HRP20020074B1 - Conjugates and methods for the production thereof, and their use for transporting molecules via biological membranes - Google Patents
Conjugates and methods for the production thereof, and their use for transporting molecules via biological membranesInfo
- Publication number
- HRP20020074B1 HRP20020074B1 HR20020074A HRP20020074A HRP20020074B1 HR P20020074 B1 HRP20020074 B1 HR P20020074B1 HR 20020074 A HR20020074 A HR 20020074A HR P20020074 A HRP20020074 A HR P20020074A HR P20020074 B1 HRP20020074 B1 HR P20020074B1
- Authority
- HR
- Croatia
- Prior art keywords
- conjugates
- production
- methods
- biological membranes
- molecules via
- Prior art date
Links
- 239000012528 membrane Substances 0.000 title abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- AIDS & HIV (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19935302A DE19935302A1 (de) | 1999-07-28 | 1999-07-28 | Konjugate und Verfahren zu deren Herstellung sowie deren Verwendung zum Transport von Molekülen über biologische Membranen |
| PCT/EP2000/006936 WO2001008707A2 (de) | 1999-07-28 | 2000-07-20 | Konjugate und verfahren zu deren herstellung sowie deren verwendung zum transport von molekülen über biologische membranen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20020074A2 HRP20020074A2 (en) | 2005-10-31 |
| HRP20020074B1 true HRP20020074B1 (en) | 2011-01-31 |
Family
ID=7916258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20020074A HRP20020074B1 (en) | 1999-07-28 | 2002-01-25 | Conjugates and methods for the production thereof, and their use for transporting molecules via biological membranes |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US8420396B2 (ru) |
| EP (1) | EP1204430B1 (ru) |
| JP (1) | JP4791665B2 (ru) |
| KR (1) | KR100721696B1 (ru) |
| CN (1) | CN1227035C (ru) |
| AR (1) | AR029385A1 (ru) |
| AT (1) | ATE447413T1 (ru) |
| AU (1) | AU776114B2 (ru) |
| BR (1) | BR0012757A (ru) |
| CA (1) | CA2377977C (ru) |
| CY (1) | CY1109744T1 (ru) |
| CZ (1) | CZ2002300A3 (ru) |
| DE (2) | DE19935302A1 (ru) |
| DK (1) | DK1204430T3 (ru) |
| EE (1) | EE05303B1 (ru) |
| ES (1) | ES2335741T3 (ru) |
| HK (1) | HK1047042A1 (ru) |
| HR (1) | HRP20020074B1 (ru) |
| HU (1) | HUP0201995A3 (ru) |
| IL (2) | IL147527A0 (ru) |
| ME (1) | MEP56408A (ru) |
| MX (1) | MXPA01013114A (ru) |
| NO (1) | NO334155B1 (ru) |
| NZ (1) | NZ516838A (ru) |
| PL (1) | PL202881B1 (ru) |
| PT (1) | PT1204430E (ru) |
| RS (2) | RS20100249A (ru) |
| RU (1) | RU2275936C2 (ru) |
| SI (1) | SI1204430T1 (ru) |
| SK (1) | SK287654B6 (ru) |
| TR (4) | TR200200222T2 (ru) |
| WO (1) | WO2001008707A2 (ru) |
| ZA (1) | ZA200200657B (ru) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030129251A1 (en) * | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
| US7026166B2 (en) * | 2002-01-22 | 2006-04-11 | Chiron Corporation | Fluorogenic dyes |
| US7704756B2 (en) | 2003-01-21 | 2010-04-27 | Novartis Vaccines And Diagnostics, Inc. | Fluorogenic dyes |
| ATE520784T1 (de) * | 2003-09-11 | 2011-09-15 | Universitaetsklinikum Schleswig Holstein Campus Luebeck | Den transmembrantransport von nukleinsäuren fördernde nukleotidsequenzen |
| JP4989225B2 (ja) * | 2003-09-25 | 2012-08-01 | コーリー ファーマシューティカル グループ，インコーポレイテッド | 核酸親油性接合体 |
| EP1645288A1 (en) * | 2004-10-07 | 2006-04-12 | CTG Pharma S.r.l. | New nuclear transcription factors regulators |
| KR100690199B1 (ko) * | 2006-04-20 | 2007-03-12 | 이화여자대학교 산학협력단 | 구리 이온 선택성을 갖는 플루오레세인 유도체, 이의제조방법 및 이를 이용한 생체 내 구리 이온 검출방법 |
| KR20100068422A (ko) * | 2007-10-09 | 2010-06-23 | 콜리 파마슈티칼 게엠베하 | 변경된 당 잔기를 함유하는 면역자극성 올리고뉴클레오티드 유사체 |
| MX342609B (es) | 2010-12-29 | 2016-10-06 | Hoffmann La Roche | Conjugados de molecula pequeña para suministro intracelular de acidos nucleicos. |
| WO2015179742A1 (en) * | 2014-05-23 | 2015-11-26 | Genzyme Corporation | Multiple oligonucleotide moieties on peptide carrier |
| US20180036312A1 (en) * | 2016-08-02 | 2018-02-08 | ISI Life Sciences Inc. | Novel Scaffolds for Intracellular Compound Delivery for the Detection of Cancer Cells |
| EP3493855A4 (en) * | 2016-08-02 | 2020-04-01 | ISI Life Sciences, Inc. | METHOD FOR DETECTION OF CANCER CELLS. |
| US10753942B2 (en) | 2017-05-15 | 2020-08-25 | Indicator Systems International, Inc. | Methods to detect remnant cancer cells |
| US10539567B2 (en) * | 2017-05-15 | 2020-01-21 | Indicator Systems International, Inc. | Biopsy methods and devices |
| KR20230096856A (ko) | 2021-12-22 | 2023-06-30 | 한국과학기술연구원 | 신규 펩타이드-올리고뉴클레오티드 접합체 및 이의 용도 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995006659A1 (en) * | 1992-07-01 | 1995-03-09 | Isis Pharmaceuticals, Inc. | Amine-derivatized nucleosides and oligonucleosides |
| EP0962497A1 (de) * | 1998-06-03 | 1999-12-08 | Roche Diagnostics GmbH | Rhodamin-Derivate und deren Verwendung in diagnostischen Systemen |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8801070D0 (sv) * | 1988-03-23 | 1988-03-23 | Pharmacia Ab | Method for immobilizing a dna sequence on a solid support |
| US6228982B1 (en) * | 1992-05-22 | 2001-05-08 | Benget Norden | Double-stranded peptide nucleic acids |
| US6335434B1 (en) * | 1998-06-16 | 2002-01-01 | Isis Pharmaceuticals, Inc., | Nucleosidic and non-nucleosidic folate conjugates |
| US6033909A (en) * | 1992-01-22 | 2000-03-07 | Hoechst Aktiengesellschaft | Oligonucleotide analogs, their preparation and use |
| KR930016437A (ko) | 1992-01-22 | 1993-08-26 | 귀틀라인, 슈미트 | 올리고뉴클레오티드 유사체, 이의 제조방법 및 용도 |
| US5633360A (en) * | 1992-04-14 | 1997-05-27 | Gilead Sciences, Inc. | Oligonucleotide analogs capable of passive cell membrane permeation |
| US5820873A (en) * | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| DE19502912A1 (de) * | 1995-01-31 | 1996-08-01 | Hoechst Ag | G-Cap Stabilisierte Oligonucleotide |
| US5698411A (en) * | 1995-05-18 | 1997-12-16 | Coulter Corporation | Method for determining activity of enzymes in metabolically active whole cells |
| AU7737196A (en) * | 1996-11-14 | 1998-06-03 | Brigham And Women's Hospital | Polyphosphoinositide binding peptides for intracellular drug delivery |
| GB9809084D0 (en) | 1998-04-28 | 1998-06-24 | Nycomed Imaging As | Improvements in or relating to diagnostic/therapeutic agents |
| US6335432B1 (en) | 1998-08-07 | 2002-01-01 | Bio-Red Laboratories, Inc. | Structural analogs of amine bases and nucleosides |
| US6080580A (en) * | 1998-10-05 | 2000-06-27 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide modulation of tumor necrosis factor-α (TNF-α) expression |
| US7005123B1 (en) | 1999-06-17 | 2006-02-28 | Universiteit Gent | Functional poly-α-amino-acid derivatives useful for the modification of biologically active materials and their application |
-
1999
- 1999-07-28 DE DE19935302A patent/DE19935302A1/de not_active Ceased
-
2000
- 2000-07-20 TR TR2002/00222T patent/TR200200222T2/xx unknown
- 2000-07-20 AU AU68252/00A patent/AU776114B2/en not_active Ceased
- 2000-07-20 CA CA2377977A patent/CA2377977C/en not_active Expired - Fee Related
- 2000-07-20 RS RSP-2010/0249A patent/RS20100249A/en unknown
- 2000-07-20 EE EEP200200035A patent/EE05303B1/xx not_active IP Right Cessation
- 2000-07-20 ME MEP-564/08A patent/MEP56408A/xx unknown
- 2000-07-20 PL PL353069A patent/PL202881B1/pl not_active IP Right Cessation
- 2000-07-20 IL IL14752700A patent/IL147527A0/xx active IP Right Grant
- 2000-07-20 TR TR2011/09493T patent/TR201109493T2/xx unknown
- 2000-07-20 DK DK00956220.8T patent/DK1204430T3/da active
- 2000-07-20 BR BR0012757-4A patent/BR0012757A/pt not_active IP Right Cessation
- 2000-07-20 RU RU2002105016/15A patent/RU2275936C2/ru not_active IP Right Cessation
- 2000-07-20 WO PCT/EP2000/006936 patent/WO2001008707A2/de active Application Filing
- 2000-07-20 MX MXPA01013114A patent/MXPA01013114A/es active IP Right Grant
- 2000-07-20 CN CNB008091757A patent/CN1227035C/zh not_active Expired - Fee Related
- 2000-07-20 SK SK117-2002A patent/SK287654B6/sk not_active IP Right Cessation
- 2000-07-20 PT PT00956220T patent/PT1204430E/pt unknown
- 2000-07-20 AT AT00956220T patent/ATE447413T1/de active
- 2000-07-20 DE DE50015781T patent/DE50015781D1/de not_active Expired - Lifetime
- 2000-07-20 JP JP2001513437A patent/JP4791665B2/ja not_active Expired - Fee Related
- 2000-07-20 ES ES00956220T patent/ES2335741T3/es not_active Expired - Lifetime
- 2000-07-20 KR KR1020027001122A patent/KR100721696B1/ko not_active IP Right Cessation
- 2000-07-20 TR TR2011/09491T patent/TR201109491T2/xx unknown
- 2000-07-20 NZ NZ516838A patent/NZ516838A/en not_active IP Right Cessation
- 2000-07-20 TR TR2007/06709T patent/TR200706709T2/xx unknown
- 2000-07-20 SI SI200031052T patent/SI1204430T1/sl unknown
- 2000-07-20 RS YUP-903/01A patent/RS51447B/sr unknown
- 2000-07-20 CZ CZ2002300A patent/CZ2002300A3/cs unknown
- 2000-07-20 HU HU0201995A patent/HUP0201995A3/hu unknown
- 2000-07-20 EP EP00956220A patent/EP1204430B1/de not_active Expired - Lifetime
- 2000-07-26 AR ARP000103870A patent/AR029385A1/es unknown
-
2002
- 2002-01-08 IL IL147527A patent/IL147527A/en not_active IP Right Cessation
- 2002-01-23 NO NO20020367A patent/NO334155B1/no not_active IP Right Cessation
- 2002-01-24 ZA ZA200200657A patent/ZA200200657B/en unknown
- 2002-01-25 HR HR20020074A patent/HRP20020074B1/xx not_active IP Right Cessation
- 2002-11-29 HK HK02108623A patent/HK1047042A1/xx not_active IP Right Cessation
-
2007
- 2007-01-11 US US11/622,156 patent/US8420396B2/en not_active Expired - Fee Related
-
2010
- 2010-01-20 CY CY20101100058T patent/CY1109744T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995006659A1 (en) * | 1992-07-01 | 1995-03-09 | Isis Pharmaceuticals, Inc. | Amine-derivatized nucleosides and oligonucleosides |
| EP0962497A1 (de) * | 1998-06-03 | 1999-12-08 | Roche Diagnostics GmbH | Rhodamin-Derivate und deren Verwendung in diagnostischen Systemen |
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