HRP20100532T1 - Izravno određivanje vitamina d u serumu ili plazmi - Google Patents
Izravno određivanje vitamina d u serumu ili plazmi Download PDFInfo
- Publication number
- HRP20100532T1 HRP20100532T1 HR20100532T HRP20100532T HRP20100532T1 HR P20100532 T1 HRP20100532 T1 HR P20100532T1 HR 20100532 T HR20100532 T HR 20100532T HR P20100532 T HRP20100532 T HR P20100532T HR P20100532 T1 HRP20100532 T1 HR P20100532T1
- Authority
- HR
- Croatia
- Prior art keywords
- vitamin
- metabolites
- serum
- solid phase
- buffer
- Prior art date
Links
- 229940046008 vitamin d Drugs 0.000 title claims abstract 22
- 210000002966 serum Anatomy 0.000 title claims abstract 8
- 229930003316 Vitamin D Natural products 0.000 claims abstract 21
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract 21
- 235000019166 vitamin D Nutrition 0.000 claims abstract 21
- 239000011710 vitamin D Substances 0.000 claims abstract 21
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract 21
- 239000002207 metabolite Substances 0.000 claims abstract 13
- 238000000034 method Methods 0.000 claims abstract 8
- 210000002381 plasma Anatomy 0.000 claims abstract 8
- 108010067770 Endopeptidase K Proteins 0.000 claims abstract 6
- 108010022999 Serine Proteases Proteins 0.000 claims abstract 6
- 102000012479 Serine Proteases Human genes 0.000 claims abstract 6
- 102000004506 Blood Proteins Human genes 0.000 claims abstract 3
- 108010017384 Blood Proteins Proteins 0.000 claims abstract 3
- 230000009137 competitive binding Effects 0.000 claims abstract 2
- 238000000746 purification Methods 0.000 claims abstract 2
- 239000007790 solid phase Substances 0.000 claims 7
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 238000012800 visualization Methods 0.000 claims 5
- 239000000872 buffer Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 3
- 229960004889 salicylic acid Drugs 0.000 claims 3
- GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 claims 2
- ZGLHBRQAEXKACO-XJRQOBMKSA-N 1alpha,25-dihydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ZGLHBRQAEXKACO-XJRQOBMKSA-N 0.000 claims 2
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 claims 2
- JWUBBDSIWDLEOM-UHFFFAOYSA-N 25-Hydroxycholecalciferol Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CCC1=C JWUBBDSIWDLEOM-UHFFFAOYSA-N 0.000 claims 2
- JWUBBDSIWDLEOM-DCHLRESJSA-N 25-Hydroxyvitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C/C=C1\C[C@@H](O)CCC1=C JWUBBDSIWDLEOM-DCHLRESJSA-N 0.000 claims 2
- JWUBBDSIWDLEOM-NQZHSCJISA-N 25-hydroxy-3 epi cholecalciferol Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@H](O)CCC1=C JWUBBDSIWDLEOM-NQZHSCJISA-N 0.000 claims 2
- KJKIIUAXZGLUND-ICCVIKJNSA-N 25-hydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)CCC1=C KJKIIUAXZGLUND-ICCVIKJNSA-N 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 150000007513 acids Chemical class 0.000 claims 2
- 239000012148 binding buffer Substances 0.000 claims 2
- 235000020964 calcitriol Nutrition 0.000 claims 2
- 239000011612 calcitriol Substances 0.000 claims 2
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 2
- 238000003018 immunoassay Methods 0.000 claims 2
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical class C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000003127 radioimmunoassay Methods 0.000 claims 2
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 claims 2
- 229960005080 warfarin Drugs 0.000 claims 2
- 102000050760 Vitamin D-binding protein Human genes 0.000 claims 1
- 108700021020 Vitamin D-binding protein Proteins 0.000 claims 1
- 238000012875 competitive assay Methods 0.000 claims 1
- 239000003398 denaturant Substances 0.000 claims 1
- 238000004925 denaturation Methods 0.000 claims 1
- 230000036425 denaturation Effects 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 239000013024 dilution buffer Substances 0.000 claims 1
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 claims 1
- 230000000367 exoproteolytic effect Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000004020 luminiscence type Methods 0.000 claims 1
- 239000010413 mother solution Substances 0.000 claims 1
- 238000000159 protein binding assay Methods 0.000 claims 1
- 230000017854 proteolysis Effects 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 230000029087 digestion Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007005099 | 2007-02-01 | ||
| PCT/EP2008/051162 WO2008092917A1 (en) | 2007-02-01 | 2008-01-30 | Direct determination of vitamin d in serum or plasma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100532T1 true HRP20100532T1 (hr) | 2010-11-30 |
Family
ID=39262786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100532T HRP20100532T1 (hr) | 2007-02-01 | 2010-09-28 | Izravno određivanje vitamina d u serumu ili plazmi |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7964363B2 (de) |
| EP (1) | EP2126586B1 (de) |
| JP (1) | JP5185291B2 (de) |
| AT (1) | ATE472734T1 (de) |
| AU (1) | AU2008209736B2 (de) |
| DE (1) | DE602008001667D1 (de) |
| DK (1) | DK2126586T3 (de) |
| ES (1) | ES2348126T3 (de) |
| HR (1) | HRP20100532T1 (de) |
| PL (1) | PL2126586T3 (de) |
| PT (1) | PT2126586E (de) |
| WO (1) | WO2008092917A1 (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5143046B2 (ja) * | 2009-02-12 | 2013-02-13 | 富士フイルム株式会社 | 被験物質の測定方法及び該測定方法を実施するためのキット |
| GB0903469D0 (en) * | 2009-03-02 | 2009-04-08 | Axis Shield Diagnostics Ltd | Assay |
| EP2427484B1 (de) * | 2009-05-06 | 2016-07-06 | OPKO Ireland Global Holdings, Limited | Verfahren und zusammensetzung zur messung der menge an vitamin-d-derivaten |
| US20110097733A1 (en) | 2009-10-27 | 2011-04-28 | Michel Anciaux | Process for the production of a hybridoma and antibody obtained therefrom, able to recognize more than one vitamin d metabolite |
| EP2372365A1 (de) * | 2010-04-01 | 2011-10-05 | Future Diagnostics B.V. | Direkt-Immunoassay auf Vitamin D |
| EP2572204B1 (de) | 2010-05-20 | 2017-12-27 | Roche Diagnostics GmbH | Freisetzungsreagens für vitamin d-verbindungen |
| WO2012091569A1 (en) * | 2010-12-28 | 2012-07-05 | Future Diagnostics B.V. | Release reagent for vitamin d |
| US9052308B2 (en) | 2011-01-07 | 2015-06-09 | The General Hospital Corporation | Assays and methods of treatment relating to vitamin D insufficiency |
| WO2014179737A2 (en) | 2013-05-03 | 2014-11-06 | The General Hospital Corporation | Assays and methods of treatment relating to vitamin d insufficiency |
| US9329190B2 (en) | 2011-01-07 | 2016-05-03 | The General Hospital Corporation | Assays and methods of treatment relating to vitamin D insufficiency |
| WO2012129650A1 (en) * | 2011-03-25 | 2012-10-04 | Nanospeed Diagnostics Inc. | Lateral flow immunoassay for detecting vitamins |
| US9140711B2 (en) | 2011-04-04 | 2015-09-22 | Immundiagnostik Ag | Determination of vitamin D metabolites in dried blood |
| US8785603B2 (en) | 2011-05-20 | 2014-07-22 | Siemens Healthcare Diagnostics Inc. | Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof |
| JP6038945B2 (ja) * | 2011-11-18 | 2016-12-07 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ビタミンｄ化合物に関する遊離試薬 |
| CA2862260A1 (en) | 2011-11-29 | 2013-06-06 | Academisch Ziekenhuis Groningen | Methods and kits for determining protein-bound biomarkers |
| JP6171333B2 (ja) * | 2012-12-26 | 2017-08-02 | 東ソー株式会社 | 安定化したビタミンｄ類標準液 |
| US10983136B2 (en) | 2013-01-28 | 2021-04-20 | Diasorin S.P.A. | Use of 1,25-dihydroxyvitamin D values in ratio with PTH as a prognostic biomarker |
| DK2759550T3 (en) * | 2013-01-28 | 2018-11-26 | Diasorin S P A | Method and kit for detecting vitamin 1,25-dihydroxy-D and related antibodies |
| US11261257B2 (en) | 2013-01-28 | 2022-03-01 | Diasorin S.P.A. | Methods for detecting 1,25-dihydroxyvitamin D and related antibodies |
| RU2621154C2 (ru) * | 2013-02-06 | 2017-05-31 | Фуджиребайо Инк. | Способ определения и набор для определения витамина d |
| US9618523B2 (en) * | 2013-02-28 | 2017-04-11 | Siemens Healthcare Diagnostics Inc. | Methods and reagents for determining isomeric analytes |
| US10073103B1 (en) | 2013-03-11 | 2018-09-11 | Theranos Ip Company, Llc | Rapid measurement of total vitamin D in blood |
| US20140273021A1 (en) * | 2013-03-14 | 2014-09-18 | Enzo Biochem, Inc. | Vitamin d assays |
| DE102013205055A1 (de) | 2013-03-21 | 2014-09-25 | Orgentec Diagnostika Gmbh | Verfahren und Reagenz zur Bestimmung von Vitamin D Metaboliten |
| ES2724537T3 (es) * | 2013-12-03 | 2019-09-11 | Immunodiagnostic Systems Ltd | Procedimiento para cuantificar un analito, y un dispositivo analítico automático configurado para poner en práctica dicho procedimiento |
| US20150212099A1 (en) | 2014-01-30 | 2015-07-30 | General Atomics | Methods and compositions for assaying vitamin d |
| AU2015220754A1 (en) | 2014-02-20 | 2016-08-25 | Immundiagnostik Ag | In vitro diagnostic and prognosis of contrast induced nephropathy (CIN) in patients undergoing coronary angiography |
| JP6456969B2 (ja) * | 2014-02-21 | 2019-01-23 | マサチューセッツ インスティテュート オブ テクノロジー | 膨張顕微鏡法 |
| ES2698518T3 (es) * | 2014-12-17 | 2019-02-05 | Siemens Healthcare Diagnostics Inc | Medición de ensayo precisa de analitos hapténicos hidrófobos |
| US10526649B2 (en) | 2015-04-14 | 2020-01-07 | Massachusetts Institute Of Technology | Augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information |
| US10059990B2 (en) | 2015-04-14 | 2018-08-28 | Massachusetts Institute Of Technology | In situ nucleic acid sequencing of expanded biological samples |
| US11408890B2 (en) | 2015-04-14 | 2022-08-09 | Massachusetts Institute Of Technology | Iterative expansion microscopy |
| EP3332258B1 (de) | 2015-08-07 | 2020-01-01 | Massachusetts Institute of Technology | Expansionsmikroskopie unter proteinrückhaltung |
| CA2994958C (en) | 2015-08-07 | 2024-02-13 | Massachusetts Institute Of Technology | Nanoscale imaging of proteins and nucleic acids via expansion microscopy |
| US10852310B2 (en) | 2015-12-11 | 2020-12-01 | Opko Diagnostics, Llc | Fluidic systems involving incubation of samples and/or reagents |
| US10338084B2 (en) | 2016-04-07 | 2019-07-02 | Quidel Corporation | Processing reagent and use thereof in assays for detection of analytes associated with a binding protein |
| CA3031355C (en) | 2016-07-29 | 2023-05-23 | Diazyme Laboratories, Inc. | Methods and compositions for assaying vitamin d |
| WO2018136856A1 (en) | 2017-01-23 | 2018-07-26 | Massachusetts Institute Of Technology | Multiplexed signal amplified fish via splinted ligation amplification and sequencing |
| WO2018157048A1 (en) | 2017-02-24 | 2018-08-30 | Massachusetts Institute Of Technology | Methods for examining podocyte foot processes in human renal samples using conventional optical microscopy |
| US20180267065A1 (en) * | 2017-03-20 | 2018-09-20 | Trustees Of Boston University | Methods relating to the measurement of vitamin d and vitamin d metabolites |
| EP3602073B1 (de) | 2017-03-28 | 2023-10-18 | Roche Diagnostics GmbH | Generische vorbehandlungsreagenzien zur analytbestimmung |
| US11180804B2 (en) | 2017-07-25 | 2021-11-23 | Massachusetts Institute Of Technology | In situ ATAC sequencing |
| EP3499235A1 (de) | 2017-12-13 | 2019-06-19 | Immundiagnostik AG | Verfahren zur messung von autoantikörpern in körperflüssigkeiten |
| DK3735591T3 (da) | 2018-01-03 | 2022-09-12 | Immundiagnostik Ag | Fremgangsmåde til måling af status af endocytisk vitamin D |
| US11873374B2 (en) | 2018-02-06 | 2024-01-16 | Massachusetts Institute Of Technology | Swellable and structurally homogenous hydrogels and methods of use thereof |
| WO2020190358A1 (en) * | 2019-03-19 | 2020-09-24 | Siemens Healthcare Diagnostics Inc. | Compositions, devices, and methods of mitigating lipoprotein interference in in vitro diagnostic assays for hydrophobic analytes |
| US11802822B2 (en) | 2019-12-05 | 2023-10-31 | Massachusetts Institute Of Technology | Multiplexed expansion (MultiExM) pathology |
| CN111024962B (zh) * | 2019-12-31 | 2023-09-19 | 复星诊断科技(上海)有限公司 | 一种用于从血清中检测叶酸含量的解离剂及检测方法 |
| CN113495159A (zh) * | 2020-03-20 | 2021-10-12 | 郑州达诺生物技术有限公司 | 一种系统反应液、一种25羟基维生素d定量检测试剂盒及其使用方法 |
| CN111521832A (zh) * | 2020-04-27 | 2020-08-11 | 四川沃文特生物技术有限公司 | 一种用于测定25-羟基-维生素d的试剂盒 |
| CN112098663B (zh) * | 2020-09-21 | 2023-03-31 | 上海科华生物工程股份有限公司 | 保持维生素d水溶液稳定的组合物及其制备方法和应用 |
| EP4222502A1 (de) | 2020-09-29 | 2023-08-09 | F. Hoffmann-La Roche AG | Verfahren zur bestimmung des vitamin-d-spiegels und metaboliten davon |
| CN112485418B (zh) * | 2020-10-26 | 2023-04-11 | 北京利德曼生化股份有限公司 | 一种用于人体维生素b12含量检测的释放剂及其应用 |
| CN113884687B (zh) * | 2021-12-08 | 2022-02-11 | 南京岚轩生物科技有限公司 | 用于检测25-羟基维生素d含量的解离剂及其制备方法 |
| CN115078578A (zh) * | 2022-06-16 | 2022-09-20 | 广州市妇女儿童医疗中心 | 一种基于液质联用的血清维生素d相关代谢物的检测方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU685301B2 (en) * | 1994-07-01 | 1998-01-15 | Akzo Nobel N.V. | A method for monitoring performance of an incubator module, said incubator module being comprised in an automated systemfor assaying multiple samples and a kit suitable for use in said method |
| US6787660B1 (en) * | 1998-06-25 | 2004-09-07 | Immundiagnostik Ag | Functional vitamin D derivatives and a method for determining 25-hydroxy-vitamin D and 1α, dihydroxy-vitamin D |
| GB0029729D0 (en) * | 2000-12-06 | 2001-01-17 | Ids Ltd | Method for detection of vitamin D metabolites |
| US7087395B1 (en) * | 2001-01-16 | 2006-08-08 | Quest Diagnostics Investments Incorporated | Vitamin D assay |
| DE10144905C2 (de) | 2001-09-12 | 2003-07-31 | Immundiagnostik Ag | Bestimmung von Vitamin-D direkt in Serum oder Plasma |
| US20040132104A1 (en) | 2003-01-07 | 2004-07-08 | Sackrison James L. | Vitamin D assay |
-
2008
- 2008-01-30 DK DK08708477.8T patent/DK2126586T3/da active
- 2008-01-30 ES ES08708477T patent/ES2348126T3/es active Active
- 2008-01-30 JP JP2009547690A patent/JP5185291B2/ja active Active
- 2008-01-30 US US12/517,754 patent/US7964363B2/en active Active
- 2008-01-30 AU AU2008209736A patent/AU2008209736B2/en not_active Ceased
- 2008-01-30 AT AT08708477T patent/ATE472734T1/de active
- 2008-01-30 DE DE602008001667T patent/DE602008001667D1/de active Active
- 2008-01-30 WO PCT/EP2008/051162 patent/WO2008092917A1/en active Application Filing
- 2008-01-30 PT PT08708477T patent/PT2126586E/pt unknown
- 2008-01-30 EP EP08708477A patent/EP2126586B1/de active Active
- 2008-01-30 PL PL08708477T patent/PL2126586T3/pl unknown
-
2010
- 2010-09-28 HR HR20100532T patent/HRP20100532T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2126586T3 (da) | 2010-10-11 |
| EP2126586A1 (de) | 2009-12-02 |
| DE602008001667D1 (de) | 2010-08-12 |
| JP5185291B2 (ja) | 2013-04-17 |
| AU2008209736B2 (en) | 2011-03-03 |
| JP2010518369A (ja) | 2010-05-27 |
| AU2008209736A1 (en) | 2008-08-07 |
| ATE472734T1 (de) | 2010-07-15 |
| ES2348126T3 (es) | 2010-11-30 |
| PL2126586T3 (pl) | 2010-12-31 |
| US20100068725A1 (en) | 2010-03-18 |
| EP2126586B1 (de) | 2010-06-30 |
| PT2126586E (pt) | 2010-09-17 |
| US7964363B2 (en) | 2011-06-21 |
| WO2008092917A1 (en) | 2008-08-07 |
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