DE60203998D1 - Verfahren zur herstellung von (e)-5-(2-bromovinyl)-2'-deoxyuridin - Google Patents

Verfahren zur herstellung von (e)-5-(2-bromovinyl)-2'-deoxyuridin

Info

Publication number
DE60203998D1
DE60203998D1 DE60203998T DE60203998T DE60203998D1 DE 60203998 D1 DE60203998 D1 DE 60203998D1 DE 60203998 T DE60203998 T DE 60203998T DE 60203998 T DE60203998 T DE 60203998T DE 60203998 D1 DE60203998 D1 DE 60203998D1
Authority
DE
Germany
Prior art keywords
bromovinyl
deoxyuridine
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60203998T
Other languages
English (en)
Other versions
DE60203998T2 (de
Inventor
Aldo Salimbeni
Alberto Maggi
Stefano Manzini
Damiano Turozzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Berlin Chemie AG
Menarini Ricerche SpA
Original Assignee
Berlin Chemie AG
Menarini Ricerche SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7675814&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60203998(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Berlin Chemie AG, Menarini Ricerche SpA filed Critical Berlin Chemie AG
Priority to DE60203998T priority Critical patent/DE60203998T2/de
Publication of DE60203998D1 publication Critical patent/DE60203998D1/de
Application granted granted Critical
Publication of DE60203998T2 publication Critical patent/DE60203998T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60203998T 2001-02-28 2002-02-21 Verfahren zur herstellung von (e)-5-(2-bromovinyl)-2'-deoxyuridin Expired - Lifetime DE60203998T2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE60203998T DE60203998T2 (de) 2001-02-28 2002-02-21 Verfahren zur herstellung von (e)-5-(2-bromovinyl)-2'-deoxyuridin

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10109657A DE10109657A1 (de) 2001-02-28 2001-02-28 Verfahren zur Herstellung von (E)-5-(2-Bromvinyl)-2`-desoxyuridin
DE10109657 2001-02-28
PCT/EP2002/001833 WO2002068443A1 (en) 2001-02-28 2002-02-21 Process for the preparation of (e)-5-(2-bromovinyl)-2'-deoxyuridine
DE60203998T DE60203998T2 (de) 2001-02-28 2002-02-21 Verfahren zur herstellung von (e)-5-(2-bromovinyl)-2'-deoxyuridin

Publications (2)

Publication Number Publication Date
DE60203998D1 true DE60203998D1 (de) 2005-06-09
DE60203998T2 DE60203998T2 (de) 2005-09-22

Family

ID=7675814

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10109657A Withdrawn DE10109657A1 (de) 2001-02-28 2001-02-28 Verfahren zur Herstellung von (E)-5-(2-Bromvinyl)-2`-desoxyuridin
DE60203998T Expired - Lifetime DE60203998T2 (de) 2001-02-28 2002-02-21 Verfahren zur herstellung von (e)-5-(2-bromovinyl)-2'-deoxyuridin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE10109657A Withdrawn DE10109657A1 (de) 2001-02-28 2001-02-28 Verfahren zur Herstellung von (E)-5-(2-Bromvinyl)-2`-desoxyuridin

Country Status (32)

Country Link
US (1) US6864366B2 (de)
EP (1) EP1363928B1 (de)
JP (1) JP2004521132A (de)
KR (1) KR100853280B1 (de)
CN (1) CN1219789C (de)
AR (1) AR032908A1 (de)
AT (1) ATE294810T1 (de)
BG (1) BG66333B1 (de)
BR (1) BRPI0207566B8 (de)
CA (1) CA2439319C (de)
CZ (1) CZ299318B6 (de)
DE (2) DE10109657A1 (de)
DK (1) DK1363928T3 (de)
EA (1) EA006156B1 (de)
EE (1) EE05249B1 (de)
ES (1) ES2239713T3 (de)
HK (1) HK1060134A1 (de)
HR (1) HRP20030671B1 (de)
HU (1) HU229136B1 (de)
IL (2) IL157573A0 (de)
MA (1) MA26267A1 (de)
MX (1) MXPA03007624A (de)
MY (1) MY133371A (de)
PE (1) PE20020892A1 (de)
PL (1) PL210150B1 (de)
PT (1) PT1363928E (de)
RS (1) RS50761B (de)
SK (1) SK287283B6 (de)
TN (1) TNSN03049A1 (de)
UA (1) UA75110C2 (de)
WO (1) WO2002068443A1 (de)
ZA (1) ZA200306639B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101066987B (zh) * 2007-06-14 2010-05-19 上海交通大学 溴呋啶的制备方法
US8933053B2 (en) 2011-03-01 2015-01-13 Nucana Biomed Limited Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer
GB201715011D0 (en) 2017-09-18 2017-11-01 Nucana Biomed Ltd Floxuridine synthesis
CN115043894A (zh) * 2022-06-22 2022-09-13 华润双鹤药业股份有限公司 一种溴夫定起始物料异构体单晶及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB215399A (en) * 1922-11-07 1924-05-07 Frederic Valerius Hetzel Improvements in sprocket-wheels
GB1601020A (en) 1978-04-24 1981-10-21 Stichting Grega Vzw 2'-deoxy-5 (2-halogenovinyl)-uridines
HU187736B (en) * 1982-08-04 1986-02-28 Mta Koezponti Kemiai Kutato Intezet,Hu Process for producing /e/ -5-/2-bromovinyl/-2-comma above-deoxyuridine and o-acyl derivatives
EP0512953B1 (de) * 1991-05-06 1995-06-07 Ciba-Geigy Ag Verfahren zur Herstellung von Benzolsulfonamiden

Also Published As

Publication number Publication date
BRPI0207566B1 (pt) 2019-04-24
BG108129A (bg) 2004-12-30
HUP0303323A3 (en) 2008-12-29
PL210150B1 (pl) 2011-12-30
BR0207566A (pt) 2004-09-14
CA2439319A1 (en) 2002-09-06
DE10109657A1 (de) 2002-09-05
HRP20030671A2 (en) 2005-06-30
JP2004521132A (ja) 2004-07-15
KR100853280B1 (ko) 2008-08-20
EA006156B1 (ru) 2005-10-27
RS50761B (sr) 2010-08-31
EE200300402A (et) 2003-12-15
CZ299318B6 (cs) 2008-06-18
BRPI0207566B8 (pt) 2021-05-25
TNSN03049A1 (en) 2005-12-23
EP1363928B1 (de) 2005-05-04
KR20030081465A (ko) 2003-10-17
DE60203998T2 (de) 2005-09-22
UA75110C2 (en) 2006-03-15
BG66333B1 (bg) 2013-06-28
CA2439319C (en) 2010-10-19
HRP20030671B1 (en) 2011-11-30
MXPA03007624A (es) 2003-12-04
IL157573A0 (en) 2004-03-28
EE05249B1 (et) 2009-12-15
WO2002068443A1 (en) 2002-09-06
CN1494550A (zh) 2004-05-05
MY133371A (en) 2007-11-30
CZ20032295A3 (cs) 2004-01-14
PE20020892A1 (es) 2002-12-26
HU229136B1 (en) 2013-08-28
SK287283B6 (sk) 2010-05-07
CN1219789C (zh) 2005-09-21
ATE294810T1 (de) 2005-05-15
YU67103A (sh) 2006-05-25
PL363611A1 (en) 2004-11-29
MA26267A1 (fr) 2004-09-01
ES2239713T3 (es) 2005-10-01
SK10642003A3 (sk) 2004-01-08
AR032908A1 (es) 2003-12-03
HUP0303323A2 (hu) 2004-01-28
IL157573A (en) 2009-09-22
US20040077586A1 (en) 2004-04-22
EA200300761A1 (ru) 2004-02-26
HK1060134A1 (en) 2004-07-30
EP1363928A1 (de) 2003-11-26
ZA200306639B (en) 2004-08-26
DK1363928T3 (da) 2005-12-12
US6864366B2 (en) 2005-03-08
PT1363928E (pt) 2005-07-29

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Legal Events

Date Code Title Description
8363 Opposition against the patent