HRP20020238A2 - 4-benzylaminoquinoline conjugates with bile acid and their heteroanalogues, methods for producing the same, medicaments containing these compounds and their use - Google Patents

4-benzylaminoquinoline conjugates with bile acid and their heteroanalogues, methods for producing the same, medicaments containing these compounds and their use

Info

Publication number
HRP20020238A2
HRP20020238A2 HR20020238A HRP20020238A HRP20020238A2 HR P20020238 A2 HRP20020238 A2 HR P20020238A2 HR 20020238 A HR20020238 A HR 20020238A HR P20020238 A HRP20020238 A HR P20020238A HR P20020238 A2 HRP20020238 A2 HR P20020238A2
Authority
HR
Croatia
Prior art keywords
compounds
benzylaminoquinoline
heteroanalogues
conjugates
producing
Prior art date
Application number
HR20020238A
Other languages
English (en)
Inventor
Armin Hofmeister
Eugen Falk
Heinz-Werner Kleeman
Hans-Willi Jansen
Martin Bickel
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999145385 external-priority patent/DE19945385A1/de
Priority claimed from DE2000128193 external-priority patent/DE10028193A1/de
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of HRP20020238A2 publication Critical patent/HRP20020238A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
HR20020238A 1999-09-22 2000-09-06 4-benzylaminoquinoline conjugates with bile acid and their heteroanalogues, methods for producing the same, medicaments containing these compounds and their use HRP20020238A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1999145385 DE19945385A1 (de) 1999-09-22 1999-09-22 Substituierte 4-Benzylaminochinoline und ihre Heteroanlagen, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE2000128193 DE10028193A1 (de) 2000-06-09 2000-06-09 Substituierte 4-Benzylamminochinoline und ihre Heteroanalogen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika, sowie sie enthaltende Medikamente
PCT/EP2000/008691 WO2001021642A1 (de) 1999-09-22 2000-09-06 4-benzylaminochinoline konjugaten mit gallensaeure und ihre heteroanalogen, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und deren anwendung

Publications (1)

Publication Number Publication Date
HRP20020238A2 true HRP20020238A2 (en) 2004-04-30

Family

ID=26005994

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020238A HRP20020238A2 (en) 1999-09-22 2000-09-06 4-benzylaminoquinoline conjugates with bile acid and their heteroanalogues, methods for producing the same, medicaments containing these compounds and their use

Country Status (26)

Country Link
US (1) US6339077B1 (cs)
EP (1) EP1218401B1 (cs)
JP (1) JP4833471B2 (cs)
KR (1) KR20030010575A (cs)
CN (1) CN1158299C (cs)
AT (1) ATE269352T1 (cs)
AU (1) AU779412B2 (cs)
BR (1) BR0014233A (cs)
CA (1) CA2385445A1 (cs)
CZ (1) CZ2002992A3 (cs)
DE (1) DE50006842D1 (cs)
DK (1) DK1218401T3 (cs)
EE (1) EE200200143A (cs)
ES (1) ES2218222T3 (cs)
HK (1) HK1049169B (cs)
HR (1) HRP20020238A2 (cs)
HU (1) HUP0203045A3 (cs)
IL (1) IL148739A0 (cs)
NO (1) NO20021337L (cs)
NZ (1) NZ517899A (cs)
PL (1) PL353992A1 (cs)
PT (1) PT1218401E (cs)
RU (1) RU2247125C2 (cs)
SK (1) SK3862002A3 (cs)
WO (1) WO2001021642A1 (cs)
YU (1) YU19302A (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576644B2 (en) 2000-09-06 2003-06-10 Bristol-Myers Squibb Co. Quinoline inhibitors of cGMP phosphodiesterase
ITMI20021025A1 (it) * 2002-05-14 2003-11-14 Nicox Sa Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale
CZ301037B6 (cs) * 2007-09-06 2009-10-21 Vysoká škola chemicko-technologická v Praze Amidové konjugáty steroidních a žlucových kyselin s D-glukosaminem a zpusob jejich prípravy
BRPI1009854A2 (pt) * 2009-03-24 2015-08-25 Abbott Lab Processo para preparar composto antiviral
WO2011123693A1 (en) * 2010-04-02 2011-10-06 Senomyx, Inc. Sweet flavor modifier
SG10201606309WA (en) 2011-08-12 2016-09-29 Senomyx Inc Sweet flavor modifier
MX394005B (es) 2014-11-07 2025-03-24 Firmenich Incorporated Acidos 4-amino-5- (ciclohexiloxi) quinolina-3-carboxilicos sustituidos como modificadores del sabor dulce.
US12186329B2 (en) 2018-08-23 2025-01-07 President And Fellows Of Harvard College Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes
EP3890745A4 (en) 2018-12-04 2022-09-14 President and Fellows of Harvard College SYNTHETIC CHOLIC ACID 7-SULPHATE DERIVATIVES AND USES THEREOF

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789678A (en) * 1986-08-25 1988-12-06 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds
JPH0667846B2 (ja) * 1989-04-28 1994-08-31 一 滝川 利胆剤
IT1259419B (it) * 1991-05-24 1996-03-18 Erba Carlo Spa Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi
TW289021B (cs) * 1993-05-08 1996-10-21 Hoechst Ag
IT1274000B (it) * 1994-04-06 1997-07-14 Alfa Wassermann Spa Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi
DE4432708A1 (de) 1994-09-14 1996-03-21 Hoechst Ag Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
JPH09315979A (ja) * 1996-05-24 1997-12-09 Tokyo Tanabe Co Ltd 利胆剤
WO1998056757A1 (fr) * 1997-06-11 1998-12-17 Sankyo Company, Limited Derives de benzylamine

Also Published As

Publication number Publication date
JP4833471B2 (ja) 2011-12-07
EP1218401A1 (de) 2002-07-03
RU2247125C2 (ru) 2005-02-27
US6339077B1 (en) 2002-01-15
PT1218401E (pt) 2004-10-29
IL148739A0 (en) 2002-09-12
HK1049169B (zh) 2005-04-22
ATE269352T1 (de) 2004-07-15
JP2003510255A (ja) 2003-03-18
HK1049169A1 (en) 2003-05-02
DE50006842D1 (de) 2004-07-22
ES2218222T3 (es) 2004-11-16
CN1374968A (zh) 2002-10-16
NZ517899A (en) 2004-03-26
SK3862002A3 (en) 2003-01-09
NO20021337D0 (no) 2002-03-18
PL353992A1 (en) 2003-12-15
CN1158299C (zh) 2004-07-21
AU779412B2 (en) 2005-01-20
HUP0203045A3 (en) 2004-06-28
KR20030010575A (ko) 2003-02-05
YU19302A (sh) 2004-11-25
DK1218401T3 (da) 2004-10-04
HUP0203045A2 (hu) 2003-01-28
CZ2002992A3 (cs) 2002-06-12
NO20021337L (no) 2002-05-15
CA2385445A1 (en) 2001-03-29
AU7515600A (en) 2001-04-24
EE200200143A (et) 2003-04-15
EP1218401B1 (de) 2004-06-16
BR0014233A (pt) 2002-05-21
WO2001021642A1 (de) 2001-03-29

Similar Documents

Publication Publication Date Title
MY133732A (en) Sulfonylcarboxamide derivatives, process for their preparation and their use as medicines
MY139303A (en) Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof
AU2002218167A1 (en) N-phenyl-2-pyrimidine-amine derivatives
MY139302A (en) Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof
WO2004037807A3 (en) Medicinal arylethanolamine compounds
CA2258548A1 (en) Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
GEP20043269B (en) Purine Derivatives, Method for Their Production and Composition Containing the Same
WO2001019780A3 (de) Neuartige aminodicarbonsäurederivate mit pharmazeutischen eigenschaften
PT1416935E (pt) Derivados de 4-amino-6-fenil-pirrolo[2,3-d]pirimidina
WO2001019776A3 (de) Neuartige dicarbonsäurederivate mit pharmazeutischen eigenschaften
IL159843A0 (en) Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
IL148103A0 (en) Novel dicarboxylic acid derivatives with pharmaceutical properties
NZ516347A (en) Indanyl-substituted benzenecarboxamides, process for their preparation, their use as a medicament and pharmaceutical formulations containing them
ES2187300A1 (es) Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.
DE602004011966D1 (en) Heterocyclylverbindungen
ID29025A (id) Fenilalkenoilguanidina-fenilalkenoilguanidina yang disubstitusi asam empedu, proses pembuatannya, penggunaannya sebagai obat atau diaknostik dan obat-obat yang mengandungnya
IL150817A0 (en) Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases
ATE366107T1 (de) Verwendung von sulfodehydroabietinsäure zur behandlung entzündlicher darmerkrankungen
IL148739A0 (en) 4-benzylaminoquinoline conjugates with bile acid and their heteroanalogues, methods for producing the same, medicaments containing these compounds and their use
IL163608A (en) Sulfonanilides are conserved in their amino / amino acids and derivatives, their process, their pharmaceutical preparations, and their conjugated antibodies and their use in the preparation of drugs for the treatment of culture disorders
IL148250A0 (en) Bile acid-substituted phenyl-alkenoylguanidines, method for producing said phenyl-alkenoylguanidines, use thereof as medicaments or diagnostic reagents and medicaments containing the same
YU25202A (sh) Supstituisani piroli kao antiproliferativna sredstva za lečenje kancera
WO2001089282A3 (en) 2-amino-3-hydroxy-4-tert-leucyl-amino-5-phenyl-pentanoic acid amide derivatives
AP9801235A0 (en) Erythromycin derivatives.
MY126998A (en) Substituted pyrroles.

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, DE

OBST Application withdrawn