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 9
- 238000000034 method Methods 0.000 claims abstract 8
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 claims abstract 7
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims abstract 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims abstract 5
- -1 C 1 -C 7 -alkyl Chemical group 0.000 claims abstract 5
- 239000012453 solvate Substances 0.000 claims abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 2
- 150000002431 hydrogen Chemical class 0.000 claims abstract 2
- 125000001624 naphthyl group Chemical group 0.000 claims abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 230000003301 hydrolyzing effect Effects 0.000 claims 2
- GXHFUVWIGNLZSC-UHFFFAOYSA-N meldrum's acid Chemical compound CC1(C)OC(=O)CC(=O)O1 GXHFUVWIGNLZSC-UHFFFAOYSA-N 0.000 claims 2
- CZRKBWYUKKBUMS-HNNXBMFYSA-N (4r)-4-[[3,5-bis(trifluoromethyl)benzoyl]-methylamino]-5-(3,4-dichlorophenyl)pent-2-enoic acid Chemical compound C([C@@H](N(C)C(=O)C=1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F)C=CC(O)=O)C1=CC=C(Cl)C(Cl)=C1 CZRKBWYUKKBUMS-HNNXBMFYSA-N 0.000 claims 1
- 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0607532A GB0607532D0 (en) | 2006-04-13 | 2006-04-13 | Organic compounds |
GB0610244A GB0610244D0 (en) | 2006-05-23 | 2006-05-23 | Organic compounds |
PCT/EP2007/003213 WO2007118651A1 (en) | 2006-04-13 | 2007-04-11 | Synthesis of acylaminoalkenylene amides useful as substance p antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20110045T1 true HRP20110045T1 (hr) | 2011-02-28 |
Family
ID=38324102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20110045T HRP20110045T1 (hr) | 2006-04-13 | 2011-01-21 | Sinteza acilaminoalkenilen amida korisnih kao antagonista supstance p |
Country Status (29)
Country | Link |
---|---|
US (2) | US8008479B2 (pt) |
EP (1) | EP2010498B1 (pt) |
JP (1) | JP5208917B2 (pt) |
KR (1) | KR20080108291A (pt) |
AR (1) | AR060506A1 (pt) |
AT (1) | ATE486853T1 (pt) |
AU (1) | AU2007237482B2 (pt) |
CA (1) | CA2645362C (pt) |
CL (1) | CL2007001040A1 (pt) |
CY (1) | CY1111294T1 (pt) |
DE (1) | DE602007010269D1 (pt) |
DK (1) | DK2010498T3 (pt) |
EC (1) | ECSP088820A (pt) |
GT (1) | GT200800209A (pt) |
HK (1) | HK1125640A1 (pt) |
HR (1) | HRP20110045T1 (pt) |
JO (1) | JO2630B1 (pt) |
MA (1) | MA30394B1 (pt) |
MX (1) | MX2008013117A (pt) |
MY (1) | MY145069A (pt) |
NO (1) | NO20084783L (pt) |
NZ (1) | NZ571142A (pt) |
PE (1) | PE20071223A1 (pt) |
PL (1) | PL2010498T3 (pt) |
PT (1) | PT2010498E (pt) |
RU (1) | RU2433122C2 (pt) |
SI (1) | SI2010498T1 (pt) |
TW (1) | TW200815358A (pt) |
WO (1) | WO2007118651A1 (pt) |
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Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU701560B2 (en) | 1995-02-22 | 1999-01-28 | Novartis Ag | 1-aryl-2-acylamino-ethane compounds and their use as neurokinin especially neurokinin 1 antagonists |
MY132550A (en) * | 1996-08-22 | 2007-10-31 | Novartis Ag | Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists |
GB0010958D0 (en) * | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
-
2007
- 2007-04-10 JO JO2007129A patent/JO2630B1/en active
- 2007-04-11 US US12/296,969 patent/US8008479B2/en not_active Expired - Fee Related
- 2007-04-11 DE DE602007010269T patent/DE602007010269D1/de active Active
- 2007-04-11 AU AU2007237482A patent/AU2007237482B2/en not_active Ceased
- 2007-04-11 DK DK07724154.5T patent/DK2010498T3/da active
- 2007-04-11 CA CA2645362A patent/CA2645362C/en not_active Expired - Fee Related
- 2007-04-11 PE PE2007000444A patent/PE20071223A1/es not_active Application Discontinuation
- 2007-04-11 MX MX2008013117A patent/MX2008013117A/es active IP Right Grant
- 2007-04-11 PL PL07724154T patent/PL2010498T3/pl unknown
- 2007-04-11 EP EP07724154A patent/EP2010498B1/en active Active
- 2007-04-11 PT PT07724154T patent/PT2010498E/pt unknown
- 2007-04-11 JP JP2009504637A patent/JP5208917B2/ja not_active Expired - Fee Related
- 2007-04-11 RU RU2008145102/04A patent/RU2433122C2/ru not_active IP Right Cessation
- 2007-04-11 SI SI200730483T patent/SI2010498T1/sl unknown
- 2007-04-11 WO PCT/EP2007/003213 patent/WO2007118651A1/en active Application Filing
- 2007-04-11 AT AT07724154T patent/ATE486853T1/de active
- 2007-04-11 KR KR1020087024839A patent/KR20080108291A/ko not_active Application Discontinuation
- 2007-04-11 NZ NZ571142A patent/NZ571142A/en not_active IP Right Cessation
- 2007-04-11 AR ARP070101533A patent/AR060506A1/es not_active Application Discontinuation
- 2007-04-12 CL CL200701040A patent/CL2007001040A1/es unknown
- 2007-04-12 TW TW096112886A patent/TW200815358A/zh unknown
-
2008
- 2008-10-08 MY MYPI20083997A patent/MY145069A/en unknown
- 2008-10-10 GT GT200800209A patent/GT200800209A/es unknown
- 2008-10-13 EC EC2008008820A patent/ECSP088820A/es unknown
- 2008-11-03 MA MA31347A patent/MA30394B1/fr unknown
- 2008-11-12 NO NO20084783A patent/NO20084783L/no not_active Application Discontinuation
-
2009
- 2009-05-15 HK HK09104457.9A patent/HK1125640A1/xx not_active IP Right Cessation
-
2011
- 2011-01-21 HR HR20110045T patent/HRP20110045T1/hr unknown
- 2011-01-26 CY CY20111100082T patent/CY1111294T1/el unknown
- 2011-07-22 US US13/188,795 patent/US20110282053A1/en not_active Abandoned
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