PT1529053E - Compostos macrólidos dotados de actividade anti-inflamatória - Google Patents

Compostos macrólidos dotados de actividade anti-inflamatória Download PDF

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Publication number
PT1529053E
PT1529053E PT03750405T PT03750405T PT1529053E PT 1529053 E PT1529053 E PT 1529053E PT 03750405 T PT03750405 T PT 03750405T PT 03750405 T PT03750405 T PT 03750405T PT 1529053 E PT1529053 E PT 1529053E
Authority
PT
Portugal
Prior art keywords
antiinflammatory activity
macrolide compounds
compounds endowed
macrolide
endowed
Prior art date
Application number
PT03750405T
Other languages
English (en)
Inventor
Mauro Napoletano
Franco Pellacini
Ermanno Moriggi
Andrea Mereu
Fernando Ornaghi
Gabriele Morazzoni
Roberto Longoni
Carlo Riva
Luciano Pacchetti
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of PT1529053E publication Critical patent/PT1529053E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT03750405T 2002-08-01 2003-07-29 Compostos macrólidos dotados de actividade anti-inflamatória PT1529053E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001726A ITMI20021726A1 (it) 2002-08-01 2002-08-01 Macrolidi ad attivita' antiinfiammatoria.
PCT/EP2003/008448 WO2004013153A2 (en) 2002-08-01 2003-07-29 Macrolide compounds endowed with antiinflammatory activity

Publications (1)

Publication Number Publication Date
PT1529053E true PT1529053E (pt) 2011-07-05

Family

ID=31198615

Family Applications (1)

Application Number Title Priority Date Filing Date
PT03750405T PT1529053E (pt) 2002-08-01 2003-07-29 Compostos macrólidos dotados de actividade anti-inflamatória

Country Status (18)

Country Link
US (2) US7488811B2 (pt)
EP (2) EP1529053B1 (pt)
JP (1) JP4589110B2 (pt)
KR (1) KR101051369B1 (pt)
CN (1) CN100335491C (pt)
AT (1) ATE509938T1 (pt)
AU (1) AU2003269861B2 (pt)
BR (1) BR0313162A (pt)
CA (1) CA2493995C (pt)
CO (1) CO5720000A2 (pt)
ES (1) ES2364647T3 (pt)
HR (1) HRP20050195B1 (pt)
IL (1) IL166527A0 (pt)
IT (1) ITMI20021726A1 (pt)
NZ (1) NZ537992A (pt)
PT (1) PT1529053E (pt)
RU (1) RU2330856C2 (pt)
WO (1) WO2004013153A2 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20021726A1 (it) * 2002-08-01 2004-02-02 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
DE60325377D1 (de) * 2002-08-29 2009-01-29 Pfizer Motilidverbindungen
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
US7407941B2 (en) 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
ITMI20040124A1 (it) 2004-01-29 2004-04-29 Zambon Spa Macrolidi ad attivita' antiinfiammatoria
EP1723159B1 (en) * 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Macrocyclic compounds and methods of making and using the same
CN108101948A (zh) * 2004-02-27 2018-06-01 瑞伯-X医药品有限公司 大环化合物以及其制作和使用方法
US7910559B2 (en) * 2005-01-13 2011-03-22 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Decladinosyl-macrolides with anti-inflammatory activity
US20080249034A1 (en) * 2005-03-21 2008-10-09 Zambon S.P.A. Use of Macrolides for Treating Intestinal Inflammation
ES2343748T3 (es) * 2005-07-06 2010-08-09 Zambon S.P.A. Formas cristalinas de compuestos macrolidos dotados de una actividad antiinflamatoria.
WO2007025089A2 (en) 2005-08-24 2007-03-01 Rib-X Pharmaceutical, Inc. Triazole compounds and methods of making and using the same
EP1934238B1 (en) * 2005-08-24 2017-06-28 Melinta Therapeutics, Inc. Triazole compounds and methods of making and using the same
PT1937642E (pt) 2005-10-19 2014-11-25 Teva Pharma Cristais de sódio de laquinimod, e processos para o fabrico dos mesmos
BRPI0619556A2 (pt) * 2005-12-08 2011-10-04 Pfizer processo para desmetilação de grupo 3' -dimetil amino de compostos eritromicina
EP2077271A4 (en) * 2006-05-01 2010-09-15 Taisho Pharmaceutical Co Ltd MACROLIDE DERIVATIVE
WO2008143729A2 (en) * 2007-02-28 2008-11-27 Rib-X Pharmaceuticals, Inc. Macrolide compounds and methods of making and using the same
CA2713776C (en) 2008-02-08 2018-06-05 Basilea Pharmaceutica Ag Macrolides as pde4 inhibitors
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
JP2012516305A (ja) * 2009-01-30 2012-07-19 グラクソ グループ リミテッド 好中球優位の炎症性疾患の治療のための９−デオキソ−９ａ−メチル−９ａ−アザ−９ａ−ホモエリスロマイシンａ誘導体
MX2011008074A (es) 2009-01-30 2011-08-17 Glaxo Group Ltd Macrolido anti-inflamatorio.
WO2011018510A1 (en) 2009-08-13 2011-02-17 Basilea Pharmaceutica Ag New macrolides and their use
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
CA2890194A1 (en) 2012-11-07 2014-05-15 Teva Pharmaceutical Industries Ltd. Amine salts of laquinimod
US20160046582A1 (en) 2013-03-14 2016-02-18 Teva Pharmaceutical Industries Ltd. Crystals of laquinimod sodium and improved process for the manufacture thereof
AU2014252462A1 (en) * 2013-04-10 2015-10-01 Probiotic Pharmaceuticals Aps Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect
GB201608236D0 (en) 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds
JP7495758B2 (ja) * 2020-01-08 2024-06-05 ベイジン コンティネント ファーマシューティカルズ カンパニー，リミテッド マクロライド化合物及びその慢性呼吸器疾患の治療用途

Family Cites Families (32)

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Publication number Priority date Publication date Assignee Title
GB1100504A (en) 1967-08-16 1968-01-24 Pliva Pharm & Chem Works Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
US3623784A (en) * 1969-11-05 1971-11-30 Massey Ferguson Ind Ltd Cabinet joint structure
US3725385A (en) 1970-11-02 1973-04-03 Abbott Lab Process for the demethylation of 3-amino macrolides
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IT1276901B1 (it) 1994-12-13 1997-11-03 Zambon Spa Derivati dell'eritromicina a 9-0-ossina dotati di attivita' antibiotica
FR2735694B1 (fr) 1995-06-20 1997-08-08 Roussel Uclaf Le cladinose a titre de medicament et les compositions pharmaceutiques les renfermant
FR2738571B1 (fr) * 1995-09-11 1997-10-17 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
AU714176B2 (en) * 1995-11-08 1999-12-23 Abbott Laboratories 3-deoxy-3-descladinose derivatives of erythromycins A and B
FR2745290B1 (fr) * 1996-02-28 1998-04-03 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
ZA987689B (en) * 1997-09-02 1999-02-24 Abbott Lab 3-descladinose 6-O substituted erythromycin derivatives
PT1025114E (pt) 1997-09-30 2004-07-30 Abbott Lab Derivados de eritromicina-cetolido 6-o-substituido 3'-n-modificados possuindo actividade antibacteriana
JPH11236395A (ja) * 1997-12-11 1999-08-31 Hokuriku Seiyaku Co Ltd エリスロマイシン誘導体
US5892008A (en) * 1997-12-16 1999-04-06 Abbott Laboratories Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
PT941998E (pt) 1998-03-03 2004-12-31 Pfizer Prod Inc Antibioticos macrolidos do tipo 3,6-cetal
IT1306205B1 (it) 1999-01-15 2001-05-30 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
DE19910159A1 (de) 1999-02-26 2000-09-14 Rosemarie Heis Spezifische lgY-Eidotterantikörper, ihre Gewinnung und ihre Verwendung
JP2000351793A (ja) * 1999-06-09 2000-12-19 Hokuriku Seiyaku Co Ltd エリスロマイシン誘導体
US6437106B1 (en) * 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
JP2001181294A (ja) * 1999-12-27 2001-07-03 Hokuriku Seiyaku Co Ltd エリスロマイシン誘導体
ITMI20021726A1 (it) * 2002-08-01 2004-02-02 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
ITMI20022292A1 (it) 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
US20060043226A1 (en) * 2004-08-24 2006-03-02 Keith Roozeboom Apparatus and method for grinding with staggered cutters
US7096915B2 (en) * 2004-11-05 2006-08-29 Hsiu-Man Yu Chen Tape-roll supporting device

Also Published As

Publication number Publication date
EP2258708A1 (en) 2010-12-08
NZ537992A (en) 2007-11-30
EP1529053B1 (en) 2011-05-18
AU2003269861B2 (en) 2010-01-21
KR20050037567A (ko) 2005-04-22
CO5720000A2 (es) 2007-01-31
ATE509938T1 (de) 2011-06-15
ES2364647T3 (es) 2011-09-08
BR0313162A (pt) 2005-07-05
WO2004013153A3 (en) 2004-04-08
CN100335491C (zh) 2007-09-05
CN1678620A (zh) 2005-10-05
RU2330856C2 (ru) 2008-08-10
WO2004013153A2 (en) 2004-02-12
US7488811B2 (en) 2009-02-10
IL166527A0 (en) 2006-01-15
ITMI20021726A1 (it) 2004-02-02
EP1529053A2 (en) 2005-05-11
JP2005538998A (ja) 2005-12-22
CA2493995A1 (en) 2004-02-12
US20060058246A1 (en) 2006-03-16
AU2003269861A1 (en) 2004-02-23
US7704960B2 (en) 2010-04-27
US20090054357A1 (en) 2009-02-26
CA2493995C (en) 2011-01-04
JP4589110B2 (ja) 2010-12-01
RU2005105592A (ru) 2005-08-27
KR101051369B1 (ko) 2011-07-22
HRP20050195A2 (en) 2005-12-31
HRP20050195B1 (hr) 2013-10-25

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