GT200600116A - Derivados de aril 1,4-pirazina sustituidos - Google Patents
Derivados de aril 1,4-pirazina sustituidosInfo
- Publication number
- GT200600116A GT200600116A GT200600116A GT200600116A GT200600116A GT 200600116 A GT200600116 A GT 200600116A GT 200600116 A GT200600116 A GT 200600116A GT 200600116 A GT200600116 A GT 200600116A GT 200600116 A GT200600116 A GT 200600116A
- Authority
- GT
- Guatemala
- Prior art keywords
- pirazina
- aril
- derivatives
- substituted
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P17/08—Antiseborrheics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Virology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Anesthesiology (AREA)
- Communicable Diseases (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS DE LA FÓRMULA GENERAL I EN LA QUE R1,R2,R3,R4,R22, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR CFR POR LO QUE SON DE UTILIDAD EN TRASTORNOS DE ANSIEDAD, DEPRESIÓN Y ESTRÉS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66291705P | 2005-03-17 | 2005-03-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT200600116A true GT200600116A (es) | 2006-11-09 |
Family
ID=36617394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT200600116A GT200600116A (es) | 2005-03-17 | 2006-03-16 | Derivados de aril 1,4-pirazina sustituidos |
Country Status (26)
Country | Link |
---|---|
US (1) | US20060211710A1 (es) |
EP (1) | EP1871763A1 (es) |
JP (1) | JP2008533124A (es) |
KR (1) | KR20070113294A (es) |
CN (1) | CN101160304A (es) |
AP (1) | AP2007004174A0 (es) |
AR (1) | AR056279A1 (es) |
AU (1) | AU2006238976A1 (es) |
BR (1) | BRPI0606284A2 (es) |
CA (1) | CA2601600C (es) |
CR (1) | CR9436A (es) |
DO (1) | DOP2006000056A (es) |
EA (1) | EA012874B1 (es) |
GT (1) | GT200600116A (es) |
IL (1) | IL185997A0 (es) |
MA (1) | MA29336B1 (es) |
MX (1) | MX2007011423A (es) |
NL (1) | NL1031384C2 (es) |
NO (1) | NO20075209L (es) |
PE (1) | PE20061108A1 (es) |
TN (1) | TNSN07355A1 (es) |
TW (1) | TWI315670B (es) |
UA (1) | UA86873C2 (es) |
UY (1) | UY29418A1 (es) |
WO (1) | WO2006114666A1 (es) |
ZA (1) | ZA200707933B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
EP2493878B1 (en) * | 2009-10-30 | 2016-10-12 | Janssen Pharmaceutica NV | Pyrazines as delta opioid receptor modulators |
AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
EP2531510B1 (en) | 2010-02-01 | 2014-07-23 | Novartis AG | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
ES2527849T3 (es) | 2010-02-02 | 2015-01-30 | Novartis Ag | Derivados de ciclohexilamida como antagonistas del receptor de CRF |
JP2022062287A (ja) * | 2019-02-27 | 2022-04-20 | 住友化学株式会社 | ピリジルピラジン化合物の製造方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5872136A (en) * | 1996-04-03 | 1999-02-16 | Merck & Co., Inc. | Arylheteroaryl inhibitors of farnesyl-protein transferase |
US5883105A (en) * | 1996-04-03 | 1999-03-16 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
US5880140A (en) * | 1996-04-03 | 1999-03-09 | Merck & Co., Inc. | Biheteroaryl inhibitors of farnesyl-protein transferase |
PA8467401A1 (es) * | 1998-02-17 | 2000-09-29 | Pfizer Prod Inc | Procedimiento para tratar la insuficiencia cardiaca |
WO2001025220A1 (en) * | 1999-10-07 | 2001-04-12 | Amgen Inc. | Triazine kinase inhibitors |
IL139197A0 (en) * | 1999-10-29 | 2001-11-25 | Pfizer Prod Inc | Use of corticotropin releasing factor antagonists and related compositions |
KR20030031886A (ko) * | 2000-02-16 | 2003-04-23 | 뉴로젠 코포레이션 | 치환된 아릴피라진 |
EP1446387B1 (en) * | 2001-11-21 | 2009-11-04 | Pharmacia & Upjohn Company LLC | Substituted aryl 1,4-pyrazine derivatives |
US6992087B2 (en) * | 2001-11-21 | 2006-01-31 | Pfizer Inc | Substituted aryl 1,4-pyrazine derivatives |
EP1499599A1 (en) * | 2002-04-26 | 2005-01-26 | Pharmacia & Upjohn Company LLC | Substituted pyrazine derivatives |
WO2004024719A1 (en) * | 2002-09-12 | 2004-03-25 | Pharmacia & Upjohn Company Llc | Substituted 1,4-pyrazine derivatives |
-
2006
- 2006-02-27 US US11/363,009 patent/US20060211710A1/en not_active Abandoned
- 2006-03-02 DO DO2006000056A patent/DOP2006000056A/es unknown
- 2006-03-06 CA CA2601600A patent/CA2601600C/en not_active Expired - Fee Related
- 2006-03-06 UA UAA200710557A patent/UA86873C2/ru unknown
- 2006-03-06 AU AU2006238976A patent/AU2006238976A1/en not_active Abandoned
- 2006-03-06 WO PCT/IB2006/000564 patent/WO2006114666A1/en active Application Filing
- 2006-03-06 EP EP06765409A patent/EP1871763A1/en not_active Withdrawn
- 2006-03-06 EA EA200701758A patent/EA012874B1/ru not_active IP Right Cessation
- 2006-03-06 AP AP2007004174A patent/AP2007004174A0/xx unknown
- 2006-03-06 MX MX2007011423A patent/MX2007011423A/es not_active Application Discontinuation
- 2006-03-06 KR KR1020077023701A patent/KR20070113294A/ko not_active Application Discontinuation
- 2006-03-06 JP JP2008501437A patent/JP2008533124A/ja not_active Ceased
- 2006-03-06 BR BRPI0606284-9A patent/BRPI0606284A2/pt not_active IP Right Cessation
- 2006-03-06 CN CNA2006800128070A patent/CN101160304A/zh active Pending
- 2006-03-13 UY UY29418A patent/UY29418A1/es not_active Application Discontinuation
- 2006-03-15 AR ARP060100986A patent/AR056279A1/es unknown
- 2006-03-15 PE PE2006000289A patent/PE20061108A1/es not_active Application Discontinuation
- 2006-03-16 TW TW095108969A patent/TWI315670B/zh not_active IP Right Cessation
- 2006-03-16 GT GT200600116A patent/GT200600116A/es unknown
- 2006-03-16 NL NL1031384A patent/NL1031384C2/nl not_active IP Right Cessation
-
2007
- 2007-09-17 MA MA30226A patent/MA29336B1/fr unknown
- 2007-09-17 TN TNP2007000355A patent/TNSN07355A1/fr unknown
- 2007-09-17 ZA ZA200707933A patent/ZA200707933B/xx unknown
- 2007-09-17 IL IL185997A patent/IL185997A0/en unknown
- 2007-10-11 NO NO20075209A patent/NO20075209L/no not_active Application Discontinuation
- 2007-10-12 CR CR9436A patent/CR9436A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1871763A1 (en) | 2008-01-02 |
NL1031384A1 (nl) | 2006-09-20 |
TWI315670B (en) | 2009-10-11 |
CR9436A (es) | 2007-11-23 |
AP2007004174A0 (en) | 2007-10-31 |
UY29418A1 (es) | 2006-10-31 |
EA012874B1 (ru) | 2009-12-30 |
UA86873C2 (en) | 2009-05-25 |
CN101160304A (zh) | 2008-04-09 |
IL185997A0 (en) | 2008-01-20 |
DOP2006000056A (es) | 2006-08-30 |
MA29336B1 (fr) | 2008-03-03 |
CA2601600C (en) | 2010-09-14 |
BRPI0606284A2 (pt) | 2009-06-09 |
US20060211710A1 (en) | 2006-09-21 |
MX2007011423A (es) | 2007-10-12 |
PE20061108A1 (es) | 2006-10-13 |
TNSN07355A1 (fr) | 2008-12-31 |
KR20070113294A (ko) | 2007-11-28 |
CA2601600A1 (en) | 2006-11-02 |
ZA200707933B (en) | 2009-08-26 |
EA200701758A1 (ru) | 2008-02-28 |
WO2006114666A8 (en) | 2008-04-03 |
JP2008533124A (ja) | 2008-08-21 |
NO20075209L (no) | 2007-10-11 |
AR056279A1 (es) | 2007-10-03 |
NL1031384C2 (nl) | 2007-01-23 |
AU2006238976A1 (en) | 2006-11-02 |
WO2006114666A1 (en) | 2006-11-02 |
TW200700067A (en) | 2007-01-01 |
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