HRP20050503A2 - Anhydrous crystalline azido cytrosine hemisulfate derivative - Google Patents

Anhydrous crystalline azido cytrosine hemisulfate derivative

Info

Publication number
HRP20050503A2
HRP20050503A2 HR20050503A HRP20050503A HRP20050503A2 HR P20050503 A2 HRP20050503 A2 HR P20050503A2 HR 20050503 A HR20050503 A HR 20050503A HR P20050503 A HRP20050503 A HR P20050503A HR P20050503 A2 HRP20050503 A2 HR P20050503A2
Authority
HR
Croatia
Prior art keywords
azido
cytrosine
anhydrous crystalline
hemisulfate
derivative
Prior art date
Application number
HR20050503A
Other languages
English (en)
Croatian (hr)
Inventor
Joseph Connolly Terrence
Armstrong Martin Joseph
Prince Anthony
Sarma Keshab
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of HRP20050503A2 publication Critical patent/HRP20050503A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
HR20050503A 2002-12-09 2005-06-03 Anhydrous crystalline azido cytrosine hemisulfate derivative HRP20050503A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43188502P 2002-12-09 2002-12-09
PCT/EP2003/013899 WO2004052906A1 (en) 2002-12-09 2003-12-08 Anhydrous crystalline azido cytosine hemisulfate derivative

Publications (1)

Publication Number Publication Date
HRP20050503A2 true HRP20050503A2 (en) 2006-12-31

Family

ID=32507815

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20050503A HRP20050503A2 (en) 2002-12-09 2005-06-03 Anhydrous crystalline azido cytrosine hemisulfate derivative

Country Status (33)

Country Link
US (1) US6864244B2 (zh)
EP (1) EP1572711B1 (zh)
JP (1) JP4563818B2 (zh)
KR (1) KR100675544B1 (zh)
CN (1) CN1314697C (zh)
AR (1) AR042312A1 (zh)
AT (1) ATE430755T1 (zh)
AU (1) AU2003292212B2 (zh)
BR (1) BR0317146A (zh)
CA (1) CA2506532C (zh)
CY (1) CY1109296T1 (zh)
DE (1) DE60327554D1 (zh)
DK (1) DK1572711T3 (zh)
ES (1) ES2324654T3 (zh)
GT (1) GT200300276A (zh)
HK (1) HK1085483A1 (zh)
HR (1) HRP20050503A2 (zh)
IL (1) IL168685A (zh)
JO (1) JO2542B1 (zh)
MX (1) MXPA05006044A (zh)
MY (1) MY130927A (zh)
NO (1) NO330454B1 (zh)
NZ (1) NZ540297A (zh)
PA (1) PA8590701A1 (zh)
PE (1) PE20040767A1 (zh)
PL (1) PL213734B1 (zh)
PT (1) PT1572711E (zh)
RU (1) RU2334756C2 (zh)
SI (1) SI1572711T1 (zh)
TW (1) TWI294882B (zh)
UY (1) UY28109A1 (zh)
WO (1) WO2004052906A1 (zh)
ZA (1) ZA200504472B (zh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1219607B1 (en) * 1999-09-02 2011-04-06 Shionogi & Co., Ltd. Integrase inhibitors containing aromatic heterocycle derivatives
CA2284459C (en) 1999-10-04 2012-12-11 Neokimia Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
US20050182252A1 (en) * 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
CN101044151B (zh) * 2004-08-23 2011-01-19 弗·哈夫曼-拉罗切有限公司 抗病毒的4＇-叠氮基-核苷
SI2084175T1 (sl) * 2006-10-10 2011-05-31 Medivir Ab Hcv nukleozidni inhibitor
JP2010515680A (ja) 2007-01-05 2010-05-13 メルク・シャープ・エンド・ドーム・コーポレイション Ｒｎａ依存性ｒｎａウイルス感染症の治療用としてのヌクレオシドアリールホスホロアミデート
GB0709791D0 (en) * 2007-05-22 2007-06-27 Angeletti P Ist Richerche Bio Antiviral agents
GB0900914D0 (en) 2009-01-20 2009-03-04 Angeletti P Ist Richerche Bio Antiviral agents
EP2619215B1 (en) 2010-09-22 2018-09-05 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
CN106061984A (zh) 2014-02-13 2016-10-26 配体药物公司 前药化合物及其用途
CN103965116B (zh) * 2014-05-06 2016-06-15 中国科学院苏州纳米技术与纳米仿生研究所 半5-氟胞嘧啶盐、其制备方法及应用
EP3164136A4 (en) 2014-07-02 2018-04-04 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
KR20220025914A (ko) 2015-03-06 2022-03-03 아테아 파마슈티컬즈, 인크. HCV 치료를 위한 β-D-2'-데옥시-2'-α-플루오로-2'-β-C-치환된-2-변형된-N6-치환된 퓨린 뉴클레오티드
CN116036114A (zh) 2016-09-07 2023-05-02 阿堤亚制药公司 用于rna病毒治疗的2’-取代的-n6-取代的嘌呤核苷酸
KR102592899B1 (ko) 2017-02-01 2023-10-24 아테아 파마슈티컬즈, 인크. C형 간염 바이러스를 치료하기 위한 뉴클레오티드 헤미-술페이트 염
CA3087932A1 (en) 2018-01-09 2019-07-18 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
CN112351799A (zh) 2018-04-10 2021-02-09 阿堤亚制药公司 具有硬化的hcv感染患者的治疗
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
CN115536710B (zh) * 2022-10-18 2024-04-16 南京工业大学 一种高品质胞苷硫酸盐晶体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0371366A1 (en) * 1988-11-21 1990-06-06 Syntex (U.S.A.) Inc. Antiviral agents
US5449664A (en) * 1988-11-21 1995-09-12 Syntex (U.S.A.) Inc. Antiviral agents
AU7623991A (en) * 1990-05-17 1991-11-21 Syntex (U.S.A.) Inc. Antiviral agents
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives

Also Published As

Publication number Publication date
PT1572711E (pt) 2009-06-25
TW200502243A (en) 2005-01-16
MXPA05006044A (es) 2005-08-18
NO20052732L (no) 2005-09-06
NZ540297A (en) 2007-05-31
DK1572711T3 (da) 2009-07-13
KR100675544B1 (ko) 2007-01-30
ES2324654T3 (es) 2009-08-12
JO2542B1 (en) 2010-09-05
PA8590701A1 (es) 2004-11-26
NO20052732D0 (no) 2005-06-07
AR042312A1 (es) 2005-06-15
RU2005121927A (ru) 2006-01-27
GT200300276A (es) 2004-09-02
JP4563818B2 (ja) 2010-10-13
CA2506532C (en) 2011-09-20
DE60327554D1 (de) 2009-06-18
IL168685A (en) 2010-11-30
US20040162265A1 (en) 2004-08-19
EP1572711B1 (en) 2009-05-06
ATE430755T1 (de) 2009-05-15
UY28109A1 (es) 2004-06-30
BR0317146A (pt) 2005-10-25
TWI294882B (en) 2008-03-21
PL377472A1 (pl) 2006-02-06
US6864244B2 (en) 2005-03-08
SI1572711T1 (sl) 2009-08-31
WO2004052906A1 (en) 2004-06-24
KR20050084217A (ko) 2005-08-26
ZA200504472B (en) 2006-02-22
NO330454B1 (no) 2011-04-18
JP2006510649A (ja) 2006-03-30
RU2334756C2 (ru) 2008-09-27
EP1572711A1 (en) 2005-09-14
PL213734B1 (pl) 2013-04-30
CN1314697C (zh) 2007-05-09
CY1109296T1 (el) 2014-07-02
CA2506532A1 (en) 2004-06-24
AU2003292212A1 (en) 2004-06-30
PE20040767A1 (es) 2004-11-06
AU2003292212B2 (en) 2009-10-01
CN1723215A (zh) 2006-01-18
HK1085483A1 (en) 2006-08-25
MY130927A (en) 2007-07-31

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