HRP20090459T1 - Aminofenil derivati kao novi inhibitori histonskih deacetilaza - Google Patents
Aminofenil derivati kao novi inhibitori histonskih deacetilaza Download PDFInfo
- Publication number
- HRP20090459T1 HRP20090459T1 HR20090459T HRP20090459T HRP20090459T1 HR P20090459 T1 HRP20090459 T1 HR P20090459T1 HR 20090459 T HR20090459 T HR 20090459T HR P20090459 T HRP20090459 T HR P20090459T HR P20090459 T1 HRP20090459 T1 HR P20090459T1
- Authority
- HR
- Croatia
- Prior art keywords
- 6alkyl
- hydrogen
- amino
- compound
- compound according
- Prior art date
Links
- -1 Aminophenyl Chemical class 0.000 title claims 8
- 102000003964 Histone deacetylase Human genes 0.000 title abstract 2
- 108090000353 Histone deacetylase Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 15
- 239000003814 drug Substances 0.000 claims abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 150000002431 hydrogen Chemical group 0.000 claims 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000001475 halogen functional group Chemical group 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 4
- 125000001544 thienyl group Chemical group 0.000 claims 4
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000000815 N-oxide group Chemical group 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229910052783 alkali metal Chemical group 0.000 claims 1
- 150000001340 alkali metals Chemical group 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06100584 | 2006-01-19 | ||
PCT/EP2007/050376 WO2007082878A1 (fr) | 2006-01-19 | 2007-01-16 | Dérivés d'aminophényle en tant que nouveaux inibiteurs d'histone désacétylase |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20090459T1 true HRP20090459T1 (hr) | 2009-09-30 |
Family
ID=36579211
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20090459T HRP20090459T1 (hr) | 2006-01-19 | 2009-08-25 | Aminofenil derivati kao novi inhibitori histonskih deacetilaza |
Country Status (19)
Country | Link |
---|---|
US (1) | US8119650B2 (fr) |
EP (1) | EP1981874B1 (fr) |
JP (1) | JP5225104B2 (fr) |
CN (1) | CN101370804B (fr) |
AT (1) | ATE432272T1 (fr) |
AU (1) | AU2007206946B2 (fr) |
CA (1) | CA2631876C (fr) |
CY (1) | CY1109331T1 (fr) |
DE (1) | DE602007001190D1 (fr) |
DK (1) | DK1981874T3 (fr) |
ES (1) | ES2327972T3 (fr) |
HK (1) | HK1128283A1 (fr) |
HR (1) | HRP20090459T1 (fr) |
ME (1) | ME01060B (fr) |
PL (1) | PL1981874T3 (fr) |
PT (1) | PT1981874E (fr) |
RS (1) | RS51191B (fr) |
SI (1) | SI1981874T1 (fr) |
WO (1) | WO2007082878A1 (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100519527C (zh) * | 2002-03-13 | 2009-07-29 | 詹森药业有限公司 | 组织蛋白去乙酰酶抑制剂 |
AU2003209727B2 (en) | 2002-03-13 | 2008-10-16 | Janssen Pharmaceutica N.V. | Sulfonylamino-derivatives as novel inhibitors of histone deacetylase |
JP4674045B2 (ja) * | 2002-03-13 | 2011-04-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼの新規な阻害剤としてのピペラジニル−、ピペリジニル−およびモルホリニル−誘導体 |
DE60321548D1 (de) * | 2002-03-13 | 2008-07-24 | Janssen Pharmaceutica Nv | Carbonylamino- derivativate als neue inhibitoren von histone deacetylase |
PL1781639T3 (pl) | 2004-07-28 | 2012-07-31 | Janssen Pharmaceutica Nv | Podstawione pochodne indolilo-alkiloaminowe jako nowe inhibitory deacetylazy histonowej |
RS51189B (sr) * | 2004-07-28 | 2010-10-31 | Janssen Pharmaceutica N.V. | Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze |
AU2006248938B2 (en) | 2005-05-18 | 2011-09-29 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
ATE509920T1 (de) * | 2005-10-27 | 2011-06-15 | Janssen Pharmaceutica Nv | Quadratsäurederivate als inhibitoren von histondeacetylase |
WO2007082878A1 (fr) | 2006-01-19 | 2007-07-26 | Janssen Pharmaceutica N.V. | Dérivés d'aminophényle en tant que nouveaux inibiteurs d'histone désacétylase |
EP1979327A1 (fr) | 2006-01-19 | 2008-10-15 | Janssen Pharmaceutica, N.V. | Dérivés de pyridine et de pyrimidine en tant qu'inhibiteurs d'histone désacétylase |
EP1979326B1 (fr) | 2006-01-19 | 2012-10-03 | Janssen Pharmaceutica N.V. | Dérivés de pyridine et de pyrimidine en tant qu'inhibiteurs d'histone désacétylase |
DK1979328T3 (da) * | 2006-01-19 | 2013-03-25 | Janssen Pharmaceutica Nv | Pyridin- og pyrimidinderivater i deres egenskab af histondeacetylasehæmmere |
US7834025B2 (en) * | 2006-01-19 | 2010-11-16 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
DK2274301T3 (da) | 2008-03-27 | 2013-01-02 | Janssen Pharmaceutica Nv | Azabicyclohexylsubstituerede indolylalkylaminoderivater som hidtil ukendte inhibitorer af histondeacetylase |
BRPI0915720A2 (pt) * | 2008-06-12 | 2015-08-04 | Janssen Pharmaceutica Nv | Moduladores de diaminopiridina, pirimidina, e piridazina do receptor de histamina h4 |
US9265734B2 (en) | 2008-09-03 | 2016-02-23 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US9540395B2 (en) | 2011-02-28 | 2017-01-10 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
DK2683371T3 (da) | 2011-03-09 | 2021-01-18 | Cereno Scient Ab | Forbindelser og fremgangsmåder til forbedring af forringet endogen fibrinolyse ved anvendelse af histondeacetylasehæmmere |
AU2014228344C1 (en) | 2013-03-15 | 2019-02-07 | Biomarin Pharmaceutical Inc. | HDAC inhibitors |
DE102015106979B4 (de) * | 2015-05-05 | 2023-01-12 | Infineon Technologies Austria Ag | Halbleiterwafer und Verfahren zum Herstellen von Halbleitervorrichtungen in einem Halbleiterwafer |
WO2023044364A1 (fr) | 2021-09-15 | 2023-03-23 | Enko Chem, Inc. | Inhibiteurs de protoporphyrinogène oxydase |
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RS51189B (sr) * | 2004-07-28 | 2010-10-31 | Janssen Pharmaceutica N.V. | Supstituisani derivati propenil piperazina kao novi inhibitori histonske deacetilaze |
PL1781639T3 (pl) | 2004-07-28 | 2012-07-31 | Janssen Pharmaceutica Nv | Podstawione pochodne indolilo-alkiloaminowe jako nowe inhibitory deacetylazy histonowej |
WO2006010749A2 (fr) | 2004-07-28 | 2006-02-02 | Janssen Pharmaceutica N.V. | Derives de piperazine de propenyle substituee comme nouveaux inhibiteurs de l'histone deacetylase |
AU2006248938B2 (en) | 2005-05-18 | 2011-09-29 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
WO2006136553A1 (fr) | 2005-06-23 | 2006-12-28 | Janssen Pharmaceutica N.V. | Dérivés d'imidazolinone et d'hydantoïne en tant que nouveaux inhibiteurs de l’histone désacétylase |
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ATE509920T1 (de) * | 2005-10-27 | 2011-06-15 | Janssen Pharmaceutica Nv | Quadratsäurederivate als inhibitoren von histondeacetylase |
WO2007082878A1 (fr) | 2006-01-19 | 2007-07-26 | Janssen Pharmaceutica N.V. | Dérivés d'aminophényle en tant que nouveaux inibiteurs d'histone désacétylase |
EP1979326B1 (fr) * | 2006-01-19 | 2012-10-03 | Janssen Pharmaceutica N.V. | Dérivés de pyridine et de pyrimidine en tant qu'inhibiteurs d'histone désacétylase |
DK1979328T3 (da) * | 2006-01-19 | 2013-03-25 | Janssen Pharmaceutica Nv | Pyridin- og pyrimidinderivater i deres egenskab af histondeacetylasehæmmere |
EP1981871B1 (fr) | 2006-01-19 | 2011-12-28 | Janssen Pharmaceutica N.V. | Dérivés d'hétérocyclylalkyle en tant que nouveaux inhibiteurs d'histone désacétylase |
EP1979327A1 (fr) * | 2006-01-19 | 2008-10-15 | Janssen Pharmaceutica, N.V. | Dérivés de pyridine et de pyrimidine en tant qu'inhibiteurs d'histone désacétylase |
US7834025B2 (en) * | 2006-01-19 | 2010-11-16 | Janssen Pharmaceutica N.V. | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase |
AU2007296259A1 (en) * | 2006-09-15 | 2008-03-20 | Janssen Pharmaceutica Nv | Combinations of class-I specific histone deacetylase inhibitors with proteasome inhibitors |
EP2234883B1 (fr) * | 2007-12-14 | 2017-08-02 | Urban Aeronautics Ltd. | Véhicule vtol et procédé de fonctionnement |
GB0901749D0 (en) | 2009-02-03 | 2009-03-11 | Oxford Nanopore Tech Ltd | Adaptor method |
-
2007
- 2007-01-16 WO PCT/EP2007/050376 patent/WO2007082878A1/fr active Application Filing
- 2007-01-16 EP EP07703891A patent/EP1981874B1/fr active Active
- 2007-01-16 SI SI200730065T patent/SI1981874T1/sl unknown
- 2007-01-16 US US12/160,140 patent/US8119650B2/en active Active
- 2007-01-16 AT AT07703891T patent/ATE432272T1/de active
- 2007-01-16 PT PT07703891T patent/PT1981874E/pt unknown
- 2007-01-16 DK DK07703891T patent/DK1981874T3/da active
- 2007-01-16 CN CN2007800030170A patent/CN101370804B/zh active Active
- 2007-01-16 CA CA2631876A patent/CA2631876C/fr active Active
- 2007-01-16 DE DE602007001190T patent/DE602007001190D1/de active Active
- 2007-01-16 ES ES07703891T patent/ES2327972T3/es active Active
- 2007-01-16 ME MEP-2009-276A patent/ME01060B/me unknown
- 2007-01-16 AU AU2007206946A patent/AU2007206946B2/en not_active Ceased
- 2007-01-16 RS RSP-2009/0384A patent/RS51191B/sr unknown
- 2007-01-16 PL PL07703891T patent/PL1981874T3/pl unknown
- 2007-01-16 JP JP2008550742A patent/JP5225104B2/ja active Active
-
2009
- 2009-06-26 HK HK09105785.9A patent/HK1128283A1/xx not_active IP Right Cessation
- 2009-08-25 HR HR20090459T patent/HRP20090459T1/hr unknown
- 2009-08-27 CY CY20091100896T patent/CY1109331T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP2009523760A (ja) | 2009-06-25 |
PL1981874T3 (pl) | 2009-10-30 |
EP1981874B1 (fr) | 2009-05-27 |
CN101370804B (zh) | 2013-05-29 |
JP5225104B2 (ja) | 2013-07-03 |
SI1981874T1 (sl) | 2009-10-31 |
EP1981874A1 (fr) | 2008-10-22 |
ME01060B (me) | 2012-10-20 |
PT1981874E (pt) | 2009-09-02 |
CA2631876A1 (fr) | 2007-07-26 |
US20090018152A1 (en) | 2009-01-15 |
CN101370804A (zh) | 2009-02-18 |
AU2007206946B2 (en) | 2011-12-15 |
RS51191B (sr) | 2010-10-31 |
CY1109331T1 (el) | 2014-07-02 |
WO2007082878A1 (fr) | 2007-07-26 |
US8119650B2 (en) | 2012-02-21 |
ES2327972T3 (es) | 2009-11-05 |
ATE432272T1 (de) | 2009-06-15 |
CA2631876C (fr) | 2014-05-27 |
DE602007001190D1 (de) | 2009-07-09 |
HK1128283A1 (en) | 2009-10-23 |
DK1981874T3 (da) | 2009-09-28 |
AU2007206946A1 (en) | 2007-07-26 |
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