HRP20090572T1 - 2-(amino-supstituirani)-4-aril piramidini i srodni spojevi korisni za liječenje inflamatornih bolesti - Google Patents
2-(amino-supstituirani)-4-aril piramidini i srodni spojevi korisni za liječenje inflamatornih bolesti Download PDFInfo
- Publication number
- HRP20090572T1 HRP20090572T1 HR20090572T HRP20090572T HRP20090572T1 HR P20090572 T1 HRP20090572 T1 HR P20090572T1 HR 20090572 T HR20090572 T HR 20090572T HR P20090572 T HRP20090572 T HR P20090572T HR P20090572 T1 HRP20090572 T1 HR P20090572T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- optionally substituted
- halo
- image
- membered heteroaryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 38
- 208000027866 inflammatory disease Diseases 0.000 title claims 3
- 125000005843 halogen group Chemical group 0.000 claims abstract 45
- 125000001931 aliphatic group Chemical group 0.000 claims abstract 40
- 125000006708 (C5-C14) heteroaryl group Chemical group 0.000 claims abstract 36
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 31
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 28
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 20
- 125000004076 pyridyl group Chemical group 0.000 claims abstract 15
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims abstract 14
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 13
- 125000000217 alkyl group Chemical group 0.000 claims abstract 12
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 12
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims abstract 11
- 125000003118 aryl group Chemical group 0.000 claims abstract 11
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 9
- 150000003839 salts Chemical class 0.000 claims abstract 9
- 125000001544 thienyl group Chemical group 0.000 claims abstract 8
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 6
- 125000005842 heteroatom Chemical group 0.000 claims abstract 6
- 125000006574 non-aromatic ring group Chemical group 0.000 claims abstract 6
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 6
- 125000002098 pyridazinyl group Chemical group 0.000 claims abstract 6
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 6
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims abstract 5
- 229910052799 carbon Inorganic materials 0.000 claims abstract 4
- 125000000714 pyrimidinyl group Chemical group 0.000 claims abstract 4
- 125000002541 furyl group Chemical group 0.000 claims abstract 3
- 125000002883 imidazolyl group Chemical group 0.000 claims abstract 3
- 125000001786 isothiazolyl group Chemical group 0.000 claims abstract 3
- 125000000842 isoxazolyl group Chemical group 0.000 claims abstract 3
- 125000001715 oxadiazolyl group Chemical group 0.000 claims abstract 3
- 125000002971 oxazolyl group Chemical group 0.000 claims abstract 3
- 125000003373 pyrazinyl group Chemical group 0.000 claims abstract 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims abstract 3
- 125000000168 pyrrolyl group Chemical group 0.000 claims abstract 3
- 125000001113 thiadiazolyl group Chemical group 0.000 claims abstract 3
- 125000000335 thiazolyl group Chemical group 0.000 claims abstract 3
- 125000001425 triazolyl group Chemical group 0.000 claims abstract 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims abstract 2
- 125000001475 halogen functional group Chemical group 0.000 claims abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 82
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 12
- 125000003386 piperidinyl group Chemical group 0.000 claims 12
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 9
- -1 -N(RB)2 Chemical group 0.000 claims 8
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 8
- 125000004193 piperazinyl group Chemical group 0.000 claims 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000005605 benzo group Chemical group 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 3
- 125000001041 indolyl group Chemical group 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 150000003536 tetrazoles Chemical group 0.000 claims 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000000945 filler Substances 0.000 claims 2
- 210000000987 immune system Anatomy 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 101100168642 Arabidopsis thaliana CRN gene Proteins 0.000 claims 1
- 101100045632 Arabidopsis thaliana TCX2 gene Proteins 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 101150103732 sol2 gene Proteins 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53489804P | 2004-01-08 | 2004-01-08 | |
| PCT/US2005/000663 WO2005066139A2 (en) | 2004-01-08 | 2005-01-10 | 2-(amino-substituted)-4-aryl pyramidines and related compounds useful for treating inflammatory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090572T1 true HRP20090572T1 (hr) | 2010-01-31 |
Family
ID=34749013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090572T HRP20090572T1 (hr) | 2004-01-08 | 2009-10-28 | 2-(amino-supstituirani)-4-aril piramidini i srodni spojevi korisni za liječenje inflamatornih bolesti |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7732444B2 (pl) |
| EP (2) | EP2123647A1 (pl) |
| JP (1) | JP2007517895A (pl) |
| AR (1) | AR047185A1 (pl) |
| AT (1) | ATE437861T1 (pl) |
| AU (1) | AU2005204060A1 (pl) |
| CA (1) | CA2559888A1 (pl) |
| CY (1) | CY1109529T1 (pl) |
| DE (1) | DE602005015677D1 (pl) |
| DK (1) | DK1701944T3 (pl) |
| ES (1) | ES2330863T3 (pl) |
| HR (1) | HRP20090572T1 (pl) |
| PL (1) | PL1701944T3 (pl) |
| PT (1) | PT1701944E (pl) |
| RS (1) | RS51091B (pl) |
| SI (1) | SI1701944T1 (pl) |
| TW (1) | TW200533357A (pl) |
| WO (1) | WO2005066139A2 (pl) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200533357A (en) * | 2004-01-08 | 2005-10-16 | Millennium Pharm Inc | 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases |
| WO2005095386A1 (en) * | 2004-03-30 | 2005-10-13 | Chiron Corporation | Substituted thiophene derivatives as anti-cancer agents |
| GB0428250D0 (en) * | 2004-12-23 | 2005-01-26 | Novartis Ag | Organic compounds |
| US20080318929A1 (en) * | 2005-12-21 | 2008-12-25 | Barbosa Antonio J M | Pyrimidine Derivatives Useful as Inhibitors of Pkc-Theta |
| US8232298B2 (en) * | 2006-03-22 | 2012-07-31 | Janssen Pharmaceutica N.V. | Inhibitors of the interaction between MDM2 and P53 |
| DK2430921T3 (en) * | 2007-04-03 | 2017-10-16 | Du Pont | SUBSTITUTED BENZEN FUNGICIDES |
| RU2498991C2 (ru) * | 2007-10-30 | 2013-11-20 | Дженентек, Инк. | Очистка антител с помощью катионообменной хроматографии |
| EP2253618A1 (en) | 2008-02-27 | 2010-11-24 | Takeda Pharmaceutical Company Limited | Compound having 6-membered aromatic ring |
| WO2010036062A2 (en) | 2008-09-25 | 2010-04-01 | Lg Electronics Inc. | A method and an apparatus for processing a signal |
| CA2789972A1 (en) * | 2010-01-11 | 2011-07-14 | Healor Ltd. | Method for treatment of inflammatory disease and disorder |
| JP2013531801A (ja) * | 2010-07-02 | 2013-08-08 | ヴェンタナ メディカル システムズ， インク． | 標的検出のためのハプテンコンジュゲート |
| RU2013143839A (ru) | 2011-02-28 | 2015-04-10 | Эррэй Биофарма Инк. | Ингибиторы сериновых/треониновых киназ |
| WO2013020062A1 (en) | 2011-08-04 | 2013-02-07 | Array Biopharma Inc. | Quinazoline compounds as serine/threonine kinase inhibitors |
| RU2650501C2 (ru) | 2012-03-01 | 2018-04-16 | Эррэй Биофарма Инк. | Ингибиторы серин/треониновых киназ |
| NZ700928A (en) | 2012-04-24 | 2017-06-30 | Vertex Pharma | Dna-pk inhibitors |
| CA2882750A1 (en) | 2012-08-27 | 2014-03-06 | Jim Blake | Serine/threonine kinase inhibitors for the treatment of hyperproliferative|diseases |
| KR102216284B1 (ko) | 2013-03-12 | 2021-02-18 | 버텍스 파마슈티칼스 인코포레이티드 | Dna-pk 억제제 |
| ES2851724T3 (es) | 2013-09-18 | 2021-09-08 | Epiaxis Therapeutics Pty Ltd | Modulación de células madre |
| HUE041877T2 (hu) | 2013-10-17 | 2019-06-28 | Vertex Pharma | (S)-N-Metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il)amino)propán-2-il)kinolin-4-karboxamid kokristályai és deuterált származékai DNS-PK inhibitorokként |
| WO2016029262A1 (en) | 2014-08-25 | 2016-03-03 | University Of Canberra | Compositions for modulating cancer stem cells and uses therefor |
| RU2758669C2 (ru) | 2016-09-27 | 2021-11-01 | Вертекс Фармасьютикалз Инкорпорейтед | Способ лечения рака с применением сочетания днк-поражающих агентов и ингибиторов днк-пк |
| WO2023104744A1 (en) | 2021-12-06 | 2023-06-15 | Helmholtz-Zentrum Dresden-Rossendorf E.V. | 3-((3-([1,1'-biphenyl]-3-ylmethoxy)phenoxy)methyl)benzonitrile derivatives and the use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5698697A (en) | 1995-07-19 | 1997-12-16 | Mitsubishi Chemical Corporation | 2-cyanopiperazine and method of producing the same |
| WO1999032121A1 (en) * | 1997-12-19 | 1999-07-01 | Smithkline Beecham Corporation | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses |
| BR9908004A (pt) | 1998-02-17 | 2001-12-18 | Tularik Inc | Composto, composição e método para prevençãoou supressão de uma infecção viral |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| WO1999065897A1 (en) | 1998-06-19 | 1999-12-23 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| EE200100341A (et) | 1998-12-24 | 2002-12-16 | Aventis Pharmaceuticals Products Inc. | Asendatud (aminoiminometüül- või aminometüül)bensoheteroarüülühendid, nende kasutamine ja farmatseutiline kompositsioon |
| US6492516B1 (en) * | 1999-05-14 | 2002-12-10 | Merck & Co., Inc. | Compounds having cytokine inhibitory activity |
| CA2376951A1 (en) * | 1999-06-30 | 2001-01-04 | Peter J. Sinclair | Src kinase inhibitor compounds |
| CZ2002534A3 (cs) | 1999-08-13 | 2002-07-17 | Vertex Pharmaceuticals Incorporated | Inhibitory protein-kináz, farmaceutické prostředky, které je obsahují, a jejich pouľití |
| GB0003224D0 (en) * | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
| US6869956B2 (en) | 2000-10-03 | 2005-03-22 | Bristol-Myers Squibb Company | Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) |
| CZ20031028A3 (cs) | 2000-10-12 | 2003-08-13 | Merck & Co., Inc. | Aza- a polyazanaftalenylkarboxamidy |
| DE60223790T4 (de) * | 2001-03-29 | 2009-05-07 | Vertex Pharmaceuticals Inc., Cambridge | Hemmer von c-jun-terminal kinase (jnk) und andere protein kinase |
| WO2002083667A2 (en) * | 2001-04-13 | 2002-10-24 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| GB0112803D0 (en) | 2001-05-25 | 2001-07-18 | Glaxo Group Ltd | Pyrimidine derivatives |
| CA2465711A1 (en) | 2001-11-07 | 2003-05-15 | F. Hoffmann-La Roche Ag | Aminopyrimidines and pyridines |
| TWI319387B (en) * | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| EP1515964A1 (en) * | 2002-06-14 | 2005-03-23 | ALTANA Pharma AG | Substituted diaminopyrimidines |
| TW200510311A (en) | 2002-12-23 | 2005-03-16 | Millennium Pharm Inc | CCr8 inhibitors |
| DE602004022633D1 (de) | 2003-01-30 | 2009-10-01 | Boehringer Ingelheim Pharma | 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen |
| EP1611123B8 (en) | 2003-04-09 | 2013-11-13 | Exelixis, Inc. | Tie-2 modulators and methods of use |
| AR044519A1 (es) * | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
| US7459460B2 (en) | 2003-05-28 | 2008-12-02 | Bristol-Myers Squibb Company | Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators |
| TW200533357A (en) * | 2004-01-08 | 2005-10-16 | Millennium Pharm Inc | 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases |
| US20060234205A1 (en) * | 2004-03-05 | 2006-10-19 | Chiron Corporation | In vitro test system for predicting patient tolerability of therapeutic agents |
| WO2005095386A1 (en) * | 2004-03-30 | 2005-10-13 | Chiron Corporation | Substituted thiophene derivatives as anti-cancer agents |
| ES2505090T3 (es) | 2004-05-07 | 2014-10-09 | Amgen Inc. | Derivados heterocíclicos nitrogenados como moduladores de proteína cinasas y su uso para el tratamiento de angiogénesis y cáncer |
| US7745437B2 (en) | 2004-06-10 | 2010-06-29 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| JP2008519034A (ja) * | 2004-11-03 | 2008-06-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネル調節剤としてのピリミジン誘導体および使用方法 |
| TWI359810B (en) | 2004-11-04 | 2012-03-11 | Mitsubishi Tanabe Pharma Corp | Carboxylic acid derivative containing thiazole rin |
| US7786132B2 (en) | 2004-12-17 | 2010-08-31 | Amgen Inc. | Aminopyrimidine compounds and methods of use |
| US20060178388A1 (en) | 2005-02-04 | 2006-08-10 | Wrobleski Stephen T | Phenyl-substituted pyrimidine compounds useful as kinase inhibitors |
| DE102005034821A1 (de) * | 2005-07-26 | 2007-02-08 | Fleissner Gmbh | Voluminöse Faserlaminate und ihre Herstellung |
| TWM293131U (en) * | 2006-01-10 | 2006-07-01 | Shuen Tai Prec Entpr Co Ltd | Handheld power hammer |
-
2005
- 2005-01-07 TW TW094100533A patent/TW200533357A/zh unknown
- 2005-01-10 CA CA002559888A patent/CA2559888A1/en not_active Abandoned
- 2005-01-10 PT PT05726205T patent/PT1701944E/pt unknown
- 2005-01-10 DK DK05726205T patent/DK1701944T3/da active
- 2005-01-10 JP JP2006549475A patent/JP2007517895A/ja active Pending
- 2005-01-10 AR ARP050100080A patent/AR047185A1/es unknown
- 2005-01-10 EP EP09009692A patent/EP2123647A1/en not_active Withdrawn
- 2005-01-10 DE DE602005015677T patent/DE602005015677D1/de active Active
- 2005-01-10 RS RSP-2009/0466A patent/RS51091B/sr unknown
- 2005-01-10 WO PCT/US2005/000663 patent/WO2005066139A2/en active Application Filing
- 2005-01-10 US US11/032,299 patent/US7732444B2/en not_active Expired - Fee Related
- 2005-01-10 ES ES05726205T patent/ES2330863T3/es active Active
- 2005-01-10 AU AU2005204060A patent/AU2005204060A1/en not_active Abandoned
- 2005-01-10 SI SI200530816T patent/SI1701944T1/sl unknown
- 2005-01-10 AT AT05726205T patent/ATE437861T1/de active
- 2005-01-10 PL PL05726205T patent/PL1701944T3/pl unknown
- 2005-01-10 EP EP05726205A patent/EP1701944B1/en active Active
-
2009
- 2009-10-27 CY CY20091101118T patent/CY1109529T1/el unknown
- 2009-10-28 HR HR20090572T patent/HRP20090572T1/hr unknown
-
2010
- 2010-04-26 US US12/767,139 patent/US8268822B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1701944B1 (en) | 2009-07-29 |
| WO2005066139A2 (en) | 2005-07-21 |
| ATE437861T1 (de) | 2009-08-15 |
| AU2005204060A1 (en) | 2005-07-21 |
| DE602005015677D1 (de) | 2009-09-10 |
| EP2123647A1 (en) | 2009-11-25 |
| EP1701944A2 (en) | 2006-09-20 |
| DK1701944T3 (da) | 2009-11-09 |
| JP2007517895A (ja) | 2007-07-05 |
| SI1701944T1 (sl) | 2010-03-31 |
| CA2559888A1 (en) | 2005-07-21 |
| US7732444B2 (en) | 2010-06-08 |
| CY1109529T1 (el) | 2014-08-13 |
| ES2330863T3 (es) | 2009-12-16 |
| PT1701944E (pt) | 2009-11-03 |
| US20110071134A1 (en) | 2011-03-24 |
| US8268822B2 (en) | 2012-09-18 |
| PL1701944T3 (pl) | 2010-01-29 |
| US20060040968A1 (en) | 2006-02-23 |
| AR047185A1 (es) | 2006-01-11 |
| WO2005066139A3 (en) | 2005-10-13 |
| TW200533357A (en) | 2005-10-16 |
| RS51091B (sr) | 2010-10-31 |
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