HRP20080064T5 - Prodrugs of piperazine and substituted piperidine antiviral agents - Google Patents

Prodrugs of piperazine and substituted piperidine antiviral agents

Info

Publication number
HRP20080064T5
HRP20080064T5 HR20080064T HRP20080064T HRP20080064T5 HR P20080064 T5 HRP20080064 T5 HR P20080064T5 HR 20080064 T HR20080064 T HR 20080064T HR P20080064 T HRP20080064 T HR P20080064T HR P20080064 T5 HRP20080064 T5 HR P20080064T5
Authority
HR
Croatia
Prior art keywords
group
phenyl
pyridinyl
heteroaryl
methoxy
Prior art date
Application number
HR20080064T
Other languages
English (en)
Croatian (hr)
Inventor
Ueda Yasutsugu
P. Connolly Timothy
F. Kadow John
A. Meanwell Nicholas
Wang Tao
Pin H. Chen Chung
Yeung Kap-Sun
Zhang Zhongxing
Kenneth Leahy David
K. Pack Shawn
Soundararajan Nachimuthu
Sirard Pierre
Levesque Kathia
Thoraval Dominique
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34963934&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20080064(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HRP20080064T3 publication Critical patent/HRP20080064T3/xx
Publication of HRP20080064T5 publication Critical patent/HRP20080064T5/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/062—Organo-phosphoranes without P-C bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HR20080064T 2004-03-15 2008-02-11 Prodrugs of piperazine and substituted piperidine antiviral agents HRP20080064T5 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55332004P 2004-03-15 2004-03-15
US63523104P 2004-12-10 2004-12-10
PCT/US2005/006980 WO2005090367A1 (fr) 2004-03-15 2005-03-03 Prodrogues de piperazine et agents antiviraux de piperidine substituee

Publications (2)

Publication Number Publication Date
HRP20080064T3 HRP20080064T3 (en) 2008-03-31
HRP20080064T5 true HRP20080064T5 (en) 2008-10-31

Family

ID=34963934

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20080064T HRP20080064T5 (en) 2004-03-15 2008-02-11 Prodrugs of piperazine and substituted piperidine antiviral agents

Country Status (27)

Country Link
US (12) US7745625B2 (fr)
EP (1) EP1725569B1 (fr)
JP (1) JP4734318B2 (fr)
KR (1) KR101153594B1 (fr)
CN (1) CN101941990B (fr)
AR (1) AR048039A1 (fr)
AT (1) ATE384728T1 (fr)
AU (1) AU2005223736C1 (fr)
BR (1) BRPI0508876B8 (fr)
CA (1) CA2560253C (fr)
CY (1) CY1107419T1 (fr)
DE (1) DE602005004517T2 (fr)
DK (1) DK1725569T3 (fr)
ES (1) ES2299022T3 (fr)
GE (1) GEP20094736B (fr)
HK (2) HK1096687A1 (fr)
HR (1) HRP20080064T5 (fr)
IL (1) IL211961A (fr)
MY (1) MY139243A (fr)
NO (1) NO336742B1 (fr)
NZ (2) NZ585294A (fr)
PE (1) PE20051151A1 (fr)
PL (1) PL1725569T3 (fr)
PT (1) PT1725569E (fr)
RS (1) RS50567B (fr)
TW (1) TWI344843B (fr)
WO (1) WO2005090367A1 (fr)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
TWI329105B (en) * 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
EP1534286B1 (fr) * 2002-07-29 2009-12-09 Rigel Pharmaceuticals, Inc. Procede de traitement ou de prevention de maladies auto-immunes au moyen de composes de 2,4-pyrimidinediamine
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
DK1656372T3 (da) * 2003-07-30 2013-07-01 Rigel Pharmaceuticals Inc 2,4-pyrimidindiaminforbindelser til anvendelse til behandling eller forebyggelse af autoimmunsygdomme
US7745625B2 (en) * 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
US7130185B2 (en) * 2004-06-02 2006-10-31 Research In Motion Limited Handheld computing device having drop-resistant LCD display
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
CA2591948C (fr) 2005-01-19 2013-11-12 Rigel Pharmaceuticals, Inc. Promedicaments de composes de 2,4-pyrimidinediamine et leurs utilisations
US7723338B2 (en) * 2005-01-31 2010-05-25 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4,7-dimethoxy-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-yl]-1,2-dioxoethyl]-piperazine
US7601715B2 (en) * 2005-06-22 2009-10-13 Bristol-Myers Squibb Company Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
US7396830B2 (en) 2005-10-04 2008-07-08 Bristol-Myers Squibb Company Piperazine amidines as antiviral agents
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
US7501419B2 (en) * 2006-04-25 2009-03-10 Bristol-Myers Squibb Company 4-Squarylpiperazine derivatives as antiviral agents
US7572810B2 (en) * 2006-06-08 2009-08-11 Bristol-Myers Squibb Company Alkene piperidine derivatives as antiviral agents
US7504399B2 (en) * 2006-06-08 2009-03-17 Bristol-Meyers Squibb Company Piperazine enamines as antiviral agents
EP2054422B1 (fr) 2006-07-20 2017-06-14 Debiopharm International SA Dérivés d'acrylamide en tant qu'inhibiteurs de fab i
WO2009158394A1 (fr) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Dicéto-azolopipéridines et azolopipérazines en tant qu’agents anti-vih
WO2009158396A1 (fr) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Dérivés de la dicétopipéridine utilisés comme inhibiteurs de fixation du vih
WO2010028108A2 (fr) * 2008-09-04 2010-03-11 Bristol-Myers Squibb Company Composition pharmaceutique stable pour l'administration optimisée d'un inhibiteur de la fixation du vih
CN102186804A (zh) * 2008-10-20 2011-09-14 克塞诺波特公司 合成左旋多巴酯前药的方法
US8399513B2 (en) 2008-10-20 2013-03-19 Xenoport, Inc. Levodopa prodrug mesylate hydrate
US8686009B2 (en) * 2009-06-25 2014-04-01 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds
AU2010315892B2 (en) * 2009-11-09 2014-09-18 Xenoport, Inc. Pharmaceutical compositions and oral dosage forms of a levodopa prodrug and methods of use
US8754068B2 (en) 2010-06-04 2014-06-17 Bristol-Myers Squibb Company Modified C-3 betulinic acid derivatives as HIV maturation inhibitors
PT2576586E (pt) 2010-06-04 2015-10-23 Bristol Myers Squibb Co Amidas c-28 de derivados de ácido betulínico c-3 modificadas como inibidores de maturação de hiv
US8450361B2 (en) 2010-08-06 2013-05-28 Bristol-Myers Squibb Company Substituted indole and azaindole oxoacetyl piperazinamide derivatives
EP2646439B1 (fr) 2010-12-02 2016-05-25 Bristol-Myers Squibb Company Amides d'alkyle comme inhibiteurs d'attachement du vih
EP2670764B1 (fr) 2011-01-31 2015-09-02 Bristol-Myers Squibb Company Amines en c28 de dérivés d'acide bétulinique modifié en c-3 en tant qu'inhibiteurs de maturation du vih
EA021726B1 (ru) 2011-01-31 2015-08-31 Бристол-Маерс Сквибб Компани Способы получения соединений, являющихся пролекарствами ингибиторов присоединения вируса вич, и их интермедиатов
MY162186A (en) 2011-01-31 2017-05-31 Viiv Healthcare Uk (No 4) Ltd C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity
EP2696937B1 (fr) 2011-04-12 2017-05-17 VIIV Healthcare UK (No.5) Limited Dérivés de thioamide, d'amidoxine et d'amidrazone comme inhibiteurs de l'attachement du vih
ES2616268T3 (es) 2011-08-29 2017-06-12 VIIV Healthcare UK (No.5) Limited Derivados condensados de diamina bicíclica como inhibidores de la unión de VIH
ES2609579T3 (es) 2011-08-29 2017-04-21 VIIV Healthcare UK (No.5) Limited Derivados espiro de diamina bicíclica como inhibidores de la unión del VIH
CN103814042B (zh) 2011-09-21 2015-08-19 百时美施贵宝公司 具有抗病毒活性的桦木酸衍生物
EP2783219A1 (fr) 2011-11-21 2014-10-01 Bristol-Myers Squibb Company Procédés permettant de déterminer la sensibilité d'un virus à un inhibiteur de fixation
US8426450B1 (en) * 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
US9248139B2 (en) 2011-12-21 2016-02-02 Bristol-Myers Squibb Company Co-processing method and formulations for HIV attachment inhibitor prodrug compound and excipients
EP2812332B1 (fr) 2012-02-08 2017-08-09 Viiv Healthcare Uk (No. 4) Limited Procédé de préparation d'un composé de promédicament à base de pipérazine inhibiteur d'attachement du vih
US8906889B2 (en) 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
WO2013138436A1 (fr) 2012-03-14 2013-09-19 Bristol-Myers Squibb Company Dérivés d'hydrazine cycliques en tant qu'inhibiteurs de fixation du vih
US8889854B2 (en) 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
IN2014KN02915A (fr) 2012-06-19 2015-05-08 Debiopharm Int Sa
US9505752B2 (en) 2012-08-09 2016-11-29 Viiv Healthcare Uk (No. 5) Limited Piperidine amide derivatives as HIV attachment inhibitors
US9655888B2 (en) 2012-08-09 2017-05-23 VIIV Healthcare UK (No.5) Limited Tricyclic alkene derivatives as HIV attachment inhibitors
JP6186010B2 (ja) 2013-02-06 2017-08-23 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｈｉｖ成熟阻害活性を有するｃ−１９修飾トリテルペノイド類
EA027861B1 (ru) 2013-02-25 2017-09-29 Бристол-Майерс Сквибб Компани C-3 алкил- и алкенилмодифицированные производные бетулиновой кислоты или их фармацевтические соли, противовирусная фармацевтическая композиция и фармацевтическая композиция для лечения вич на их основе
PT2978763T (pt) * 2013-03-27 2018-04-16 Viiv Healthcare Uk No 5 Ltd Derivados de 2-cetoamida como inibidores da ligação do vih
JP2016515579A (ja) * 2013-03-27 2016-05-30 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｈｉｖ結合阻害剤としてのピペラジンおよびホモピペラジン誘導体
AU2015243500B2 (en) 2014-04-11 2017-03-30 ViiV Healthcare UK (No.4) Limited Triterpenoids with HIV maturation inhibitory activity, substituted in position 3 by a non-aromatic ring carrying a haloalkyl substituent
WO2015195776A1 (fr) 2014-06-19 2015-12-23 Bristol-Myers Squibb Company Dérivés d'acide bétulinique présentant une activité inhibitrice de maturation du vih
US9969767B2 (en) 2014-11-14 2018-05-15 VIIV Healthcare UK (No.5) Limited Oxolupene derivatives
CA2967684A1 (fr) 2014-11-14 2016-05-19 VIIV Healthcare UK (No.5) Limited Analogues de l'acide betulinique substitues par aryle en c17
KR20170097145A (ko) 2014-12-18 2017-08-25 비브 헬스케어 유케이 (넘버4) 리미티드 Ｐｙｂｒｏｐ를 사용하여 할로겐화된 아자인돌 화합물을 제조하는 방법
PT3233853T (pt) 2014-12-18 2019-05-27 Viiv Healthcare Uk No 4 Ltd Processo para preparar compostos de azaindole halogenados utilizando boroxina
AU2016248235A1 (en) 2015-04-14 2017-10-19 Viiv Healthcare Uk (No 4) Limited Crystalline forms of modified triterpenoid hydrochloride salts with HIV maturation inhibitor activity
AU2016331065B2 (en) 2015-10-01 2021-04-29 Olema Pharmaceuticals, Inc. Tetrahydro-1H-pyrido(3,4-b)indole anti-estrogenic drugs
WO2017102893A1 (fr) * 2015-12-14 2017-06-22 Ludwig-Maximilians-Universität München Dérivés hydrosolubles de composés 3,5-diphényl-diazole
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
US20190030025A1 (en) 2016-02-04 2019-01-31 VIIV Healthcare UK (No.5) Limited Fostemsavir for use in heavily treatment-experienced hiv-1 infected individuals
TN2018000293A1 (en) 2016-02-26 2020-01-16 Debiopharm Int Sa Medicament for treatment of diabetic foot infections
RU2020116458A (ru) 2017-11-21 2021-12-23 Пфайзер Инк. Кристаллическая соль 2-амино-2-(гидроксиметил)пропан-1,3-диола и 4-(4-(1-изопропил-7-оксо-1,4,6,7-тетрагидроспиро[индазол-5,4ʼ-пиперидин]-1ʼ-карбонил)-6-метоксипиридин-2-ил)бензойной кислоты
EP3911651B1 (fr) 2019-01-17 2024-01-10 ViiV Healthcare UK (No.4) Limited Procédé de préparation de fostemsavir
WO2023114951A1 (fr) 2021-12-17 2023-06-22 Viiv Healthcare Company Polythérapies pour infections par vih et utilisations associées
WO2024094690A1 (fr) 2022-11-02 2024-05-10 VIIV Healthcare UK (No.5) Limited Protéines de liaison à un antigène

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2101017C (fr) 1992-07-24 1999-10-26 Masahiko Higuma Cartouche d'encre, tete d'imprimante a jet d'encre et imprimante a jet d'encre
US6469006B1 (en) 1999-06-15 2002-10-22 Bristol-Myers Squibb Company Antiviral indoleoxoacetyl piperazine derivatives
US20020061892A1 (en) 2000-02-22 2002-05-23 Tao Wang Antiviral azaindole derivatives
US6476034B2 (en) * 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
DE60113543T2 (de) * 2000-07-10 2006-07-13 Bristol-Myers Squibb Co. Zusammensetzung und antivirale wirkung von substituierten indol-oxo-aceto-piperidin-derivaten
US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
RU2303038C2 (ru) * 2001-02-02 2007-07-20 Бристол-Маерс Сквибб Компани Азаиндолоксоуксусные производные пиперазины и фармацевтическая композиция на их основе
US20030207910A1 (en) * 2001-02-02 2003-11-06 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
AU2003215469A1 (en) 2002-03-28 2003-10-13 Procyon Biopharma Inc. Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors
US7745625B2 (en) * 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
US7776863B2 (en) 2004-03-24 2010-08-17 Bristol-Myers Squibb Company Methods of treating HIV infection
US7130185B2 (en) * 2004-06-02 2006-10-31 Research In Motion Limited Handheld computing device having drop-resistant LCD display
US7723338B2 (en) * 2005-01-31 2010-05-25 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4,7-dimethoxy-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-yl]-1,2-dioxoethyl]-piperazine
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
EA021726B1 (ru) * 2011-01-31 2015-08-31 Бристол-Маерс Сквибб Компани Способы получения соединений, являющихся пролекарствами ингибиторов присоединения вируса вич, и их интермедиатов
EP2812332B1 (fr) * 2012-02-08 2017-08-09 Viiv Healthcare Uk (No. 4) Limited Procédé de préparation d'un composé de promédicament à base de pipérazine inhibiteur d'attachement du vih

Also Published As

Publication number Publication date
CN101941990A (zh) 2011-01-12
CA2560253A1 (fr) 2005-09-29
RS50567B (sr) 2010-05-07
CA2560253C (fr) 2013-01-15
US20160361328A1 (en) 2016-12-15
ES2299022T3 (es) 2008-05-16
DE602005004517T2 (de) 2009-01-22
NO20064062L (no) 2006-12-08
US8168615B2 (en) 2012-05-01
AU2005223736B2 (en) 2011-05-26
NZ585294A (en) 2011-09-30
KR101153594B1 (ko) 2012-07-05
RU2374256C2 (ru) 2009-11-27
DE602005004517D1 (de) 2008-03-13
US8871771B2 (en) 2014-10-28
US20050209246A1 (en) 2005-09-22
JP2007529519A (ja) 2007-10-25
TWI344843B (en) 2011-07-11
NZ549867A (en) 2010-07-30
US20120238755A1 (en) 2012-09-20
EP1725569B1 (fr) 2008-01-23
IL211961A (en) 2013-08-29
AU2005223736A1 (en) 2005-09-29
MY139243A (en) 2009-09-30
US20100210599A1 (en) 2010-08-19
US20200046743A1 (en) 2020-02-13
US20150232414A1 (en) 2015-08-20
US20180000849A1 (en) 2018-01-04
AU2005223736C1 (en) 2011-10-06
US20210023098A1 (en) 2021-01-28
JP4734318B2 (ja) 2011-07-27
US11369624B2 (en) 2022-06-28
US20190111066A1 (en) 2019-04-18
WO2005090367A1 (fr) 2005-09-29
AR048039A1 (es) 2006-03-22
NO336742B1 (no) 2015-10-26
US8461333B2 (en) 2013-06-11
CN101941990B (zh) 2012-04-25
CY1107419T1 (el) 2012-12-19
BRPI0508876B1 (pt) 2020-05-26
EP1725569A1 (fr) 2006-11-29
HK1148533A1 (en) 2011-09-09
US7745625B2 (en) 2010-06-29
PE20051151A1 (es) 2006-01-20
ATE384728T1 (de) 2008-02-15
BRPI0508876A (pt) 2007-09-04
TW200600096A (en) 2006-01-01
HRP20080064T3 (en) 2008-03-31
US20150315218A1 (en) 2015-11-05
DK1725569T3 (da) 2008-06-02
KR20060129533A (ko) 2006-12-15
BRPI0508876B8 (pt) 2021-05-25
PT1725569E (pt) 2008-03-28
US20150025240A1 (en) 2015-01-22
GEP20094736B (en) 2009-07-27
HK1096687A1 (en) 2007-06-08
US20130253196A1 (en) 2013-09-26
RU2006136390A (ru) 2008-04-27
PL1725569T3 (pl) 2008-09-30

Similar Documents

Publication Publication Date Title
HRP20080064T3 (en) Prodrugs of piperazine and substituted piperidine antiviral agents
RS51949B (en) INHIBITORI KINAZE
RS51674B (en) PIPERIDIN-4-IL-PIRIDAZIN-3-ILAMINE DERIVATIVES AS A FAST DISSOCATING DOPAMIN 2 RECEIVER ANTAGONISTS
RS53021B (en) INDOLIC, AZAINDOL AND RELATED HETEROCYCLIC 4-ALKENYL PIPERIDINE AMIDES
RS53153B (en) ANTAGONISTS OF HYSTAMINE -3 RECEPTORS
HRP20070510T3 (en) Benzimidazole derivative and its use as a ii receptor antagonist
RS52562B (en) (3-ARIL-PIPERAZINE-1-IL) DERIVATI 6,7-DIALCOKSIQUINZOLINE, 6,7-DIALCOKSIFTALAZINE I
MEP22008A (en) Derivatives of n-[heteroaryl(piperidine-2-yl)methyl]benzamide, preparation method thereof and application of same in therapeutics
RS51995B (en) NEW UNITS AS OPIOID RECEPTOR MODULATORS
RS54260B1 (en) AMINODIHYDROTIAZINE DERIVATIVES AS BACE INHIBITORS FOR ALZHEIMER DISEASE TREATMENT
RS52489B (en) COMPOSITION AND ANTI-VIRUS ACTIVITY OF DERIVATIVES OF SUBSTITUTED AZAINDOLOXSOACETATE PIPERAZINE
RS51385B (en) HETEROAROMATIC COMPOUNDS OF HINOLINE AND THEIR USE AS PDE10 INHIBITORS
RS50606B (sr) Supstituisani morfolin i tiomorfolin derivati
YU48854B (sh) Derivati n-(4-piperidinil) (dihidrobenzofuran ili dihidro-2h-benzopiran)karboksamida i postupak za njihovo dobijanje
MEP10709A (en) 2-ARYL-6-PHENYLIMIDAZO[1,2-alpha]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
HRP20041008B1 (hr) Derivati triazola kao antagonisti receptora tahikinina
RS52702B (en) CARBASOL UNITS AND THERAPEUTIC USE OF THE COMPOUNDS
CO5280070A1 (es) Compuestos, composiciones farmaceuticas de indazol y metodos para mediar o inhibir la proliferacion celular
RS52545B (en) INHIBITORI PROTEIN APOPTOZE (IAP)
RS52326B (en) Phenyl-piperazine Derivatives As Serotonin Resorption Inhibitors
RS50380B (sr) Inhibitori tirozin kinaze
EA200970656A1 (ru) Вич-ингибирующие 5,6-замещенные пиримидины
RS53038B (en) OXADIAZOLA DERIVATIVE Activate Sphingosine-1-Phosphate (SIP)
RS52191B (en) TETRAHYDROCYCLOPENT (B) INDOLE UNITS AS MODULATORS OF ANDROGENIC RECEPTORS
WO2002094794A8 (fr) Derives de 4(phenyl-piperazine-methyle) benzamide et utilisation de ces derives pour le traitement de la douleur, de l'anxiete ou des troubles gastro-intestinaux