HRP20030671B1 - Process for the preparation of (e)-5-(2-bromvinil)-2'-deoxyuridine - Google Patents

Process for the preparation of (e)-5-(2-bromvinil)-2'-deoxyuridine

Info

Publication number
HRP20030671B1
HRP20030671B1 HR20030671A HRP20030671A HRP20030671B1 HR P20030671 B1 HRP20030671 B1 HR P20030671B1 HR 20030671 A HR20030671 A HR 20030671A HR P20030671 A HRP20030671 A HR P20030671A HR P20030671 B1 HRP20030671 B1 HR P20030671B1
Authority
HR
Croatia
Prior art keywords
formula
group
deoxyuridine
halogen
preparation
Prior art date
Application number
HR20030671A
Other languages
English (en)
Croatian (hr)
Inventor
Salimbeni Aldo
Alberto Maggi Carlo
Manzini Stefano
Turozzi Damiano
Original Assignee
Menarini Ricerche S.P.A.
Berlin-Chemie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7675814&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20030671(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Menarini Ricerche S.P.A., Berlin-Chemie Ag filed Critical Menarini Ricerche S.P.A.
Publication of HRP20030671A2 publication Critical patent/HRP20030671A2/hr
Publication of HRP20030671B1 publication Critical patent/HRP20030671B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HR20030671A 2001-02-28 2002-02-21 Process for the preparation of (e)-5-(2-bromvinil)-2'-deoxyuridine HRP20030671B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10109657A DE10109657A1 (de) 2001-02-28 2001-02-28 Verfahren zur Herstellung von (E)-5-(2-Bromvinyl)-2`-desoxyuridin
PCT/EP2002/001833 WO2002068443A1 (en) 2001-02-28 2002-02-21 Process for the preparation of (e)-5-(2-bromovinyl)-2'-deoxyuridine

Publications (2)

Publication Number Publication Date
HRP20030671A2 HRP20030671A2 (en) 2005-06-30
HRP20030671B1 true HRP20030671B1 (en) 2011-11-30

Family

ID=7675814

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20030671A HRP20030671B1 (en) 2001-02-28 2002-02-21 Process for the preparation of (e)-5-(2-bromvinil)-2'-deoxyuridine

Country Status (31)

Country Link
US (1) US6864366B2 (cs)
EP (1) EP1363928B1 (cs)
JP (1) JP2004521132A (cs)
KR (1) KR100853280B1 (cs)
CN (1) CN1219789C (cs)
AR (1) AR032908A1 (cs)
AT (1) ATE294810T1 (cs)
BG (1) BG66333B1 (cs)
BR (1) BRPI0207566B8 (cs)
CA (1) CA2439319C (cs)
CZ (1) CZ299318B6 (cs)
DE (2) DE10109657A1 (cs)
DK (1) DK1363928T3 (cs)
EA (1) EA006156B1 (cs)
EE (1) EE05249B1 (cs)
ES (1) ES2239713T3 (cs)
HR (1) HRP20030671B1 (cs)
HU (1) HU229136B1 (cs)
IL (2) IL157573A0 (cs)
MA (1) MA26267A1 (cs)
MX (1) MXPA03007624A (cs)
MY (1) MY133371A (cs)
PE (1) PE20020892A1 (cs)
PL (1) PL210150B1 (cs)
PT (1) PT1363928E (cs)
RS (1) RS50761B (cs)
SK (1) SK287283B6 (cs)
TN (1) TNSN03049A1 (cs)
UA (1) UA75110C2 (cs)
WO (1) WO2002068443A1 (cs)
ZA (1) ZA200306639B (cs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101066987B (zh) * 2007-06-14 2010-05-19 上海交通大学 溴呋啶的制备方法
LT3447061T (lt) 2011-03-01 2022-01-25 NuCana plc Farmacinė vaisto forma, apimanti 5-fluor-2'-deoksiuridinofosforamidato darinį, skirtą naudoti vėžio gydymui
GB201715011D0 (en) 2017-09-18 2017-11-01 Nucana Biomed Ltd Floxuridine synthesis
CN115043894A (zh) * 2022-06-22 2022-09-13 华润双鹤药业股份有限公司 一种溴夫定起始物料异构体单晶及其制备方法和应用
KR20240086637A (ko) 2022-12-10 2024-06-18 (주)일승 Ptc 히터

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB215399A (en) * 1922-11-07 1924-05-07 Frederic Valerius Hetzel Improvements in sprocket-wheels
DE2915254A1 (de) * 1978-04-24 1979-11-15 Stichting Rega V Z W Neue chemische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel mit antiviraler wirkung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU187736B (en) * 1982-08-04 1986-02-28 Mta Koezponti Kemiai Kutato Intezet,Hu Process for producing /e/ -5-/2-bromovinyl/-2-comma above-deoxyuridine and o-acyl derivatives
EP0512953B1 (de) * 1991-05-06 1995-06-07 Ciba-Geigy Ag Verfahren zur Herstellung von Benzolsulfonamiden

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB215399A (en) * 1922-11-07 1924-05-07 Frederic Valerius Hetzel Improvements in sprocket-wheels
DE2915254A1 (de) * 1978-04-24 1979-11-15 Stichting Rega V Z W Neue chemische verbindungen, verfahren zu deren herstellung und deren verwendung als arzneimittel mit antiviraler wirkung

Also Published As

Publication number Publication date
CA2439319A1 (en) 2002-09-06
PT1363928E (pt) 2005-07-29
EE05249B1 (et) 2009-12-15
ZA200306639B (en) 2004-08-26
DE10109657A1 (de) 2002-09-05
WO2002068443A1 (en) 2002-09-06
CA2439319C (en) 2010-10-19
EP1363928A1 (en) 2003-11-26
EA200300761A1 (ru) 2004-02-26
US20040077586A1 (en) 2004-04-22
HRP20030671A2 (en) 2005-06-30
PL363611A1 (en) 2004-11-29
CZ20032295A3 (cs) 2004-01-14
MY133371A (en) 2007-11-30
BRPI0207566B8 (pt) 2021-05-25
EP1363928B1 (en) 2005-05-04
ES2239713T3 (es) 2005-10-01
IL157573A (en) 2009-09-22
RS50761B (sr) 2010-08-31
BG108129A (bg) 2004-12-30
BRPI0207566B1 (pt) 2019-04-24
DE60203998T2 (de) 2005-09-22
CN1494550A (zh) 2004-05-05
US6864366B2 (en) 2005-03-08
BR0207566A (pt) 2004-09-14
UA75110C2 (en) 2006-03-15
JP2004521132A (ja) 2004-07-15
PE20020892A1 (es) 2002-12-26
BG66333B1 (bg) 2013-06-28
TNSN03049A1 (en) 2005-12-23
SK287283B6 (sk) 2010-05-07
AR032908A1 (es) 2003-12-03
DE60203998D1 (de) 2005-06-09
ATE294810T1 (de) 2005-05-15
HU229136B1 (en) 2013-08-28
MA26267A1 (fr) 2004-09-01
YU67103A (sh) 2006-05-25
KR20030081465A (ko) 2003-10-17
KR100853280B1 (ko) 2008-08-20
HUP0303323A3 (en) 2008-12-29
EE200300402A (et) 2003-12-15
PL210150B1 (pl) 2011-12-30
SK10642003A3 (sk) 2004-01-08
HK1060134A1 (en) 2004-07-30
CZ299318B6 (cs) 2008-06-18
IL157573A0 (en) 2004-03-28
CN1219789C (zh) 2005-09-21
MXPA03007624A (es) 2003-12-04
DK1363928T3 (da) 2005-12-12
HUP0303323A2 (hu) 2004-01-28
EA006156B1 (ru) 2005-10-27

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