HRP20041230B1 - Postupak pripreme sterilnog pripravka hijaluronske kiseline visoke molekularne težine - Google Patents

Postupak pripreme sterilnog pripravka hijaluronske kiseline visoke molekularne težine

Info

Publication number
HRP20041230B1
HRP20041230B1 HRP20041230AA HRP20041230A HRP20041230B1 HR P20041230 B1 HRP20041230 B1 HR P20041230B1 HR P20041230A A HRP20041230A A HR P20041230AA HR P20041230 A HRP20041230 A HR P20041230A HR P20041230 B1 HRP20041230 B1 HR P20041230B1
Authority
HR
Croatia
Prior art keywords
molecular weight
high molecular
preparing
hyaluronic acid
weight hyaluronic
Prior art date
Application number
HRP20041230AA
Other languages
English (en)
Inventor
Stefano Carlino
Original Assignee
Laboratoire Medidom S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31502852&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20041230(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Laboratoire Medidom S.A. filed Critical Laboratoire Medidom S.A.
Publication of HRP20041230A2 publication Critical patent/HRP20041230A2/xx
Publication of HRP20041230B1 publication Critical patent/HRP20041230B1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)

Abstract

Postupak pripreme sterilnog vodenog pripravka soli hijaluronske kiseline visoke molekularne težine određene koncentracije spremnog za upotrebu sadrži slijedeće korake: pribavljanje vodenog pripravka hijaluronske kiseline visoke molekularne težine koncentracije manje nego što se želi u finalnom pripravku; propuštanje naznačenog vodenog pripravka kroz filter koji ima pore manje od 0.45µm; koncentriranje naznačenog vodenog pripravka korištenjem vakuuma te isparavanjem vode sve dok se ne postigne određena željena koncentracija.
HRP20041230AA 2002-08-07 2004-12-30 Postupak pripreme sterilnog pripravka hijaluronske kiseline visoke molekularne težine HRP20041230B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02405681 2002-08-07
PCT/IB2003/003524 WO2004014399A1 (en) 2002-08-07 2003-08-04 Process for preparing a sterile high molecular weight hyaluronic acid formulation

Publications (2)

Publication Number Publication Date
HRP20041230A2 HRP20041230A2 (en) 2005-06-30
HRP20041230B1 true HRP20041230B1 (hr) 2013-02-28

Family

ID=31502852

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20041230AA HRP20041230B1 (hr) 2002-08-07 2004-12-30 Postupak pripreme sterilnog pripravka hijaluronske kiseline visoke molekularne težine

Country Status (21)

Country Link
US (1) US7939655B2 (hr)
EP (1) EP1526859B1 (hr)
JP (1) JP4597672B2 (hr)
KR (1) KR101169473B1 (hr)
CN (1) CN100366296C (hr)
AU (1) AU2003255892B2 (hr)
BR (1) BRPI0312669B8 (hr)
CA (1) CA2492739C (hr)
DK (1) DK1526859T3 (hr)
ES (1) ES2397382T3 (hr)
HK (1) HK1080715A1 (hr)
HR (1) HRP20041230B1 (hr)
IL (1) IL166231A (hr)
MX (1) MXPA05000533A (hr)
NO (1) NO334523B1 (hr)
NZ (1) NZ538019A (hr)
PL (1) PL217885B1 (hr)
PT (1) PT1526859E (hr)
SI (1) SI1526859T1 (hr)
WO (1) WO2004014399A1 (hr)
ZA (1) ZA200500259B (hr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1326883C (zh) * 2005-11-04 2007-07-18 山东福瑞达生物化工有限公司 一种透明质酸钙的制备方法
CN100478360C (zh) * 2006-10-31 2009-04-15 山东福瑞达生物化工有限公司 将浓缩用于透明质酸或其盐的生产的方法
WO2009063291A1 (en) 2007-11-13 2009-05-22 Bio-Technology General (Israel) Ltd. Dilute filtration sterilization process for viscoelastic biopolymers
KR101449687B1 (ko) * 2008-03-13 2014-10-14 주식회사 바이오랜드 저분자 및 고분자 히알루론산과 유근피로부터 분리된다당체 추출물을 함유하는 노화방지용 조성물
US8283463B2 (en) * 2010-02-09 2012-10-09 Bausch & Lomb Incorporated Sterile hyaluronic acid solutions
KR101379930B1 (ko) * 2011-12-12 2014-04-14 가톨릭대학교 산학협력단 후발성 백내장 억제용 조성물 및 이의 제조 방법
CN112118849A (zh) 2018-02-06 2020-12-22 瑞珍实验室 交联透明质酸及与prp/bmc的组合
CN118512390A (zh) * 2018-09-20 2024-08-20 香港科技大学 滴眼剂组合物
WO2020057606A1 (en) * 2018-09-20 2020-03-26 The Hong Kong University Of Science And Technology Eyedrop compositions

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
JPH0247101A (ja) * 1988-08-09 1990-02-16 Showa Sangyo Co Ltd 高分子量のヒアルロン酸を製造する方法
US5093487A (en) * 1986-01-06 1992-03-03 Mobay Corporation Low viscosity high molecular weight filter sterilizable hyaluronic acid
WO2000044925A1 (en) * 1999-01-28 2000-08-03 Chemedica S.A. Process for purifying high molecular weight hyaluronic acid
US20020120132A1 (en) * 2000-12-15 2002-08-29 Al Prescott Method for purifying high molecular weight hyaluronic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1251151B (it) * 1991-08-05 1995-05-04 Fidia Spa Materiale spugnoso essenzialmente costituito da acido ialuronico,o suoi derivati
IT1259090B (it) 1992-04-17 1996-03-11 Fidia Spa Biomaterialli per protesi d'osso
JP2844296B2 (ja) * 1993-06-29 1999-01-06 正樹 佐久間 真空濃縮装置
CN1064372C (zh) * 1994-08-26 2001-04-11 顾其胜 透明质酸钠制剂的制备方法
KR19980080116A (ko) 1997-03-27 1998-11-25 히라따 다다시 히알루론산 나트륨의 정제법
EP1217008B1 (en) 2000-12-19 2006-03-01 Seikagaku Corporation Photocurable hyaluronic acid derivative and process for producing the same, and photocured crosslinked hyaluronic acid derivative and medical material using the same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4141973B1 (hr) * 1975-10-17 1989-08-08
US5093487A (en) * 1986-01-06 1992-03-03 Mobay Corporation Low viscosity high molecular weight filter sterilizable hyaluronic acid
JPH0247101A (ja) * 1988-08-09 1990-02-16 Showa Sangyo Co Ltd 高分子量のヒアルロン酸を製造する方法
WO2000044925A1 (en) * 1999-01-28 2000-08-03 Chemedica S.A. Process for purifying high molecular weight hyaluronic acid
US20020120132A1 (en) * 2000-12-15 2002-08-29 Al Prescott Method for purifying high molecular weight hyaluronic acid

Also Published As

Publication number Publication date
JP2005536530A (ja) 2005-12-02
KR101169473B1 (ko) 2012-07-30
HRP20041230A2 (en) 2005-06-30
IL166231A0 (en) 2006-01-15
DK1526859T3 (da) 2013-02-04
CN100366296C (zh) 2008-02-06
PT1526859E (pt) 2013-01-25
NO20051181L (no) 2005-05-06
MXPA05000533A (es) 2005-04-19
US7939655B2 (en) 2011-05-10
IL166231A (en) 2011-10-31
CN1674920A (zh) 2005-09-28
AU2003255892B2 (en) 2008-02-21
BRPI0312669B1 (pt) 2015-08-11
EP1526859B1 (en) 2012-10-24
BR0312669A (pt) 2005-04-26
KR20050044900A (ko) 2005-05-13
NZ538019A (en) 2006-02-24
SI1526859T1 (sl) 2013-01-31
WO2004014399A1 (en) 2004-02-19
NO334523B1 (no) 2014-03-31
EP1526859A1 (en) 2005-05-04
JP4597672B2 (ja) 2010-12-15
CA2492739C (en) 2011-05-31
HK1080715A1 (en) 2006-05-04
ZA200500259B (en) 2005-12-28
PL373893A1 (en) 2005-09-19
AU2003255892A1 (en) 2004-02-25
BRPI0312669B8 (pt) 2021-05-25
US20060052336A1 (en) 2006-03-09
PL217885B1 (pl) 2014-08-29
ES2397382T3 (es) 2013-03-06
CA2492739A1 (en) 2004-02-19

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