HRP20050195B1 - Makrolidni spojevi s protuupalnim djelovanjem - Google Patents
Makrolidni spojevi s protuupalnim djelovanjemInfo
- Publication number
- HRP20050195B1 HRP20050195B1 HRP20050195AA HRP20050195A HRP20050195B1 HR P20050195 B1 HRP20050195 B1 HR P20050195B1 HR P20050195A A HRP20050195A A HR P20050195AA HR P20050195 A HRP20050195 A HR P20050195A HR P20050195 B1 HRP20050195 B1 HR P20050195B1
- Authority
- HR
- Croatia
- Prior art keywords
- antiinflammatory activity
- macrolide compounds
- compounds endowed
- macrolide
- endowed
- Prior art date
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 3
- 239000003120 macrolide antibiotic agent Substances 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- YHVUVJYEERGYNU-UHFFFAOYSA-N 4',8-Di-Me ether-5,7,8-Trihydroxy-3-(4-hydroxybenzyl)-4-chromanone Natural products COC1(C)CC(O)OC(C)C1O YHVUVJYEERGYNU-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- AJSDVNKVGFVAQU-BIIVOSGPSA-N cladinose Chemical group O=CC[C@@](C)(OC)[C@@H](O)[C@H](C)O AJSDVNKVGFVAQU-BIIVOSGPSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Opisani su makrolidni spojevi obdareni protuupalnim djelovanjem, a osobito makrolidni derivati s protuupalnim djelovanjem, koji nemaju kladinozu u položaju 3, njihove farmaceutski prihvatljive soli i farmaceutski sastavi koji ih sadrže kao djelotvorne agense.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT001726A ITMI20021726A1 (it) | 2002-08-01 | 2002-08-01 | Macrolidi ad attivita' antiinfiammatoria. |
PCT/EP2003/008448 WO2004013153A2 (en) | 2002-08-01 | 2003-07-29 | Macrolide compounds endowed with antiinflammatory activity |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20050195A2 HRP20050195A2 (en) | 2005-12-31 |
HRP20050195B1 true HRP20050195B1 (hr) | 2013-10-25 |
Family
ID=31198615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20050195AA HRP20050195B1 (hr) | 2002-08-01 | 2005-02-28 | Makrolidni spojevi s protuupalnim djelovanjem |
Country Status (18)
Country | Link |
---|---|
US (2) | US7488811B2 (hr) |
EP (2) | EP1529053B1 (hr) |
JP (1) | JP4589110B2 (hr) |
KR (1) | KR101051369B1 (hr) |
CN (1) | CN100335491C (hr) |
AT (1) | ATE509938T1 (hr) |
AU (1) | AU2003269861B2 (hr) |
BR (1) | BR0313162A (hr) |
CA (1) | CA2493995C (hr) |
CO (1) | CO5720000A2 (hr) |
ES (1) | ES2364647T3 (hr) |
HR (1) | HRP20050195B1 (hr) |
IL (1) | IL166527A0 (hr) |
IT (1) | ITMI20021726A1 (hr) |
NZ (1) | NZ537992A (hr) |
PT (1) | PT1529053E (hr) |
RU (1) | RU2330856C2 (hr) |
WO (1) | WO2004013153A2 (hr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20021726A1 (it) * | 2002-08-01 | 2004-02-02 | Zambon Spa | Macrolidi ad attivita' antiinfiammatoria. |
PT1532131E (pt) | 2002-08-29 | 2009-02-18 | Pfizer | Compostos motilidos |
AR043050A1 (es) | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
US7407941B2 (en) | 2003-08-26 | 2008-08-05 | Pfizer, Inc. | N-desmethyl-N-substituted-11-deoxyerythromycin compounds |
ITMI20040124A1 (it) * | 2004-01-29 | 2004-04-29 | Zambon Spa | Macrolidi ad attivita' antiinfiammatoria |
CN1950388A (zh) * | 2004-02-27 | 2007-04-18 | 瑞伯-X医药品有限公司 | 大环化合物以及其制作和使用方法 |
JP5383037B2 (ja) * | 2004-02-27 | 2014-01-08 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | 大環状化合物およびそれらを製造し使用する方法 |
US7910559B2 (en) * | 2005-01-13 | 2011-03-22 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | Decladinosyl-macrolides with anti-inflammatory activity |
US20080249034A1 (en) * | 2005-03-21 | 2008-10-09 | Zambon S.P.A. | Use of Macrolides for Treating Intestinal Inflammation |
WO2007003422A1 (en) * | 2005-07-06 | 2007-01-11 | Zambon S.P.A. | Crystalline forms of macrolide compounds endowed with antiinflammatory activity |
WO2007025089A2 (en) | 2005-08-24 | 2007-03-01 | Rib-X Pharmaceutical, Inc. | Triazole compounds and methods of making and using the same |
US8278281B2 (en) | 2005-08-24 | 2012-10-02 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
SI1937642T1 (sl) | 2005-10-19 | 2015-01-30 | Teva Pharmaceutical Industries Ltd. | Kristali natrijevega lakvinimoda in postopek za njihovo pripravo |
JP2009518396A (ja) * | 2005-12-08 | 2009-05-07 | ファイザー・インク | エリスロマイシン化合物の3’−ジメチルアミノ基を脱メチルする方法 |
CN103193840A (zh) | 2006-05-01 | 2013-07-10 | 大正制药株式会社 | 大环内酯衍生物 |
WO2008106204A1 (en) * | 2007-02-28 | 2008-09-04 | Rib-X-Pharmaceuticals, Inc. | Macrolide compounds and methods of making and using the same |
WO2009106419A1 (en) | 2008-02-08 | 2009-09-03 | Basilea Pharmaceutica Ag | New macrolides and their use |
TW200946109A (en) * | 2008-05-09 | 2009-11-16 | Enanta Pharm Inc | Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides |
SG172782A1 (en) | 2009-01-30 | 2011-08-29 | Glaxo Group Ltd | Anti-inflammatory macrolide |
WO2010086350A1 (en) | 2009-01-30 | 2010-08-05 | Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. | 9-deoxo- 9a-methyl- 9a- aza- 9a-h0m0erythr0mycin a derivatives for the treatment of neutrophil dominated inflammatory diseases |
US8865662B2 (en) | 2009-08-13 | 2014-10-21 | Basilea Pharmaceutica Ag | Macrolides and their use |
WO2011131749A1 (en) | 2010-04-23 | 2011-10-27 | Glaxo Group Limited | New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases |
MX2015005632A (es) | 2012-11-07 | 2016-02-05 | Teva Pharma | Sales de amina de laquinimod. |
CA2901849A1 (en) | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Crystals of laquinimod sodium and improved process for the manufacture thereof |
US20160031925A1 (en) * | 2013-04-10 | 2016-02-04 | Probiotic Pharmaceuticals Aps | Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect |
GB201608236D0 (en) | 2016-05-11 | 2016-06-22 | Fidelta D O O | Seco macrolide compounds |
EP4051687A4 (en) * | 2020-01-08 | 2022-12-21 | Beijing Continent Pharmaceuticals Co., Ltd. | MACROLIDE COMPOUND AND USE THEREOF FOR THE TREATMENT OF CHRONIC RESPIRATORY DISEASE |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3923784A (en) * | 1973-09-10 | 1975-12-02 | Hoffmann La Roche | Erythromycin a derivatives |
US4743593A (en) * | 1984-12-08 | 1988-05-10 | Beecham Group P.L.C. | 9,11-O-methylene derivatives of 9-dihydroerythromycin |
EP0682038A1 (en) * | 1993-01-26 | 1995-11-15 | Taisho Pharmaceutical Co. Ltd | 5-o-desosaminylerythronolide derivative |
FR2735694A1 (fr) * | 1995-06-20 | 1996-12-27 | Roussel Uclaf | Le cladinose a titre de medicament et les compositions pharmaceutiques les renfermant |
US5969161A (en) * | 1995-09-11 | 1999-10-19 | Hoechst Marion Roussel | 5-O-deaominyl 6-O-methyl erythronolide a derivatives, method for preparing same and application thereof for preparing biologically active products |
WO2000042055A2 (en) * | 1999-01-15 | 2000-07-20 | Zambon Group S.P.A. | Macrolides with anti-inflammatory activity |
JP2001181294A (ja) * | 1999-12-27 | 2001-07-03 | Hokuriku Seiyaku Co Ltd | エリスロマイシン誘導体 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1100504A (en) * | 1967-08-16 | 1968-01-24 | Pliva Pharm & Chem Works | Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide |
US3623784A (en) * | 1969-11-05 | 1971-11-30 | Massey Ferguson Ind Ltd | Cabinet joint structure |
US3725385A (en) | 1970-11-02 | 1973-04-03 | Abbott Lab | Process for the demethylation of 3-amino macrolides |
US3928387A (en) * | 1974-02-04 | 1975-12-23 | Hoffmann La Roche | Antibiotic 1745A/X and methods for the production thereof |
EP0254534A3 (en) | 1986-07-24 | 1991-04-17 | William S. Robinson | Erythromycin derivatives and compositions and use for inhibiting virus replication and disease |
IL114589A (en) * | 1990-11-21 | 1999-12-22 | Roussel Uclaf | Intermediates for the preparation of the history of erythromycin |
WO1992016226A1 (en) | 1991-03-19 | 1992-10-01 | Smithkline Beecham Corporation | Il-1 inhibitors |
US6096715A (en) * | 1993-05-07 | 2000-08-01 | City Of Hope | Chimeric DNA-RNA catalytic sequences |
KR970704455A (ko) | 1994-08-12 | 1997-09-06 | 우에하라 아끼라 | 인터류킨 5 생성 억제제(Interleukin 5 Production Inhibitor) |
AU3192695A (en) | 1994-08-12 | 1996-03-07 | Taisho Pharmaceutical Co., Ltd. | Interleukin-5 production inhibitor |
IT1276901B1 (it) | 1994-12-13 | 1997-11-03 | Zambon Spa | Derivati dell'eritromicina a 9-0-ossina dotati di attivita' antibiotica |
AU714176B2 (en) * | 1995-11-08 | 1999-12-23 | Abbott Laboratories | 3-deoxy-3-descladinose derivatives of erythromycins A and B |
FR2745290B1 (fr) * | 1996-02-28 | 1998-04-03 | Roussel Uclaf | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
ZA987689B (en) * | 1997-09-02 | 1999-02-24 | Abbott Lab | 3-descladinose 6-O substituted erythromycin derivatives |
PL339575A1 (en) | 1997-09-30 | 2000-12-18 | Abbott Lab | 3'-n-modified, 6-o-substituted ketolydic derivatives of erythromycin exhibiting antibacterial activity |
JPH11236395A (ja) * | 1997-12-11 | 1999-08-31 | Hokuriku Seiyaku Co Ltd | エリスロマイシン誘導体 |
US5892008A (en) * | 1997-12-16 | 1999-04-06 | Abbott Laboratories | Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives |
EP0941998B1 (en) * | 1998-03-03 | 2004-09-01 | Pfizer Products Inc. | 3,6-ketal macrolide antibiotics |
DE19910159A1 (de) | 1999-02-26 | 2000-09-14 | Rosemarie Heis | Spezifische lgY-Eidotterantikörper, ihre Gewinnung und ihre Verwendung |
JP2000351793A (ja) * | 1999-06-09 | 2000-12-19 | Hokuriku Seiyaku Co Ltd | エリスロマイシン誘導体 |
US6437106B1 (en) * | 1999-06-24 | 2002-08-20 | Abbott Laboratories | Process for preparing 6-o-substituted erythromycin derivatives |
ITMI20021726A1 (it) * | 2002-08-01 | 2004-02-02 | Zambon Spa | Macrolidi ad attivita' antiinfiammatoria. |
ITMI20022292A1 (it) | 2002-10-29 | 2004-04-30 | Zambon Spa | 9a-azalidi ad attivita' antiinfiammatoria. |
US20060043226A1 (en) * | 2004-08-24 | 2006-03-02 | Keith Roozeboom | Apparatus and method for grinding with staggered cutters |
US7096915B2 (en) * | 2004-11-05 | 2006-08-29 | Hsiu-Man Yu Chen | Tape-roll supporting device |
-
2002
- 2002-08-01 IT IT001726A patent/ITMI20021726A1/it unknown
-
2003
- 2003-07-29 BR BR0313162-9A patent/BR0313162A/pt not_active IP Right Cessation
- 2003-07-29 CN CNB038210533A patent/CN100335491C/zh not_active Expired - Fee Related
- 2003-07-29 EP EP03750405A patent/EP1529053B1/en not_active Expired - Lifetime
- 2003-07-29 ES ES03750405T patent/ES2364647T3/es not_active Expired - Lifetime
- 2003-07-29 KR KR1020057001887A patent/KR101051369B1/ko not_active IP Right Cessation
- 2003-07-29 US US10/522,671 patent/US7488811B2/en not_active Expired - Fee Related
- 2003-07-29 PT PT03750405T patent/PT1529053E/pt unknown
- 2003-07-29 AU AU2003269861A patent/AU2003269861B2/en not_active Ceased
- 2003-07-29 JP JP2004525393A patent/JP4589110B2/ja not_active Expired - Fee Related
- 2003-07-29 RU RU2005105592/04A patent/RU2330856C2/ru not_active IP Right Cessation
- 2003-07-29 WO PCT/EP2003/008448 patent/WO2004013153A2/en active Application Filing
- 2003-07-29 NZ NZ537992A patent/NZ537992A/en not_active IP Right Cessation
- 2003-07-29 AT AT03750405T patent/ATE509938T1/de active
- 2003-07-29 CA CA2493995A patent/CA2493995C/en not_active Expired - Fee Related
- 2003-07-29 EP EP10180640A patent/EP2258708A1/en not_active Withdrawn
-
2005
- 2005-01-27 IL IL16652705A patent/IL166527A0/xx not_active IP Right Cessation
- 2005-02-28 HR HRP20050195AA patent/HRP20050195B1/hr not_active IP Right Cessation
- 2005-02-28 CO CO05018584A patent/CO5720000A2/es active IP Right Grant
-
2008
- 2008-10-28 US US12/259,335 patent/US7704960B2/en not_active Expired - Fee Related
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3923784A (en) * | 1973-09-10 | 1975-12-02 | Hoffmann La Roche | Erythromycin a derivatives |
US4743593A (en) * | 1984-12-08 | 1988-05-10 | Beecham Group P.L.C. | 9,11-O-methylene derivatives of 9-dihydroerythromycin |
EP0682038A1 (en) * | 1993-01-26 | 1995-11-15 | Taisho Pharmaceutical Co. Ltd | 5-o-desosaminylerythronolide derivative |
FR2735694A1 (fr) * | 1995-06-20 | 1996-12-27 | Roussel Uclaf | Le cladinose a titre de medicament et les compositions pharmaceutiques les renfermant |
US5969161A (en) * | 1995-09-11 | 1999-10-19 | Hoechst Marion Roussel | 5-O-deaominyl 6-O-methyl erythronolide a derivatives, method for preparing same and application thereof for preparing biologically active products |
WO2000042055A2 (en) * | 1999-01-15 | 2000-07-20 | Zambon Group S.P.A. | Macrolides with anti-inflammatory activity |
JP2001181294A (ja) * | 1999-12-27 | 2001-07-03 | Hokuriku Seiyaku Co Ltd | エリスロマイシン誘導体 |
Also Published As
Publication number | Publication date |
---|---|
WO2004013153A3 (en) | 2004-04-08 |
JP2005538998A (ja) | 2005-12-22 |
BR0313162A (pt) | 2005-07-05 |
KR20050037567A (ko) | 2005-04-22 |
US20090054357A1 (en) | 2009-02-26 |
CN1678620A (zh) | 2005-10-05 |
WO2004013153A2 (en) | 2004-02-12 |
KR101051369B1 (ko) | 2011-07-22 |
CN100335491C (zh) | 2007-09-05 |
EP1529053B1 (en) | 2011-05-18 |
IL166527A0 (en) | 2006-01-15 |
AU2003269861A1 (en) | 2004-02-23 |
ATE509938T1 (de) | 2011-06-15 |
JP4589110B2 (ja) | 2010-12-01 |
NZ537992A (en) | 2007-11-30 |
US7488811B2 (en) | 2009-02-10 |
AU2003269861B2 (en) | 2010-01-21 |
EP2258708A1 (en) | 2010-12-08 |
ES2364647T3 (es) | 2011-09-08 |
ITMI20021726A1 (it) | 2004-02-02 |
RU2330856C2 (ru) | 2008-08-10 |
EP1529053A2 (en) | 2005-05-11 |
CA2493995C (en) | 2011-01-04 |
PT1529053E (pt) | 2011-07-05 |
HRP20050195A2 (en) | 2005-12-31 |
US20060058246A1 (en) | 2006-03-16 |
US7704960B2 (en) | 2010-04-27 |
CO5720000A2 (es) | 2007-01-31 |
CA2493995A1 (en) | 2004-02-12 |
RU2005105592A (ru) | 2005-08-27 |
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Legal Events
Date | Code | Title | Description |
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A1OB | Publication of a patent application | ||
ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20130709 Year of fee payment: 11 |
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PBON | Lapse due to non-payment of renewal fee |
Effective date: 20140729 |