HRP20050224B1 - Novel combination of glucocorticoid and pde-4-inhibitors for treating respiratory diseases, allergic diseases, asthma and copd - Google Patents
Novel combination of glucocorticoid and pde-4-inhibitors for treating respiratory diseases, allergic diseases, asthma and copdInfo
- Publication number
- HRP20050224B1 HRP20050224B1 HR20050224A HRP20050224A HRP20050224B1 HR P20050224 B1 HRP20050224 B1 HR P20050224B1 HR 20050224 A HR20050224 A HR 20050224A HR P20050224 A HRP20050224 A HR P20050224A HR P20050224 B1 HRP20050224 B1 HR P20050224B1
- Authority
- HR
- Croatia
- Prior art keywords
- diseases
- pde
- glucocorticoid
- copd
- asthma
- Prior art date
Links
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title abstract 3
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title abstract 3
- 201000009961 allergic asthma Diseases 0.000 title abstract 2
- 208000026935 allergic disease Diseases 0.000 title abstract 2
- 208000006673 asthma Diseases 0.000 title abstract 2
- 239000003862 glucocorticoid Substances 0.000 title abstract 2
- 208000023504 respiratory system disease Diseases 0.000 title abstract 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 2
- YPZVAYHNBBHPTO-MXRBDKCISA-N loteprednol Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)OCCl)[C@@H]4[C@@H]3CCC2=C1 YPZVAYHNBBHPTO-MXRBDKCISA-N 0.000 abstract 1
- 229960001798 loteprednol Drugs 0.000 abstract 1
- DPHDSIQHVGSITN-UHFFFAOYSA-N n-(3,5-dichloropyridin-4-yl)-2-[1-[(4-fluorophenyl)methyl]-5-hydroxyindol-3-yl]-2-oxoacetamide Chemical compound C1=C(C(=O)C(=O)NC=2C(=CN=CC=2Cl)Cl)C2=CC(O)=CC=C2N1CC1=CC=C(F)C=C1 DPHDSIQHVGSITN-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10236688 | 2002-08-09 | ||
| PCT/EP2003/008607 WO2004019984A1 (de) | 2002-08-09 | 2003-08-04 | Neue kombination von glucocorticoiden und pde-4-inhibitoren zur behandlung von atemwegserkrankungen, allergischen erkrankungen, asthma und copd |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20050224A2 HRP20050224A2 (en) | 2005-04-30 |
| HRP20050224B1 true HRP20050224B1 (en) | 2007-12-31 |
Family
ID=31968961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20050224A HRP20050224B1 (en) | 2002-08-09 | 2005-03-08 | Novel combination of glucocorticoid and pde-4-inhibitors for treating respiratory diseases, allergic diseases, asthma and copd |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20050288265A1 (xx) |
| EP (1) | EP1526870B1 (xx) |
| JP (1) | JP2005539042A (xx) |
| CN (1) | CN1308038C (xx) |
| AT (1) | ATE361076T1 (xx) |
| AU (1) | AU2003255365B2 (xx) |
| CA (1) | CA2492645A1 (xx) |
| CY (1) | CY1107696T1 (xx) |
| DE (1) | DE50307184D1 (xx) |
| DK (1) | DK1526870T3 (xx) |
| EA (1) | EA008981B1 (xx) |
| ES (1) | ES2285238T3 (xx) |
| HK (1) | HK1078463A1 (xx) |
| HR (1) | HRP20050224B1 (xx) |
| MX (1) | MXPA05001573A (xx) |
| NO (1) | NO20051212D0 (xx) |
| PT (1) | PT1526870E (xx) |
| UA (1) | UA82323C2 (xx) |
| WO (1) | WO2004019984A1 (xx) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10241407A1 (de) * | 2002-09-06 | 2004-03-18 | Elbion Ag | Behandlung nicht allergischer Rhinitis durch selektive Phosphodiesterase 4-Hemmstoffe |
| WO2005074918A1 (en) | 2004-02-06 | 2005-08-18 | Benzstrasse 1 D-61352 Bad Homburd | The combination of anticholinergics and glucocorticoids for the long-term treatment of asthma and copd |
| PL1713471T3 (pl) | 2004-02-06 | 2012-06-29 | Meda Pharma Gmbh & Co Kg | Kombinacja środków antycholinergicznych i inhibitorów fosfodiesterazy typu 4 do leczenia chorób oddechowych |
| JP4991693B2 (ja) | 2005-03-16 | 2012-08-01 | メダ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 呼吸器疾患の治療のための抗コリン作用薬及びロイコトリエン受容体アンタゴニストの組み合わせ剤 |
| US8506934B2 (en) | 2005-04-29 | 2013-08-13 | Robert I. Henkin | Methods for detection of biological substances |
| JP5107933B2 (ja) | 2005-12-21 | 2012-12-26 | メダ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 炎症性疾患の治療に使用する、抗コリン作用薬類、β２−アドレナリン受容体のアゴニスト類、抗ロイコトリエン（ロイコトリエン受容体のアンタゴニスト）類、グルココルチコイド類および／またはＰＤＥ４阻害剤類の新規配合薬 |
| JP2009529053A (ja) * | 2006-03-07 | 2009-08-13 | コンビナトアールエックス インコーポレーティッド | 免疫炎症性障害の処置のための組成物および方法 |
| US8293489B2 (en) | 2007-01-31 | 2012-10-23 | Henkin Robert I | Methods for detection of biological substances |
| US8580801B2 (en) | 2008-07-23 | 2013-11-12 | Robert I. Henkin | Phosphodiesterase inhibitor treatment |
| CN102309756A (zh) * | 2010-07-02 | 2012-01-11 | 天津金耀集团有限公司 | 含有磷酸二酯酶4抑制剂和糖皮质激素的治疗皮肤病的复方药物 |
| US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| EP4008355A1 (en) | 2012-05-03 | 2022-06-08 | Kala Pharmaceuticals, Inc. | Pharmaceutical nanoparticles showing improved mucosal transport |
| WO2013166408A1 (en) * | 2012-05-03 | 2013-11-07 | Kala Pharmaceuticals, Inc. | Pharmaceutical nanoparticles showing improved mucosal transport |
| US10864219B2 (en) | 2012-05-03 | 2020-12-15 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| US20160030435A1 (en) * | 2013-03-15 | 2016-02-04 | Robert I HENKIN | Phosphodiesterase inhibitor treatment |
| WO2015126944A1 (en) | 2014-02-18 | 2015-08-27 | Henkin Robert I | Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE449106B (sv) * | 1980-07-10 | 1987-04-06 | Otsuka Pharma Co Ltd | Steroid med anti-inflammatorisk verkan samt komposition innehallande denna |
| US4996335A (en) * | 1980-07-10 | 1991-02-26 | Nicholas S. Bodor | Soft steroids having anti-inflammatory activity |
| EP1014943B1 (de) * | 1997-02-05 | 2002-06-19 | Jago Research Ag | Medizinische aerosolformulierungen |
| DE19917504A1 (de) * | 1999-04-17 | 2000-10-19 | Dresden Arzneimittel | Verwendung von Hydroxyindolen, die Inhibitoren der Phosphodiesterase 4 sind, zur Therapie chronisch obstruktiver Lungenerkrankungen |
| ES2262072T3 (es) * | 1998-04-28 | 2006-11-16 | Elbion Ag | Derivados de indol y su utilizacion como inhibidores de la fosfodiesterasa 4. |
| DE19947234A1 (de) * | 1999-09-30 | 2001-04-05 | Asta Medica Ag | Neue Kombination von Loteprednol und Antihistaminika |
| ECSP003747A (es) * | 1999-11-02 | 2002-05-23 | Smithkline Beecham Corp | Metodo y composiciones para el tratamiento de las enfermedades pulmonares |
| US20040214805A1 (en) * | 1999-11-02 | 2004-10-28 | Smithkline Beecham Corporation | Method and compositions for treating pulmonary diseases |
| PT1289945E (pt) * | 2000-05-19 | 2004-10-29 | Alcon Inc | Derivados dissulfureto de anilina para o tratamento de doencas alergicas |
| GB0123951D0 (en) * | 2001-10-05 | 2001-11-28 | Glaxo Group Ltd | Therapies for treating respiratory diseases |
| CN1585641A (zh) * | 2001-11-05 | 2005-02-23 | 默克专利有限公司 | 亚肼基－丙二腈化合物 |
| US20030092706A1 (en) * | 2001-11-09 | 2003-05-15 | Johannes Barsig | Combination |
-
2003
- 2003-04-08 UA UAA200500512A patent/UA82323C2/uk unknown
- 2003-08-04 WO PCT/EP2003/008607 patent/WO2004019984A1/de active IP Right Grant
- 2003-08-04 DE DE50307184T patent/DE50307184D1/de not_active Expired - Lifetime
- 2003-08-04 US US10/523,802 patent/US20050288265A1/en not_active Abandoned
- 2003-08-04 CN CNB038190575A patent/CN1308038C/zh not_active Expired - Fee Related
- 2003-08-04 ES ES03790851T patent/ES2285238T3/es not_active Expired - Lifetime
- 2003-08-04 AU AU2003255365A patent/AU2003255365B2/en not_active Ceased
- 2003-08-04 EP EP03790851A patent/EP1526870B1/de not_active Expired - Lifetime
- 2003-08-04 PT PT03790851T patent/PT1526870E/pt unknown
- 2003-08-04 DK DK03790851T patent/DK1526870T3/da active
- 2003-08-04 AT AT03790851T patent/ATE361076T1/de not_active IP Right Cessation
- 2003-08-04 MX MXPA05001573A patent/MXPA05001573A/es active IP Right Grant
- 2003-08-04 CA CA002492645A patent/CA2492645A1/en not_active Abandoned
- 2003-08-04 JP JP2004531853A patent/JP2005539042A/ja active Pending
- 2003-08-04 EA EA200500328A patent/EA008981B1/ru not_active IP Right Cessation
-
2005
- 2005-03-08 HR HR20050224A patent/HRP20050224B1/xx not_active IP Right Cessation
- 2005-03-08 NO NO20051212A patent/NO20051212D0/no not_active Application Discontinuation
- 2005-11-18 HK HK05110373A patent/HK1078463A1/xx not_active IP Right Cessation
-
2007
- 2007-07-12 CY CY20071100927T patent/CY1107696T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1078463A1 (en) | 2006-03-17 |
| US20050288265A1 (en) | 2005-12-29 |
| CN1308038C (zh) | 2007-04-04 |
| DE50307184D1 (de) | 2007-06-14 |
| WO2004019984A1 (de) | 2004-03-11 |
| ATE361076T1 (de) | 2007-05-15 |
| JP2005539042A (ja) | 2005-12-22 |
| EA200500328A1 (ru) | 2005-06-30 |
| EP1526870A1 (de) | 2005-05-04 |
| CN1674939A (zh) | 2005-09-28 |
| HRP20050224A2 (en) | 2005-04-30 |
| NO20051212L (no) | 2005-03-08 |
| UA82323C2 (uk) | 2008-04-10 |
| MXPA05001573A (es) | 2005-04-25 |
| AU2003255365A1 (en) | 2004-03-19 |
| PT1526870E (pt) | 2007-07-09 |
| CY1107696T1 (el) | 2013-04-18 |
| EA008981B1 (ru) | 2007-10-26 |
| CA2492645A1 (en) | 2004-03-11 |
| DK1526870T3 (da) | 2007-09-10 |
| AU2003255365B2 (en) | 2009-02-19 |
| NO20051212D0 (no) | 2005-03-08 |
| ES2285238T3 (es) | 2007-11-16 |
| EP1526870B1 (de) | 2007-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| PNAN | Change of the applicant name, address/residence |
Owner name: VIATRIS GMBH & CO.KG, DE |
|
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| PNAN | Change of the applicant name, address/residence |
Owner name: MEDA PHARMA GMBH & CO. KG, DE |
|
| B1PR | Patent granted | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20090803 Year of fee payment: 7 |
|
| PBON | Lapse due to non-payment of renewal fee |
Effective date: 20100805 |