CN100591689C - 苯并氮杂环庚三烯化合物的固体盐及其在制备药物化合物中的应用 - Google Patents

苯并氮杂环庚三烯化合物的固体盐及其在制备药物化合物中的应用 Download PDF

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Publication number
CN100591689C
CN100591689C CN03802391A CN03802391A CN100591689C CN 100591689 C CN100591689 C CN 100591689C CN 03802391 A CN03802391 A CN 03802391A CN 03802391 A CN03802391 A CN 03802391A CN 100591689 C CN100591689 C CN 100591689C
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CN
China
Prior art keywords
salt
salts
preparation
composition
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN03802391A
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English (en)
Chinese (zh)
Other versions
CN1617883A (zh
Inventor
J·A·范德尔登
P·P·G·德琼
P·F·C·范德梅杰
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Abbott Healthcare Products BV
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Solvay Pharmaceuticals BV
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Publication of CN1617883A publication Critical patent/CN1617883A/zh
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Publication of CN100591689C publication Critical patent/CN100591689C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN03802391A 2002-01-16 2003-01-15 苯并氮杂环庚三烯化合物的固体盐及其在制备药物化合物中的应用 Expired - Fee Related CN100591689C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP02075621.9 2002-01-16
EP02075621 2002-01-16
NL1019762 2002-01-17
NL1019762 2002-01-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN200910141767A Division CN101654437A (zh) 2002-01-16 2003-01-15 苯并氮杂环庚三烯化合物的固体盐及其在制备药物化合物中的应用

Publications (2)

Publication Number Publication Date
CN1617883A CN1617883A (zh) 2005-05-18
CN100591689C true CN100591689C (zh) 2010-02-24

Family

ID=26077601

Family Applications (1)

Application Number Title Priority Date Filing Date
CN03802391A Expired - Fee Related CN100591689C (zh) 2002-01-16 2003-01-15 苯并氮杂环庚三烯化合物的固体盐及其在制备药物化合物中的应用

Country Status (15)

Country Link
US (1) US6998398B2 (enExample)
EP (1) EP1468010A1 (enExample)
JP (1) JP4384495B2 (enExample)
KR (1) KR100979077B1 (enExample)
CN (1) CN100591689C (enExample)
AU (1) AU2003206755B2 (enExample)
BR (1) BR0306701A (enExample)
CA (1) CA2473447A1 (enExample)
HR (1) HRP20040560A2 (enExample)
IL (1) IL162645A0 (enExample)
MX (1) MXPA04006887A (enExample)
NO (1) NO330528B1 (enExample)
PL (1) PL371511A1 (enExample)
RU (1) RU2303041C2 (enExample)
WO (1) WO2003059939A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050009031A (ko) * 2003-07-15 2005-01-24 엘지전자 주식회사 1회 기록 가능한 광디스크 및 광디스크의 관리정보 기록방법
SA04250283B1 (ar) * 2003-09-26 2008-05-26 سولفاي فارماسيتيكالز جي أم بي أتش مشتقات من amidomethy1-substituted1-(carboxyalkyl)-cyclopentylcarbonylamino-benzazepine-N-acetic acid
AR046454A1 (es) * 2003-11-18 2005-12-07 Solvay Pharm Gmbh Uso de un compuesto de acido benzazepin-n-acetico, composicion farmaceutica, y procedimiento para la produccion de dicha composicion farmaceutica
US20050267124A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous producing system and PDEV inhibiitors
MX2007006279A (es) 2004-12-15 2007-06-14 Solvay Pharm Gmbh Composiciones farmaceuticas que comprenden inhibidores de nep, inhibidores del sistema de produccion de endotelina endogena, e inhibidores de hmg coa-reductasa.
US20060159748A1 (en) * 2004-12-23 2006-07-20 Rajesh Jain Oral immediate release formulation of a poorly water-soluble active substance
US20060205625A1 (en) * 2005-02-18 2006-09-14 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
WO2007054975A1 (en) * 2005-11-08 2007-05-18 Panacea Biotec Ltd Pharmaceutical compositions for the treatment of cardiovascular and other associated disorders
HU227696B1 (en) * 2006-04-13 2011-12-28 Egyt Gyogyszervegyeszeti Gyar Zinc salt of rosuvastatin, process for its preparation and pharmaceutical compositions containing it
PL424452A1 (pl) * 2018-01-31 2019-08-12 Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu
PL424453A1 (pl) 2018-01-31 2019-08-12 Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością Sposoby zmniejszania szkodliwego działania niedoboru perfuzji narządów miąższowych przez inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5783573A (en) * 1996-09-18 1998-07-21 Solvay Pharmaceuticals Gmbh Pharmaceuticals which promote gastrointestinal blood circulation
CN1217334A (zh) * 1997-11-12 1999-05-26 索尔瓦药物有限公司 磷酸取代的苯并氮杂卓酮－n－醋酸衍生物、制法和药物
CN1059436C (zh) * 1995-03-23 2000-12-13 索尔瓦药物有限公司 苯并氮杂䓬－、苯并氧氮杂䓬－和苯并硫氮杂䓬－n－乙酸衍生物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19906310A1 (de) * 1999-02-16 2000-08-17 Solvay Pharm Gmbh Arzneimittel zur Behandlung von Bluthochdruck
DE19932555A1 (de) * 1999-07-13 2001-01-18 Solvay Pharm Gmbh Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1059436C (zh) * 1995-03-23 2000-12-13 索尔瓦药物有限公司 苯并氮杂䓬－、苯并氧氮杂䓬－和苯并硫氮杂䓬－n－乙酸衍生物
US5783573A (en) * 1996-09-18 1998-07-21 Solvay Pharmaceuticals Gmbh Pharmaceuticals which promote gastrointestinal blood circulation
CN1217334A (zh) * 1997-11-12 1999-05-26 索尔瓦药物有限公司 磷酸取代的苯并氮杂卓酮－n－醋酸衍生物、制法和药物

Also Published As

Publication number Publication date
KR100979077B1 (ko) 2010-08-31
EP1468010A1 (en) 2004-10-20
US20050038012A1 (en) 2005-02-17
KR20040089106A (ko) 2004-10-20
CN1617883A (zh) 2005-05-18
AU2003206755B2 (en) 2008-07-17
NO330528B1 (no) 2011-05-09
JP4384495B2 (ja) 2009-12-16
IL162645A0 (en) 2005-11-20
RU2303041C2 (ru) 2007-07-20
US6998398B2 (en) 2006-02-14
HRP20040560A2 (en) 2004-10-31
BR0306701A (pt) 2004-12-28
JP2005520809A (ja) 2005-07-14
RU2004124840A (ru) 2006-01-20
CA2473447A1 (en) 2003-07-24
MXPA04006887A (es) 2004-12-06
PL371511A1 (en) 2005-06-27
NO20043295L (no) 2004-08-06
WO2003059939A1 (en) 2003-07-24
HK1072946A1 (zh) 2005-09-16
AU2003206755A1 (en) 2003-07-30

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