HRP20020350A2 - Tetrahydrothiopy ranphtalazinone derivatives as pde4 inhibitors - Google Patents

Tetrahydrothiopy ranphtalazinone derivatives as pde4 inhibitors Download PDF

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Publication number
HRP20020350A2
HRP20020350A2 HR20020350A HRP20020350A HRP20020350A2 HR P20020350 A2 HRP20020350 A2 HR P20020350A2 HR 20020350 A HR20020350 A HR 20020350A HR P20020350 A HRP20020350 A HR P20020350A HR P20020350 A2 HRP20020350 A2 HR P20020350A2
Authority
HR
Croatia
Prior art keywords
substances
formula
alkoxy
image
hydrogen
Prior art date
Application number
HR20020350A
Other languages
English (en)
Croatian (hr)
Inventor
Armin Hatzelmann
Daniela Bundschuh
Hans-Peter Kley
Jan Geert Sterk
Ivonne Johanna Van Der Laan
Hendrik Timmermann
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of HRP20020350A2 publication Critical patent/HRP20020350A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR20020350A 1999-10-25 2000-10-24 Tetrahydrothiopy ranphtalazinone derivatives as pde4 inhibitors HRP20020350A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99121243 1999-10-25
US20395000P 2000-05-12 2000-05-12
PCT/EP2000/010445 WO2001030777A1 (en) 1999-10-25 2000-10-24 Tetrahydrothiopy ranphthalazinone derivatives as pde4 inhibitors

Publications (1)

Publication Number Publication Date
HRP20020350A2 true HRP20020350A2 (en) 2004-02-29

Family

ID=26153155

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020350A HRP20020350A2 (en) 1999-10-25 2000-10-24 Tetrahydrothiopy ranphtalazinone derivatives as pde4 inhibitors

Country Status (20)

Country Link
US (2) US6544993B1 (cs)
EP (1) EP1244654A1 (cs)
JP (1) JP2003512466A (cs)
KR (1) KR20020043238A (cs)
CN (1) CN1146562C (cs)
AU (1) AU781137B2 (cs)
BR (1) BR0014990A (cs)
CA (1) CA2388119A1 (cs)
CZ (1) CZ20021457A3 (cs)
EA (1) EA005856B1 (cs)
HK (1) HK1047276A1 (cs)
HR (1) HRP20020350A2 (cs)
HU (1) HUP0203487A2 (cs)
IL (1) IL148807A0 (cs)
MX (1) MXPA02003581A (cs)
NO (1) NO20021959L (cs)
PL (1) PL354979A1 (cs)
SK (1) SK7232002A3 (cs)
TR (1) TR200201128T2 (cs)
WO (1) WO2001030777A1 (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02003581A (es) * 1999-10-25 2002-10-23 Altana Pharma Ag Derivados de ranftalazinona de tetrahidrotiopia como inhibidores pde4.
AU2002234634B2 (en) * 2001-02-15 2007-07-26 Takeda Gmbh Phthalayinone-piperidino-derivatives as PDE4 inhibitors
SK14352003A3 (sk) * 2001-04-25 2004-04-06 Altana Pharma Ag Piperazino-deriváty, farmaceutický prostriedok s ich obsahom a ich použitie
HRP20030868A2 (en) 2001-04-25 2005-08-31 Altana Pharma Ag Novel phthalazinones
TWI347845B (en) * 2002-03-06 2011-09-01 Nycomed Gmbh Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same
AU2003260371A1 (en) * 2002-08-10 2004-03-11 Altana Pharma Ag Piperidine-n-oxide-derivatives
EP1537100B1 (en) 2002-08-10 2007-04-25 ALTANA Pharma AG Pyrrolidinedione substituted piperidine-phthalazones as pde4 inhibitors
HRP20050199A2 (hr) * 2002-08-10 2006-04-30 Altana Pharma Ag Novi derivati piridazinona
AU2003255376A1 (en) * 2002-08-10 2004-03-11 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
RS20050523A (sr) * 2003-01-14 2007-09-21 Altana Pharma Ag., Pde4 inhibitori za tretman neoplazmi limfocitnih ćelija
WO2005075437A1 (en) * 2004-02-04 2005-08-18 Altana Pharma Ag Pyridazinone derivatives and their use as pde4 inhibitors
ES2304692T3 (es) * 2004-02-04 2008-10-16 Nycomed Gmbh Derivados de 2-(piperidin-4-il)-4,5-dihidro-2h-piridazin-3-ona como inhibidores de pde4.
PT2589599E (pt) * 2004-03-03 2014-09-02 Takeda Gmbh Novas hidroxi-6-heteroarilfenantridinas e sua utilização como inibidores de pde4
PL2651417T3 (pl) * 2010-12-16 2017-08-31 Calchan Limited Pochodne pirolopirymidyny hamujące ASK1
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
NZ712180A (en) 2013-03-13 2017-01-27 Flatley Discovery Lab Llc Pyridazinone compounds and methods for the treatment of cystic fibrosis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9204808D0 (en) * 1992-03-04 1992-04-15 Rhone Poulenc Rorer Ltd Novel compositions of matter
PL309257A1 (en) 1992-12-02 1995-10-02 Pfizer Pirocatechin doethers as selective inhibitors of ped iv
DE19533975A1 (de) 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
WO1998031674A1 (en) * 1997-01-15 1998-07-23 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinones
WO1999031071A1 (en) 1997-12-15 1999-06-24 Byk Gulden Lomberg Chemische Fabrik Gmbh New phthalazinones
IL136359A (en) * 1997-12-15 2003-03-12 Byk Gulden Lomberg Chem Fab Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same
JP2002506856A (ja) 1998-03-14 2002-03-05 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング フタラジノンｐｄｅｉｉｉ／ｉｖ阻害剤
MXPA02003581A (es) * 1999-10-25 2002-10-23 Altana Pharma Ag Derivados de ranftalazinona de tetrahidrotiopia como inhibidores pde4.

Also Published As

Publication number Publication date
PL354979A1 (en) 2004-03-22
CA2388119A1 (en) 2001-05-03
AU1515101A (en) 2001-05-08
SK7232002A3 (en) 2002-09-10
HK1047276A1 (zh) 2003-02-14
BR0014990A (pt) 2002-06-18
HUP0203487A2 (hu) 2003-02-28
CN1382137A (zh) 2002-11-27
NO20021959D0 (no) 2002-04-25
IL148807A0 (en) 2002-09-12
EA005856B1 (ru) 2005-06-30
AU781137B2 (en) 2005-05-05
NO20021959L (no) 2002-05-29
JP2003512466A (ja) 2003-04-02
EP1244654A1 (en) 2002-10-02
US6544993B1 (en) 2003-04-08
CZ20021457A3 (cs) 2002-07-17
KR20020043238A (ko) 2002-06-08
MXPA02003581A (es) 2002-10-23
TR200201128T2 (tr) 2002-08-21
US20030166655A1 (en) 2003-09-04
US6846821B2 (en) 2005-01-25
WO2001030777A1 (en) 2001-05-03
CN1146562C (zh) 2004-04-21
EA200200381A1 (ru) 2002-10-31

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ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
OBST Application withdrawn