GT200300276A - Nuevo hemisulfato anhidro cristalino 1-[4(s)-azido-2(s), 3(r)-dihidroxi-4-(hidroximetil)-1(r)-ciclopentil] citosina utilcomo agente antiviral - Google Patents

Nuevo hemisulfato anhidro cristalino 1-[4(s)-azido-2(s), 3(r)-dihidroxi-4-(hidroximetil)-1(r)-ciclopentil] citosina utilcomo agente antiviral

Info

Publication number
GT200300276A
GT200300276A GT200300276A GT200300276A GT200300276A GT 200300276 A GT200300276 A GT 200300276A GT 200300276 A GT200300276 A GT 200300276A GT 200300276 A GT200300276 A GT 200300276A GT 200300276 A GT200300276 A GT 200300276A
Authority
GT
Guatemala
Prior art keywords
utilcomo
cytynos
antiiral
ciclopentil
dihydroxi
Prior art date
Application number
GT200300276A
Other languages
English (en)
Inventor
Terrence Joseph Connolly
Joseph Armstrong Martin
Anthony Prince
Keshab Sarma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200300276A publication Critical patent/GT200300276A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE AL COMPUESTO QUE FIGURA EN EL RESUMEN Y QUE PRESENTA UNA MAYOR ESTABILIDAD Y MEJORES PROPIEDADES FISICAS, LAS CUALES FACILITAN LA OBTENCION, MANIPULACION Y FORMULACION POR LO QUE SU UTILIDAD PARA TRATAR PATOLOGIAS TALES COMO LA HEPATITIS C LA HACEN VENTAJOSA.
GT200300276A 2002-12-09 2003-12-08 Nuevo hemisulfato anhidro cristalino 1-[4(s)-azido-2(s), 3(r)-dihidroxi-4-(hidroximetil)-1(r)-ciclopentil] citosina utilcomo agente antiviral GT200300276A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43188502P 2002-12-09 2002-12-09

Publications (1)

Publication Number Publication Date
GT200300276A true GT200300276A (es) 2004-09-02

Family

ID=32507815

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200300276A GT200300276A (es) 2002-12-09 2003-12-08 Nuevo hemisulfato anhidro cristalino 1-[4(s)-azido-2(s), 3(r)-dihidroxi-4-(hidroximetil)-1(r)-ciclopentil] citosina utilcomo agente antiviral

Country Status (33)

Country Link
US (1) US6864244B2 (es)
EP (1) EP1572711B1 (es)
JP (1) JP4563818B2 (es)
KR (1) KR100675544B1 (es)
CN (1) CN1314697C (es)
AR (1) AR042312A1 (es)
AT (1) ATE430755T1 (es)
AU (1) AU2003292212B2 (es)
BR (1) BR0317146A (es)
CA (1) CA2506532C (es)
CY (1) CY1109296T1 (es)
DE (1) DE60327554D1 (es)
DK (1) DK1572711T3 (es)
ES (1) ES2324654T3 (es)
GT (1) GT200300276A (es)
HK (1) HK1085483A1 (es)
HR (1) HRP20050503A2 (es)
IL (1) IL168685A (es)
JO (1) JO2542B1 (es)
MX (1) MXPA05006044A (es)
MY (1) MY130927A (es)
NO (1) NO330454B1 (es)
NZ (1) NZ540297A (es)
PA (1) PA8590701A1 (es)
PE (1) PE20040767A1 (es)
PL (1) PL213734B1 (es)
PT (1) PT1572711E (es)
RU (1) RU2334756C2 (es)
SI (1) SI1572711T1 (es)
TW (1) TWI294882B (es)
UY (1) UY28109A1 (es)
WO (1) WO2004052906A1 (es)
ZA (1) ZA200504472B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001017968A1 (fr) * 1999-09-02 2001-03-15 Shionogi & Co., Ltd. Inhibiteur d'integrase contenant des derives heterocycliques aromatiques
CA2284459C (en) * 1999-10-04 2012-12-11 Neokimia Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
US20050182252A1 (en) * 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
CA2577526A1 (en) * 2004-08-23 2006-03-02 Joseph Armstrong Martin Antiviral 4'-azido-nucleosides
ES2358853T3 (es) * 2006-10-10 2011-05-16 Medivir Ab Inhibidor nucleosídico de vhc.
US8071568B2 (en) 2007-01-05 2011-12-06 Merck Sharp & Dohme Corp. Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
GB0709791D0 (en) * 2007-05-22 2007-06-27 Angeletti P Ist Richerche Bio Antiviral agents
GB0900914D0 (en) 2009-01-20 2009-03-04 Angeletti P Ist Richerche Bio Antiviral agents
WO2012040124A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
EP3623364A1 (en) 2014-02-13 2020-03-18 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
CN103965116B (zh) * 2014-05-06 2016-06-15 中国科学院苏州纳米技术与纳米仿生研究所 半5-氟胞嘧啶盐、其制备方法及应用
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
EP3265102A4 (en) 2015-03-06 2018-12-05 ATEA Pharmaceuticals, Inc. Beta-d-2'-deoxy-2'alpha-fluoro-2'-beta-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment
PT3512863T (pt) 2016-09-07 2022-03-09 Atea Pharmaceuticals Inc Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna
SG10202012214WA (en) 2017-02-01 2021-01-28 Atea Pharmaceuticals Inc Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus
JP2021509907A (ja) 2018-01-09 2021-04-08 リガンド・ファーマシューティカルズ・インコーポレイテッド アセタール化合物およびその治療的使用
TW202012001A (zh) 2018-04-10 2020-04-01 美商亞堤製藥公司 C型肝炎病毒(hcv)感染硬化之患者的治療
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
CN115536710B (zh) * 2022-10-18 2024-04-16 南京工业大学 一种高品质胞苷硫酸盐晶体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ231444A (en) * 1988-11-21 1992-09-25 Syntex Inc 2'-deoxy-4'-azido-substituted nucleosides and medicaments
US5449664A (en) * 1988-11-21 1995-09-12 Syntex (U.S.A.) Inc. Antiviral agents
AU7623991A (en) * 1990-05-17 1991-11-21 Syntex (U.S.A.) Inc. Antiviral agents
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives

Also Published As

Publication number Publication date
US6864244B2 (en) 2005-03-08
CA2506532C (en) 2011-09-20
HRP20050503A2 (en) 2006-12-31
MXPA05006044A (es) 2005-08-18
ES2324654T3 (es) 2009-08-12
PT1572711E (pt) 2009-06-25
SI1572711T1 (sl) 2009-08-31
DK1572711T3 (da) 2009-07-13
JP4563818B2 (ja) 2010-10-13
CA2506532A1 (en) 2004-06-24
UY28109A1 (es) 2004-06-30
DE60327554D1 (de) 2009-06-18
NO330454B1 (no) 2011-04-18
PL213734B1 (pl) 2013-04-30
US20040162265A1 (en) 2004-08-19
EP1572711A1 (en) 2005-09-14
TWI294882B (en) 2008-03-21
BR0317146A (pt) 2005-10-25
CN1314697C (zh) 2007-05-09
MY130927A (en) 2007-07-31
NZ540297A (en) 2007-05-31
JO2542B1 (en) 2010-09-05
TW200502243A (en) 2005-01-16
RU2005121927A (ru) 2006-01-27
KR100675544B1 (ko) 2007-01-30
PA8590701A1 (es) 2004-11-26
NO20052732D0 (no) 2005-06-07
KR20050084217A (ko) 2005-08-26
RU2334756C2 (ru) 2008-09-27
ATE430755T1 (de) 2009-05-15
CY1109296T1 (el) 2014-07-02
CN1723215A (zh) 2006-01-18
AR042312A1 (es) 2005-06-15
WO2004052906A1 (en) 2004-06-24
NO20052732L (no) 2005-09-06
ZA200504472B (en) 2006-02-22
EP1572711B1 (en) 2009-05-06
PE20040767A1 (es) 2004-11-06
IL168685A (en) 2010-11-30
PL377472A1 (pl) 2006-02-06
AU2003292212A1 (en) 2004-06-30
AU2003292212B2 (en) 2009-10-01
JP2006510649A (ja) 2006-03-30
HK1085483A1 (en) 2006-08-25

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