HRP20070560T3 - Inhibitori dpp-iv - Google Patents

Inhibitori dpp-iv

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Publication number
HRP20070560T3
HRP20070560T3 HR20070560T HRP20070560T HRP20070560T3 HR P20070560 T3 HRP20070560 T3 HR P20070560T3 HR 20070560 T HR20070560 T HR 20070560T HR P20070560 T HRP20070560 T HR P20070560T HR P20070560 T3 HRP20070560 T3 HR P20070560T3
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HR
Croatia
Prior art keywords
dpp
inhibitors
compounds
relates
medicament
Prior art date
Application number
HR20070560T
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English (en)
Inventor
John Edwards Paul
Lopez-Canet Meritxell
Feurer Achim
Cerezo-Galvez Silvia
Giulio Matassa Victor
Nordhoff Sonja
Thiemann Meinolf
Hill Oliver
Original Assignee
Santhera Pharmaceuticals (Schweiz) Ag
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Publication date
Application filed by Santhera Pharmaceuticals (Schweiz) Ag filed Critical Santhera Pharmaceuticals (Schweiz) Ag
Publication of HRP20070560T3 publication Critical patent/HRP20070560T3/hr

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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
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    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

Spoj formule (I) ili njegova farmaceutski prihvatljiva sol, naznačen time, štoZ je odabran iz skupine koju sačinjavajufenil; naftil; C3-7 cikloalkil;heterocikl; iheterobicikl; pri tome Z je po potrebi supstituiran s jednim, ili neovisno jednog od drugog, s više halogena; CN; OH; =O, pri tome prsten je barem djelomično zasićen; C1-6 alkil, po potrebi supstituiran s jednim ili više F; iO-C1-6 alkil, po potrebi supstituiran s jednim ili više F; R1, R2, R4, R5 su neovisno jedan o drugog odabrani iz skupine koju sačinjavajuH; F; OH; C1-6 alkil, popotrebi supstituiran s jednim ili više F; iO-C1-6alkil, po potrebi supstituiran s jednim ili više F; i/ili R1 i R2, po potrebi zajedno formiraju C3-7 cikloalkil, koji je po potrebi supstituiran s jednim ili više F; i/ili R2 i R3, po potrebi zajednoformiraju C3-7 cikloalkil, koji je po potrebi supstituiran s jednim ili više F; i/ili R3 i R4, po potrebi zajedno formiraju C3-7 cikloalkil, koji je po potrebi supstituiran s jednim ili više F; i/iliR4 i R5, po potrebi zajedno formiraju C3-7 cikloalkil, koji je po potrebi supstituiran s jednim iliviše F; R3 je H ili C1-6 alkil; X je odabran iz skupine koju sačinjavajuH; F, iC1-6 alkil, koji je po potrebi supstituiran s jednim ili više F; n je 0 ili 1; A1, A2 su nezavisno jedan od drugog odabrani iz skupine koju sačinjavajuH; halogen, C1-6 alkil, po potrebi supstituiran s jednim ili više F; iR6; pod uvjetom da jedan od A1 i A2 bude R6;R6 je-C(R7R8)-Y-T; R7 i R8 su neovisno jedan o drugomeodabrani iz skupine koju sačinjavaju H; F; iC1-6 alkil, po potrebi supstituiran s jednim ili više F; i/ili R7 i R8 po potrebi zajedno formiraju C3-7 cikloalkil, koji je po potrebi supstituiran s jednim ili više F; Y je odabran iz skupine koju sačinjavaju-O-;-C1-6 alkil-O; -N(R9)-;-C1-6 alkil-N(R9)-;-S-;-C1-6 alkil-S-;-S(O)-; -C1-6 alkil-S(O)-; S(O)2-; i-C1-6 alkil-S(O)2-;pri tome svaki C1-6 alkilpo potrebi supstituiran s jednim ili više F; R9, T su neovisno jedan od drugoga T1-T2 ili T2;T1 je odabran iz skupine koju sačinjavaju-C1-6 alkil; -C1-6 alkil-O-;C1-6 alkil-N(R10)-;-C(O)-; -C(O)O-C1-6alkil-;-C(O)O-C1-6alkil-O-;-C(O)O-C1-6alkil-N(R10)-;-C(O)O-;-C(O)O-C1-6alkil-;-C(O)O-C1-6alkil-O-;-C(O)N(R10)-C1-6alkil-;-C(O)O-C1-6alkil-N(R10)-;-C(O)N(R10)-;-C(O)N(R10)-C1-6alkil-;-C(O)N(R10)-C1-6alkil-O-;-C(O)N(R10)-C1-6alkil-N(R11),-S(O2)-;-S(O2)-C1-6alkil-;-S(O2)-C1-6alkil-O; i-S(O2)-C1-6alkil-N(R10)-;pri čemu je svaki C1-6 alkil po potrebi supstituiran s jednim ili više F; R10, R11 su nezavisno jedan od drugog H ili C1-6 alkil, koji su po potrebi supstituirani s jednim ili više F; T2 je odabran iz skupine koju sačinjavajuH; CF3;fenil; naftil; pri tome fenil i naftil su po potrebi supstituirani s jednim, ili nezavisno jedan od drugog, više halogena; CN; R12,COOH; OH; C(O)NH2;S(O)2NH2;COOT3,OT3;C(O)NHT3,S(O)2NHT3; iliT3;C3-7 cikloalkil; heterocikl; iheterobicikl; pri čemu C3-7 cikloalkil, heterocikl i heterobicikl su po potrebi supstituirani s jednim, ili nezavisno jedan od drugog, više halog
HR20070560T 2003-12-09 2007-12-12 Inhibitori dpp-iv HRP20070560T3 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03028211A EP1541143A1 (en) 2003-12-09 2003-12-09 Dpp-iv inhibitors
PCT/EP2004/014040 WO2005056003A1 (en) 2003-12-09 2004-12-09 Dpp-iv inhibitors

Publications (1)

Publication Number Publication Date
HRP20070560T3 true HRP20070560T3 (hr) 2008-01-31

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HR20070560T HRP20070560T3 (hr) 2003-12-09 2007-12-12 Inhibitori dpp-iv

Country Status (24)

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US (1) US20080027035A1 (hr)
EP (2) EP1541143A1 (hr)
JP (1) JP2007513910A (hr)
KR (1) KR100845397B1 (hr)
CN (1) CN1905868A (hr)
AT (1) ATE372767T1 (hr)
AU (1) AU2004296553B2 (hr)
BR (1) BRPI0417458A (hr)
CA (1) CA2548742A1 (hr)
CY (1) CY1106969T1 (hr)
DE (1) DE602004008895T2 (hr)
DK (1) DK1613304T3 (hr)
ES (1) ES2291966T3 (hr)
HK (1) HK1087022A1 (hr)
HR (1) HRP20070560T3 (hr)
IL (1) IL176062A0 (hr)
MX (1) MXPA06006652A (hr)
NO (1) NO20062644L (hr)
PL (1) PL1613304T3 (hr)
PT (1) PT1613304E (hr)
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