HRP20030834A2 - Novel sulfonic acid derivatives - Google Patents
Novel sulfonic acid derivatives Download PDFInfo
- Publication number
- HRP20030834A2 HRP20030834A2 HR20030834A HRP20030834A HRP20030834A2 HR P20030834 A2 HRP20030834 A2 HR P20030834A2 HR 20030834 A HR20030834 A HR 20030834A HR P20030834 A HRP20030834 A HR P20030834A HR P20030834 A2 HRP20030834 A2 HR P20030834A2
- Authority
- HR
- Croatia
- Prior art keywords
- benzyl
- piperazin
- oxo
- ethoxy
- alkyl
- Prior art date
Links
- 150000003458 sulfonic acid derivatives Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 158
- AFVFQIVMOAPDHO-UHFFFAOYSA-N methanesulfonic acid Substances CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 60
- 229940098779 methanesulfonic acid Drugs 0.000 claims description 58
- 150000003839 salts Chemical class 0.000 claims description 42
- 201000010099 disease Diseases 0.000 claims description 34
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 22
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 21
- 206010061218 Inflammation Diseases 0.000 claims description 20
- 230000001684 chronic effect Effects 0.000 claims description 20
- 125000001153 fluoro group Chemical group F* 0.000 claims description 20
- 208000015181 infectious disease Diseases 0.000 claims description 20
- 230000004054 inflammatory process Effects 0.000 claims description 20
- 230000001154 acute effect Effects 0.000 claims description 19
- 230000002265 prevention Effects 0.000 claims description 15
- 102000004500 CCR1 Receptors Human genes 0.000 claims description 14
- 108010017319 CCR1 Receptors Proteins 0.000 claims description 14
- 208000031886 HIV Infections Diseases 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 14
- 208000037803 restenosis Diseases 0.000 claims description 14
- 241000124008 Mammalia Species 0.000 claims description 12
- 125000001072 heteroaryl group Chemical group 0.000 claims description 11
- 125000005843 halogen group Chemical group 0.000 claims description 10
- 239000003937 drug carrier Substances 0.000 claims description 9
- 206010027654 Allergic conditions Diseases 0.000 claims description 8
- 201000001320 Atherosclerosis Diseases 0.000 claims description 8
- 208000023275 Autoimmune disease Diseases 0.000 claims description 8
- 206010006458 Bronchitis chronic Diseases 0.000 claims description 8
- 108700012434 CCL3 Proteins 0.000 claims description 8
- 102000000013 Chemokine CCL3 Human genes 0.000 claims description 8
- 208000037357 HIV infectious disease Diseases 0.000 claims description 8
- 206010006451 bronchitis Diseases 0.000 claims description 8
- 208000007451 chronic bronchitis Diseases 0.000 claims description 8
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 8
- 230000004968 inflammatory condition Effects 0.000 claims description 8
- 206010025135 lupus erythematosus Diseases 0.000 claims description 8
- 230000003612 virological effect Effects 0.000 claims description 8
- 238000002689 xenotransplantation Methods 0.000 claims description 8
- 230000002401 inhibitory effect Effects 0.000 claims description 7
- 230000003042 antagnostic effect Effects 0.000 claims description 6
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 5
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 5
- 108010055166 Chemokine CCL5 Proteins 0.000 claims description 4
- QPHMXMCMIVAMHA-OAHLLOKOSA-N [5-chloro-2-[2-[(2r)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]methanesulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Cl)=CC=2)CS(O)(=O)=O)C)N1CC1=CC=C(F)C=C1 QPHMXMCMIVAMHA-OAHLLOKOSA-N 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 3
- LRSUNAXOENULRV-OTOKDRCRSA-N 1-[5-bromo-2-[2-[(2R)-2-ethyl-4-[(4-fluorophenyl)methyl]piperazin-1-yl]-2-oxoethoxy]phenyl]ethanesulfonic acid Chemical compound BrC=1C=CC(=C(C=1)C(C)S(=O)(=O)O)OCC(=O)N1[C@@H](CN(CC1)CC1=CC=C(C=C1)F)CC LRSUNAXOENULRV-OTOKDRCRSA-N 0.000 claims description 2
- OYPOXEJAPMIVLW-KWCCSABGSA-N 1-[5-bromo-2-[2-[(2R)-4-[(3,4-difluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]pyridin-3-yl]ethanesulfonic acid Chemical compound BrC=1C=C(C(=NC=1)OCC(=O)N1[C@@H](CN(CC1)CC1=CC(=C(C=C1)F)F)C)C(C)S(=O)(=O)O OYPOXEJAPMIVLW-KWCCSABGSA-N 0.000 claims description 2
- NUZQMANMNUMOAL-GICMACPYSA-N 1-[5-bromo-2-[2-[(2R)-4-[(4-chlorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]pyridin-3-yl]ethanesulfonic acid Chemical compound BrC=1C=C(C(=NC=1)OCC(=O)N1[C@@H](CN(CC1)CC1=CC=C(C=C1)Cl)C)C(C)S(=O)(=O)O NUZQMANMNUMOAL-GICMACPYSA-N 0.000 claims description 2
- IMEDYHGOKLSKHN-GICMACPYSA-N 1-[5-bromo-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]pyridin-3-yl]ethanesulfonic acid Chemical compound BrC=1C=C(C(=NC=1)OCC(=O)N1[C@@H](CN(CC1)CC1=CC=C(C=C1)F)C)C(C)S(=O)(=O)O IMEDYHGOKLSKHN-GICMACPYSA-N 0.000 claims description 2
- YRDZAOQVTVKRRW-OTOKDRCRSA-N 1-[5-chloro-2-[2-[(2R)-2-ethyl-4-[(4-fluorophenyl)methyl]piperazin-1-yl]-2-oxoethoxy]phenyl]ethanesulfonic acid Chemical compound ClC=1C=CC(=C(C=1)C(C)S(=O)(=O)O)OCC(=O)N1[C@@H](CN(CC1)CC1=CC=C(C=C1)F)CC YRDZAOQVTVKRRW-OTOKDRCRSA-N 0.000 claims description 2
- LZQODEFYLJQRQT-KWCCSABGSA-N 1-[5-chloro-2-[2-[(2R)-4-[(3,4-difluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]pyridin-3-yl]ethanesulfonic acid Chemical compound ClC=1C=C(C(=NC=1)OCC(=O)N1[C@@H](CN(CC1)CC1=CC(=C(C=C1)F)F)C)C(C)S(=O)(=O)O LZQODEFYLJQRQT-KWCCSABGSA-N 0.000 claims description 2
- XCGHRRLCLBTYEM-GICMACPYSA-N 1-[5-chloro-2-[2-[(2R)-4-[(4-chlorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]pyridin-3-yl]ethanesulfonic acid Chemical compound ClC=1C=C(C(=NC=1)OCC(=O)N1[C@@H](CN(CC1)CC1=CC=C(C=C1)Cl)C)C(C)S(=O)(=O)O XCGHRRLCLBTYEM-GICMACPYSA-N 0.000 claims description 2
- FNBVVJKJDBTORG-GICMACPYSA-N 1-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]pyridin-3-yl]ethanesulfonic acid Chemical compound ClC=1C=C(C(=NC=1)OCC(=O)N1[C@@H](CN(CC1)CC1=CC=C(C=C1)F)C)C(C)S(=O)(=O)O FNBVVJKJDBTORG-GICMACPYSA-N 0.000 claims description 2
- VRUDKJPYVFRBBX-OAHLLOKOSA-N 2-[5-bromo-2-[2-[(2r)-4-[(3,4-difluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]ethanesulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Br)=CC=2)CCS(O)(=O)=O)C)N1CC1=CC=C(F)C(F)=C1 VRUDKJPYVFRBBX-OAHLLOKOSA-N 0.000 claims description 2
- CHDPNXNAVPGAAA-MRXNPFEDSA-N 2-[5-bromo-2-[2-[(2r)-4-[(4-chlorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]ethanesulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Br)=CC=2)CCS(O)(=O)=O)C)N1CC1=CC=C(Cl)C=C1 CHDPNXNAVPGAAA-MRXNPFEDSA-N 0.000 claims description 2
- PXWOBMRTPFXOGY-MRXNPFEDSA-N 2-[5-bromo-2-[2-[(2r)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]ethanesulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Br)=CC=2)CCS(O)(=O)=O)C)N1CC1=CC=C(F)C=C1 PXWOBMRTPFXOGY-MRXNPFEDSA-N 0.000 claims description 2
- AUIQCQWZFIWSSP-OAHLLOKOSA-N 2-[5-chloro-2-[2-[(2r)-4-[(3,4-difluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]ethanesulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Cl)=CC=2)CCS(O)(=O)=O)C)N1CC1=CC=C(F)C(F)=C1 AUIQCQWZFIWSSP-OAHLLOKOSA-N 0.000 claims description 2
- PAXVZZUONUBUPS-MRXNPFEDSA-N 2-[5-chloro-2-[2-[(2r)-4-[(4-chlorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]ethanesulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Cl)=CC=2)CCS(O)(=O)=O)C)N1CC1=CC=C(Cl)C=C1 PAXVZZUONUBUPS-MRXNPFEDSA-N 0.000 claims description 2
- GXLCEYKCEBPXFC-MRXNPFEDSA-N 2-[5-chloro-2-[2-[(2r)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]ethanesulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Cl)=CC=2)CCS(O)(=O)=O)C)N1CC1=CC=C(F)C=C1 GXLCEYKCEBPXFC-MRXNPFEDSA-N 0.000 claims description 2
- ZIHKEIPAQFVXNU-MRXNPFEDSA-N 3-[5-bromo-2-[2-[(2r)-4-[(3,4-difluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]propane-1-sulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Br)=CC=2)CCCS(O)(=O)=O)C)N1CC1=CC=C(F)C(F)=C1 ZIHKEIPAQFVXNU-MRXNPFEDSA-N 0.000 claims description 2
- AXTHMCMQGKXCBJ-QGZVFWFLSA-N 3-[5-bromo-2-[2-[(2r)-4-[(4-chlorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]propane-1-sulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Br)=CC=2)CCCS(O)(=O)=O)C)N1CC1=CC=C(Cl)C=C1 AXTHMCMQGKXCBJ-QGZVFWFLSA-N 0.000 claims description 2
- URRMRUXNUBCJDM-QGZVFWFLSA-N 3-[5-bromo-2-[2-[(2r)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]propane-1-sulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Br)=CC=2)CCCS(O)(=O)=O)C)N1CC1=CC=C(F)C=C1 URRMRUXNUBCJDM-QGZVFWFLSA-N 0.000 claims description 2
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- HNBSERWKRHKCMX-QGZVFWFLSA-N 3-[5-chloro-2-[2-[(2r)-4-[(4-chlorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]propane-1-sulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Cl)=CC=2)CCCS(O)(=O)=O)C)N1CC1=CC=C(Cl)C=C1 HNBSERWKRHKCMX-QGZVFWFLSA-N 0.000 claims description 2
- XLWPPEVBTQMFFH-QGZVFWFLSA-N 3-[5-chloro-2-[2-[(2r)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]propane-1-sulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Cl)=CC=2)CCCS(O)(=O)=O)C)N1CC1=CC=C(F)C=C1 XLWPPEVBTQMFFH-QGZVFWFLSA-N 0.000 claims description 2
- 229910006074 SO2NH2 Inorganic materials 0.000 claims description 2
- FRHLFLPPLAREKK-HXUWFJFHSA-N [5-bromo-2-[2-[(2r)-2-ethyl-4-[(4-fluorophenyl)methyl]piperazin-1-yl]-2-oxoethoxy]phenyl]methanesulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Br)=CC=2)CS(O)(=O)=O)CC)N1CC1=CC=C(F)C=C1 FRHLFLPPLAREKK-HXUWFJFHSA-N 0.000 claims description 2
- UESSYESONQWENT-CQSZACIVSA-N [5-bromo-2-[2-[(2r)-4-[(3,4-difluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]methanesulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Br)=CC=2)CS(O)(=O)=O)C)N1CC1=CC=C(F)C(F)=C1 UESSYESONQWENT-CQSZACIVSA-N 0.000 claims description 2
- RNWMNCCEEYEWPA-CYBMUJFWSA-N [5-bromo-2-[2-[(2r)-4-[(3,4-difluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]pyridin-3-yl]methanesulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Br)=CN=2)CS(O)(=O)=O)C)N1CC1=CC=C(F)C(F)=C1 RNWMNCCEEYEWPA-CYBMUJFWSA-N 0.000 claims description 2
- JSTGWXAWHCSFFA-OAHLLOKOSA-N [5-bromo-2-[2-[(2r)-4-[(4-chlorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]methanesulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Br)=CC=2)CS(O)(=O)=O)C)N1CC1=CC=C(Cl)C=C1 JSTGWXAWHCSFFA-OAHLLOKOSA-N 0.000 claims description 2
- OJPMXAXPLGPPPW-CQSZACIVSA-N [5-bromo-2-[2-[(2r)-4-[(4-chlorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]pyridin-3-yl]methanesulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Br)=CN=2)CS(O)(=O)=O)C)N1CC1=CC=C(Cl)C=C1 OJPMXAXPLGPPPW-CQSZACIVSA-N 0.000 claims description 2
- XSZZHSBIEJXDNP-OAHLLOKOSA-N [5-bromo-2-[2-[(2r)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]methanesulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Br)=CC=2)CS(O)(=O)=O)C)N1CC1=CC=C(F)C=C1 XSZZHSBIEJXDNP-OAHLLOKOSA-N 0.000 claims description 2
- XOTHDYWEBDXQRM-CQSZACIVSA-N [5-bromo-2-[2-[(2r)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]pyridin-3-yl]methanesulfonic acid Chemical compound C([C@H](N(CC1)C(=O)COC=2C(=CC(Br)=CN=2)CS(O)(=O)=O)C)N1CC1=CC=C(F)C=C1 XOTHDYWEBDXQRM-CQSZACIVSA-N 0.000 claims description 2
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- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29946101P | 2001-06-20 | 2001-06-20 | |
| PCT/IB2002/001403 WO2002102787A2 (fr) | 2001-06-20 | 2002-04-18 | Nouveaux derives d'acide sulfonique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20030834A2 true HRP20030834A2 (en) | 2004-08-31 |
Family
ID=23154893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20030834A HRP20030834A2 (en) | 2001-06-20 | 2003-10-14 | Novel sulfonic acid derivatives |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US6974817B2 (fr) |
| EP (1) | EP1430041A2 (fr) |
| JP (2) | JP3829136B2 (fr) |
| KR (1) | KR20040012956A (fr) |
| CN (1) | CN1529699A (fr) |
| AP (1) | AP1564A (fr) |
| AR (1) | AR036094A1 (fr) |
| BG (1) | BG108426A (fr) |
| BR (1) | BR0210531A (fr) |
| CA (1) | CA2447865C (fr) |
| CZ (1) | CZ20033455A3 (fr) |
| DO (1) | DOP2002000399A (fr) |
| EA (1) | EA006447B1 (fr) |
| EC (1) | ECSP034917A (fr) |
| EE (1) | EE200400023A (fr) |
| GT (1) | GT200200095A (fr) |
| HR (1) | HRP20030834A2 (fr) |
| HU (1) | HUP0400369A2 (fr) |
| IL (1) | IL158461A0 (fr) |
| IS (1) | IS6987A (fr) |
| MA (1) | MA27033A1 (fr) |
| MX (1) | MXPA03011954A (fr) |
| NO (1) | NO20035694D0 (fr) |
| OA (1) | OA12623A (fr) |
| PA (1) | PA8548501A1 (fr) |
| PE (1) | PE20030127A1 (fr) |
| PL (1) | PL366900A1 (fr) |
| SK (1) | SK15722003A3 (fr) |
| SV (1) | SV2003001099A (fr) |
| TN (1) | TNSN03140A1 (fr) |
| UA (1) | UA74266C2 (fr) |
| UY (1) | UY27338A1 (fr) |
| WO (1) | WO2002102787A2 (fr) |
| YU (1) | YU94103A (fr) |
| ZA (1) | ZA200307736B (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040012956A (ko) * | 2001-06-20 | 2004-02-11 | 화이자 프로덕츠 인코포레이티드 | 설폰산 유도체 |
| US7655658B2 (en) * | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| US7456184B2 (en) * | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| US7732451B2 (en) * | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
| JP2005504043A (ja) * | 2001-08-10 | 2005-02-10 | パラチン テクノロジーズ インク． | 生物学的に活性な金属ペプチド類のペプチド模倣体類 |
| US7354923B2 (en) * | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US20040116441A1 (en) * | 2002-10-30 | 2004-06-17 | Pfizer Inc | Methods of using sulfonic acid derivatives |
| MXPA05009771A (es) | 2003-03-14 | 2005-10-26 | Ono Pharmaceutical Co | Derivados heterociclicos que contienen nitrogeno y medicamentos que los contienen como el ingrediente activo. |
| US7968548B2 (en) | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
| US20050119275A1 (en) * | 2003-06-24 | 2005-06-02 | Pfizer Inc. | Salt and crystal forms of (5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-phenyl)-methanesulfonic acid |
| US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| MX2007001215A (es) | 2004-08-06 | 2007-04-17 | Otsuka Pharma Co Ltd | Compuestos aromaticos. |
| AU2005283326B2 (en) | 2004-09-13 | 2011-07-21 | Ono Pharmaceutical Co., Ltd. | Nitrogenous heterocyclic derivative and medicine containing the same as an active ingredient |
| PT1957073E (pt) | 2005-12-05 | 2014-05-12 | Otsuka Pharma Co Ltd | Medicamento |
| BRPI0708731A2 (pt) | 2006-03-10 | 2011-06-07 | Ono Pharmaceutical Co | derivado heterocìclico nitrogenado, e agente farmacêutico compreendendo o derivado como ingrediente ativo |
| US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
| UA95978C2 (ru) | 2006-10-02 | 2011-09-26 | Оцука Фармас'Ютікел Ко., Лтд. | Ингибитор активации stat3/5 |
| US8716235B2 (en) * | 2012-04-18 | 2014-05-06 | Albert Einstein College Of Medicine Of Yeshiva University | Method for inhibiting metastasis by using anti-CCL3 antibodies |
| FR3029112A1 (fr) * | 2014-12-02 | 2016-06-03 | Pf Medicament | Dispersion solide a base de derives d'heteroarylsulfonamides a usage pharmaceutique |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE640616A (fr) | 1962-12-19 | |||
| US3492397A (en) | 1967-04-07 | 1970-01-27 | Warner Lambert Pharmaceutical | Sustained release dosage in the pellet form and process thereof |
| US4060598A (en) | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
| US3538214A (en) | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
| US4173626A (en) | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
| US6207665B1 (en) * | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| IL151923A0 (en) * | 2000-03-31 | 2003-04-10 | Pfizer Prod Inc | Novel piperazine derivatives |
| CA2423789A1 (fr) | 2000-10-19 | 2002-04-25 | Pfizer Products Inc. | Derives de piperazine pontes |
| KR20040012956A (ko) * | 2001-06-20 | 2004-02-11 | 화이자 프로덕츠 인코포레이티드 | 설폰산 유도체 |
-
2002
- 2002-04-18 KR KR10-2003-7016677A patent/KR20040012956A/ko not_active Application Discontinuation
- 2002-04-18 BR BR0210531-4A patent/BR0210531A/pt not_active IP Right Cessation
- 2002-04-18 UA UA20031211973A patent/UA74266C2/uk unknown
- 2002-04-18 IL IL15846102A patent/IL158461A0/xx unknown
- 2002-04-18 JP JP2003506260A patent/JP3829136B2/ja not_active Expired - Fee Related
- 2002-04-18 CN CNA028102207A patent/CN1529699A/zh active Pending
- 2002-04-18 MX MXPA03011954A patent/MXPA03011954A/es active IP Right Grant
- 2002-04-18 WO PCT/IB2002/001403 patent/WO2002102787A2/fr active Application Filing
- 2002-04-18 YU YU94103A patent/YU94103A/sh unknown
- 2002-04-18 CZ CZ20033455A patent/CZ20033455A3/cs unknown
- 2002-04-18 SK SK1572-2003A patent/SK15722003A3/sk not_active Application Discontinuation
- 2002-04-18 EA EA200301276A patent/EA006447B1/ru not_active IP Right Cessation
- 2002-04-18 HU HU0400369A patent/HUP0400369A2/hu unknown
- 2002-04-18 OA OA1200300324A patent/OA12623A/en unknown
- 2002-04-18 CA CA2447865A patent/CA2447865C/fr not_active Expired - Fee Related
- 2002-04-18 EP EP02722615A patent/EP1430041A2/fr not_active Withdrawn
- 2002-04-18 TN TNPCT/IB2002/001403A patent/TNSN03140A1/fr unknown
- 2002-04-18 PL PL02366900A patent/PL366900A1/xx not_active Application Discontinuation
- 2002-04-18 EE EEP200400023A patent/EE200400023A/xx unknown
- 2002-05-20 DO DO2002000399A patent/DOP2002000399A/es unknown
- 2002-05-22 GT GT200200095A patent/GT200200095A/es unknown
- 2002-06-18 PE PE2002000520A patent/PE20030127A1/es not_active Application Discontinuation
- 2002-06-18 UY UY27338A patent/UY27338A1/es not_active Application Discontinuation
- 2002-06-19 US US10/175,645 patent/US6974817B2/en not_active Expired - Fee Related
- 2002-06-19 AR ARP020102298A patent/AR036094A1/es unknown
- 2002-06-19 SV SV2002001099A patent/SV2003001099A/es not_active Application Discontinuation
- 2002-06-20 AP APAP/P/2002/002560A patent/AP1564A/en active
- 2002-06-20 PA PA20028548501A patent/PA8548501A1/es unknown
-
2003
- 2003-10-03 ZA ZA200307736A patent/ZA200307736B/en unknown
- 2003-10-09 IS IS6987A patent/IS6987A/is unknown
- 2003-10-14 HR HR20030834A patent/HRP20030834A2/hr not_active Application Discontinuation
- 2003-12-08 BG BG108426A patent/BG108426A/xx unknown
- 2003-12-10 MA MA27429A patent/MA27033A1/fr unknown
- 2003-12-19 NO NO20035694A patent/NO20035694D0/no not_active Application Discontinuation
- 2003-12-19 EC EC2003004917A patent/ECSP034917A/es unknown
-
2005
- 2005-07-15 US US11/182,996 patent/US20050250790A1/en not_active Abandoned
-
2006
- 2006-04-06 JP JP2006105403A patent/JP2006232846A/ja active Pending
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| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| OBST | Application withdrawn |