HRP20080603T3 - NOVEL 17beta HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS - Google Patents
NOVEL 17beta HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORSInfo
- Publication number
- HRP20080603T3 HRP20080603T3 HR20080603T HRP20080603T HRP20080603T3 HR P20080603 T3 HRP20080603 T3 HR P20080603T3 HR 20080603 T HR20080603 T HR 20080603T HR P20080603 T HRP20080603 T HR P20080603T HR P20080603 T3 HRP20080603 T3 HR P20080603T3
- Authority
- HR
- Croatia
- Prior art keywords
- halogen
- alkyl
- optionally substituted
- nitrile
- bond
- Prior art date
Links
- 108010070743 3(or 17)-beta-hydroxysteroid dehydrogenase Proteins 0.000 title 1
- 102100034067 Dehydrogenase/reductase SDR family member 11 Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 13
- 150000002825 nitriles Chemical group 0.000 abstract 8
- 150000002367 halogens Chemical class 0.000 abstract 7
- 125000001424 substituent group Chemical group 0.000 abstract 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000005843 halogen group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000004442 acylamino group Chemical group 0.000 abstract 3
- 125000003368 amide group Chemical group 0.000 abstract 3
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 3
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 3
- 125000004104 aryloxy group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004659 aryl alkyl thio group Chemical group 0.000 abstract 2
- 125000005110 aryl thio group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229940124530 sulfonamide Drugs 0.000 abstract 2
- 150000003456 sulfonamides Chemical group 0.000 abstract 2
- 150000003573 thiols Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03104169 | 2003-11-12 | ||
| EP04105313 | 2004-10-26 | ||
| PCT/EP2004/052925 WO2005047303A2 (en) | 2003-11-12 | 2004-11-11 | NOVEL 17β HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20080603T3 true HRP20080603T3 (en) | 2009-03-31 |
Family
ID=34593637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20080603T HRP20080603T3 (en) | 2003-11-12 | 2008-11-21 | NOVEL 17beta HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1685150B1 (xx) |
| JP (1) | JP4778438B2 (xx) |
| KR (1) | KR101070025B1 (xx) |
| AR (1) | AR046580A1 (xx) |
| AT (1) | ATE407139T1 (xx) |
| AU (1) | AU2004289459B2 (xx) |
| BR (1) | BRPI0416551A (xx) |
| CA (1) | CA2545704C (xx) |
| DE (1) | DE602004016373D1 (xx) |
| DK (1) | DK1685150T3 (xx) |
| ES (1) | ES2314478T3 (xx) |
| HK (1) | HK1099309A1 (xx) |
| HR (1) | HRP20080603T3 (xx) |
| IL (1) | IL175220A (xx) |
| NO (1) | NO20062679L (xx) |
| PL (1) | PL1685150T3 (xx) |
| PT (1) | PT1685150E (xx) |
| RU (1) | RU2369614C2 (xx) |
| SA (1) | SA04250373B1 (xx) |
| SI (1) | SI1685150T1 (xx) |
| TW (1) | TWI331154B (xx) |
| WO (1) | WO2005047303A2 (xx) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004025985A1 (de) * | 2004-05-21 | 2005-12-15 | Schering Ag | Estriol- und Estetrol-Prodrugs |
| DE102004025966A1 (de) * | 2004-05-21 | 2005-12-15 | Schering Ag | Estradiol-Prodrugs |
| CN102796160A (zh) * | 2005-05-26 | 2012-11-28 | 索尔瓦药物有限公司 | 17β-HSD1和STS抑制剂 |
| US8030298B2 (en) | 2005-05-26 | 2011-10-04 | Abbott Products Gmbh | 17β-HSD1 and STS inhibitors |
| WO2007096647A2 (en) * | 2006-02-27 | 2007-08-30 | Sterix Limited | Diaryl compounds as non-steroidal inhibitors of 17-beta hydroxysteroid dehydrogenase and/or steroid sulphatase for the treatment of oestrogen-related diseases such as hormone dependent breast cancer |
| US8080540B2 (en) | 2006-09-19 | 2011-12-20 | Abbott Products Gmbh | Therapeutically active triazoles and their use |
| RU2469042C2 (ru) * | 2006-09-19 | 2012-12-10 | Зольвай Фармасьютиклз Гмбх | Терапевтически активные триазолы и их использование |
| US8314119B2 (en) | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| CN101568547B (zh) * | 2006-11-30 | 2014-06-25 | 索尔瓦药物有限公司 | 作为17βHSD抑制剂的被取代的雌三烯衍生物 |
| US8288367B2 (en) | 2006-11-30 | 2012-10-16 | Solvay Pharmaceuticals Gmbh | Substituted estratriene derivatives as 17BETA HSD inhibitors |
| DE102007015169A1 (de) | 2007-03-27 | 2008-10-02 | Universität des Saarlandes Campus Saarbrücken | 17Beta-Hydroxysteroid-Dehydrogenase-Typ1-Inhibitoren zur Behandlung hormonabhängiger Erkrankungen |
| DE102007040243A1 (de) * | 2007-08-25 | 2009-02-26 | Universität des Saarlandes | 17Beta-Hydroxysteriod-Dehydrogenase Typ1 Inhibitoren zur Behandlung hormonabhängiger Erkrankungen |
| KR20130108586A (ko) | 2010-09-23 | 2013-10-04 | 애브비 인코포레이티드 | 아자아다만탄 유도체의 일수화물 |
| EP2688901B1 (en) | 2011-03-25 | 2019-05-08 | Université Laval | INHIBITORS OF 17ß-HSD1, 17ß-HSD3 AND 17ß-HSD10 |
| JP6461127B2 (ja) | 2013-06-25 | 2019-01-30 | フォレンド ファーマ リミテッド | １７βヒドロキシステロイド脱水素酵素、タイプＩの阻害剤としての治療活性エストラトリエンチアゾール誘導体 |
| US9663549B2 (en) * | 2013-06-25 | 2017-05-30 | Forendo Pharma Ltd. | Therapeutically active 17-nitrogen substituted estratreinthiazole derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase |
| CN105518017B (zh) | 2013-06-25 | 2020-07-14 | 佛恩多制药有限公司 | 治疗活性的作为1型17β-羟基类固醇脱氢酶抑制剂的雌三烯噻唑衍生物 |
| WO2016102776A1 (en) | 2014-12-23 | 2016-06-30 | Forendo Pharma Ltd | Prodrugs of 17.beta.-hsd1 -inhibitors |
| JP6545266B2 (ja) * | 2014-12-23 | 2019-07-17 | フォレンド ファーマ リミテッド | １７β‐ＨＳＤ１抑制剤のプロドラッグ |
| CZ307437B6 (cs) | 2016-06-07 | 2018-08-22 | Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. | 15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz |
| DK3634975T3 (da) * | 2017-06-08 | 2024-05-27 | Organon R&D Finland Ltd | 17-oximer af 15.beta.-[3-propanamido]-substituerede estra-1,3,5(10)-trien-17-oner til anvendelse i inhibition af 17.beta.-hydroxysteroid-dehydrogenaser |
| EP3891167A1 (en) * | 2018-12-05 | 2021-10-13 | Forendo Pharma Ltd | Estra-1,3,5(10)-triene compounds condensed in position 16(17) with a pyrazole ring as inhibitors of 17-hsd1 |
-
2004
- 2004-11-09 TW TW093134102A patent/TWI331154B/zh not_active IP Right Cessation
- 2004-11-11 PL PL04804529T patent/PL1685150T3/pl unknown
- 2004-11-11 AR ARP040104159A patent/AR046580A1/es not_active Application Discontinuation
- 2004-11-11 BR BRPI0416551-9A patent/BRPI0416551A/pt not_active IP Right Cessation
- 2004-11-11 AT AT04804529T patent/ATE407139T1/de active
- 2004-11-11 RU RU2006120488/04A patent/RU2369614C2/ru not_active IP Right Cessation
- 2004-11-11 ES ES04804529T patent/ES2314478T3/es active Active
- 2004-11-11 JP JP2006538862A patent/JP4778438B2/ja not_active Expired - Fee Related
- 2004-11-11 WO PCT/EP2004/052925 patent/WO2005047303A2/en active IP Right Grant
- 2004-11-11 DK DK04804529T patent/DK1685150T3/da active
- 2004-11-11 EP EP04804529A patent/EP1685150B1/en active Active
- 2004-11-11 SI SI200430862T patent/SI1685150T1/sl unknown
- 2004-11-11 DE DE602004016373T patent/DE602004016373D1/de active Active
- 2004-11-11 AU AU2004289459A patent/AU2004289459B2/en not_active Ceased
- 2004-11-11 CA CA2545704A patent/CA2545704C/en not_active Expired - Fee Related
- 2004-11-11 PT PT04804529T patent/PT1685150E/pt unknown
- 2004-11-20 SA SA4250373A patent/SA04250373B1/ar unknown
-
2006
- 2006-04-26 IL IL175220A patent/IL175220A/en not_active IP Right Cessation
- 2006-06-09 NO NO20062679A patent/NO20062679L/no not_active Application Discontinuation
- 2006-06-09 KR KR1020067011469A patent/KR101070025B1/ko not_active IP Right Cessation
-
2007
- 2007-06-13 HK HK07106357.7A patent/HK1099309A1/xx not_active IP Right Cessation
-
2008
- 2008-11-21 HR HR20080603T patent/HRP20080603T3/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004016373D1 (de) | 2008-10-16 |
| RU2006120488A (ru) | 2008-01-10 |
| SI1685150T1 (sl) | 2008-12-31 |
| IL175220A (en) | 2010-12-30 |
| NO20062679L (no) | 2006-08-10 |
| AU2004289459B2 (en) | 2010-08-19 |
| AR046580A1 (es) | 2005-12-14 |
| EP1685150B1 (en) | 2008-09-03 |
| AU2004289459A1 (en) | 2005-05-26 |
| ES2314478T3 (es) | 2009-03-16 |
| TW200521133A (en) | 2005-07-01 |
| TWI331154B (en) | 2010-10-01 |
| KR101070025B1 (ko) | 2011-10-04 |
| SA04250373B1 (ar) | 2009-12-22 |
| HK1099309A1 (en) | 2007-08-10 |
| JP4778438B2 (ja) | 2011-09-21 |
| PT1685150E (pt) | 2008-11-12 |
| DK1685150T3 (da) | 2008-12-01 |
| WO2005047303A2 (en) | 2005-05-26 |
| BRPI0416551A (pt) | 2007-02-27 |
| JP2007510697A (ja) | 2007-04-26 |
| RU2369614C2 (ru) | 2009-10-10 |
| WO2005047303A3 (en) | 2005-08-25 |
| ATE407139T1 (de) | 2008-09-15 |
| PL1685150T3 (pl) | 2009-02-27 |
| IL175220A0 (en) | 2006-09-05 |
| EP1685150A2 (en) | 2006-08-02 |
| CA2545704A1 (en) | 2005-05-26 |
| CA2545704C (en) | 2012-06-26 |
| KR20060121171A (ko) | 2006-11-28 |
| SA04250373A (ar) | 2005-12-03 |
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