HRP20050858A2 - Method for the production of an extract of ivy leaves - Google Patents
Method for the production of an extract of ivy leaves Download PDFInfo
- Publication number
- HRP20050858A2 HRP20050858A2 HR20050858A HRP20050858A HRP20050858A2 HR P20050858 A2 HRP20050858 A2 HR P20050858A2 HR 20050858 A HR20050858 A HR 20050858A HR P20050858 A HRP20050858 A HR P20050858A HR P20050858 A2 HRP20050858 A2 HR P20050858A2
- Authority
- HR
- Croatia
- Prior art keywords
- extract
- hederin
- water
- ivy
- leaves
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 83
- 239000000284 extract Substances 0.000 title claims abstract description 69
- 238000004519 manufacturing process Methods 0.000 title claims description 13
- 240000008669 Hedera helix Species 0.000 title description 2
- KEOITPILCOILGM-FCWYPSSHSA-N Sapindoside A Natural products O=C(O)[C@]12[C@H](C=3[C@](C)([C@@]4(C)[C@@H]([C@]5(C)[C@H]([C@@](CO)(C)[C@@H](O[C@@H]6[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O)[C@H](C)O7)[C@H](O)[C@H](O)CO6)CC5)CC4)CC=3)CC1)CC(C)(C)CC2 KEOITPILCOILGM-FCWYPSSHSA-N 0.000 claims abstract description 63
- KBYYTUYPCGPQNK-UHFFFAOYSA-N alpha-hederin Natural products CC1OC(OC2C(O)C(CO)OC2OC3CCC4(C)C(CCC5(C)C4CC=C6C7CC(C)(C)CCC7(CCC56C)C(=O)O)C3(C)CO)C(O)C(O)C1O KBYYTUYPCGPQNK-UHFFFAOYSA-N 0.000 claims abstract description 63
- KEOITPILCOILGM-LLJOFIFVSA-N kalopanaxsaponin A Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@@H]2[C@@]([C@H]3[C@]([C@@H]4[C@@]([C@@]5(CC[C@]6(CCC(C)(C)C[C@H]6C5=CC4)C(O)=O)C)(C)CC3)(C)CC2)(C)CO)OC[C@H](O)[C@@H]1O KEOITPILCOILGM-LLJOFIFVSA-N 0.000 claims abstract description 63
- 241000208341 Hedera Species 0.000 claims abstract description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 42
- 230000008569 process Effects 0.000 claims abstract description 37
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 56
- 238000000605 extraction Methods 0.000 claims description 37
- 238000000855 fermentation Methods 0.000 claims description 27
- 230000004151 fermentation Effects 0.000 claims description 27
- RYHDIBJJJRNDSX-MCGLQMIESA-N Hederacoside C Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](OC[C@@H]2[C@H]([C@H](O)[C@@H](O)[C@H](OC(=O)[C@@]34[C@@H](CC(C)(C)CC3)C=3[C@@]([C@]5(C)CC[C@H]6[C@](C)(CO)[C@@H](O[C@H]7[C@@H]([C@@H](O)[C@@H](O)CO7)O[C@H]7[C@@H]([C@H](O)[C@@H](O)[C@H](C)O7)O)CC[C@]6(C)[C@H]5CC=3)(C)CC4)O2)O)[C@H](O)[C@H]1O RYHDIBJJJRNDSX-MCGLQMIESA-N 0.000 claims description 16
- RYHDIBJJJRNDSX-UHFFFAOYSA-N kalopanax-saponin B Natural products OC1C(O)C(O)C(C)OC1OC1C(CO)OC(OCC2C(C(O)C(O)C(OC(=O)C34C(CC(C)(C)CC3)C=3C(C5(C)CCC6C(C)(CO)C(OC7C(C(O)C(O)CO7)OC7C(C(O)C(O)C(C)O7)O)CCC6(C)C5CC=3)(C)CC4)O2)O)C(O)C1O RYHDIBJJJRNDSX-UHFFFAOYSA-N 0.000 claims description 16
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 11
- 230000008961 swelling Effects 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 238000001704 evaporation Methods 0.000 claims description 5
- 230000008020 evaporation Effects 0.000 claims description 5
- 210000002345 respiratory system Anatomy 0.000 claims description 5
- 238000005325 percolation Methods 0.000 claims description 4
- 238000001694 spray drying Methods 0.000 claims description 3
- 239000003814 drug Substances 0.000 description 25
- 229940079593 drug Drugs 0.000 description 20
- 238000006243 chemical reaction Methods 0.000 description 14
- 230000000694 effects Effects 0.000 description 9
- 241000196324 Embryophyta Species 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 6
- 229930182490 saponin Natural products 0.000 description 6
- 150000007949 saponins Chemical class 0.000 description 6
- 235000017709 saponins Nutrition 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 238000003306 harvesting Methods 0.000 description 4
- 229930187944 Hederacoside Natural products 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 102000012740 beta Adrenergic Receptors Human genes 0.000 description 3
- 108010079452 beta Adrenergic Receptors Proteins 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- NTWLPZMPTFQYQI-UHFFFAOYSA-N (3alpha)-olean-12-ene-3,23-diol Natural products C1CC(O)C(C)(CO)C2CCC3(C)C4(C)CCC5(C)CCC(C)(C)CC5C4=CCC3C21C NTWLPZMPTFQYQI-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- GCGBHJLBFAPRDB-UHFFFAOYSA-N Hederagenin Natural products CC1(C)CCC2(CCC3(C)C4CCC5C(C)(CO)C(O)CCC5(C)C4CC=C3C2C1)C(=O)O GCGBHJLBFAPRDB-UHFFFAOYSA-N 0.000 description 2
- MLWBUURUTWPMOO-UHFFFAOYSA-N Hederasaponin C Natural products CC1OC(OC2C(O)COC(OC3CCC4(C)C(CCC5(C)C4CC=C6C7CC(C)(C)CCC7(CCC56C)C(=O)OC8OC(COC9OC(CO)C(OC%10OC(C)C(O)C(O)C%10O)C(O)C9O)C(O)C(O)C8O)C3(C)CO)C2O)C(O)C(O)C1O MLWBUURUTWPMOO-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- GCGBHJLBFAPRDB-KCVAUKQGSA-N Scutellaric acid Natural products CC1(C)CC[C@@]2(CC[C@@]3(C)[C@@H]4CC[C@H]5[C@@](C)(CO)[C@H](O)CC[C@]5(C)[C@H]4CC=C3[C@@H]2C1)C(=O)O GCGBHJLBFAPRDB-KCVAUKQGSA-N 0.000 description 2
- 102000030621 adenylate cyclase Human genes 0.000 description 2
- 108060000200 adenylate cyclase Proteins 0.000 description 2
- 210000000621 bronchi Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- PGOYMURMZNDHNS-MYPRUECHSA-N hederagenin Chemical compound C1C[C@H](O)[C@@](C)(CO)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C PGOYMURMZNDHNS-MYPRUECHSA-N 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000002048 spasmolytic effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000010409 thin film Substances 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229930185042 hederasaponin Natural products 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000001303 quality assessment method Methods 0.000 description 1
- 238000012372 quality testing Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229930182493 triterpene saponin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10315931A DE10315931A1 (de) | 2003-04-02 | 2003-04-02 | Verfahren zur Herstellung eines Extraktes aus Efeublättern |
| PCT/EP2004/003420 WO2004087183A1 (de) | 2003-04-02 | 2004-03-31 | Verfahren zur herstellung eines extraktes aus efeublättern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20050858A2 true HRP20050858A2 (en) | 2006-02-28 |
Family
ID=33103257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20050858A HRP20050858A2 (en) | 2003-04-02 | 2005-09-28 | Method for the production of an extract of ivy leaves |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20060057236A1 (sr) |
| EP (1) | EP1608388B1 (sr) |
| JP (1) | JP2006522051A (sr) |
| KR (1) | KR100763866B1 (sr) |
| CN (1) | CN1767842A (sr) |
| AT (1) | ATE375165T1 (sr) |
| BR (1) | BRPI0409067A (sr) |
| CY (1) | CY1108040T1 (sr) |
| DE (2) | DE10315931A1 (sr) |
| DK (1) | DK1608388T3 (sr) |
| EA (1) | EA200501534A1 (sr) |
| ES (1) | ES2295846T3 (sr) |
| HR (1) | HRP20050858A2 (sr) |
| MX (1) | MXPA05010573A (sr) |
| PL (1) | PL1608388T3 (sr) |
| PT (1) | PT1608388E (sr) |
| RS (1) | RS20050740A (sr) |
| WO (1) | WO2004087183A1 (sr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10345343A1 (de) * | 2003-09-19 | 2005-04-14 | Engelhard Arzneimittel Gmbh & Co. Kg | Verfahren zur Herstellung eines Extrakts aus Efeublättern und nach diesem Verfahren hergestellter Extrakt |
| CN101235068B (zh) * | 2007-01-29 | 2010-08-25 | 中南大学 | 一种从常春藤中制备常春藤苷c的方法 |
| ES2637807T3 (es) * | 2008-06-13 | 2017-10-17 | Ahn-Gook Pharmaceutical Co., Ltd. | Extracto de rhizoma coptidis y uso novedoso del mismo en el tratamiento de enfermedad respiratoria |
| CN102245192A (zh) * | 2008-10-31 | 2011-11-16 | 比诺里卡公司 | 来自植物提取物的水解物和包含该水解物的抗菌剂 |
| KR101278706B1 (ko) * | 2011-11-04 | 2013-06-25 | 한국 한의학 연구원 | 송악 추출물을 포함하는 당뇨합병증의 예방 또는 치료용 약학적 조성물 및 건강기능식품 |
| KR102216470B1 (ko) * | 2013-11-01 | 2021-02-17 | 주식회사 클라시아 | 천연물 조성물 |
| CN103588832B (zh) * | 2013-11-26 | 2017-01-04 | 陕西嘉禾生物科技股份有限公司 | 从常春藤叶中分离常春藤苷c及苷元的方法 |
| CN103800930A (zh) * | 2014-02-25 | 2014-05-21 | 云南天宏香精香料有限公司 | 一种空气清新剂及制备方法 |
| WO2016009001A1 (en) | 2014-07-17 | 2016-01-21 | Hexal Ag | Orodispersible film |
| KR101751516B1 (ko) | 2016-01-19 | 2017-06-27 | 양지화학 주식회사 | 생약의 안정화 건조분말을 포함하는 복합 액상 약학 조성물 |
| CN107536859A (zh) * | 2017-07-18 | 2018-01-05 | 浙江康恩贝中药有限公司 | 一种常春藤炮制品的制备方法 |
| KR102048233B1 (ko) | 2018-02-28 | 2019-11-25 | 충남대학교산학협력단 | 아이비엽 추출물을 함유하는 경구용 서방성 제제 및 이의 제조방법 |
| EP3939596A1 (en) * | 2020-07-14 | 2022-01-19 | Bimeda Animal Health Limited | A composition for treating helminth infestation in a mammal |
| KR102401605B1 (ko) * | 2021-10-08 | 2022-05-25 | 인선열 | 스틱형 건초사료 및 그 제조방법 |
| CN114805466B (zh) * | 2022-04-15 | 2023-06-20 | 湖南朗林生物资源股份有限公司 | 一种常春藤提取物的制备方法 |
| CN115260274B (zh) * | 2022-08-05 | 2023-07-25 | 大连工业大学 | 一种从唐古特铁线莲中制备常春藤皂苷c的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2707675A1 (de) * | 1977-02-23 | 1978-08-24 | Evers & Co Pharma | Arzneimittel zur aufloesung bzw. teilweisen aufloesung von gallensteinen |
| FR2499405A1 (fr) * | 1981-02-10 | 1982-08-13 | Biotherm | Composition cosmetique amincissante et anti-cellulitique a base d'un extrait de plante contenant des saponines, un extrait d'arnica montana l. et d'un extrait de noix de cola et son procede d'application |
| KR20040106201A (ko) * | 2003-12-03 | 2004-12-17 | 주식회사 성일바이오엑스 | 천식억제용 헤데라헬리시스 잎 추출물의 제조방법 |
-
2003
- 2003-04-02 DE DE10315931A patent/DE10315931A1/de not_active Withdrawn
-
2004
- 2004-03-31 WO PCT/EP2004/003420 patent/WO2004087183A1/de active IP Right Grant
- 2004-03-31 RS YUP-2005/0740A patent/RS20050740A/sr unknown
- 2004-03-31 PT PT04724580T patent/PT1608388E/pt unknown
- 2004-03-31 ES ES04724580T patent/ES2295846T3/es not_active Expired - Lifetime
- 2004-03-31 EA EA200501534A patent/EA200501534A1/ru unknown
- 2004-03-31 AT AT04724580T patent/ATE375165T1/de active
- 2004-03-31 EP EP04724580A patent/EP1608388B1/de not_active Expired - Lifetime
- 2004-03-31 MX MXPA05010573A patent/MXPA05010573A/es active IP Right Grant
- 2004-03-31 DK DK04724580T patent/DK1608388T3/da active
- 2004-03-31 KR KR1020057018469A patent/KR100763866B1/ko not_active IP Right Cessation
- 2004-03-31 JP JP2006504936A patent/JP2006522051A/ja not_active Withdrawn
- 2004-03-31 DE DE502004005201T patent/DE502004005201D1/de not_active Expired - Lifetime
- 2004-03-31 CN CNA2004800085146A patent/CN1767842A/zh active Pending
- 2004-03-31 BR BRPI0409067-5A patent/BRPI0409067A/pt not_active Application Discontinuation
- 2004-03-31 PL PL04724580T patent/PL1608388T3/pl unknown
-
2005
- 2005-09-28 HR HR20050858A patent/HRP20050858A2/hr not_active Application Discontinuation
- 2005-09-30 US US11/241,120 patent/US20060057236A1/en not_active Abandoned
-
2007
- 2007-12-14 CY CY20071101596T patent/CY1108040T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0409067A (pt) | 2006-03-28 |
| US20060057236A1 (en) | 2006-03-16 |
| PT1608388E (pt) | 2007-10-29 |
| JP2006522051A (ja) | 2006-09-28 |
| CY1108040T1 (el) | 2013-09-04 |
| DK1608388T3 (da) | 2008-01-02 |
| PL1608388T3 (pl) | 2008-03-31 |
| CN1767842A (zh) | 2006-05-03 |
| EA200501534A1 (ru) | 2006-04-28 |
| ATE375165T1 (de) | 2007-10-15 |
| DE502004005201D1 (de) | 2007-11-22 |
| EP1608388A1 (de) | 2005-12-28 |
| KR100763866B1 (ko) | 2007-10-08 |
| MXPA05010573A (es) | 2006-03-09 |
| KR20060008310A (ko) | 2006-01-26 |
| WO2004087183A1 (de) | 2004-10-14 |
| DE10315931A1 (de) | 2004-11-04 |
| RS20050740A (en) | 2007-08-03 |
| EP1608388B1 (de) | 2007-10-10 |
| ES2295846T3 (es) | 2008-04-16 |
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