HRP20040931A2 - Acyl-3-carboxyphenylurea derivatives, method for production and use thereof - Google Patents
Acyl-3-carboxyphenylurea derivatives, method for production and use thereof Download PDFInfo
- Publication number
- HRP20040931A2 HRP20040931A2 HR20040931A HRP20040931A HRP20040931A2 HR P20040931 A2 HRP20040931 A2 HR P20040931A2 HR 20040931 A HR20040931 A HR 20040931A HR P20040931 A HRP20040931 A HR P20040931A HR P20040931 A2 HRP20040931 A2 HR P20040931A2
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- cycloalkyl
- alkynyl
- phenyl
- alkenyl
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims description 91
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 66
- 239000013543 active substance Substances 0.000 claims description 32
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- 125000000217 alkyl group Chemical group 0.000 claims description 25
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 24
- 125000000304 alkynyl group Chemical group 0.000 claims description 20
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 18
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 18
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 18
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- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims description 12
- 125000000623 heterocyclic group Chemical group 0.000 claims description 12
- 229910052757 nitrogen Inorganic materials 0.000 claims description 12
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 12
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 10
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
- C07C275/48—Y being a hydrogen or a carbon atom
- C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10215908A DE10215908B4 (de) | 2002-04-11 | 2002-04-11 | Acyl-3-carboxyphenyl-harnstoffderivate und deren Verwendung als Arzneimittel |
| PCT/EP2003/003254 WO2003084923A1 (de) | 2002-04-11 | 2003-03-28 | Acyl-3-carboxyphenyl-harnstoffderivate, verfahren zu deren herstellung und deren verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20040931A2 true HRP20040931A2 (en) | 2005-02-28 |
Family
ID=28684936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20040931A HRP20040931A2 (en) | 2002-04-11 | 2004-10-07 | Acyl-3-carboxyphenylurea derivatives, method for production and use thereof |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1497263B1 (ja) |
| JP (1) | JP4328212B2 (ja) |
| KR (1) | KR20040097332A (ja) |
| CN (1) | CN1263734C (ja) |
| AR (1) | AR039402A1 (ja) |
| AT (1) | ATE404532T1 (ja) |
| AU (1) | AU2003232192A1 (ja) |
| BR (1) | BR0309130A (ja) |
| CA (1) | CA2481819A1 (ja) |
| DE (2) | DE10215908B4 (ja) |
| HK (1) | HK1075650A1 (ja) |
| HR (1) | HRP20040931A2 (ja) |
| HU (1) | HUP0500203A2 (ja) |
| IL (1) | IL164248A0 (ja) |
| MA (1) | MA27195A1 (ja) |
| MX (1) | MXPA04009239A (ja) |
| NO (1) | NO20044881L (ja) |
| NZ (1) | NZ535833A (ja) |
| PL (1) | PL371317A1 (ja) |
| RS (1) | RS88704A (ja) |
| RU (1) | RU2004133046A (ja) |
| TW (1) | TW200401765A (ja) |
| WO (1) | WO2003084923A1 (ja) |
| ZA (1) | ZA200407361B (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL164249A0 (en) * | 2002-04-11 | 2005-12-18 | Aventis Pharma Gmbh | Acyl-3-carboxphenylurea derivatives, processes forpreparing them and their use |
| DE10306502B4 (de) * | 2003-02-17 | 2005-03-17 | Aventis Pharma Deutschland Gmbh | Substituierte 3-(Benzoylureido)-thiophenderivate und sie enthaltende Arzneimittel |
| DE10308355A1 (de) | 2003-02-27 | 2004-12-23 | Aventis Pharma Deutschland Gmbh | Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| DE10308352A1 (de) | 2003-02-27 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| US7148246B2 (en) | 2003-02-27 | 2006-12-12 | Sanofi-Aventis Deutschland Gmbh | Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals |
| DE10308353A1 (de) | 2003-02-27 | 2004-12-02 | Aventis Pharma Deutschland Gmbh | Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10308351A1 (de) | 2003-02-27 | 2004-11-25 | Aventis Pharma Deutschland Gmbh | 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7241787B2 (en) | 2004-01-25 | 2007-07-10 | Sanofi-Aventis Deutschland Gmbh | Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments |
| EP1586573B1 (en) | 2004-04-01 | 2007-02-07 | Sanofi-Aventis Deutschland GmbH | Oxadiazolones, processes for their preparation and their use as pharmaceuticals |
| DE102005026762A1 (de) | 2005-06-09 | 2006-12-21 | Sanofi-Aventis Deutschland Gmbh | Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62111961A (ja) * | 1985-09-30 | 1987-05-22 | ユニオン・カ−バイド・コ−ポレ−シヨン | 殺虫性１−（４−アリ−ルオキシフエニル）−３−ベンゾイル尿素化合物及び製造方法 |
| GB9313268D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Chemical compounds |
| AP9600817A0 (en) * | 1995-06-06 | 1996-07-31 | Pfizer | Novel cryatal form of anhydrous 7-( [1A,5A,6A]-6-amino3-3-azabicyclo [3.1.0.] hex-3-yl) -6-fluro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt. |
| WO2000056707A1 (en) * | 1999-03-24 | 2000-09-28 | Sepracor, Inc. | Diaryl thioethers, compositions and uses thereof |
| AR028253A1 (es) * | 2000-03-16 | 2003-04-30 | Pfizer Prod Inc | Inhibidores de la glucogeno fosforilasa |
| SK17252002A3 (sk) * | 2000-06-09 | 2003-05-02 | Aventis Pharma Deutschland Gmbh | Deriváty acylfenylmočoviny, spôsoby ich výroby a použitie ako liečivo |
| GB0021831D0 (en) * | 2000-09-06 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| PE20021091A1 (es) * | 2001-05-25 | 2003-02-04 | Aventis Pharma Gmbh | Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion |
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Also Published As
| Publication number | Publication date |
|---|---|
| RS88704A (en) | 2007-02-05 |
| NO20044881L (no) | 2005-01-07 |
| AR039402A1 (es) | 2005-02-16 |
| DE10215908A1 (de) | 2003-11-06 |
| BR0309130A (pt) | 2005-02-01 |
| NZ535833A (en) | 2006-03-31 |
| WO2003084923A1 (de) | 2003-10-16 |
| CN1263734C (zh) | 2006-07-12 |
| IL164248A0 (en) | 2005-12-18 |
| DE50310320D1 (de) | 2008-09-25 |
| CA2481819A1 (en) | 2003-10-16 |
| HUP0500203A2 (hu) | 2005-06-28 |
| PL371317A1 (en) | 2005-06-13 |
| TW200401765A (en) | 2004-02-01 |
| KR20040097332A (ko) | 2004-11-17 |
| MA27195A1 (fr) | 2005-01-03 |
| MXPA04009239A (es) | 2005-01-25 |
| ZA200407361B (en) | 2006-02-22 |
| EP1497263A1 (de) | 2005-01-19 |
| CN1646486A (zh) | 2005-07-27 |
| EP1497263B1 (de) | 2008-08-13 |
| ATE404532T1 (de) | 2008-08-15 |
| DE10215908B4 (de) | 2005-08-18 |
| HK1075650A1 (en) | 2005-12-23 |
| JP4328212B2 (ja) | 2009-09-09 |
| RU2004133046A (ru) | 2005-04-20 |
| JP2005522481A (ja) | 2005-07-28 |
| AU2003232192A1 (en) | 2003-10-20 |
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