HRP20090618T1 - Uporaba peptida koji proizlaze iz b beta lanca humanog fibrinogena za liječenje šoka - Google Patents
Uporaba peptida koji proizlaze iz b beta lanca humanog fibrinogena za liječenje šoka Download PDFInfo
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- HRP20090618T1 HRP20090618T1 HR20090618T HRP20090618T HRP20090618T1 HR P20090618 T1 HRP20090618 T1 HR P20090618T1 HR 20090618 T HR20090618 T HR 20090618T HR P20090618 T HRP20090618 T HR P20090618T HR P20090618 T1 HRP20090618 T1 HR P20090618T1
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 11
- 230000035939 shock Effects 0.000 title claims abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 102000009123 Fibrin Human genes 0.000 claims abstract 4
- 108010073385 Fibrin Proteins 0.000 claims abstract 4
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims abstract 4
- 229950003499 fibrin Drugs 0.000 claims abstract 4
- 102000008790 VE-cadherin Human genes 0.000 claims abstract 3
- 230000004071 biological effect Effects 0.000 claims abstract 3
- 108010018828 cadherin 5 Proteins 0.000 claims abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims abstract 3
- 230000001939 inductive effect Effects 0.000 claims abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract 3
- 229920006395 saturated elastomer Polymers 0.000 claims abstract 3
- 229930195734 saturated hydrocarbon Natural products 0.000 claims abstract 3
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims abstract 3
- 150000001413 amino acids Chemical class 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract 2
- 210000000056 organ Anatomy 0.000 claims 3
- 208000032456 Hemorrhagic Shock Diseases 0.000 claims 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- 206010049771 Shock haemorrhagic Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 241000712892 Arenaviridae Species 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 231100000699 Bacterial toxin Toxicity 0.000 claims 1
- 206010053567 Coagulopathies Diseases 0.000 claims 1
- 208000001490 Dengue Diseases 0.000 claims 1
- 206010012310 Dengue fever Diseases 0.000 claims 1
- 241000711950 Filoviridae Species 0.000 claims 1
- 241000710831 Flavivirus Species 0.000 claims 1
- 206010022657 Intestinal infarction Diseases 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- 206010053159 Organ failure Diseases 0.000 claims 1
- 241000150350 Peribunyaviridae Species 0.000 claims 1
- 208000006193 Pulmonary infarction Diseases 0.000 claims 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 239000000688 bacterial toxin Substances 0.000 claims 1
- 208000015294 blood coagulation disease Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 208000025729 dengue disease Diseases 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 230000002008 hemorrhagic effect Effects 0.000 claims 1
- 206010019680 hepatic infarction Diseases 0.000 claims 1
- 150000002430 hydrocarbons Chemical group 0.000 claims 1
- 239000012678 infectious agent Substances 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 201000007970 necrotizing fasciitis Diseases 0.000 claims 1
- 230000007575 pulmonary infarction Effects 0.000 claims 1
- 201000004193 respiratory failure Diseases 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 238000007631 vascular surgery Methods 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/363—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Uporaba, naznačena time, da se koristi peptid opće formule IIgdjeR1 i R2, jednaki ili različiti, označavaju vodik, zasićeni ili nezasićeni ugljikovodični udio koji sadrži od 1 do 10 atoma ugljika, Z1 označava histidin udio, Arg označava arginin udio, Z3 označava prolin ili valin udio, Z4 označava leucin ili valin udio, Z5 je peptidni udio koji proizlazi od B?-lanca fibrina, pri čemu navedeni peptid ima biološka svojstva slaganja s inducibilnim VE-kadherin vezujućim motivom na B?-lancu (npr. B?15-42) humanog fibrina, za izradu farmaceutskog pripravka za liječenje šoka. Patent sadrži još 5 patentnih zahtjeva.
Claims (6)
1. Uporaba, naznačena time, da se koristi peptid opće formule II
[image]
gdje
R1 i R2, jednaki ili različiti, označavaju vodik, zasićeni ili nezasićeni ugljikovodični udio koji sadrži od 1 do 10 atoma ugljika,
Z1 označava histidin udio,
Arg označava arginin udio,
Z3 označava prolin ili valin udio,
Z4 označava leucin ili valin udio,
Z5 je peptidni udio koji proizlazi od Bβ-lanca fibrina,
pri čemu navedeni peptid ima biološka svojstva slaganja s inducibilnim VE-kadherin vezujućim motivom na Bβ-lancu (npr. Bβ15-42) humanog fibrina, za izradu farmaceutskog pripravka za liječenje šoka.
2. Uporaba u skladu sa zahtjevom 1, naznačena time, da zasićeni ili nezasićeni ugljikovodični udio u značenju R1 i R2 sadrži od 1 do 3 atoma ugljika.
3. Uporaba u skladu s bilo kojim zahtjevom 1 ili 2, naznačena time, da Z5 je peptidni udio koji sadrži aminokiselinske sekvence
[image]
Z1 je histidin udio,
Arg je arginin udio,
Z3 je prolin udio, te
Z4 je leucin udio.
4. Uporaba, naznačena time, da se koristi peptid koji pokazuje N-terminalnu sekvencu
[image]
pri čemu navedeni peptid ima biološka svojstva slaganja s inducibilnim VE-kadherin vezujućim motivom na Bβ-lancu (npr. Bβ15-42) humanog fibrina, za izradu farmaceutskog pripravka za liječenje šoka.
5. Uporaba u skladu sa zahtjevom 4, naznačena time, da peptid je
[image]
6. Uporaba u skladu s bilo kojim zahtjevom 1 do 5, naznačena time, da je šok povezan s jednim ili više iz skupine koju čine bakterijski toksini, diseminirana intravaskularna koagulopatija, nekrotizirajući fascitis, hemoragički šok nakon virusne infekcije posebno one koju izazove filovirus, arenaviridae, bunyaviridae, flavivirus, dengue, akutno hemoragičko respiratorno zatajenje izazvano infektivnim agensima ili autoimunom bolesti, zatajenje organa nakon ozljede organa posebno onog koje izazove infarkt miokarda, vaskularna kirurgija, stezanje organa stezaljkama, hemoragički šok, plućni infarkt, infarkt jetre, infarkt crijeva, kirurški postupci i udar, te disfunkcija presađenih organa.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0108704A AT414097B (de) | 2004-06-25 | 2004-06-25 | Pharmazeutische zubereitung zur behandlung von schock |
AT0004005A AT501263B1 (de) | 2005-01-13 | 2005-01-13 | Pharmazeutische zubereitung zur behandlung von schock |
PCT/AT2005/000228 WO2006000007A1 (de) | 2004-06-25 | 2005-06-24 | Verwendung von peptiden, die aus der a alpha oder der b beta kette des humanen fibrinogens abgeleitet wurden, zur behandlung von schock |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20090618T1 true HRP20090618T1 (hr) | 2010-01-31 |
Family
ID=35058593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20090618T HRP20090618T1 (hr) | 2004-06-25 | 2009-11-18 | Uporaba peptida koji proizlaze iz b beta lanca humanog fibrinogena za liječenje šoka |
Country Status (20)
Country | Link |
---|---|
US (1) | US20080249006A1 (hr) |
EP (1) | EP1691827B1 (hr) |
JP (1) | JP2008503503A (hr) |
AT (1) | ATE439856T1 (hr) |
AU (1) | AU2005256121B2 (hr) |
BR (1) | BRPI0506148A (hr) |
CA (1) | CA2544676A1 (hr) |
CY (1) | CY1109631T1 (hr) |
DE (1) | DE502005007926D1 (hr) |
DK (1) | DK1691827T3 (hr) |
EA (1) | EA008799B1 (hr) |
ES (1) | ES2331958T3 (hr) |
HK (1) | HK1093308A1 (hr) |
HR (1) | HRP20090618T1 (hr) |
IL (1) | IL173969A (hr) |
NZ (1) | NZ545634A (hr) |
PL (1) | PL1691827T3 (hr) |
PT (1) | PT1691827E (hr) |
SI (1) | SI1691827T1 (hr) |
WO (1) | WO2006000007A1 (hr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT502987A1 (de) * | 2005-12-23 | 2007-07-15 | Fibrex Medical Res & Dev Gmbh | Pharmazeutische zusammensetzung zur behandlung von hämorrhagischem schock und seinen folgeerscheinungen |
EP1987063B1 (en) * | 2006-02-23 | 2009-09-23 | Fibrex Medical Research & Development GmbH | Peptides and peptide derivatives, the production thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition |
MX2008010930A (es) * | 2006-02-23 | 2008-10-29 | Fibrex Medical Res & Dev Gmbh | Peptidos y derivados de peptido asi como composiciones farmaceuticas que los contienen. |
WO2007095659A1 (de) * | 2006-02-23 | 2007-08-30 | Fibrex Medical Research & Development Gmbh | Peptide und peptid-derivate, herstellun derselben sowie deren verwendung zur herstellung eines therapeutisch und/oder präventiv wirkenden arzneimittels |
WO2009039542A2 (en) * | 2007-09-24 | 2009-04-02 | Fibrex Medical Research & Development Gmbh | Methods of screening for compounds having anti- inflammatory activity and/or prevent / treat vascular leak |
JP5410997B2 (ja) * | 2008-01-31 | 2014-02-05 | 則行 川村 | うつ病およびうつ状態のマーカーおよびそれを用いた検出・診断 |
US7884074B2 (en) * | 2008-05-15 | 2011-02-08 | Ikaria Development Subsidiary Two, LLC | Compounds and methods for prevention and/or treatment of inflammation using the same |
US8088890B2 (en) * | 2008-09-26 | 2012-01-03 | Fibrex Medical Research & Development Gmbh | Peptides and peptidomimetic compounds, the manufacturing thereof as well as their use for preparing a therapeutically and/or preventively active pharmaceutical composition |
WO2010043444A2 (en) * | 2008-10-15 | 2010-04-22 | Fibrex Medical Research & Development Gmbh | Pharmaceutical preparation for the treatment and/or prevention of ischemia/reperfusion injury and the sequels thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
DE19729591A1 (de) * | 1997-07-10 | 1999-02-11 | Therasorb Medizinische Systeme | Mittel zur Behandlung und/oder Prophylaxe von Mikrozirkulationsstörungen |
HUP0401536A3 (en) * | 2000-12-12 | 2008-09-29 | Fibrex Medical Res & Dev Gmbh | Peptides and/or proteins and use thereof for the production of a therapeutic and/or prophylactic medicament |
AU2002249261A1 (en) * | 2001-03-06 | 2002-09-19 | Axxima Pharmaceuticals Ag | Use of mek inhibitors for treating inflammation and virus induced hemorrhagic shock |
MX2008010930A (es) * | 2006-02-23 | 2008-10-29 | Fibrex Medical Res & Dev Gmbh | Peptidos y derivados de peptido asi como composiciones farmaceuticas que los contienen. |
-
2005
- 2005-06-24 DE DE502005007926T patent/DE502005007926D1/de active Active
- 2005-06-24 WO PCT/AT2005/000228 patent/WO2006000007A1/de not_active Application Discontinuation
- 2005-06-24 ES ES05752350T patent/ES2331958T3/es active Active
- 2005-06-24 BR BRPI0506148-2A patent/BRPI0506148A/pt not_active IP Right Cessation
- 2005-06-24 JP JP2007516870A patent/JP2008503503A/ja active Pending
- 2005-06-24 NZ NZ545634A patent/NZ545634A/en not_active IP Right Cessation
- 2005-06-24 AT AT05752350T patent/ATE439856T1/de active
- 2005-06-24 EA EA200600561A patent/EA008799B1/ru not_active IP Right Cessation
- 2005-06-24 AU AU2005256121A patent/AU2005256121B2/en not_active Ceased
- 2005-06-24 PT PT05752350T patent/PT1691827E/pt unknown
- 2005-06-24 DK DK05752350T patent/DK1691827T3/da active
- 2005-06-24 PL PL05752350T patent/PL1691827T3/pl unknown
- 2005-06-24 CA CA002544676A patent/CA2544676A1/en not_active Abandoned
- 2005-06-24 US US10/596,103 patent/US20080249006A1/en not_active Abandoned
- 2005-06-24 SI SI200530842T patent/SI1691827T1/sl unknown
- 2005-06-24 EP EP05752350A patent/EP1691827B1/de active Active
-
2006
- 2006-02-27 IL IL173969A patent/IL173969A/en not_active IP Right Cessation
- 2006-12-27 HK HK06114161.8A patent/HK1093308A1/xx not_active IP Right Cessation
-
2009
- 2009-11-13 CY CY20091101198T patent/CY1109631T1/el unknown
- 2009-11-18 HR HR20090618T patent/HRP20090618T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
DE502005007926D1 (de) | 2009-10-01 |
IL173969A0 (en) | 2006-07-05 |
CY1109631T1 (el) | 2014-08-13 |
SI1691827T1 (sl) | 2010-01-29 |
EP1691827A1 (de) | 2006-08-23 |
HK1093308A1 (en) | 2007-03-02 |
EA200600561A1 (ru) | 2006-08-25 |
PT1691827E (pt) | 2009-11-23 |
AU2005256121A1 (en) | 2006-04-27 |
AU2005256121A8 (en) | 2008-08-21 |
JP2008503503A (ja) | 2008-02-07 |
AU2005256121B2 (en) | 2011-03-03 |
IL173969A (en) | 2011-06-30 |
US20080249006A1 (en) | 2008-10-09 |
PL1691827T3 (pl) | 2010-01-29 |
ES2331958T3 (es) | 2010-01-21 |
ATE439856T1 (de) | 2009-09-15 |
WO2006000007A1 (de) | 2006-01-05 |
BRPI0506148A (pt) | 2006-10-24 |
NZ545634A (en) | 2009-09-25 |
EA008799B1 (ru) | 2007-08-31 |
DK1691827T3 (da) | 2009-12-14 |
CA2544676A1 (en) | 2006-01-05 |
EP1691827B1 (de) | 2009-08-19 |
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