HRP20040560A2 - Solid salts benzazepine compounds and their use in the preparation of pharmaceuticals compounds - Google Patents

Solid salts benzazepine compounds and their use in the preparation of pharmaceuticals compounds Download PDF

Info

Publication number
HRP20040560A2
HRP20040560A2 HR20040560A HRP20040560A HRP20040560A2 HR P20040560 A2 HRP20040560 A2 HR P20040560A2 HR 20040560 A HR20040560 A HR 20040560A HR P20040560 A HRP20040560 A HR P20040560A HR P20040560 A2 HRP20040560 A2 HR P20040560A2
Authority
HR
Croatia
Prior art keywords
salt
compound
group
compounds
solution
Prior art date
Application number
HR20040560A
Other languages
English (en)
Croatian (hr)
Inventor
Joris
De Jong Paulus
Paulus
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of HRP20040560A2 publication Critical patent/HRP20040560A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR20040560A 2002-01-16 2003-01-15 Solid salts benzazepine compounds and their use in the preparation of pharmaceuticals compounds HRP20040560A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02075621 2002-01-16
NL1019762 2002-01-17
PCT/EP2003/000515 WO2003059939A1 (en) 2002-01-16 2003-01-15 Solid salts benzazepine compounds and their use in the preparation of pharmaceuticals compounds

Publications (1)

Publication Number Publication Date
HRP20040560A2 true HRP20040560A2 (en) 2004-10-31

Family

ID=26077601

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20040560A HRP20040560A2 (en) 2002-01-16 2003-01-15 Solid salts benzazepine compounds and their use in the preparation of pharmaceuticals compounds

Country Status (15)

Country Link
US (1) US6998398B2 (enExample)
EP (1) EP1468010A1 (enExample)
JP (1) JP4384495B2 (enExample)
KR (1) KR100979077B1 (enExample)
CN (1) CN100591689C (enExample)
AU (1) AU2003206755B2 (enExample)
BR (1) BR0306701A (enExample)
CA (1) CA2473447A1 (enExample)
HR (1) HRP20040560A2 (enExample)
IL (1) IL162645A0 (enExample)
MX (1) MXPA04006887A (enExample)
NO (1) NO330528B1 (enExample)
PL (1) PL371511A1 (enExample)
RU (1) RU2303041C2 (enExample)
WO (1) WO2003059939A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050009031A (ko) * 2003-07-15 2005-01-24 엘지전자 주식회사 1회 기록 가능한 광디스크 및 광디스크의 관리정보 기록방법
SA04250283B1 (ar) * 2003-09-26 2008-05-26 سولفاي فارماسيتيكالز جي أم بي أتش مشتقات من amidomethy1-substituted1-(carboxyalkyl)-cyclopentylcarbonylamino-benzazepine-N-acetic acid
AR046454A1 (es) * 2003-11-18 2005-12-07 Solvay Pharm Gmbh Uso de un compuesto de acido benzazepin-n-acetico, composicion farmaceutica, y procedimiento para la produccion de dicha composicion farmaceutica
US20050267124A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous producing system and PDEV inhibiitors
MX2007006279A (es) 2004-12-15 2007-06-14 Solvay Pharm Gmbh Composiciones farmaceuticas que comprenden inhibidores de nep, inhibidores del sistema de produccion de endotelina endogena, e inhibidores de hmg coa-reductasa.
US20060159748A1 (en) * 2004-12-23 2006-07-20 Rajesh Jain Oral immediate release formulation of a poorly water-soluble active substance
US20060205625A1 (en) * 2005-02-18 2006-09-14 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
WO2007054975A1 (en) * 2005-11-08 2007-05-18 Panacea Biotec Ltd Pharmaceutical compositions for the treatment of cardiovascular and other associated disorders
HU227696B1 (en) * 2006-04-13 2011-12-28 Egyt Gyogyszervegyeszeti Gyar Zinc salt of rosuvastatin, process for its preparation and pharmaceutical compositions containing it
PL424452A1 (pl) * 2018-01-31 2019-08-12 Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu
PL424453A1 (pl) 2018-01-31 2019-08-12 Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością Sposoby zmniejszania szkodliwego działania niedoboru perfuzji narządów miąższowych przez inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19638020A1 (de) * 1996-09-18 1998-03-19 Solvay Pharm Gmbh Die gastrointestinale Durchblutung fördernde Arzneimittel
DE19750002A1 (de) * 1997-11-12 1999-05-20 Solvay Pharm Gmbh Phosphonsäure-substituierte Benzazepinon-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19906310A1 (de) * 1999-02-16 2000-08-17 Solvay Pharm Gmbh Arzneimittel zur Behandlung von Bluthochdruck
DE19932555A1 (de) * 1999-07-13 2001-01-18 Solvay Pharm Gmbh Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen

Also Published As

Publication number Publication date
KR100979077B1 (ko) 2010-08-31
EP1468010A1 (en) 2004-10-20
US20050038012A1 (en) 2005-02-17
KR20040089106A (ko) 2004-10-20
CN1617883A (zh) 2005-05-18
AU2003206755B2 (en) 2008-07-17
NO330528B1 (no) 2011-05-09
JP4384495B2 (ja) 2009-12-16
IL162645A0 (en) 2005-11-20
RU2303041C2 (ru) 2007-07-20
US6998398B2 (en) 2006-02-14
CN100591689C (zh) 2010-02-24
BR0306701A (pt) 2004-12-28
JP2005520809A (ja) 2005-07-14
RU2004124840A (ru) 2006-01-20
CA2473447A1 (en) 2003-07-24
MXPA04006887A (es) 2004-12-06
PL371511A1 (en) 2005-06-27
NO20043295L (no) 2004-08-06
WO2003059939A1 (en) 2003-07-24
HK1072946A1 (zh) 2005-09-16
AU2003206755A1 (en) 2003-07-30

Similar Documents

Publication Publication Date Title
FI108637B (fi) Menetelmä lääkeaineena käyttökelpoisen (+)-(S)-2-(3-bentsoyylifenyyli)propaanihapon trometamiinisuolan valmistamiseksi
CA2691442C (en) Antiviral compounds
KR101986272B1 (ko) 삼환식 화합물, 이를 포함하는 조성물 및 그의 용도
EP3784649B1 (en) Process for the synthesis of (s)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid
EA020489B1 (ru) Модуляторы фармакокинетических свойств лекарственных средств
HRP20040560A2 (en) Solid salts benzazepine compounds and their use in the preparation of pharmaceuticals compounds
EP0752992B1 (fr) DERIVES D'IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-4-ONE ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
CN101250183A (zh) 一种雷贝拉唑的光学异构体及其制备方法、医药用途
CN114929682B (zh) 苯并硫代吡喃酮类化合物的盐及其制备方法和用途
KR102170422B1 (ko) 토파시티닙의 신규 염, 이의 제조방법 및 이를 포함하는 약학 조성물
JP2005239611A (ja) ピラゾロピリミジン誘導体およびその用途
HUT75341A (en) New salts of 2-[(2,6-dichloro-phenyl)-amino]-phenyl-acetoxy-acetic acid with organic bases, pharmaceutical compns. contg. them and process for preparing the said compds.
CH641775A5 (fr) N-(1-methyl 2-pyrrolidinyl methyl) 2,3-dimethoxy 5-methylsulfamoyl benzamide et ses derives, son procede de preparation et composition le renferment.
TWI284039B (en) Solid salts of benzazepine compounds and their use in the preparation of pharmaceutical compounds
ZA200405263B (en) Solid salts benzazepine compounds and their use in the preparation of pharmaceutical compounds.
CA2744448A1 (en) Polymorphs
HK40113586A (en) Process for the synthesis of (s) 3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid
JPH10168090A (ja) アポトーシス誘導剤
HK1137993A (en) Solid salts benzazepine compounds and their use in the preparation of pharmaceuticals compounds
HK1072946B (en) Solid salts benzazepine compounds and their use in the preparation of pharmaceuticals compounds
HK40048148B (en) Process for the synthesis of (s)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid
HK40048148A (en) Process for the synthesis of (s)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid
CN103288664A (zh) 一种新的bapta衍生物、其制备方法及其医药用途
JPWO1997017972A1 (ja) コレステロール低下剤組成物

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
ODRP Renewal fee for the maintenance of a patent

Payment date: 20101223

Year of fee payment: 9

OBST Application withdrawn